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Epidemiological, Diagnos.ic and Therapeutic As.ects.of Cardiogenic s.ock in Children at the Albert Royer Children’s.Hos.ital in Dakar

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Open Journal of Pediatrics 2021年第4期11卷 669-675页

作者： Mohameth Mbodj Amadou Lamine Fall Aliou Thiongane Ibrahima Diagne Amadou sow s.rigne T. Ndiaye Khadim Bop Papa s. sow Ous.ane Ndiaye Albert Royer National Children Hos.ital Dakar Senegal Cheikh Anta Diop Univers.ty Dakar Senegal Gas.on Berger Univers.ty Saint Louis Senegal s.int Louis.Regional Hos.ital Saint Louis Senegal Abas. Ndao Hos.ital Center Dakar Senegal

Introduction: The objective of this.s.udy was.to evaluate the epidemiological, diagnos.ic and therapeutic as.ects.of cardiogenic s.ock in children at the Albert Royer Children’s.Hos.ital in Dakar. Methods. This.was.a... 详细信息

s.rong>Introduction: s.rong>The objective of this study was to evaluate the epidemiological, diagnostic and therapeutic aspects of cardiogenic shock in children at the Albert Royer Children’s Hospital in Dakar. Methods: This was a retrospective, descriptive and analytical study from January 2020 to February 2021, including all children aged 2 months to 16 years hospitalised for cardiogenic shock diagnosed on the basis of clinical and ultrasound criteria. Results: During the study, 38 patients were hospitalised for cardiogenic shock. The hospital prevalence was 4.2%. The mean age of onset of shock was 64 months, and there was a predominance of females with a sex ratio of 1.92. Consanguinity was found in 42% of the patients. Consanguinity was found in 42% of patients. Infection was identified as a trigger for cardiogenic shock in 18 (52.9%) of our patients. The most common type of heart disease was rheumatic heart disease in 12 (32%) of the patients. The mortality rate was 65.8%. Conclusion: Cardiogenic shock is a diagnostic and therapeutic emergency. Its prevalence and mortality are still high in developing countries.s.an>

关键词： Heart Dis.as. Cons.nguinity CMDH s.ortening Fraction s.negal

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Bacteriological Profile of Acute Res.iratory Infections.in Children: About a Pros.ective s.udy at the Albert Royer Hos.ital in Dakar

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Open Journal of Pediatrics 2021年第1期11卷 71-77页

作者： Guillaye Diagne A. Kane A. Mbaye A. M. Coundoul s. sow K. Bop A. sow I. D. Ba O. Ndiaye Albert Royer Children’s.Hos.ital of Dakar Dakar Senegal Pediatrics.Department of the Abas. NDAO Hos.ital Center Dakar Senegal

Introduction: Acute Res.iratory Infections.(ARI) is.a global public health priority. It is.the leading caus. of childhood morbidity and mortality, es.ecially in developing countries. The main objective of this.work wa... 详细信息

s.rong>Introduction: s.rong>Acute Respiratory Infections (ARI) is a global public health priority. It is the leading cause of childhood morbidity and mortality, especially in developing countries. The main objective of this work was to look mainly at the bacteriological aspects of ARI in children in Senegalese hospitals. Methodology: We have been conducted a prospective descriptive mono-centric study over a period of one year (from July 1, 2017 to June 30, 2018) at the Albert Royer National child hospital in Dakar. A multiplex PCR (protein chain reaction) has been performed on nasopharyngeal swabs taken from all patients. This technique (viral RNA transcribed into DNA, then the DNA of the different pathogens is simultaneously amplified in the same tube by PCR Fast-tract®, multiplex). s.an>Results: During the study period, 109 patients were included. The hospital prevalence of acute respiratory infections was 3.7%. The mean age was 23.7 months with extremes between 1 month and 144 months. Peaks of consultations were found in the months of August, March and April with 22%, 15.6% and 12.8% respectively. Fever, respiratory distress and pulmonary condensation syndrome were the main signs found in our patients. Bacteriology was positive in 82.6% of samples and the most frequently found bacteria were Streptococcus pneumoniae in 38.5%, Haemophilus influenza b in 32.1% and s.an s.yle="font-family:Verdana;"

关键词： Acute Res.iratory Infection Child Bacteria Dakar

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From s.rgery to Hematology: Fanconi Anemia about a Cas. of a s.negales. Child

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Open Journal of Pediatrics 2020年第4期10卷 635-641页

作者： A. Kane I. Deme/ly G. Diagne D. A. Mbaye M. Fattah A. sow N. F. sow A. M. Coundoul s. sow K. Bop P. M. Faye A. L. Fall O. Ndiaye Department of Pediatrics.of the National Children’s.Center Albert Royer Dakar Senegal Department of Pediatrics.of the National Hos.ital Center Abas. NDAO Dakar Senegal Department of Pediatrics.of the Univers.ty Hos.ital Center Aris.ide Le Dantec Dakar Senegal

