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Erythrocyte invasions and receptor heterogeneity in field isolates of Nanay river basin Iquitos

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 589-593页

作者： Kuppusamy Chenniappan sarah H johns Laboratorio de Investigacion deproductos Naturales Antiparasitarios de la Amazonia UNAPPampa chicaIquitosPeru 065

Objective:To determine whether the requirements for sialic acid varies and whether several types of silaic acid independent receptors utilized for invasion mechanisms of fresh filed isolates collected around Nanay river basin,***:The field isolates were cultured as described previously by Jensen and Trager and MR4 protocol with little *** erythrocytes preparation and subsequent enzyme treatment was done as described previously by *** little *** assay was performed as described previously by sharma et al with little ***:The Nanay river basin isolates showed five types of invasion mechanisms or types of receptors-ligand *** we observed that an equal numbers of neuraminidase sensitive and resistant invasion receptor-ligand interaction profiles as the most common receptor-ligand invasion *** resistance trypsin sensitive chymotrypsin sensitive(NM_RT_sCT_s) invasion of receptor-ligand interaction profile was found in seven isolates,Five field isolates and one reference strain showed neuraminidase sensitive, trypsin sensitive and chymotrypsin resistant(NM_RT_sCT_R) invasion of receptor-ligand interactions, six isolates including one reference strains dd2 showed neuraminidase sensitive,trypsin and chymotrypsin resistance(NM_sT_RCT_R) indicating its dependence on sialic acids and independence of trypsin and chymotrypsin sensitive *** isolates showed neuraminidase sensitive, trypsin sensitive and chymotrypsin sensitive(NM_sT_sCT_s) invasion of receptor-ligand interactions, seven isolates were neuraminidase resistant,trypsin sensitive and chymotrypsin resistance (NM_RT_sCT_R) invasion of receptor-ligand interactions,indicating its dependence on trypsin sensitive ***:The Nanay river basin isolates showed five types of invasion mechanisms or types of receptors-ligand interactions.A full understanding of theses invasion mechanisms may allow the developm

关键词： Nanay river basin Invasion sialic acid Plasmodium falciparum Malaria

Post-endoscopic retrograde cholangiopancreatography pancreatitis:a review

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Journal of Pancreatology 2024年第1期7卷 28-34页

作者： Parth s.Patel Venkata s.Akshintala Department of Gastroenterology Johns Hopkins Medical InstitutionsBaltimoreMD

Endoscopic retrograde cholangiopancreatography(ERCP)has continued to develop over recent decades with regard to both indications for its use and improvements in *** most common complication is post-ERCP pancreatitis(PEP)with incidence rates being reported at~10%.The exact mechanism of PEP is unknown but is likely multifactorial with papillary edema contributing to the activation of the inflammatory cascade playing an important *** risk factors include patient-related factors(female sex,younger age,sphincter of Oddi dysfunction,and history of PEP)and procedure-related factors(difficult cannulation,multiple pancreatic duct guidewire passes,pancreatic acinarization,multiple pancreatic duct contrast injections,and precut sphincterotomy).several preventative prophylactic strategies have been posited;however,current guidelines recommend the use of rectal non-steroidal anti-inflammatory drugs(NsAIDs),aggressive intravenous(IV)fluid hydration,and pancreatic duct *** patient selection and the use of noninvasive imaging modalities for diagnosis of pancreaticobiliary abnormalities is a key aspect in *** studies continue to explore various pharmacologic,procedure-related,and combination strategies for prevention and will be important as the use of ERCP continues to grow.

关键词： ERCP Pancreatitis PEP risk factors Prevention

The magnetosheath at high spectral resolution

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Earth and Planetary Physics 2024年第1期8卷 234-246页

作者： K.D.Küntz D.Koutroumpa W.R.Dunn A.Foster F.s.Porter D.G.sibeck B.Walsh The Henry A.Rowland Department of Physics and Astronomy Johns Hopkins University3701 San Martin DriveBaltimoreMD21218USA NAsA Goddard space Flight Center 8800 Greenbelt RoadGreenbeltMD 20771USA LATMOs-OVsQ CNRSUVSQ Paris-SaclaySorbonne Université11 Boulevard d’Alembert78280GuyancourtFrance Department of Physics and Astronomy University College LondonLondonUK The Centre for Planetary science at UCL/Birkbeck Gower StreetLondon WC1E 6BTUK Center for Astrophysics Harvard University&Smithsonian Institution60 Garden StreetCambridgeMA 02138USA Center for space Physics Boston University110 Cummington MallBostonMAUSA

