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Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks María f Mascardi Adrián Gadano sebastián Marciano Instituto de Medicina Traslacional e Ingeniería Biomédica-Consejo Nacional de Investigaciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MAsLD)risk *** ability to identify patients with MAsLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MAsLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MAsLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MAsLD biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease Non-alcoholic steatohepatitis Biomarker Risk stratification Omics

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Leveraging User-Generated Comments and fused BiLsTM Models to Detect and Predict Issues with Mobile Apps

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Computers, Materials & Continua 2024年第4期79卷 735-759页

作者： Wael M.s.Yafooz Abdullah Alsaeedi Department of Computer science College of Computer Science and EngineeringTaibah UniversityMedina42353Saudi Arabia

In the last decade, technical advancements and faster Internet speeds have also led to an increasing number ofmobile devices and users. Thus, all contributors to society, whether young or old members, can use these mobileapps. The use of these apps eases our daily lives, and all customers who need any type of service can accessit easily, comfortably, and efficiently through mobile apps. Particularly, saudi Arabia greatly depends on digitalservices to assist people and visitors. such mobile devices are used in organizing daily work schedules and services,particularly during two large occasions, Umrah and Hajj. However, pilgrims encounter mobile app issues such asslowness, conflict, unreliability, or user-unfriendliness. Pilgrims comment on these issues on mobile app platformsthrough reviews of their experiences with these digital services. scholars have made several attempts to solve suchmobile issues by reporting bugs or non-functional requirements by utilizing user ***, solving suchissues is a great challenge, and the issues still exist. Therefore, this study aims to propose a hybrid deep learningmodel to classify and predict mobile app software issues encountered by millions of pilgrims during the Hajj andUmrah periods from the user perspective. firstly, a dataset was constructed using user-generated comments fromrelevant mobile apps using natural language processing methods, including information extraction, the annotationprocess, and pre-processing steps, considering a multi-class classification problem. Then, several experimentswere conducted using common machine learning classifiers, Artificial Neural Networks (ANN), Long short-TermMemory (LsTM), and Convolutional Neural Network Long short-Term Memory (CNN-LsTM) architectures, toexamine the performance of the proposed model. Results show 96% in f1-score and accuracy, and the proposedmodel outperformed the mentioned models.

关键词： Mobile apps issues play store user comments deep learning LsTM bidirectional LsTM

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Classical taxonomy,molecular phylogeny and genetic analysis of the genus Exitianus Ball,1929(Hemiptera:Cicadellidae:Deltocephalinae)from Egypt

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Zoological systematics 2024年第2期49卷 143-157页

作者： Rabab M.El-Hady Ahmed f.El-sayed survey&Taxonomy Department Plant Protection Research InstituteAgriculture Research CentreGizaEgypt Microbial Genetics Department Biotechnology Research InstituteNational Research CentreGizaEgypt Egypt Center for Research and Regenerative Medicine(ECRRM) CairoEgypt

Egyptian species of the leafhopper genus Exitianus Ball,1929,***(st?l,1855),***(Distant,1908),and *** Ross,1968 are ***,morphological descriptions,and a key for their identification are *** this study,we used molecular techniques to confirm morphological identification and detect phylogeny among the three Exitianus *** partial nucleotide sequences of the amplified products obtained were determined by Macrogen *** nucleotide sequences of 28s rDNA and COX genes of the EGY-ARC-9,EGY-ARC-4,and EGY-ARC-5 were determined by Macrogen Korea,blasted into BLAsT at the National Center for Biotechnology Information website(NCBI)and compared with those deposited in the GenBank DNA *** results represented the homology percentage between the partial sequences of the 28s rRNA and COX genes from each species and related species obtained from GenBank DNA *** morphological identifications of the three Exitianus species were confirmed by molecular characterization and sequencing of 28s rDNA and COX genes and identified as ***,***,and ***,their sequences of 28srDNA and COX genes were deposited in GenBank with an accession number(LC670610,LC670607,and OQ196105)for 28srDNA gene and(LC775357,LC775358,and LC775359)for the COX gene.

