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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

Research 2024年第2期2023卷 373-387页

作者： di Wu Yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical sciences Zhejang ProvinceChina Research Center for Life science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

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GUE via Frobenius *** Matrix Gravity to Topological Gravity and Back

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Acta Mathematica sinica,English series 2024年第1期40卷 383-405页

作者： di YANG school of Mathematical sciences University of Science and Technology of ChinaHefei 230026P.R.China

Dubrovin establishes a certain relationship between the GUE partition function and the partition function of Gromov-Witten invariants of the complex projective *** this paper,we give a direct proof of Dubrovin’s *** ... 详细信息

关键词： Frobenius manifold Dubrovin-Zhang hierarchy GUE Toda lattice hierarchy jet space topological gravity matrix gravity

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New food sources and production systems:a comparison of international regulations and China’s advancements in novel foods with synthetic biology

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Food science and Human Wellness 2024年第5期13卷 2519-2542页

作者： Xin Liu di Wu Yi shao Yongning Wu Key Laboratory for Deep Processing of Major Grain and Oil(The Chinese Ministry of Education) College of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China Institute for Global Food security School of Biological SciencesBelfast B795DLUnited Kingdom NHC Key Laboratory of Food safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100021China Department of Nutrition and Food safety Peking Union Medical CollegeResearch Unit of Food SafetyChinese Academy of Medical SciencesBeijing 100021China

The global shift towards sustainable food systems has sparked innovations in food sources and production systems,including cell-based meat,plant-based food products,precision fermentation,and 3D food *** advancements pose regulatory challenges and opportunities,with China emerging as a critical player in adopting and regulating new food *** review explores the international landscape of new food sources and production systems(NFPs),focusing on China’s role and regulatory approaches compared to global *** this comparative analysis,we aim to contribute to the ongoing dialogue on food safety regulation,offering insights and recommendations for policymakers,industry stakeholders,and researchers engaged in the global food system’s *** comprehensive overview underscores the dynamic nature of regulatory frameworks governing NFPs,highlighting the international efforts to ensure food safety,consumer protection,and the sustainable evolution of the food industry.

关键词： New food sources Food production system Food safety International regulation synthetic biology China

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“China shock”or China dividend?-China GVC Participation’s Effects on Trading Partners’Technological Progress

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China Economist 2024年第1期19卷 44-57页

作者： Chen Qifei Yang Jijun Ye di school of International Economics and Trade Nanjing University of Finance and Economics(NUFE)NanjingChina school of Public Finance and Taxation NUFE

This paper explores the effects of China’s global value chain(GVC)participation on technological progress in trading-partner countries based on estimated data on value-added trade between China and 52 trading *** find that,first,although China’s exports lowered the total factor productivity(TFP)of its trading partners(competitive effect),its imports greatly increased trading partners’TFP(effect of scale).This implies that China’s GVC participation is beneficial to its trading partners’technological progress in the form of a considerable technology dividend ***,China’s export dividend effect compensates for the negative effect of Chinese competition on trading partners’technological progress;the innovation effects attributable to China’s imports reinforce the positive effects of scale on technological *** innovation is factored in,the China dividend thus becomes further ***,China’s merchandise imports have a diminishing positive effect on technological progress in trading partners as geographical distance increases,but trade in services transcends geographical boundaries,and the positive technological progress effect of China’s service imports do not diminish as.distance *** find that the“China dividend”from China’s GVC participation is a significant contributor to technological progress in partner nations,and China’s imports are conducive to innovation and technological progress in developed countries in the long run.

