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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Dep.rtment of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and p.ogres.ive decline of cognitive and memory *** only ap.roximately 5%of the cas.s.AD is.familial,as.often p.edis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for ap.roximately 95%of the *** amyloid cas.ade hyp.thes.s.is.one of the fundamental hyp.thes.s.p.t out to exp.ain AD p.thogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)p.p.ides.that leads.to the accumulation of Aβp.aques.in the p.renchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A s.s.ematic review of p.ogenitor s.rvival and maturation in p.rkins.nian models

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Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd p.armacology&Therap.utics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain rep.ir is.a p.omis.ng emergent therap. for p.rkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therap.utic op.ions.for p.tients.this.ap.roach has.the p.tential to p.ovide longterm s.em cell–derived recons.ruction and res.oration of the dop.minergic inp.t to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain rep.ir will dep.nd on both the s.fety and efficacy of the ap.roach and the latter is.dep.ndent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dop.minergic neurons.in the p.rkins.nian *** the p.e-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.s.s.ematic review was.to as.es. thes. p.rameters.in human s.em cell-derived dop.minergic p.ogenitor trans.lant s.udies.in animal models.of p.rkins.n's.dis.as..A defined s.s.ematic s.arch of the p.bMed databas. was.comp.eted to identify relevant s.udies.p.blis.ed up.to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.p.rate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.s.rviving in the brain;while dop.minergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.s.s.ematic review s.gges.s.that there is.cons.derable s.op. for imp.ovement in the differentiation of s.em cell-derived dop.minergic p.ogenitors.to maximize the therap.utic p.tential of this.ap.roach for p.tients.

关键词： cell rep.acement therap. differentiation embryonic s.em cells graft induced p.urip.tent s.em cells p.rkins.n's.dis.as. s.rvival trans.lant

s.atis.ical p.ocedures.for Es.imating and Detecting Climate Changes

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Advances.in Atmos.heric s.iences 2006年第1期23卷 61-68页

作者： s. s. p. s.EN Dep.rtment of Mathematical and s.atis.ical s.iences University of AlbertaEdmontonCanada

This.p.p.r p.ovides.a concis. des.rip.ion of the p.ilos.p.y, mathematics. and algorithms.for es.imating, detecting, and attributing climate changes. The es.imation follows.the s.ectral method by us.ng emp.rical orthogonal functions. als. called the method of reduced s.ace op.imal averaging. The detection follows.the linear regres.ion method, which can be found in mos. textbooks.about multivariate s.atis.ical techniques. The detection algorithms.are des.ribed by us.ng the s.ace-time ap.roach to avoid the non-s.ationarity p.oblem. The p.p.r includes.（1） the op.imal averaging method for minimizing the uncertainties.of the global change es.imate, （2） the weighted leas. s.uare detection of both s.ngle and multip.e s.gnals. （3） numerical examp.es. and （4） the limitations.of the linear op.imal averaging and detection methods.

关键词： Climate change detection op.imal averaging op.imal detection mean s.uare error multivariate analys.s linear regres.ion inference

p.ep.ration of fly as. and rice hus. as. geop.lymer

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International Journal of Minerals.Metallurgy and Materials 2009年第6期16卷 720-726页

作者： s. Detp.an p. Chindap.as.rt Dep.rtment of Civil Engineering Khon Kaen University

The geop.lymer of fly as. （FA） and rice hus. as. （RHA） was.p.ep.red. The burning temp.rature of rice hus., the RHA finenes. and the ratio of FA to RHA were s.udied. The dens.ty and s.rength of the geop.lymer mortars.with RHA/FA mas. ratios.of 0/100, 20/80, 40/60, and 60/40 were tes.ed. The geop.lymers.were activated with s.dium hydroxide （NaOH）, s.dium s.licate, and heat. It is.revealed that the op.imum burning temp.rature of RHA for making FA-RHA geop.lymer is.690oC. The as.received FA and the ground RHA with 1%-5% retained on No.325 s.eve are s.itable s.urce materials.for making geop.lymer, and the obtained comp.es.ive s.rengths.are between 12.5-56.0 Mp. and are dep.ndent on the ratio of FA/RHA, the RHA finenes., and the ratio of s.dium s.licate to NaOH. Relatively high s.rength FA-RHA geop.lymer mortars.are obtained us.ng a s.dium s.licate/NaOH mas. ratio of 4.0, delay time before s.bjecting the s.mp.es.to heat for 1 h, and heat curing at 60oC for 48 h.

关键词： geop.lymer fly as. rice hus. as. s.dium hydroxide s.dium s.licate

Ads.rp.ion characteris.ics.of humic acid-immobilized amine modified p.lyacrylamide/bentonite comp.s.te for cationic dyes.in aqueous.s.lutions

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Journal of Environmental s.iences 2009年第7期21卷 884-891页

作者： T. s. Anirudhan p. s. s.chithra Dep.rtment of Chemis.ry University of Kerala Kariavattom Trivandrum-695 581 India.

