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Erythrocyte invasions and receptor heterogeneity in field isolates of Nanay river basin Iquitos

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 589-593页

作者： Kuppusamy Chenniappan sarah H johns Laboratorio de Investigacion deproductos Naturales Antiparasitarios de la Amazonia UNAPPampa chicaIquitosPeru 065

Objective:To determine whether the requirements for sialic acid varies and whether several types of silaic acid independent receptors utilized for invasion mechanisms of fresh filed isolates collected around Nanay river basin,***:The field isolates were cultured as described previously by Jensen and Trager and MR4 protocol with little *** erythrocytes preparation and subsequent enzyme treatment was done as described previously by *** little *** assay was performed as described previously by sharma et al with little ***:The Nanay river basin isolates showed five types of invasion mechanisms or types of receptors-ligand *** we observed that an equal numbers of neuraminidase sensitive and resistant invasion receptor-ligand interaction profiles as the most common receptor-ligand invasion *** resistance trypsin sensitive chymotrypsin sensitive(NM_RT_sCT_s) invasion of receptor-ligand interaction profile was found in seven isolates,Five field isolates and one reference strain showed neuraminidase sensitive, trypsin sensitive and chymotrypsin resistant(NM_RT_sCT_R) invasion of receptor-ligand interactions, six isolates including one reference strains dd2 showed neuraminidase sensitive,trypsin and chymotrypsin resistance(NM_sT_RCT_R) indicating its dependence on sialic acids and independence of trypsin and chymotrypsin sensitive *** isolates showed neuraminidase sensitive, trypsin sensitive and chymotrypsin sensitive(NM_sT_sCT_s) invasion of receptor-ligand interactions, seven isolates were neuraminidase resistant,trypsin sensitive and chymotrypsin resistance (NM_RT_sCT_R) invasion of receptor-ligand interactions,indicating its dependence on trypsin sensitive ***:The Nanay river basin isolates showed five types of invasion mechanisms or types of receptors-ligand interactions.A full understanding of theses invasion mechanisms may allow the developm

关键词： Nanay river basin Invasion sialic acid Plasmodium falciparum Malaria

Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes

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stroke & Vascular Neurology 2020年第2期5卷 128-137页

作者： Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li s.claiborne johns.on Yongjun Wang Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases(NCRC-ND) BeijingChina Advanced Innovation Center for Human Brain Projection Capital Medical UniversityBeijingChina Dell Medical school University of TexasAustinTexasUSA

Background The effect of cerebral small vessel disease(CsVD)and intracranial arterial stenosis(ICAs)on stroke outcomes remains *** Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)*** assessed the associations of burdens of CsVD and ICAs with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin scale(mRs)scores using ordinal logistic regression *** Among the 1045 patients,CsVD was present in 830 cases(79.4%)and ICAs in 460(44.0%).Patients with>1 ICAs segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CsVD and the occurrence of new strokes was *** presence of severe CsVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p1 ICAs segment(cOR 2.15,95%CI 1.57 to 2.93,ps associated with higher mRs *** CsVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAs,was associated with a higher risk of bleeding ***-point modified CsVD score improved the predictive power for bleeding events and *** CsVD is associated with more disability and bleeding events,and ICAs is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 *** and ICAs may represent different vascular pathologies and play distinct roles in stroke outcomes.

关键词： intracranial bleeding Acute

Post-endoscopic retrograde cholangiopancreatography pancreatitis:a review

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Journal of Pancreatology 2024年第1期7卷 28-34页

作者： Parth s.Patel Venkata s.Akshintala Department of Gastroenterology Johns Hopkins Medical InstitutionsBaltimoreMD

Endoscopic retrograde cholangiopancreatography(ERCP)has continued to develop over recent decades with regard to both indications for its use and improvements in *** most common complication is post-ERCP pancreatitis(PEP)with incidence rates being reported at~10%.The exact mechanism of PEP is unknown but is likely multifactorial with papillary edema contributing to the activation of the inflammatory cascade playing an important *** risk factors include patient-related factors(female sex,younger age,sphincter of Oddi dysfunction,and history of PEP)and procedure-related factors(difficult cannulation,multiple pancreatic duct guidewire passes,pancreatic acinarization,multiple pancreatic duct contrast injections,and precut sphincterotomy).several preventative prophylactic strategies have been posited;however,current guidelines recommend the use of rectal non-steroidal anti-inflammatory drugs(NsAIDs),aggressive intravenous(IV)fluid hydration,and pancreatic duct *** patient selection and the use of noninvasive imaging modalities for diagnosis of pancreaticobiliary abnormalities is a key aspect in *** studies continue to explore various pharmacologic,procedure-related,and combination strategies for prevention and will be important as the use of ERCP continues to grow.