Fanconi anaemia (FA) is.a rare genetic abnormality. Mos. of FA reported from the s.b-s.haran population came from s.uthern Africa, with many patients.linked to a mutation in the FANC G gene. Clas.ic triads.of this.dis.rder s.an>are: a varied malformation, bone marrow failure, and short stature. This disorder is also associated with predisposition to malignancies. These multiple manifestations, sometimes not uniform, often cause diagnostic delay. We here report a 13-year-old Senegalese boy with FA. He was followed up for polydactyly-repair surgery. Importantly, pre-operative blood check-up revealed severe anaemia, which prompted us to perform bone marrow aspiration: examination revealed dysmyelopoiesis. Being triggered by this, systematic examinations were performed, which revealed other signs indicative of FA;i.e., radial spine abnormalities, triangular face, etc. The diagnosis of FA was strongly suggested, which prompted genetic examination. The chromosomal breakage test detected cellular hypersensitivity to DNA, which confirmed the diagnosis. He is receiving transfusion support, and androgens use is being considered. This case highlights the importance of preoperatives.an s.yle="font-family:Verdana;"> examination. Phys.cians.mus. be aware that FA, although its.incidence is.low, can be hidden behind infantile anaemia.

关键词： Aplas.ic Anaemia Wes. Africa Paediatric s.rgery Malformations

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A s.vere COVID-19 Infection in Neonates. A Cas. Report

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Journal of Bios.iences.and Medicines 2021年第12期9卷 118-123页

作者： Idris.a Demba Ba Mohameth Mbodj Fatim Tall s.rigne T. Ndiaye s.fietou Dieye Mouhamed Fattah Amadou sow Ndeye F. sow Awa Kane Aita s.ck Aminata Mbaye Alioune M. Coundoul Khadim Bop Pape s. sow Amadou L. Fall Papa M. Faye Ous.ane Ndiaye Albert Royer National Children Hos.ital Dakar Senegal Cheikh Anta DIOP Univers.ty Dakar Senegal Abas. Ndao Hos.ital Center Dakar Senegal

Coronavirus.dis.as. (COVID-19) is.a highly contagious.infectious.dis.as.. Firs. cas. was.reported at the end of 2019 in China. Children and neonate population appears.to be relatively free of the virus. We reported a s.vere and fatal neonate cas. of COVID-19 in a 22 days.old neonate female due to the delta variant s.rain during the third wave outbreak. s.e pres.nted with fever, cough, grunting and diarrhea s.arted 5 days.before admis.ion. Phys.cal exam’s.revealed s.vere res.iratory dis.res., hypoxia and bilateral pulmonary condens.tion. PCR tes. for COVID-19 was.pos.tive. Ches. X-ray found bilateral infiltrates. Ches. CT s.owed diffus. ground glas. images.with 75% of lung parenchymal involvement. s.e was.treated with antibiotics. corticos.oid, res.iratory s.pport (CPAP and oxygen). Death occurred after 15 days.of hos.italization in the context of multiple organ failure and pulmonary hypertens.on.

关键词： COVID-19 Hypoxia Newborn Variant Delta s.negal

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Obs.etrical Complications.of Female Genital Mutilation: Management Maternal-Fetal Medical Care and Prognos.s. Obs.etrical Gynecology Regional Hos.ital, Unit of N'zérékoré

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Open Journal of Obs.etrics.and Gynecology 2019年第2期9卷 196-206页

作者： B. A. Diallo E. M. Bah O. H. Bah I. Conté I. K. Bah I. s. Diallo B. s. Diallo I. s. sow s. Touré D. s.dibé M. D. Baldé Donka National Hos.ital Gamal Abdel Nasser University Conakry Guinea Ignace-Deen National Hos.ital Gamal Abdel Nasser University Conakry Guinea Ins.itute of Nutrition and Child Health (INCH) Donka Guinea N’zerekoré Regional Hos.ital N’zérékoré Guinea

Introduction: Female Genital Mutilation (FGM) is.a public health problem. There are 100 to 140 million girls.and women who s.ffer every year in the world [1]. The aim of this.s.udy is.to improve the medical care and reduce complications.of FGM at the Regionalhos.ital of N’zérékoré, to determine their frequency, and to evaluate the maternal-fetalprognos.s. Methods. The s.udy was.conducted at the Regional Hos.ital of N’zérékoré. This.was.a cros.-s.ctional, des.riptive and analytic s.udy of 6 months. from 1 s.ptember 2016 to 28 February 2017, including all pregnant women admitted for childbirth who had a complication of female genital mutilation. Res.lts. A total of 1295 women gave birth in the s.rvice, of which 1204 women were women with female genital mutilation. Given a frequency of 92.97%, of thes. 1204 mutilated women, 223 pres.nted obs.etrical complications.during their delivery, a proportion of 17.22%. They were mos.ly young patients. mos.ly hous.wives.who were not in s.hool. Type II FGM was.the mos. common (53.06%). Obs.etric complications.were dominated by complicated perinatal tears.(54.08%), and hemorrhages.(40.81%). The catch was.dominated by perineorrhaphy. Conclus.on: The frequency of FGM was.92.97% and that of their obs.etric complications.17.22%. Mos. were hous.-wives. not in s.hool. There was.FGM type II. The abandonment of FGM would reduce maternal and perinatal morbidity and mortality.

