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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 345-358页

作者： Zan Zhou Thomas Man-Hoi lok Wan-Huan Zhou Department of Civil and Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina

surface wave inversion is a key step in the application of surface waves to soil velocity ***,a common practice for the process of inversion is that the number of soil layers is assumed to be known before using heuristic search algorithms to compute the shear wave velocity profile or the number of soil layers is considered as an optimization ***,an improper selection of the number of layers may lead to an incorrect shear wave velocity *** this study,a deep learning and genetic algorithm hybrid learning procedure is proposed to perform the surface wave inversion without the need to assume the number of soil ***,a deep neural network is adapted to learn from a large number of synthetic dispersion curves for inferring the layer ***,the shear-wave velocity profile is determined by a genetic algorithm with the known layer *** applying this procedure to both simulated and real-world cases,the results indicate that the proposed method is reliable and efficient for surface wave inversion.

关键词： surface wave inversion analysis shear-wave velocity profile deep neural network genetic algorithm

spreadsheet quality assurance:a literature review

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frontiers of Computer science 2024年第2期18卷 61-82页

作者： Pak-lok POON Man fai LAU Yuen Tak YU sau-fun TANG school of Engineering and Technology Central Queensland UniversityMelbourne 3000Australia Department of Computing Technologies Swinburne University of TechnologyHawthorn 3122Australia Department of Computer science City University of Hong KongHong Kong SAR 999077China The Royal Victorian Eye and Ear Hospital East Melbourne 3002Australia

spreadsheets are very common for information processing to support decision making by both professional developers and non-technical end ***,business intelligence and artificial intelligence are increasingly popular in the industry nowadays,where spreadsheets have been used as,or integrated into,intelligent or expert systems in various application ***,it has been repeatedly reported that faults often exist in operational spreadsheets,which could severely compromise the quality of conclusions and decisions based on the *** a view to systematically examining this problem via survey of existing work,we have conducted a comprehensive literature review on the quality issues and related techniques of spreadsheets over a 35.5-year period(from January 1987 to June 2022)for target journals and a 10.5-year period(from January 2012 to June 2022)for target *** other findings,two major ones are:(a)spreadsheet quality is best addressed throughout the whole spreadsheet life cycle,rather than just focusing on a few specific stages of the life cycle.(b)Relatively more studies focus on spreadsheet testing and debugging(related to fault detection and removal)when compared with spreadsheet specification,modeling,and design(related to development).As prevention is better than cure,more research should be performed on the early stages of the spreadsheet life *** by our comprehensive review,we have identified the major research gaps as well as highlighted key research directions for future work in the area.

关键词： decision support system end-user computing end-user programming Excel spreadsheet

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乙型肝炎现行和最新疗法（节译）

传染病网络动态 2007年第1期 22-25页

作者： Anna s.f.lok 杨月（编译）

治疗乙型肝炎的目的是为了预防肝硬化、肝衰竭和肝癌（HCC）。在2006年治疗乙型肝炎方案的国家级研讨会上，提出了对乙型肝炎治疗应答的标准定义（表1）。该定义强调对于停止治疗的指征来说应答不是必要的，因为几乎所有获得治疗应答的... 详细信息

治疗乙型肝炎的目的是为了预防肝硬化、肝衰竭和肝癌（HCC）。在2006年治疗乙型肝炎方案的国家级研讨会上，提出了对乙型肝炎治疗应答的标准定义（表1）。该定义强调对于停止治疗的指征来说应答不是必要的，因为几乎所有获得治疗应答的患者仍持续携带着HBV。因此停止治疗通常伴随着病毒和生化的反弹，且肝炎复发和肝脏失代偿的病例罕见。

关键词：乙型肝炎新疗法治疗应答肝脏失代偿肝炎复发肝硬化肝衰竭国家级

A path planning algorithm for a crop monitoring fixed-wing unmanned aerial system

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science China(Information sciences) 2024年第8期67卷 5-23页

作者： Longhao QIAN Yi lok LO Hugh Hong-tao LIU Institute of Aerospace studies University of Toronto Department of Mechanical Engineering The University of Hong Kong

With the growing demand for automation in agriculture, industries increasingly rely on drones to perform crop monitoring and surveillance. In this regard, fixed-wing unmanned aerial systems(UAss)are viable platforms for scanning a large crop field, given their payload capacity and range. To achieve maximum coverage without landing for battery replacement, an algorithm for producing a minimal required energy survey path is essential. Hence, an energy-aware coverage path planning algorithm is proposed *** constraints for a fixed-wing UAs to fly at low altitudes while achieving full coverage of the crop field are first analyzed. Then, the full path is decomposed into straight-line and U-turn primitives. finally, an algorithm to calculate a combination of straight-line segments and U-turns is proposed to obtain the path with minimum required energy consumption. The genetic algorithm is used to efficiently determine the order of the straight-line paths to traverse. Case studies show that the proposed algorithm can produce planning results for a convex-polygon-shaped crop field.