While we eagerly anticipate sMILE’s(solar wind Magnetosphere Ionosphere Link Explorer)unprecedented X-ray observations of the Earth’s magnetosheath and the initiation of a new era of magnetospheric research,it seems appropriate to look ahead to the abilities of the next generation of astrophysics *** these,the Line Emission Mapper(LEM),a large aperture micro-calorimeter based mission,is currently planned to be able to observe the magnetosheath at high spectral resolution(~2 eV).With a field of view of~30′,LEM will allow higher spatial resolution and higher cadence measurement of the motion of a very small portion of the magnetopause over relatively short periods of time(multiple hours),complementing sMILE’s global ***’s strength is its spectral *** will be able to measure the abundance of a broad range of elements and ionization states,many of which are inaccessible to current in situ instruments,and will be able to separate the emission from the magnetosheath from the emission from the cosmic X-ray background using the difference in their relative velocities.

关键词： magnetosheath charge exchange solar wind abundances

Electrochemical synthesis of Novel Zn-Doped TiO_2 Nanotube/ZnO Nanoflake Heterostructure with Enhanced DssC Efficiency

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Nano-Micro Letters 2016年第4期8卷 381-387页

作者： Aijo John K johns Naduvath sudhanshu Mallick Jacob W.Pledger s.K.Remillard P.A.De Young Manju Thankamoniamma T.shripathi Rachel Reena Philip Department of Physics Union Christian College Department of Metallurgical Engineering and Material science Indian Institute of Technology Present Address Department of Physics St.Thomas College Department of Physics Hope College Department of Physics Sree Sankara College UGC-DAE Consortium for scientific Research Indore

The paper reports the fabrication of Zn-doped TiO_2 nanotubes(Zn-TONT)/ZnO nanoflakes heterostructure for the first time,which shows improved performance as a photoanode in dye-sensitized solar cell(DssC).The layered structure of this novel nanoporous structure has been analyzed unambiguously by Rutherford backscattering spectroscopy,scanning electron microscopy,and X-ray *** cell using the heterostructure as photoanode manifests an enhancement of about an order in the magnitude of the short circuit current and a seven-fold increase in efficiency,over pure TiO_2 *** further reveal that the Zn-TONT is preferentially oriented in [001] direction and there is a Ti metal-depleted interface layer which leads to better band alignment in DssC.

关键词： Zn-doped TiO2 nanotubes ZnO nanoflakes Heterostructures DssC

The Green formula and heredity of algebras

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science China Mathematics 2005年第5期48卷 610-617页

作者： ZHANG Guanglian & WANG shuai Department of Mathematical sciences, Tsinghua University, Beijing 100084, China Yancheng Teachers College, Yancheng 224002, China Department of Mathematics, johns Hopkins University, Baltimore, MD21218, U.s.A. Department of Mathematical sciences Tsinghua University Beijing China Yancheng Teachers College Yancheng China Department of Mathematics Johns Hopkins University Baltimore USA

Let A be a finite dimensional algebra over a field k with q elements. It is shown that the Green formula is true in mod-A if and only if A is a hereditary algebra.

关键词： Green formula idempotent ideal hereditary algebra.

Gene screen for Breast Cancer Better than Pathologist's "Eye"

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当代外语研究 2006年第11期 6-7页

作者： johns Hopkins 姜彬 Medical Institutions

医学研究人员最近发现了诊断肿瘤的新方法。根据约翰·霍普金斯大学医学研究中心的实验,研究人员通过从人体器官的体液中采集到某种特殊类别的细胞,并由其DNA信息中筛离出与肿瘤有关的化学成分。这种诊断方式较以往的病理学分析方式又... 详细信息

医学研究人员最近发现了诊断肿瘤的新方法。根据约翰·霍普金斯大学医学研究中心的实验,研究人员通过从人体器官的体液中采集到某种特殊类别的细胞,并由其DNA信息中筛离出与肿瘤有关的化学成分。这种诊断方式较以往的病理学分析方式又有了新的突破。

关键词：研究人员肿瘤医学研究中心霍普金斯大学特殊类化学成分新方法人体器官病理学家诊断方式

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Biology / 1st ed.