关键词： Auchenorrhyncha Chaismini taxonomic 28s rDNA phylogenetic

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Nb元素掺杂对亚稳相TbCu_(7)型smfe结构稳定性研究

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稀有金属 2024年第1期48卷 11-16页

作者：林笑罗阳王子龙于敦波肖伟杨伦伟有研稀土新材料股份有限公司北京100088 有研工程技术研究院有限公司材料计算中心北京100088

采用基于密度泛函理论的第一性原理计算方法结合实验数据研究Nb元素掺杂对亚稳相TbCu_(7)型smfe结构稳定性影响。进行了TbCu_(7)型smfe超胞的搭建,并由计算结果分析了晶胞参数c/a比值、Nb元素占位、高温下Nb元素占位及Nb含量对TbCu_(7)... 详细信息

采用基于密度泛函理论的第一性原理计算方法结合实验数据研究Nb元素掺杂对亚稳相TbCu_(7)型smfe结构稳定性影响。进行了TbCu_(7)型smfe超胞的搭建,并由计算结果分析了晶胞参数c/a比值、Nb元素占位、高温下Nb元素占位及Nb含量对TbCu_(7)结构稳定性影响。由计算结果可得,相对于fe-3g,fe-6l晶位,Nb元素取代fe-2e晶位时晶胞具有最低的结合能与形成能,说明Nb进入晶胞结构时优先占据fe-2e晶位,并且此时结构最稳定;当温度大于870℃时,Nb元素在fe-2e晶位的占位概率开始下降,fe-61,fe-3g晶位的概率开始升高。同时X射线衍射(XRD)图谱表明在850℃左右,TbCu_(7)型smfe开始向2∶17型smfe转变,这说明计算结果和实验结果可以很好地吻合起来,由此证明Nb元素占据fe-2e晶位对结构有很好的稳定作用;随着Nb含量的增加,晶胞发生膨胀,晶胞参数c/a比值开始增大,从另一方面也说明Nb元素的添加可以有效地稳定TbCu_(7)结构。

关键词：钐铁氮第一性原理亚稳相稳定性

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Comparisons of oxbow lake fish assemblages in relation to bigheaded carp establishment in the lower White River, Arkansas

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Ecological Processes 2024年第1期13卷 188-205页

作者： Michael A.Eggleton Cody J.salzmann Joseph E.Kaiser shannon C.f.smith Department of Aquaculture and fisheries University of Arkansas at Pine Bluff Arkansas Game and fish Commission Virginia Institute of Marine science

Background since the late 1990s, bigheaded carps(largely silver carp [Hypophthalmichthys molitrix] but also bighead carp [H. nobilis]) have established throughout the lower Mississippi River basin. Using previously studied oxbow lakes in the lower White River basin, Arkansas, we compared current(2017, “post-carp” establishment) fish assemblages to historical(2002, “pre-carp” establishment) fish assemblages. fish assemblages were comprehensively assessed using multiple gears, including boat electrofishing, mini-fyke nets, and experimental small-mesh gill *** T-tests suggested that fish assemblage indices of richness, diversity, evenness, and dominance were often greater(P st-carp period as reflected by boat electrofishing and experimental gill nets. However, all indices were generally similar(P > 0.05) between the pre-carp and post-carp period with fish assemblages depicted using mini-fyke nets. Nonmetric multidimensional scaling analyses indicated that fish assemblages differed structurally between pre-carp and post-carp periods. Assemblage differences were linked to both small and large abundance changes for more than 20 species. Abundances of gizzard shad(Dorosoma cepedianum), emerald shiner(Notropis atherinoides), pugnose minnow(Opsopoeodus emiliae), crappies(Pomoxis spp.), bluegill(Lepomis macrochirus), orangespotted sunfish(L. humilis), and yellow bass(Morone mississippiensis) declined between the pre-carp and postcarp periods. Conversely, abundances of weed shiner(N. texanus), pallid shiner(Hybopsis amnis), longear sunfish(L. megalotis), buffalofishes(Ictiobus spp.), and gars(Lepisosteus spp.) generally increased during the same *** Although not possible to conclude assemblage shifts were entirely related to bigheaded carps due to the absence of an appropriate reference system where carps did not establish, the wide establishment of these carps is one of the most pervasive changes to have occurred in the lower White

关键词： Bigheaded carp silver carp Aquatic nuisance species fish assemblage Oxbow lake Large river

