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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced micros.s.ems

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Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain injury res.arch:Traumatic brain injury(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic injury damage

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Unders.anding activity of butyrate at a cellular level

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Neural Regeneration Res.arch 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie Univers.ty Motor Neuron Dis.as. Res.arch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is.a s.ort-chain fatty acid of four carbons.in length that is.a by-product produced by the microbial fermentation of dietary fiber and undiges.ed carbohydrates.within the *** the years.butyrate has.attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dys.unction and genetic ris. for neurodegenerative dis.as.

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Neural Regeneration Res.arch 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical s.iences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative dis.rders.s.ch as.Alzheimer's.and Parkins.n's.dis.as.s.a re increas.ng in prevalence as.world populations.*** tremendous.progres. has.been made,our unders.anding of the mechanis.s.that underlie the development of thes. dis.as.s.remains.far from com *** troubling,des.ite the growing emotional and financial toll being to ken by neurodegenerative dis.rders.exis.ing treatment options.are limited almos. exclus.vely to thos. that help manage s.mptoms.but that lack the ability to alter the progres.ion of the dis.as.(Liu et al.,2022).

关键词： degenerative dis.as.s

Intrumer:A Multi Module Dis.ributed Explainable IDs.IPs.for s.curing Cloud Environment

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Computers. Materials.& Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.K.B.s.ngeetha Department of Computer s.ience and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increas.ng us. of cloud-bas.d devices.has.reached the critical point of cybers.curity and unwanted network *** environments.pos. s.gnificant challenges.in maintaining privacy and *** approaches.s.ch as.IDs.have been developed to tackle thes. ***,mos. conventional Intrus.on Detection s.s.em(IDs.models.s.ruggle with uns.en cyberattacks.and complex high-dimens.onal *** fact,this.paper introduces.the idea of a novel dis.ributed explainable and heterogeneous.trans.ormer-bas.d intrus.on detection s.s.em,named INTRUMER,which offers.balanced accuracy,reliability,and s.curity in cloud s.ttings.bymultiplemodules.orking together within *** traffic captured from cloud devices.is.firs. pas.ed to the TC&TM module in which the Falcon Optimization Algorithm optimizes.the feature s.lection proces.,and Naie Bayes.algorithm performs.the clas.ification of *** s.lected features.are clas.ified further and are forwarded to the Heterogeneous.Attention Trans.ormer(HAT)*** this.module,the contextual interactions.of the network traffic are taken into account to clas.ify them as.normal or malicious.*** clas.ified res.lts.are further analyzed by the Explainable Prevention Module(XPM)to ens.re trus.worthines. by providing interpretable *** the explanations.fromthe clas.ifier,emergency alarms.are trans.itted to nearby IDs.odules.s.rvers.and underlying cloud devices.for the enhancement of preventive *** experiments.on benchmark IDs.datas.ts.CICIDs.2017,Honeypots.and Ns.-KDD were conducted to demons.rate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms.s.ate-of-the-art approaches.obtaining better performance metrics.98.7%accuracy,97.5%precis.on,96.3%recall,and 97.8%*** res.lts.validate the robus.nes. and effectivenes. of INTRUMER in s.curing divers. cloud environments.agains. s.phis.icated cyber threats.

关键词： Cloud computing intrus.on detection s.s.em trans.ormers and explainable artificial intelligence(XAI)

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

Women in vis.al neural regeneration res.arch

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Neural Regeneration Res.arch 2025年第2期20卷 489-490页

作者： Tonia s.Rex David J.Calkins Vanderbilt Eye Ins.itute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks.the 60^(th)annivers.ry of Title IX and 25 years.s.nce the New York Times.revealed bias.agains. female faculty members.at the Mas.achus.tts.Ins.itute of *** take an opportunity here to examine the s.ate of gender bias.in a relatively new yet already prominent field,neural regeneration in the vis.al s.s.em,for which there is.a well-defined context us.ful for this.*** National Eye Ins.itute(NEI)provided the firs. round of res.arch funding for its.Audacious.Goals.Initiative(AGI)on vis.al neural regeneration in 2013 and the las. round in ***,we focus.on this.*** s.urces.included PubMed,the National s.ience Foundation(Ns.),the NEI,the Blue Ridge Ins.itute for Medical Res.arch and data from the major profes.ional organization for eye and vis.on res.arch,the As.ociation for Res.arch in Vis.on and Ophthalmology(ARVO).

关键词： neural vis.al Times

Unlocking hypoglycemia–as.ociated brain microvas.ular dys.unction:critical ins.ghts.from proteomic analys.s

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Neural Regeneration Res.arch 2025年第6期20卷 1707-1708页

作者： s.va s.V.P.s.kamuri Anil s.kamuri Department of Chemis.ry Auburn University at MontgomeryMontgomeryALUSA Vas.ular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to wors.ned brain function in diabetic s.bjects.Hypoglycemia is.characterized by a decline in circulatory glucos. levels.below s.a nda rd phys.ological *** hypoglycemia,clas.ified as.level 1 hypoglycemia,is.defined by blood glucos. levels.below 70 mg/dL and can be effectively addres.ed through carbohydrate *** hypoglycemia,denoted by blood glucos. levels.les. than 54 mg/dL,pos.s.a life-threatening ris. if left *** with type 1 and type 2 diabetes.undergoing ins.lin treatment are particularly s.s.eptible to hypoglycemia due to impaired counterregulatory mechanis.s.

关键词： impaired intake critical