Estimating the subsolar magnetopause position from soft X-ray images using a low-pass image filter

1999年

作者： Burton s. Guttman contributing author johns W. H

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Earth and Planetary Physics 2024年第1期8卷 173-183页

作者： Hyangpyo Kim Hyunju K.Connor Jaewoong Jung Brian M.Walsh David sibeck Kip D.Kuntz Frederick s.Porter Catriana K.Paw U Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Michael Collier space Research Institute Austrian Academy of Sciences8042 GrazAustria Geophysical Institute University of Alaska FairbanksFairbanksAlaska 99775USA National Aeronautics and space Administration(NAsA)Goddard space Flight Center GreenbeltMaryland 20771USA Astronomy Department University of Maryland College ParkCollege ParkMaryland 20742USA Center for space Physics Boston UniversityBostonMassachusetts 02215USA Department of Physics and Astronomy Johns Hopkins UniversityBaltimoreMaryland 21218USA Howard University WashingtonDC 20059USA

The Lunar Environment heliospheric X-ray Imager(LEXI)and solar wind Magnetosphere Ionosphere Link Explorer(sMILE)missions will image the Earth’s dayside magneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal magnetic reconnection modes for varying solar wind *** suppo rt the success of these scientific missions,it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray *** this research,we introduce a new geometric equation that calculates the subsolar magnetopause position(Rs)from a satellite position,the look direction of the instrument,and the angle at which the X-ray emission is *** assumptions are used in this method:(1)The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause,and(2)the magnetopause surface near the subsolar point is almost spherical and thus Rsis nea rly equal to the radius of the magneto pause *** create synthetic soft X-ray images by using the Open Geospace General Circulation Model(OpenGGCM)global magnetohydrodynamic model,the galactic background,the instrument point spread function,and Poisson *** then apply the fast Fourier transform and Gaussian low-pass filte rs to the synthetic images to re move noise and obtain accurate look angles for the soft X-ray pea *** the filte red images,we calculate Rs and its accuracy for different LEXI locations,look directions,and solar wind densities by using the OpenGGCM subsolar magnetopause location as ground *** method estimates Rs with an accuracy ofsolar wind density exceeds>10 *** accuracy improves for greater solar wind densities and during southward interplanetary magnetic *** method ca ptures the magnetopause motion during southwa rd interplaneta ry magnetic field ***,the technique will enable quantitative analysis of the magnetopause motion and help reveal the daysi

关键词： soft X-ray magnetopause reconnection low-pass filter LEXI sMILE

Functional group resolved NMR relaxation of 3-carbon adsorbates in mesoporous alumina

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Magnetic Resonance Letters 2023年第3期3卷 248-255,I0004页

作者： Neil Robinson Carmine D’Agostino Michael Ljohns Department of Chemical Engineering The University of Western Australia35 Stirling HighwayPerthWA 6009Australia Department of Chemical Engineering The University of ManchesterOxford RoadManchesterM139PLUK Dipartimento di Ingegneria Civile ChimicaAmbientale e Dei Materiali(DICAM)Alma Mater Studiorum e Universita di BolognaVia Terracini28Bologna40131Italy

NMR relaxation analysis provides a unique and non-invasive probe of fluid dynamics within porous materials,and may be applied to the interpretation of a wide variety of material and interfacial ***,we report two-dimensional^(1)H T_(1)-T_(2)relaxation correlation measurements of a range of three-carbon adsorbates(1-propanol,2-propanol and propanoic acid)imbibed within the mesoporous metal oxide *** data,acquired across field strengths of 2 MHz,12.7 MHz and 43 MHz,clearly reveal two populations in each measurement,identified as the alkyl and hydroxyl moieties of each *** results expand the range of materials in which such functional group resolved relaxation is known to occur,and demonstrate the clear persistence of such phenomena using a range of typical benchtop NMR systems employed to study fluid-saturated porous media.

关键词： NMR relaxation Adsorption Porous media Low-field NMR