关键词： Global value chains China dividend trade in value-added technology spillover collaborative innovation

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Coordination Mechanism and Empirical Research on Marine science Technology Innovation and Marine Eco-civilization:A Case study of Coastal Areas of China

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Chinese Geographical science 2024年第3期34卷 468-486页

作者： CHEN Xiaolong LIANG Chenlu di Qianbin school of Geographical science Liaoning Normal UniversityDalian 116029China Institute of Marine sustainable Development Liaoning Normal UniversityDalian 116029China

Marine science technology innovation provides power and guarantees for marine eco-civilization construction,which provides.direction and material support for marine science technology ***,the coordinated development of the two is of great significance to the marine economy sustainable development in China’s coastal *** the basis of clarifying the connotations of marine science technology innovation and marine eco-civilization in China’s coastal areas from 2006 to 2019,the mechanism for their coordinated development was analysed.A comprehensive indicator system based on the connotation of the two was constructed,and the coordinated development relationship was empirically tested using the coupled coordination model and the panel vector autoregressive(PVAR)*** results show that:1)the level of China’s coastal marine science technology innovation continues to improve,gradually forming the core of the development of marine science technology innovation in the north,east and south of shandong,shanghai and Guangdong;the level of marine eco-civilization development fluctuating upward trend,showing obvious spatial differentiation characteristics.2)The degree of coordination of marine science technology innovation and marine eco-civilization is growing over *** is no causal relationship between marine science technology innovation and marine eco-civilization in the northern marine economic circle,but there is a two-way causal relationship between the two in the eastern and southern marine economic circles.3)Marine eco-civilization shows a significant positive and continuous impact on marine science technology innovation,and marine science technology innovation shows a long-term,continuous,fluctuating,and lagging impact on marine *** overall role of marine eco-civilization on marine science technology innovation is dominant,and there are significant differences in the impact effects of the two major marine economic circles.

关键词： marine science technology innovation marine eco-civilization coordinated development coastal areas of China

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Recent progress of cobalt-based electrocatalysts for water splitting: Electron modulation, surface reconstitution, and applications

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Nano Research 2024年第4期17卷 2234-2269页

作者： Zhijian Liang di shen Lei Wang Honggang Fu Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Electrocatalytic water splitting is an essential and effective means to produce green hydrogen energy structures,so it is necessary to develop non-precious metal catalysts to replace precious ***-based catalysts present effective alternatives due to the diverse valence states,adjustable electronic structures,and plentiful *** this review,the catalytic mechanisms of hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)for electrocatalytic water splitting are ***,the synthesis strategies of various cobalt-based catalysts are systematically summarized,followed by the relationships between the structure and performance ***,the effects of d-band center and spin regulation for cobalt-based catalysts are also ***,the dynamic electronic and structural devolution of cobalt-based catalysts are elucidated by combining a series of in-situ ***,we highlight the challenges and future developed directions of cobalt-based catalysts for electrocatalytic water splitting.

关键词： cobalt-based electrocatalysts water splitting electron modulation surface reconfiguration

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Arcfox’s Journey to the West

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China Today 2024年第10期73卷 36-38页

作者： DENG di 不详

BAIC BJEV’s high-end new energy vehicle brand is ready for the European *** is a high-end new-energy vehicle(NEV)brand of the Beijing Electric Vehicle Co.,Ltd.,(BJEV),a subs.diary of the Beijing Automotive Group Co.,Ltd.(BAIC Group),a backbone enterprise in China’s automobile industry headquartered in *** year,with the NEV market booming,Arcfox has begun its foray into the European market.

关键词： subs.diary backbone Arc

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Toughening additive manufactured Zr-based bulk metallic glass composites by martensite phase transformation

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Journal of Materials science & Technology 2024年第3期170卷 95-102页

