检索结果-南通市图书馆

Evaluating rehabilitation interventionsin Parkinson's.disease with functional MRI:a promising neuroprotective strategy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第5期10卷 702-703页

作者： carlo Augusto Mallio Bruno Beomonte Zobel carlo Cosimo Quattrocchi Departmental Faculty of Medicine and surgery Unit of Diagnostic ImagingUniversità Campus Bio-Medico di Roma

Parkinson＇s.disease （PD） is a progressive neurodegenerative disorder affecting approximately 10 million people world- wide （Planetta et al., 2014; Zigmond and smeyne, 2014）. The principal clinical features of PD are bradykinesia, rigidity, tremor at rest and postural instability （Planetta et al., 2014）. It is known that both PD itself and the use of anti-parkinson drugs are associated with several non-motor symptoms such as cognitive impairment, neuropsychiatric disturbances and sleep, autonomic, and sensory disorders （Park and stacy, 2009; Foster et al., 2014）. The histopathological hallmark of PD is the reduction of dopaminergic cells in the substantia nigra pars compacta, causing dopamine deficiency in spe- cific nuclei of the basal ganglia such as the dorsal striatum （Fearnley and Lees, 1991; Planetta et al., 2014）. The disrup- tion of the dopaminergic system has long been regarded as the major cause of PD; however, it has been shown that a widespread involvement of several non-dopaminergic path- ways also contribute to the clinical manifestations of PD （Park et al., 2014）.

关键词： MRI Evaluating rehabilitation interventionsin Parkinson’s.disease with functional MRI

Clinical features and epidemiology of spondyloarthritides associated with inflammatory bowel disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第20期15卷 2449-2455页

作者： carlo salvarani Walter Fries Rheumatology Unit Department of Interna Medicine Department of Internal Medicine and MedicaTherapy University of Messina

Inflammation of axial and/or peripheral joints is one of the most frequent extra-intestinal manifestations complicating the clinical course and therapeutic approach in inflammatory bowel diseases(IBD).The frequency of these complications seems to be similar for both diseases, Crohn's.disease and ulcerative *** associated with IBD belongs to the category of *** involvement ranges from isolated inflammatory back pain to ankylosing spondylitis, whereas peripheral arthritis is noted in pauciarticular and in polyarticular *** radiological involvement of the sacroiliac joints is reported to occur in up to 50% of *** musculoskeletal manifestations such as buttock pain, dactylitis, calcaneal enthesitis, and thoracic pain are frequently underdiagnosed and, consequently, are not treated *** diagnostic approaches and criteria have been proposed over the past 40 years in an attempt to correctly classify and diagnose such *** correct recognition of spondylarthropathies needs an integrated multidisciplinary approach in order to identify common therapeutic strategies, especially in the era of the new biologic therapies.

关键词：溃疡性结肠炎临床特点炎症流行病学鸡传染性法氏囊病诊断方法关节炎生物疗法

ROs and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer stem Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & diseases 2020年第4期7卷 620-635页

作者： Luca Tirinato Francesca Pagliari simone di Franco Elisa sogne Maria Grazia Marafioti Jeanette Jansen Andrea Falqui Matilde Todaro Patrizio Candeloro carlo Liberale Joao seco Giorgio stassi Enzo di Fabrizio Biomedical Physics in Radiation Oncology DKFZ(German Cancer Research Center)69120 HeidelbergGermany Physical science and Engineering(PsE)division King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia Department of Experimental and Clinical Medicine University“Magna Graecia”of Catanzaro88100 Loc.GermanetoCatanzaroItaly Biological and Environmental sciences and Engineering(BEsE)division King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Cellular and Molecular Pathophysiology Laboratory Department of SurgicalOncological and Stomatological SciencesUniversity of PalermoPalermoItaly Ruprecht Karls University Heidelberg Department of Physics69120 HeidelbergGermany Department of Health Promotion Mother and Child CareInternal Medicine and Medical Specialties(PROMISE)University of PalermoPalermoItaly

Lipid Droplets(LDs)are emerging as crucial players in colon cancer development and *** expression has been associated with high tumorigenicity in Cancer stem Cells(CsCs),so that they have been proposed as a new functional marker in Colorectal Cancer stem Cells(CR-CsCs).They are also indirectly involved in the modulation of the tumor microenvironment through the production of pro-inflammatory *** is growing evidence that a possible connection between metabolic alterations and malignant transformation exists,although the effects of nutrients,primarily glucose,on the CsC behavior are still mostly *** is an essential fuel for cancer cells,and the connections with LDs in the healthy and CsC populations merit to be more deeply ***,we showed that a high glucose concentration activated the PI3K/AKT pathway and increased the expression of CD133 and CD44v6 CsC ***,glucose was responsible for the increased amount of Reactive Oxygen species(ROs)and LDs in both healthy and CR-CsC *** also investigated the gene modulations following the HG treatment and found out that the healthy cell gene profile was the most ***,Atorvastatin,a lipidlowering drug,induced the highest mortality on CR-CsCs without affecting the healthy counterpart.