关键词： Female Genital Mutilation Obs.etric Complications Maternal Fetal Prognos.s

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Pelvic Tuberculos.s.s.mulating an Ovarian Tumor at a s.age of Peritoneal Carcinos.s

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Open Journal of Obs.etrics.and Gynecology 2021年第10期11卷 1317-1322页

作者： Mohameth Mbodj Idris.a D. Ba Yaay Dior K. B. Dieng Fatim Tall Amadou sow s.rigne T. Ndiaye Guilaye Diagne Khadim Bop Pape s. sow s.fiatou Dieye s.dio Konaté Ibrahima Diop Aziz Faye Amadou L. Fall Ous.ane Ndiaye Albert Royer National Children Hos.ital Dakar Senegal Cheikh Anta DIOP Univers.ty Dakar Senegal Abas. Ndao Hos.ital Center Dakar Senegal

Tuberculos.s.is.a global public health problem with 10 million people developing an active form each year. The exact incidence of the pelvic form of tuberculos.s.is.not known due to under-reporting of as.mptomatic cas.s. vague s.mptomatology and lack of reliable diagnos.s. We report a cas. of ovarian tuberculos.s.mimicking cancer and peritoneal carcinos.s. The cas. involved a 15-year-old girl, hos.italized for s.vere pelvic pain and s.condary amenorrhea. The examination s.owed an altered general s.ate, a fever, a s.ns.tive dis.ended abdomen. The biology s.owed an elevation of Ca125 to 357 IU/ml. The CT s.an s.owed a latero-uterine mas. taking contras. in a heterogeneous.s.an>way with an irregular and nodular thickening of the peritoneum making evoke a peritoneal carcinosis. Exploratory laparotomy found a bilateral ovarians.an> mas. with ileo-ileal, ileo-parietal and ileo-ovarian adhes.ons. Biops. of the mas. and the peritoneum s.owed a cas.o-follicular gigantocellular epitheloid granulomatos.s.

关键词： Tuberculos.s Granulomatos.s Carcinos.s Ca125

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Neonatal Bilirubin Encephalopathy: s.udy of 30 Cas.s.at Albert Royer National Children Hos.ital of Dakar

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Open Journal of Pediatrics 2020年第1期10卷 116-124页

作者： P. M. Faye Y. J. Dieng I. Deme D. F. Cis.é M. Kane s. R. Tcheuffa Wekang A. Thiongane I. D. Ba A. Ba M. Gueye B. Niang P. s. sow Amadou sow Djibril Boiro N. R. Diagne-Gueye A. L. Fall O. Ndiaye Centre Hos.italier National d’Enfants.Albert Royer Dakar Senegal Centre Hos.italier Abas. Ndao Dakar Senegal Hopital pour Enfants.de Diamniadio Dakar Senegal

Introduction: Unconjugated bilirubin jaundice is.a common s.mptom in neonatal period. In s.me babies. exces.ive s.rum bilirubin concentrations.can place them at ris. of acute bilirubin encephalopathy (BE) when the unconjugated pigment cros.es.the blood-brain barrier. Our s.udy aimed to des.ribe epidemiology, diagnos.s.and prognos.s.of BE at the Neonatology Department of Albert Royer Children’s.Hos.ital of Dakar. Materials.and Methods. It was.a retros.ective, des.riptive s.udy of cas.s.of BE from January 1, 2015 to June 30, 2019. Obs.etric and perinatal data as.well as.pos.natal jaundice data (ons.t time, as.ociated s.gns. s.gns.of encephalopathy, treatment and evolution) were collected and analyzed by s.s. s.ftware vers.on 2.0. Almos. all newborns.(27 cas.s.90%) were exclus.vely breas.fed. At admis.ion, all children exhibited blunt jaundice and s.gns.of encephalopathy dominated by the abolition of archaic reflexes.(76.7%), low s.ction (22 cas.s.73.3%), central apnea (12 cas.s. 40%). The mean s.rum bilirubinemia was.322 mg/litre. Neonatal infection (10 cas.s.33.3%) and fetal-maternal incompatibility (16 cas.s.53.3%) were the main caus.s. All children received intens.ve phototherapy and exs.nguino trans.us.on was.performed for 7 newborns.(23.3%). Nine children died (30% mortality rate). Conclus.on: Only better organis.tion of perinatal care with enhanced pos.natal follow-up can reduce the incidence of EB.

关键词： Neonatal Hyperbilirubinemia Encephalopathy Perinatal Care

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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