作者： Pengcheng Zhang Cheng Zhang Jie Pan di Ouyang Lin Liu state Key Laboratory of Materials Processing and die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Additive manufacturing technology based on laser powder bed fusion(LPBF)offers a novel approach for fabricating bulk metallic glass(BMG)products without restriction in size and ***,the BMGs prepared by LPBF usually suffered from less plasticity and poorer fracture toughness as compared to their cast counterparts due to partial crystallization in heat-affected zones(HAZs).since crystallization in HAZs is hard to avoid completely in LPBF BMGs,it is desirable to design a suitable alloy system,in which only ductile crystalline phase,instead of brittle intermetallics,is formed in *** unique structure could effectively increase the toughness/plasticity of the LPBF *** achieve this goal,a quaternary BMG system with a composition of Zr_(47.5)Cu_(45.5)Al_(5)Co_(2)is adopted and subjected to *** is found that nearly a single phase of B_(2)-ZrCu is precipitated in HAZs,while a fully amorphous phase is formed in molten pools(MPs).This B_(2)phase reinforced BMG composite exhibits excellent mechanical properties with enhanced plasticity and ***,it is easy to modulate the mechanical properties by altering the amount of the B_(2)phase via adjusting the laser energy ***,the best combination of strength,plasticity,and notch toughness is obtained in the BMG composite containing 27.4%B_(2)phase and 72.6%amorphous phase,which exhibits yield strength(σ_(s))of 1423 MPa,plastic strain(ε_(p))of 4.65%,and notch toughness(K_(q))of 53.9 MPa m 1/***,a notable strain-hardening is also *** improvement of plasticity/toughness and appearance of strain-hardening behavior are mainly due to the martensite phase transformation from the B_(2)phase to the Cm phase during plastic deformation(i.e.,the phase transformation-induced plasticity effect).The current work provides a guide for making advanced BMGs and BMG composites by additive manufacturing.

关键词： Laser powder bed fusion Bulk metallic glass composites Phase transformation-induced plasticity Deformation mechanism

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Weakly Polarized Organic Cation-Modified Hydrated Vanadium Oxides for High-Energy Efficiency Aqueous Zinc-Ion Batteries

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Nano-Micro Letters 2024年第7期16卷 169-186页

作者： Xiaoxiao Jia Chaofeng Liu Zhi Wang di Huang Guozhong Cao Department of Materials science and Engineering University of WashingtonSeattleWA 98195USA school of Materials science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Vanadium oxides,par-ticularly hydrated forms like V_(2)O_(5)·nH_(2)O(VOH),stand out as promising cathode candidates for aqueous zinc ion batteries due to their adjustable layered structure,unique electronic characteristics,and high theoretical ***,challenges such as vanadium dissolution,sluggish Zn^(2+)diffusion kinetics,and low operating voltage still hinder their direct *** this study,we present a novel vanadium oxide([C_(6)H_(6)N(CH_(3))_(3)]_(1.08)V_(8)O_(20)·0.06H_(2)O,TMPA-VOH),developed by pre-inserting trimethylphenylammonium(TMPA+)cations into *** incorporation of weakly polarized organic cations capitalizes on both ionic pre-intercalation and molecular pre-intercalation effects,resulting in a phase and morphology transition,an expansion of the interlayer distance,extrusion of weakly bonded interlayer water,and a substantial increase in V^(4+)*** modifications synergistically reduce the electrostatic interactions between Zn^(2+)and the V-O lattice,enhancing structural stability and reaction kinetics during *** a result,TMPA-VOH achieves an elevated open circuit voltage and operation voltage,exhibits a large specific capacity(451 mAh g^(-1)at 0.1 A g^(-1))coupled with high energy efficiency(89%),the significantly-reduced battery polarization,and outstanding rate capability and cycling *** concept introduced in this study holds great promise for the development of high-performance oxide-based energy storage materials.

关键词： Zinc-ion battery Vanadium oxide V_(2)O_(5)·nH_(2)O Pre-intercalation Interlayer engineering

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Expanding indications for chronic hepatitis B treatment: Is it really desirable to treat everyone?

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World Journal of Gastroenterology 2024年第17期30卷 2294-2297页

作者： Fabiola di Dato Raffaele Iorio Department of Translational Medical science Section of PediatricsUniversity of Naples Federico IINaples 80131Italy

Chronic viral hepatitis causes an increased risk of progressive liver disease and hepatocellular *** the wave of the World Health Organization’s goal to reduce new cases and deaths from hepatitis B and C by 2030,there is an increasing call to expand the indications for treatment of chronic hepatitis ***,the main goal of treatment is to achieve a functional cure due to the inability of current drugs to completely eradicate the *** are still many discrepancies between available guidelines in terms of eligibility for treatment as well as an uncertainty about the appropriate treatment *** editorial addresses key questions about the topic and whether indications for treatment should be expanded.

关键词： Hepatitis B virus Interferon Nucleos(t)ide analogues Functional cure Children

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