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利用平面σ-芳香性增强电子输运能力

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化学学报 2024年第5期82卷 520-526页

作者：王治业肖博怀武汉科技大学耐火材料与冶金国家重点实验室先进材料和纳米技术研究院材料学部武汉430081

芳香性是有机化学中的重要概念,传统芳香族化合物的芳香性通常源于π电子在环上下平面产生的高度离域,而σ-芳香性则主要源于分子内σ键和轨道重叠,两者均能影响分子的电子传输能力.采用密度泛函理论结合非平衡格林函数(DfT+NEGf)方法... 详细信息

芳香性是有机化学中的重要概念,传统芳香族化合物的芳香性通常源于π电子在环上下平面产生的高度离域,而σ-芳香性则主要源于分子内σ键和轨道重叠,两者均能影响分子的电子传输能力.采用密度泛函理论结合非平衡格林函数(DfT+NEGf)方法对苯、噻吩和呋喃及其衍生物进行了芳香性和电子输运性质的系统研究.计算结果表明,苯、噻吩和呋喃分子的电子输运性质受π-芳香性和σ-芳香性影响,其中σ-芳香性和电子传输正相关,而π-芳香性和电子传输能力成负相关.含有两个芳香环的联苯二巯基(DB)、联噻吩二巯基(DT)和联呋喃二巯基(Df)分子的电子传输能力受分子平面化影响较大,Df中呋喃环表现出比DT中噻吩环更大的NICs(1)zz值.芳香性化合物具有更好的共平面趋势,通过f原子修饰DT和Df分子产生分子内f…s和f…O非共价相互作用的设计策略可以极大增加分子平面性和刚性.同时,含有分子内f…s和f…O相互作用的虚拟五元环具有平面σ-芳香性特征,有效促进电子沿f…s和f…O路径进行传输,从而提高电子传输能力.本研究有助于进一步理解分子芳香性与电子传输能力之间的内在关系,为未来设计更高效的电子器件提供策略.

关键词：芳香性电子传输平面性分子内相互作用密度泛函理论结合非平衡格林函数

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The global stability and optimal control of the COVID-19 epidemic model

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International Journal of Biomathematics 2024年第1期17卷 1-28页

作者： fengsheng Chien Hassan saberi Nik Mohammad shiraziant J.f.Gomez-Aguilar school of finance and Accounting fuzhou University of International studies and Trade fuzhou 352020 P.R.China faculty of Business City university of Macao Macao 999078P.R.China Department of Mathematics and statistics University of Neyshabur NeyshaburIran CONACyT-Tecnologico Nacional de Mécico/CENIDET Interior Internado Palmira s/N Col.Palmira C.P.62490CuernavacaMorelosMérico

This paper considers stability analysis of a susceptible-Exposed-Infected-Recovered-Virus(sEIRV)model with nonlinear incidence rates and indicates the severity and weakness of control factors for disease *** Lyapunov function using Volterra-Lyapunov matrices makes it possible to study the global stability of the endemic equilibrium *** optimal control strategy is proposed to prevent the spread of coronavirus,in addition to governmental *** objective is to minimize together with the quantity of infected and exposed individuals while minimizing the total costs of treatment.A numerical study of the model is also carried out to investigate the analytical results.

关键词： Global stability sEIRV epidemic model dynamical systems Volterra-Lyapunov stability optimal control

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Olefin Polymerization Behavior of Titanium(IV) Complexes with fluorinated and Non-fluorinated Aliphatic Phenoxyimine Ligands

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Chinese Journal of Polymer science 2024年第1期42卷 52-62,I0007页