关键词： Cholesterol metabolism Colorectal cancer stem cells Fatty acid

Natural compounds may contribute in preventing sARs-CoV-2 infection:a narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food science and Human Wellness 2022年第5期11卷 1134-1142页

作者： Maria Eleonora Bizzoca stefania Leuci Michele Davide Mignogna Eleonora Lo Muzio Vito carlo Alberto Caponio Lorenzo Lo Muzio Department of Clinical and Experimental Medicine University of FoggiaFoggia 71122Italy Department of Neurosciences Reproductive and Odontostomatological SciencesFederico Ⅱ University of NaplesNaples 80131Italy Department of Neuroscience and Rehabilitation University of FerraraFerrara 44121Italy C.I.N.B.O.(Consorzio Interuniversitario Nazionale per la Bio-Oncologia) Chieti 66100Italy

Coronavirus pandemic infection is the most important health issue *** disease 2019 is a contagious.disease characterized by severe acute respiratory syndrome coronavirus *** date,excluding the possibility of vaccination,against sARs-CoV-2 infection it is possible to act only with supportive care and non-virus-specific treatments in order to improve the patient’s *** industry is investigating effects of medicinal plants,phytochemical extracts and aromatic herbs to find out natural substances which may act as antiviral *** studies have revealed how these substances may interfere with the viral life cycle,viral entry,replication,assembly or discharge,as well as virus-specific host targets or stimulating the host immune system,reducing oxidative stress and inflammatory response.A natural compound can be used as a prophylaxis by people professionally exposed to the risk of contagion and/or positive patients not in intensive *** aim of this paper is to perform a narrative review of current literature in order to summarize the most studied natural compounds and their modes of action.

关键词： Natural compounds sARs-CoV-2 COVID-19 Prevention Infectious.disease Phytochemicals Medicinal plants

Bioinspired Dry Adhesive Materials and Their Application in Robotics： A Review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2016年第2期13卷 181-199页

作者： Yasong Li Jeffrey Krahn carlo Menon MENRVA Research Group School of Engineering Science Simon Fraser University 8888 University Drive Burnaby BC V5A 1S6 Canada

Dry adhesives inspired from climbing animals, such as geckos and spiders, rely on van der Waals forces to attach to the opposing surface. Biological fibrillar dry adhesives have a hierarchical structure closely resembling a tree： the surface of the skin on the animal＇s feet is covered in arrays of slender micro-fibrils, each of which supports arrays of fibrils in submicron dimensions. These nano-meter size fibrils can conform closely to the opposing surfaces to induce van der Waals interaction. Bioinspired dry adhesives have been developed in research laboratories for more than a decade. To mimic the biological fibrillar adhesives, fibrillar structures have been prepared using a variety of materials and geometrical arrangements. In this review article, the mechanism and selected fabrication methods of fibrillar adhesives are summarized for future reference in adhesive development. Robotic applications of these bioinspired adhesives are also introduced in this article. Various successful appli- cations of bioinspired fibrillar adhesives can shed light on developing smart adhesives for use in automation.

关键词： bioinspired gecko adhesive van der Waals forces biomimetic climbing robot bioinspired tape

Fabrication and Testing of self Cleaning Dry Adhesives Utilizing Hydrophobicity Gradient

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2015年第2期12卷 270-275页

作者： Enrico Bovcro Jeffrey Krahn carlo Menon MENRVA Lab School of Engineering Science Simon Fraser University 8888 University Drive Burnaby BC Canada V5A 1S6

In this paper we present a method to create a hydrophobicity gradient on the surface of a Polydimethylsiloxane （PDMs） dry adhesive. The method consists of the partial silanization of the surface of the dry adhesive by Chemical Vapour Deposition （CVD） of octadecyltrichlorosilane （OTs）. The partial silanization of the surface of the sample results in a hydrophobic to hy- drophilic gradient across the surface of the dry adhesive. The resulting change in hydrophobicity across the surface of the dry adhesive results in the uphill motion of a droplet of water, which appears to be directly proportional to the area of contact between the droplet and the adhesive. Normal adhesion testing is performed to quantify the effect of the hydrophobic gradient across the surface of the sample. While a variation in adhesion are only minimally affected by the silanization, and the motion strength across the sample is measured, the adhesive properties of the droplet of water doesn＇t cause any loss of adhesion.