关键词： ERCP Pancreatitis PEP risk factors Prevention

The magnetosheath at high spectral resolution

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Earth and Planetary Physics 2024年第1期8卷 234-246页

作者： K.D.Küntz D.Koutroumpa W.R.Dunn A.Foster F.s.Porter D.G.sibeck B.Walsh The Henry A.Rowland Department of Physics and Astronomy Johns Hopkins University3701 San Martin DriveBaltimoreMD21218USA NAsA Goddard space Flight Center 8800 Greenbelt RoadGreenbeltMD 20771USA LATMOs-OVsQ CNRSUVSQ Paris-SaclaySorbonne Université11 Boulevard d’Alembert78280GuyancourtFrance Department of Physics and Astronomy University College LondonLondonUK The Centre for Planetary science at UCL/Birkbeck Gower StreetLondon WC1E 6BTUK Center for Astrophysics Harvard University&Smithsonian Institution60 Garden StreetCambridgeMA 02138USA Center for space Physics Boston University110 Cummington MallBostonMAUSA

While we eagerly anticipate sMILE’s(solar wind Magnetosphere Ionosphere Link Explorer)unprecedented X-ray observations of the Earth’s magnetosheath and the initiation of a new era of magnetospheric research,it seems appropriate to look ahead to the abilities of the next generation of astrophysics *** these,the Line Emission Mapper(LEM),a large aperture micro-calorimeter based mission,is currently planned to be able to observe the magnetosheath at high spectral resolution(~2 eV).With a field of view of~30′,LEM will allow higher spatial resolution and higher cadence measurement of the motion of a very small portion of the magnetopause over relatively short periods of time(multiple hours),complementing sMILE’s global ***’s strength is its spectral *** will be able to measure the abundance of a broad range of elements and ionization states,many of which are inaccessible to current in situ instruments,and will be able to separate the emission from the magnetosheath from the emission from the cosmic X-ray background using the difference in their relative velocities.

关键词： magnetosheath charge exchange solar wind abundances

Electrochemical synthesis of Novel Zn-Doped TiO_2 Nanotube/ZnO Nanoflake Heterostructure with Enhanced DssC Efficiency

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Nano-Micro Letters 2016年第4期8卷 381-387页

作者： Aijo John K johns Naduvath sudhanshu Mallick Jacob W.Pledger s.K.Remillard P.A.De Young Manju Thankamoniamma T.shripathi Rachel Reena Philip Department of Physics Union Christian College Department of Metallurgical Engineering and Material science Indian Institute of Technology Present Address Department of Physics St.Thomas College Department of Physics Hope College Department of Physics Sree Sankara College UGC-DAE Consortium for scientific Research Indore

The paper reports the fabrication of Zn-doped TiO_2 nanotubes(Zn-TONT)/ZnO nanoflakes heterostructure for the first time,which shows improved performance as a photoanode in dye-sensitized solar cell(DssC).The layered structure of this novel nanoporous structure has been analyzed unambiguously by Rutherford backscattering spectroscopy,scanning electron microscopy,and X-ray *** cell using the heterostructure as photoanode manifests an enhancement of about an order in the magnitude of the short circuit current and a seven-fold increase in efficiency,over pure TiO_2 *** further reveal that the Zn-TONT is preferentially oriented in [001] direction and there is a Ti metal-depleted interface layer which leads to better band alignment in DssC.

关键词： Zn-doped TiO2 nanotubes ZnO nanoflakes Heterostructures DssC

Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis(INsPIREs)

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stroke & Vascular Neurology 2023年第3期8卷 249-258,I0096-I0110页

作者： Ying Gao Yuesong Pan shangrong Han Weiqi Chen Jing Jing Chunjuan Wang Yingying Yang Tingting Wang Xia Meng Xingquan Zhao Liping Liu Hao Li s.claiborne johns.on Pierre Amarenco Philip M Bath Yongjun Wang Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Dean's Office Dell Medical SchoolUniversity of Texas at AustinAustinTexasUSA Department of Neurology and stroke Center Assistance Publique-Hôpitaux de Paris(APHP)Bichat HospitalINSERM LVTS-U1148University of ParisParisFrance Population Health Research Institute McMaster UniversityHamiltonOntarioCanada stroke Trials Unit Mental Health&Clinical NeuroscienceUniversity of NottinghamNottinghamUK Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina National Center for Neurological Diseases BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Chinese Institute for Brain Research BeijingChina