关键词： aerial survey energy minimization fixed-wing UAs genetic algorithm path planning

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ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 721-722页

作者： Hiu Chuen lok Glenda M.Halliday Woojin scott Kim Brain and Mind Centre&school of Medical sciences The University of SydneySydneyNSWAustralia

ATP-binding cassette(ABC)transporters are ubiquitous membrane-bound proteins that are responsible for the translocation of a broad spectrum of substrates across cellular membranes,including lipids,amino acids,nucleosides,sugars,and ***,ABC transporters are highly expressed in the *** their functions in the brain still need to be elucidated,several members are implicated in the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease(AD),Parkinson’s disease(PD),and frontotemporal *** this perspective,we will review current knowledge of ABC transporters in the central nervous system in terms of physiological functions and pathology in ***,we will explore the possibilities of ABC transporters as potential targets in the development of therapeutics for neurodegenerative diseases.

关键词： sugar degenerative diseases

fE65:a hub for neurodevelopment

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Neural Regeneration Research 2024年第9期19卷 1883-1884页

作者： Yuqi Zhai Laura lok-Haang Ng Dennis Dik-Long Chau Kwok-fai Lau school of Life sciences Faculty of ScienceThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

fE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during ***65 belongs to the fE65 protein *** family is comprised of three memb... 详细信息

关键词： family development partner

Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi Tanaka Hyung-lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRIsPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRf2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCfA

（二）何时开始及终止治疗：不同感染年龄的乙型肝炎是否可用同一标准？

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传染病网络动态 2007年第9期 34-35页

作者： Bulent Degertekin Anna s.f.lok 刘旭华（编译）杨露绮（审校）

目前的乙型肝炎指南推荐只有HBV DNA高水平的活动期或进展期慢性乙型肝炎才进行抗病毒治疗，对于HBeAg阳性的乙肝患者发生HBeAg血清学转换后半年可以停药。本刊刊登Lai和Yuen的观点，认为这一标准不适用于围生期感染的慢性乙肝患者，他... 详细信息

目前的乙型肝炎指南推荐只有HBV DNA高水平的活动期或进展期慢性乙型肝炎才进行抗病毒治疗，对于HBeAg阳性的乙肝患者发生HBeAg血清学转换后半年可以停药。本刊刊登Lai和Yuen的观点，认为这一标准不适用于围生期感染的慢性乙肝患者，他们建议幼年期感染者即便是ALT正常也需要治疗，HBeAg阳性的乙肝患者发生HBeAg血清学转换后仍继续治疗。

关键词：慢性乙型肝炎终止治疗感染年龄 HBeAg阳性标准慢性乙肝患者血清学转换抗病毒治疗

Thermo-kinetic characteristics on stabilizing hetero-phase interface of metal matrix composites by crystal plasticity finite element method

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Journal of Materials science & Technology 2024年第2期169卷 53-67页

作者： Y.B.Zhang s.J.song f.Liu state Key Laboratory of solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an 710072China

Using dislocation-based constitutive modeling in three-dimension crystal plasticity finite element(3D CPfE)simulations,co-deformation and instability of hetero-phase interface in different material systems were herein studied for polycrystalline metal matrix composites(MMCs).Local stress and strain fields in two types of 3layer MMCs such as fcc/fcc Cu-Ag and fcc/bcc Cu-Nb have been predicted under simple compressive ***,more severe strain-induced interface instability can be observed in the fcc/bcc systems than in the fcc/fcc systems upon refining to metallic nanolayered composites(MNCs).By detailed analysis of stress and strain localization,it has been demonstrated that the interface instability is always accompanied by high-stress concentration,i.e.,thermodynamic characteristics,or high strain prevention i.e.,kinetic characteristics,at the hetero-phase *** then follows that the thermodynamic driving forceG and the kinetic energy barrier Q during dislocation and shear banding can be adopted to classify the deformation modes,following the so-called thermo-kinetic *** by inserting a high density of high-energy interfaces into the Cu-Nb composites,such thermo-kinetic integration at the hetero-phase interface allows a successful establishment of MMCs with the high△G-high Q deformation mode,which ensures high hardening and uniform strain distri-bution,thus efficiently suppressing the shear band,stabilizing the hetero-phase interface,and obtaining an exceptional combination in strength and *** hetero-phase interface chosen by a couple of thermodynamics and kinetics can be defined as breaking the thermo-kinetic correlation and has been proposed for artificially designing MNCs.

关键词： Thermodynamics and kinetics Physics-based constitutive modeling Hetero-phase interface Crystal plasticity finite element