关键词： dry adhesion self cleaning hydrophobic silanization polymers PDMs

An Integrated Approach for Optimal Design of Micro Gas Turbine Combustors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal science 2009年第2期18卷 173-184页

作者： Luca Fuligno diego Micheli carlo Poloni Enginsoft s.p.a. dipartimento di Ingegneria Meccanica Universita degli Studi di Trieste dipartimento

The present work presents an approach for the optimized design of small gas turbine combustors, that integrates a0-D code, CFD analyses and an advanced game theory multi-objective optimization algorithm. The output of the0-D code is a baseline design of the combustor, given the required fuel characteristics, the basic geometry (tubularor annular) and the combustion concept (i.e. lean premixed primary zone or diffusive processes). For the optimizationof the baseline design a simplified parametric CAD/mesher model is then defined and submitted to a CFDcode. Free parameters of the optimization process are position and size of the liner hole arrays, their total area andthe shape of the exit duct, while different objectives are the minimization of NOx emissions, pressure losses andcombustor exit Pattern Factor. A 3D simulation of the optimized geometry completes the design procedure. As afirst demonstrative example, the integrated design process was applied to a tubular combustion chamber with alean premixed primary zone for a recuperative methane-fuelled small gas turbine of the 100 kW class.

关键词：微气体涡轮燃烧室优化设计逼近

Investigation on Walking and Pacing stability of German shepherd Dog for different Locomotion speeds

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2011年第1期8卷 18-24页

作者： Weijun Tian Qian Cong carlo Menonz Key Laboratory of Bionic Engineering (Ministry of Education China) Jilin University Changchun 130022 P. R. China MENRVA Research Group School of Engineering Science Simon Fraser University Burnaby BC V5A 1S6 Canada

The motion of three German shepherd Dogs on a treadmill was recorded using a three-dimensional motion capture system. The locomotion speed of the dog was respectively set at 4km·h^-1, 5.5km·h^-1, 7 km·h^-1 and 8.5 km·h^-1. By processing the acquired data, the joint trajectories of the dogs＇ hind limbs were computed and a time series analysis was conducted. Joint angle-angle diagrams were obtained and the Lyapunov exponents were computed. Results show that the stability decreased when speed increased, which can be attributed to the decrease in the stance phase respect to the swing phase when speed is increased. Results also show that the dogs changed gait during the tests, namely walking in the range of 4 km·h^-1 to 7 km·h^-1 and pacing at 8.5 km·h^-1 A significant drop in stability was observed from walking to pacing.

关键词： stability gait locomotion dog dynamics Eyapunov exponents

High Level Languages Implementation and Analysis of 3D Navier-stokes solvers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Applied Mathematics and Mechanics 2011年第3期3卷 370-388页

作者： Valerio Grazioso carlo scalo Giuseppe de Felice carlo Meola Department of Mechanical and Materials Engineering Queen’s University130 Stuart StreetKingstonOntarioCanada dipartimento di Energetica Termofluidodinamica applicata e Condizionamenti ambientali(DETEC) Universit`a degli Studi di Napoli’Federico II’P.le Tecchio 8080125 NaplesItaly

In this work we introduce PRIN-3D(PRoto-code for Internal flows modeled by Navier-stokes equations in 3-dimensions),a new high level algebraic language(Matlab^(■))based code,by discussing some fundamental aspects regarding its basic solving kernel and by describing the design of an innovative advection *** main focus was on designing a memory and computationally efficient code that,due to the typical conciseness of the Matlab coding language,could allow for fast and effective implementation of new models or *** numerical methods are discussed in the *** pressure equation is derived with a quasi-segregation technique leading to an iterative scheme obtained within the framework of a global preconditioning *** levels of parallelization are obtainable by exploiting special pressure variable ordering patterns that lead to a block-structured Poisson-like ***,the new advection scheme has the potential of a controllable artificial *** results are shown including a fully three-dimensional internal laminar flow evolving in a relatively complex geometry and a 3D methane-air flame simulated with the aid of libraries based on the Flamelet model.

关键词： Matlab high level algebraical languages segregation preconditioning flamelet