Background It remains unclear if intensive antiplatelet and statin treatments begun within 24-72 hours of cerebral ischaemic events from intracranial or extracranial atherosclerosis is effective or *** The Intensive statin and Antiplatelet Therapy for High-risk Intracranial or Extracranial Atherosclerosis(INsPIREs)trial is a randomised,double-blind,placebo-controlled,multicentre and 2×2 factorial trial.6100 individuals between the ages of 35 and 80 who have experienced a mild ischaemic stroke or high-risk transient ischaemic attack(TIA)within the previous 72 hours that is attributed to≥50%atherosclerotic stenosis of a major intracranial or extracranial artery or multiple infarctions of atherosclerotic origin will be enrolled in the *** subjects will be randomised 1:1:1:1 to one of four groups:(1)intensive antiplatelet therapy(combined clopidogrel and aspirin for days 1-21,then aspirin placebo and clopidogrel for days 22-90)plus immediate intensive statin therapy(atorvastatin at a dose of 80 mg daily for the first 21 days,then 40 mg daily for days 22-90);(2)intensive antiplatelet therapy plus delayed intensive statin therapy(atorvastatin placebo for days 1-3,followed by 40 mg per day of atorvastatin for days 4-90);(3)standard antiplatelet therapy(combination of clopidogrel placebo with aspirin for 90 days)plus immediate intensive statin therapy and(4)standard antiplatelet therapy plus delayed intensive statin *** primary efficacy endpoint is any new stroke(ischaemic or haemorrhagic)within 90 days after *** primary safety endpoint is moderate to severe bleeding at 90 *** The INsPIREs trial will assess the efficacy and safety of intensive antiplatelet therapy and immediate intensive statin therapy begun within 72 hours of onset in decreasing the recurrent stroke at 90 days in patients with acute mild ischaemic stroke or high-risk TIA of intracranial or extracranial atherosclerosis origin.

关键词： intracranial atherosclerosis random

The Green formula and heredity of algebras

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science China Mathematics 2005年第5期48卷 610-617页

作者： ZHANG Guanglian & WANG shuai Department of Mathematical sciences, Tsinghua University, Beijing 100084, China Yancheng Teachers College, Yancheng 224002, China Department of Mathematics, johns Hopkins University, Baltimore, MD21218, U.s.A. Department of Mathematical sciences Tsinghua University Beijing China Yancheng Teachers College Yancheng China Department of Mathematics Johns Hopkins University Baltimore USA

Let A be a finite dimensional algebra over a field k with q elements. It is shown that the Green formula is true in mod-A if and only if A is a hereditary algebra.

关键词： Green formula idempotent ideal hereditary algebra.

Clopidogrel with aspirin in High- risk patients with Acute Non- disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicentre randomised trial

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stroke & Vascular Neurology 2021年第2期6卷 280-285页

作者： Yongjun Wang claiborne johns.on Philip M Bath Xia Meng Jing Jing Xuewei Xie Anxin Wang Yuesong Pan Anding Xu Qiang Dong Yilong Wang Xingquan Zhao Zixiao Li Hao Li Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina The University of Texas at Austin Dell Medical school AustinTexasUSA stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Department of Neurology The First Affiliated HospitalJinan University GuangzhouGuangzhouGuangdongChina Department of Neurology Huashan HospitalState Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Background In patients with a minor ischaemic stroke or transient ischaemic attack(TIA),separate trials have shown that dual antiplatelet therapy with clopidogrel plus aspirin(clopidogrel-aspirin)or ticagrelor plus aspirin(ticagrelor-aspirin)are more effective than aspirin alone in stroke secondary ***,these two sets of combination have not been directly *** clopidogrel was less effective in stroke patients who were CYP2C19 loss-of function(LOF)allele carriers,whether ticagrelor-aspirin is clinically superior to clopidogrel-aspirin in this subgroup of patients with stroke is *** To describe the rationale and design considerations of the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events(CHANCE-2)*** CHANCE-2 is a randomised,double-blind,double-dummy,placebo-controlled,multicentre trial that compares two dual antiplatelet strategies for minor stroke or TIA patients who are CYP2C19 LOF allele carriers:ticagrelor(180 mg loading dose on day 1 followed by 90 mg twice daily on days 2-90)or clopidogrel(300 mg loading dose on day 1 followed by 75 mg daily on days 2-90),plus open-label aspirin with a dose of 75-300 mg on day 1 followed by 75 mg daily on day *** will be followed for 1 *** outcomes The primary efficacy outcome is any stroke(ischaemic or haemorrhagic)within 3 months and the primary safety outcome is any severe or moderate bleeding event within 3 *** The CHANCE-2 trial will evaluate whether ticagrelor-aspirin is superior to clopidogrel-aspirin for minor stroke or TIA patients who are CYP2C19 LOF allele carriers.

关键词： CYP2C19 aspirin patients

Gene screen for Breast Cancer Better than Pathologist's "Eye"

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当代外语研究 2006年第11期 6-7页

作者： johns Hopkins 姜彬 Medical Institutions

医学研究人员最近发现了诊断肿瘤的新方法。根据约翰·霍普金斯大学医学研究中心的实验,研究人员通过从人体器官的体液中采集到某种特殊类别的细胞,并由其DNA信息中筛离出与肿瘤有关的化学成分。这种诊断方式较以往的病理学分析方式又... 详细信息

医学研究人员最近发现了诊断肿瘤的新方法。根据约翰·霍普金斯大学医学研究中心的实验,研究人员通过从人体器官的体液中采集到某种特殊类别的细胞,并由其DNA信息中筛离出与肿瘤有关的化学成分。这种诊断方式较以往的病理学分析方式又有了新的突破。

关键词：研究人员肿瘤医学研究中心霍普金斯大学特殊类化学成分新方法人体器官病理学家诊断方式