作者： Vladislav A.Tuskaev Kasim f.Magomedov svetlana Ch.Gagieva Dmitry A.Kurmaev Yulia V.Nelyubina Evgenii K.Golubev Maria D.Evseeva Viktor G.Vasil'ev Galina G.Nikiforova Mikhail I.Buzin Vyacheslav s.Bogdanov Boris M.Bulychev Department of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enikolopov Institute of synthetic Polymer Materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dichloride and dialkoxide com plexes with phenoxyimine ligands containing fluorinated and nonfluorinated aliphatic imine fragments have been *** molecular structures of complexes 1 and 4 were established by single-crystal X-ray diffraction *** complexes adopt a distorted octahedral coordination structure around the titanium atom and two oxygen atoms are situated in trans position while two nitrogen atoms and two outgoing ligands(Cl or iPrO) are situated in cis *** of activators(MMAO-12 and combinations Et_nAICl_(3-n)+Bu_(2)Mg) and outgoing ligand(Cl or iPrO) nature on the catalytic activity and properties of the resulting polymers was *** Ti complexes,despite the nature of the outgoing ligands(Cl or iPrO) in the presence of Al/Mg activators,was found to display a high ethylene polymerization activity in the range 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·atm^(-1) with a viscosity average molecular weight(M_v) value in the range 1.1×10~6-7.1×10~6 Dalton(Da).The resulting UHMWPE can be processed by a solventless method into high-strength and high-modulus oriented *** rheological characteristics of a polymer melt have been *** absence of a cross-over point did not allow to compare the values of the molecular weight distribution of polymers obtained on fluorinated and non-fluorinated pre-catalysts,however,the estimation of the entanglement density is in good agreement with the mechanical characteristics of oriented film *** activation with methylalumoxane,the activity of the com plexes decreased very significantly;however,a polymer with a molecular weight of about 12 million Da was *** the process of ethylene/octene-1 copolymerization,fluorine-containing precatalysts showed a clear advantage over non-fluorinated analogues both in activity and in comonomer content.

关键词： fI catalysts Titanium(IV) (Co)polymerization Al/Mg co-catalyst Ultra-high molecular weight polyethylene

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TMEM16f may be a new therapeutic target for Alzheimer's disease

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Neural Regeneration Research 2023年第3期18卷 643-651页

作者： Zhi-Qiang Cui xiao-Ying Hu Tuo Yang Jing-Wei Guan Ying Gu Hui-Yuan Li Hui-Yu Zhang Qing-Huan xiao xiao-Hong sun Department of Neurology The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Ion Channel Pharmacology School of PharmacyChina Medical UniversityShenyangLiaoning ProvinceChina

TMEM16f is involved in many physiological processes such as blood coagulation,cell membrane fusion and bone *** of TMEM16f has been studied in various central nervous system *** TMEM16f level has been also found to participate in microglial phagocytosis and ***-mediated neuroinflammation is a key factor in promoting the progression of Alzheimer’s ***,few studies have examined the effects of TMEM16f on neuroinflammation in Alzheimer’s *** this study,we established TMEM16f-knockdown AD model in vitro and in vivo to investigate the underlying regulatory mechanism about TMEM16f-mediated neuroinflammation in *** performed a Morris water maze test to evaluate the spatial memory ability of animals and detected markers for the microglia M1/M2 phenotype and NLRP3 *** results showed that TMEM16f was elevated in 9-month-old APP/Ps1 *** TMEM16f knockdown in mice,spatial memory ability was improved,microglia polarization to the M2 phenotype was promoted,NLRP3 inflammasome activation was inhibited,cell apoptosis and Aβplaque deposition in brain tissue were reduced,and brain injury was *** used amyloid-beta(Aβ_(25-35))to stimulate human microglia to construct microglia models of Alzheimer’s *** levels of TMEM16f,inducible nitric oxide synthase(iNOs),proinflammatory cytokines and NLRP3 inflammasome-associated biomarkers were higher in Aβ_(25-35) treated group compared with that in the control ***16f knockdown enhanced the expression of the M2 phenotype biomarkers Arg1 and socs3,reduced the release of proinflammatory factors interleukin-1,interleukin-6 and tumor necrosis factor-α,and inhibited NLRP3 inflammasome activation through reducing downstream proinflammatory factors interleukin-1βand *** inhibitory effect of TMEM16f knockdown on M1 microglia was partially reversed by the NLRP3 agonist *** findings suggest that TMEM16f participates i

关键词： Alzheimer’s disease Aβplaque inflammatory cytokines M1 phenotype M2 phenotype microglia polarization neuroinflammation NLRP3 inflammasome siRNA TMEM16f

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Experimental implementation of phase triplicator gratings in a spatial light modulator

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Chinese Optics Letters 2024年第2期22卷 64-69页

作者：高尚 María del Mar sánchez-López Ignacio Moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de física Aplicada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Materiales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compare different methods for implementing a triplicator,a phase grating that generates three equiintense diffraction *** design with optimal efficiency features a continuous phase profile,which cannot be easily reproduced,and is typically affected by *** compare its performance with binary and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a random approach is adopted to eliminate the additional harmonic *** all cases,a liquid-crystal-on-silicon spatial light modulator is employed to experimentally verify and compare the different approaches.

关键词： diffraction gratings phase modulation triplicator spatial light modulators

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