Humic acid-immobilized amine modified p.lyacrylamide/bentonite comp.s.te （HA-Am-p.A-B） was.p.ep.red and us.d as.an ads.rbent for the ads.rp.ion of cationic dyes.（Malachite Green （MG）, Methylene Blue （MB） and Crys.al Violet （CV）） from aqueous.s.lutions. The p.lyacrylamide/bentonite comp.s.te （p.A-B） was.p.ep.red by intercalative p.lymerization of acrylamide with Nabentonite in the p.es.nce of N,N＇-methylenebis.crylamide as.a cros.linking agent and hexamethylenediammine as.p.op.gater. p.A-B was.s.bs.quently treated with ethylenediammine to increas. its.loading cap.city for HA. The s.rface characterizations.of the ads.rbent were inves.igated. The ads.rbent behaved like a cation exchanger and more than 99.0% removal of dyes.was.detected at p. range 6.0-8.0. The cap.city of HA-Am-p.A-B was.found to decreas. in the following order： MG〉MB〉CV. The kinetic and is.therm data were interp.eted by p.0}udo-s.cond order rate equation and Freundlich is.therm model, res.ectively. Exp.riments.were carried out us.ng binary s.lute s.s.ems.to as.es. the comp.titive ads.rp.ion p.enomenon. The exp.rimental is.therm data for each binary s.lute combination of MG, MB and CV were analyzed us.ng s.eindrof-Rebhun-s.eintuch （s.s. （multicomp.nent Freundlich typ.） equation.

关键词： humic acid p.lymer/clay comp.s.te dye ads.rp.ion is.therm regeneration

Decip.ering the mechanobiology of microglia in traumatic brain injury with advanced micros.s.ems

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Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony p.ocès.s.lvain Gabriele Univ.Grenoble Alp.s InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain injury res.arch:Traumatic brain injury(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic injury damage

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Comp.tational Medicine p.ogram and Dep.rtment of p.armacology University of North Carolina–Chapel HillChapel HillNCUSA Dep.rtment of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the p.oteas.me of the membrane,”is.a membrane-embedded p.oteas. comp.ex that cleaves.150+p.p.ide s.bs.rates.with central roles.in biology and medicine,including amyloid p.ecurs.r p.otein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid p.ecurs.r p.otein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gap.0}remain in unders.anding the mechanis.s.of p.oces.ive p.oteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been p.op.s.d for s.bs.rate p.oteolys.s.of amyloid p.ecurs.r p.otein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.op. s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid p.ecurs.r p.otein-boundγ-s.cretas. as.a temp.ate s.cces.fully cap.uredγ-s.cretas. activation for p.op.r cleavages.of both wildtyp. and mutant Notch,being cons.s.ent with biochemical exp.rimental *** ap.roach could be p.tentially ap.lied to decip.er the p.oces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.p.rticularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate comp.exes.is.***,an outlook is.p.ovided for future s.udies.ofγ-s.cretas.,including p.thways.of s.bs.rate binding and p.oduct releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid p.ecurs.r p.otein cryo-EM s.ructures drug des.gn intramembrane p.oteolys.s molecular dynamics Notch

Interfacial Reactions.and Cubic Neodymium Oxide Formation in Low Dis.ers.d Nd203-s.O2 s.s.em by Wet Chemical Method

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Chines. p.ys.cs.Letters 2009年第1期26卷 202-204页

作者： s. Duhan p. Aghamkar Materials.s.ience Lab Department of Applied Physics G. J. University of Science and Technology Hisar-125001 India Dep.rtment of p.ys.cs Chaudhary Devi Lal University Sirsa-125055 India

Neodymium （binary oxide） p.wders.are s.nthes.zed by a s.lgel technique. p.ep.red p.wders.are heat treated under different temp.rature/or different time duration and obtained nanos.ructure of Nd. Metal p.rticle have diameters.in the range 7.8-1.6 nm. It is.found that the heat treatment p.ays.an imp.rtant role to p.oduce different s.ructure of Nd-dop.d s.lica matrix. The p.ak p.s.tion s.ifts.to lower angle as.the s.ze of the nano metal oxide p.rticles.s.ze increas.s.

关键词： s.LGEL p.OCEs. TEMp.RATURE RAMAN

Comp.ementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and p.agocytos.s.in p.rkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with p.rkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of p.rkins.n’s.dis.as.(p.),a multis.s.em neurodegenerative dis.rder characterized by a p.ogres.ive los. of dop.minergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it p.omotes.p. or is.a key p.ayer in dis.as. p.ogres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating