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Cytotoxicity and Aris.olochic Acid Content of Medicinally Us.d As.rum s.ecies

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Cytotoxicity and Aristolochic Acid Content of Medicinally Us...

Amplitude analys.s.of the decays.D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

第十四届全国中药和天然药物学术研讨会

作者： Johanna Michl Olus.eyi Bello Geoffrey C.Kite Monique s.J.s.mmonds.Michael heinrich UCL s.hool of Pharmacy London Royal Botanical Gardens KewSurrey

＜正＞As.rum s.ecies.are us.d as.herbal medicines.in many parts.of the world,including Europe and *** As.rum s.ecies.are lis.ed in the Chines. Pharmacopeia under the Pin Yin name Xixin（1）.s.milar to Aris.olochia s.ecies.they contain aris.olochic acid（AA）analogues.compounds.known for their nephrotoxic and carcinogenic effects.2）.s. far,little is.known

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Chines. Phys.cs.C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achas.v P.Adlars.n O.Afedulidis.X.C.Ai R.Aliberti A.Amoros. Q.An Y.Bai O.Bakina I.Balos.ino Y.Ban H.-R.Bao V.Batozs.aya K.Begzs.ren N.Berger M.Berlows.i M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.s.Chen M.L.Chen s.J.Chen s.L.Chen s.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen s.K.Choi X.Chu G.Cibinetto F.Cos.io J.J.Cui H.L.Dai J.P.Dai A.Dbeys.i R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denys.nko M.Des.efanis.F.De Mori B.Fang s.s.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fis.her M.Frits.h C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao s.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gers.beck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du s.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl s.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Gus.ov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris.K.K.He K.L.He F.H.Heins.us.C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.s.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hus.ain F.H\"olzken N.H\"us.en N.in der Wies.he M.Irs.ad J.Jacks.n s.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang s.s.Jiang T.J.Jiang X.s.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao s.Jin Y.Jin M.Q.Jing X.M.Jing T.Johans.on s.Kabana N.Kalantar-Nayes.anaki X.L.Kang X.s.Kang M.Kavats.uk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kues.ner X.Kui A.Kups. W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.s.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li s.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Ins.itute of High Energy Phys.cs Chinese Academy of SciencesBeijing 100049China Beihang Univers.ty Beijing 100191China Bochum Ruhr-Univers.ty D-44780 BochumGermany Budker Ins.itute of Nuclear Phys.cs.s. RAs.BINP) Novosibirsk 630090Russia Carnegie Mellon Univers.ty PittsburghPennsylvania 15213USA Central China Normal Univers.ty Wuhan 430079China Central s.uth Univers.ty Changsha 410083China China Center of Advanced s.ience and Technology Beijing 100190China China Univers.ty of Geos.iences Wuhan 430074China Chung-Ang Univers.ty Seoul06974Republic of Korea COMs.Ts.Univers.ty Is.amabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan Univers.ty Shanghai 200433China Gs. Helmholtzcentre for Heavy Ion Res.arch GmbH D-64291 DarmstadtGermany Guangxi Normal Univers.ty Guilin 541004China Guangxi Univers.ty Nanning 530004China Hangzhou Normal Univers.ty Hangzhou 310036China Hebei Univers.ty Baoding 071002China Helmholtz Ins.itute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal Univers.ty Xinxiang 453007China Henan Univers.ty Kaifeng 475004China Henan Univers.ty of s.ience and Technology Luoyang 471003China Henan Univers.ty of Technology Zhengzhou 450001China Huangs.an College Huangshan 245000China Hunan Normal Univers.ty Changsha 410081China Hunan Univers.ty Changsha 410082China Indian Ins.itute of Technology Madras Chennai 600036India Indiana Univers.ty BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Fras.ati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Fras.ati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Fras.ati University of PerugiaI-06100PerugiaItaly INFN s.zione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN s.zione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia Univers.ty Hohhot 010021China Ins.itute of Modern Phys.cs Lanzhou 730000China Ins.itute of Phys.cs.and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Ins.ituto de A

Us.ng e^(+)e^(−)annihilation data corres.onding to an integrated luminos.ty of 2.93 fb^(−1)taken at the center-of-mas. energy√s.3.773 GeV with the BEs.II detector,a joint amplitude analys.s.is.performed on the decays.D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions.of individual components.are obtained,and large interferences.among the dominant components.of the decays.D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(s.are obs.rved in both *** the obtained amplitude model,the CP-even fractions.of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(s.at).±1.5_(s.s..))%and(68.9±1.5_(s.at).±2.4_(s.s..))%,*** branching fractions.of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are meas.red to be(0.688±0.010_(s.at.)±0.010_(s.s..))%and(0.951±0.025_(s.at.)±0.021_(s.s..))%,*** amplitude analys.s.provides.an important model for the binning s.rategy in meas.ring the s.rong phas. parameters.of D^(0)→4πwhen us.d to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BEs.II D^(0)mes.n decays amplitude analys.s CP-even fraction

Remote s.ns.ng to detect deterioration of Flooding Pampa rangeland by the us. of glyphos.te

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Remote sensing to detect deterioration of Flooding Pampa ran...

Determination of the number ofψ(3686)events.taken at BEs.

ⅩⅪ International Gras.land Congres. and the Ⅷ International Rangeland Congres.

作者： Jacobo,E Rodriguez,A heinrich,N Facultad,L Univers.dad de Buenos.Aires.Av.s.n Martin 4453 Buenos.Aires.1417 Argentina

Introduction A technique bas.d on s.raying glyphos.te to Flooding Pampa’s.rangelands.in late s.mmer has.been wides.read during the las. *** technique eliminates.green vegetation growing in late s.mmer with the aim of improve germination and es.ablis.ment of cool s.as.n(C) annual gras.es.which,in turn,increas.s.winter forage offer and allows.increment of

关键词： temperate gras.lands photos.nthetically active radiation abs.rbed s.as.nal variation

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Chines. Phys.cs.C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achas.v P.Adlars.n O.Afedulidis.X.C.Ai R.Aliberti A.Amoros. Q.An Y.Bai O.Bakina I.Balos.ino Y.Ban H.-R.Bao V.Batozs.aya K.Begzs.ren N.Berger M.Berlows.i M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.s.Chen H.Y.Chen M.L.Chen s.J.Chen s.L.Chen s.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen s.K.Choi G.Cibinetto F.Cos.io J.J.Cui H.L.Dai J.P.Dai A.Dbeys.i R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denys.nko M.Des.efanis.F.De Mori B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du s.X.Du Y.Y.Duan Z.H.Duan P.Egorov Y.H.Fan J.Fang J.Fang s.s.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng M.Frits.h C.D.Fu J.L.Fu Y.W.Fu H.Gao X.B.Gao Y.N.Gao Yang Gao s.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gers.beck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl s.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Gus.ov J.Gutierrez K.L.Han T.T.Han F.Hanis.h X.Q.Hao F.A.Harris.K.K.He K.L.He F.H.Heins.us.C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu s.L.Hu T.Hu Y.Hu G.s.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hus.ain F.Hölzken N.Hüs.en N.in der Wies.he J.Jacks.n s.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang s.s.Jiang T.J.Jiang X.s.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao s.Jin Y.Jin M.Q.Jing X.M.Jing T.Johans.on s.Kabana N.Kalantar-Nayes.anaki X.L.Kang X.s.Kang M.Kavats.uk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kues.ner X.Kui N.Kumar A.Kups. W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.s.Li Ke Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li s.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Ins.itute of High Energy Phys.cs Beijing 100049China Beihang Univers.ty Beijing 100191China Bochum Ruhr-Univers.ty D-44780BochumGermany Budker Ins.itute of Nuclear Phys.cs.s. RAs.BINP) Novosibirsk 630090Russia Carnegie Mellon Univers.ty PittsburghPennsylvania 15213USA Central China Normal Univers.ty Wuhan 430079China Central s.uth Univers.ty Changsha 410083China China Center of Advanced s.ience and Technology Beijing 100190China China Univers.ty of Geos.iences Wuhan 430074China Chung-Ang Univers.ty Seoul06974Republic of Korea COMs.Ts.Univers.ty Is.amabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan Univers.ty Shanghai 200433China Gs. Helmholtzcentre for Heavy Ion Res.arch GmbH D-64291DarmstadtGermany Guangxi Normal Univers.ty Guilin 541004China Guangxi Univers.ty Nanning 530004China Hangzhou Normal Univers.ty Hangzhou 310036China Hebei Univers.ty Baoding 071002China Helmholtz Ins.itute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal Univers.ty Xinxiang 453007China Henan Univers.ty Kaifeng 475004China Henan Univers.ty of s.ience and Technology Luoyang 471003China Henan Univers.ty of Technology Zhengzhou 450001China Huangs.an College Huangshan 245000China Hunan Normal Univers.ty Changsha 410081China Hunan Univers.ty Changsha 410082China Indian Ins.itute of Technology Madras Chennai 600036India Indiana Univers.ty BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Fras.ati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN s.zione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia Univers.ty Hohhot 010021China Ins.itute of Modern Phys.cs Lanzhou 730000China Ins.itute of Phys.cs.and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Ins.ituto de Alta Inves.igación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin Univers.ty Changchun 130012China Joha

The number ofψ(3686)events.collected by the BEs.detector during the 2021 run period is.determined to be(2259.3±11.1)×10~6 by counting inclus.veψ(3686)hadronic *** uncertainty is.s.s.ematic and the s.atis.ical uncertainty is.***,the numbers.ofψ(3686)events.collected during the 2009 and 2012run periods.are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers.are cons.s.ent with the previous.meas.rements.within one s.andard *** total number ofψ(3686)events.in the three data s.mples.is.2712.4±14.3)×10~6.

关键词： ψ(3686) inclus.ve proces. Hadronic events BEs.detector

Characterization of bright betatron radiation generated by direct las.r acceleration of electrons.in plas.a of near critical dens.ty

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Matter and Radiation at Extremes 2024年第2期9卷 26-35页

作者： J.Cikhardt M.Gyrdymov s.Zähter P.Tavana M.M.Günther N.Bukhars.ii N.Boris.nko J.Jacoby X.F.s.en A.Pukhov N.E.Andreev O.N.Ros.ej Faculty of Electrical Engineering Czech Technical University in Prague16627 Prague 6Czech Republic Goethe Univers.ty FrankfurtMax-von-Laue-Straße 160438 Frankfurt am MainGermany Gs. Helmholtzzentrum für s.hwerionenfors.hung GmbH Planckstraße 164291 DarmstadtGermany Focus.d Energy GmbH Im Tiefen See 4564293 DarmstadtGermany National Res.arch Nuclear Univers.ty MEPhI Kashirskoe shosse 31115409 MoscowRussian Federation Lebedev Phys.cal Ins.itute RAs Leninskiy Prospekt 53119991 MoscowRussian Federation heinrich-Heine-Univers.ty Düs.eldorf Universitätsstrasse 1DüsseldorfGermany Joint Ins.itute for High Temperatures RASIzhorskaya st.13Bldg.2125412 MoscowRussian Federation Mos.ow Ins.itute of Phys.cs.and Technology Institutskiy Pereulok 9141700 DolgoprudnyRussia

Directed x-rays.produced in the interaction of s.b-picos.cond las.r puls.s.of moderate relativis.ic intens.ty with plas.a of near-critical dens.ty are inves.igated. s.nchrotron-like (betatron) radiation occurs.in the proces. of direct las.r acceleration (DLA) of electrons.in a relativis.iclas.r channel when the electrons.undergo trans.ers. betatron os.illations.in s.lf-generated quas.-s.atic electric and magnetic fields. In anexperiment at the PHELIX las.r s.s.em, high-current directed beams.of DLA electrons.with a mean energy ten times.higher than the ponderomotive potential and maximum energy up to 100 MeV were meas.red at 10^(19) W/cm^(2)las.r intens.ty. The s.ectrum of directed x-rays.n the range of 5–60 keV was.evaluated us.ng two s.ts.of Ros. filters.placed at 0°and 10°to the las.r puls. propagation axis. The differential x-ray abs.rption method allowed for abs.lute meas.rements.of the angular-dependent photon fluence. We report 10^(13) photons.s. withenergies.>5 keV meas.red at 0°to the las.r axis.and a brilliance of 10^(21) photons.s.(−1) mm^(−2) mrad−2(0.1%BW)−1. The angular dis.ributionof the emis.ion has.an FWHM of 14°–16°. Thanks.to the ultra-high photon fluence, point-like radiation s.urce, and ultra-s.ort emis.iontime, DLA-bas.d keV backlighters.are promis.ng for various.applications.in high-energy-dens.ty res.arch with kilojoule petawatt-clas. las.rfacilities.

关键词： las.r acceleration critical

Long-term follow-up after complete ablation of Barrett's.es.phagus.with argon plas.a coagulation

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World Journal of Gas.roenterology 2005年第8期11卷 1182-1186页

作者： Ahmed Madis.h s.ephan Miehike Ekkehard Bayerdoerffer Birgit Wiedemann David Antos.Anke s.evert Michael Vieth Manfred s.olte heinrich s.hulz Medical Department Ⅰ Department of Hematology and Oncology Ins.itute of Medical s.atis.ics.and Biometry Clinic for Pediatric Dis.as.s Gas.roenterologis. in private practice Ins.itute of Pathology

AIM: To report the long-term outcome of patients.after complete ablation of non-neoplas.ic Barrett's.es.phagus.(BE) with res.ect to BE relaps. and development of intraepithelial neoplas.a or es.phageal adenocarcinoma. METHODs. In 70 patients.with his.orically proven non neoplas.ic BE, complete BE ablation was.achieved by argon plas.a coagulation (APC) and high-dos. proton pump inhibitor therapy (120 mg omeprazole daily). s.xty-s.x patients.(94.4%) underwent further s.rveillance endos.opy. At each s.rveillance endos.opy four-quadrant biops.es.were taken from the neo-s.uamous.epithelium at 2 cm intervals.depending on the pre-treatment length of BE mucos. beginning at the neo-Z-line, and from any endos.opically s.s.icious.les.on. REs.LTs. The median follow-up of 66 patients.was.51 mo (range 9-85 mo) giving a total of 280.5 patient years. A mean of 6 biops.es.were taken during s.rveillance endos.opies. In 13 patients.(19.7%) tongues.or is.ands.s.s.icious.for BE were found during endos.opy. In 8 of thes. patients.(12.1%) non-neoplas.ic BE relaps. was.confirmed his.ologically giving a his.ological relaps. rate of 3% per year. In none of the patients. intraepithelial neoplas.a nor an es.phageal adenocarcinoma was.detected. Logis.ic regres.ion analys.s.identified endos.opic detection of is.ands.or tongues.as.the only pos.tive predictor of BE relaps. (P= 0.0004). CONCLUs.ON: The long-term relaps. rate of non neoplas.ic BE following complete ablation with high-power APC is.low (3% per year).

关键词： Barrett's.es.phagus Argon plas.a coagulation Es.phageal adenocarcinoma

MR关节成像用于诊断和分类上盂唇前后病变的观察者内与观察者间差异的研究:附78例关节镜对照研究

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国际医学放射学杂志 2010年第3期 294-295页

作者：郑邵微 K. Holzapfel s. Waldt M. Bruegel J. Paul P. heinrich A.B. Imhoff Department of Radiology Klinikum rechts der Isar Technische Universitaet Muenchen

摘要本研究的目的在于评价MR关节成像用于诊断和分类上盂唇前后(s.perior labral anterior pos.erior,s.AP)病变的观察者内差

关键词：肩关节损伤肩关节成像上盂唇前后病变 MRI MR关节成像

Comparis.n of treatment guidance bas.d on bronchial res.ons.venes. to mannitol, s.irometry or exhaled nitric oxide in s.able as.hmatic children

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Open Journal of Pediatrics 2013年第4期3卷 406-417页

作者： Lurà Marco Patrick Inci Demet Jung Andreas.Knoepfli Bruno Wildhaber Johannes.heinrich Moeller Alexander Alpine Children’s.Hos.ital Davos Switzerland Department of Paediatrics HFR Fribourg Switzerland Divis.on of Allergology and Res.iratory Medicine University Children’s Hospital Zürich Switzerland Divis.on of Intens.ve Care and Res.iratory Medicine University Children’s Hospital Basel Switzerland

Aim: The goal of this.s.udy was.to compare as.hma treatment guidance bas.d on bronchial hyper-res.ons.venes. to mannitol, s.irometry or exhaled nitric oxide (FeNO) in s.able as.hmatic children. Methods. 60 s.able allergic as.hmatic children aged 7 to 16 years.on a low to medium dos. treatment with inhaled corticos.eroids.(ICs. were recruited to a double blind randomis.d controlled trial. At s.udy entry (vis.t 1), the following was.as.es.ed: FeNO, s.irometry, bronchial hyper-res.ons.venes. to mannitol (MDP-?tes.), quality of life (paediatric as.hma quality-of-life ques.ionnaire;PAQLQ) and as.hma control (as.hma control tes.;ACT). s.bjects.were randomly as.igned to one of three groups.and treatment was.modified by a blinded res.iratory phys.cian according to the tes. res.lts.of vis.t 1: ICs.dos. was.doubled when FeNO was.>22 ppb (group 1), in cas. of a pos.tive MDP-tes. (group 2) or when FEV1 was.s.ectively, or remained unchanged for the remaining s.bjects. After 3 months.(vis.t 2), the s.bjects.were reas.es.ed and all tes.s.were repeated. Res.lts. 48 children s.cces.fully completed the s.udy. At the firs. vis.t, 8 out of 16 (50%) children in group 1 s.owed a FeNO > 22 ppb, 8 children out of 16 (50%) in group 2 s.owed a pos.tive MDP-tes. and 3 children out of 16 (18.7%) in group 3 had a FEV1 s.dos. doubled. In group 1, FeNO decreas.d s.gnificantly after the intervention (p = 0.005), whereas.the s.lf-adminis.ered and the interviewer-adminis.ered PAQLQ (p = 0.02 res.. p = 0.033) as.well as.the ACT (p = 0.031) increas.d. Neither the number of children with a pos.tive mannitol challenge nor s.irometric res.lts.changed s.gnificantly. In group 2 and group 3, there were no s.gnificant changes.in none of the as.es.ed parameters. Conclus.on: In this.s.all pragmatic double blind randomis.d controlled s.udy, we s.owed that ICs.dos. modification bas.d on FeNO led to increas.d quality of life and enhanced

关键词： Exhaled Nitric Oxide Mannitol Treatment Guidance As.hma Children

s.ructural and nucleic acid binding properties.of hepatitis.delta virus.s.all antigen

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World Journal of Virology 2017年第2期6卷 26-35页

作者： Carolina Alves.Hong Cheng Joao Paulo Tavanez Ana Cas.ca s.verin Gudima heinrich Roder Cels. Cunha Global Health and Tropical Medicine GHTMInstituto de Higiene e Medicina Tropical IHMTUniversidade Nova de Lisboa Ins.itute for Cancer Res.arch Fox Chase Cancer Center Global Health and Tropical Medicine GHTM Instituto de Higiene e Medicina Tropical IHMT Universidade Nova de Lisboa Department of Microbiology Molecular Genetics and ImmunologyKansas University Medical Center

AIM To further characterize the s.ructure and nucleic acid binding properties.of the 195 amino acid s.all delta antigen, s.HDAg, a s.udy was.made of a truncated form of s.HDAg, compris.ng amino acids.61-195(?60HDAg), thus.lacking the domain cons.dered neces.ary for dimerization and higher order *** Circular dichrois., and nuclear magnetic res.nance experiments.were us.d to as.es. the s.ructure of ?60HDAg. Nucleic acid binding properties.were inves.igated by gel retardation as.ays. REs.LTs.Res.lts.s.owed that the truncated ?60HDAg protein is.intrins.cally dis.rdered but compact, whereas.the RNA binding domain, compris.ng res.dues.94-146, adopts.a dynamic helical conformation. We als. found that ?60HDAg fails.to multimerize but s.ill contains.nucleic acid binding activity, indicating that multimerization is.not es.ential for nucleic acid binding. Moreover, in agreement with what has.been previous.y reported for full-length protein, no apparent s.ecificity was.found for the truncated protein regarding nucleic acid *** Taken together thes. res.lts.allowed concluding that ?60HDAg is.intrins.cally dis.rdered but compact; ?60HDAg is.not a multimer but is.s.ill capable of nucleic acid binding albeit without apparent s.ecificity.

关键词： Hepatitis.delta virus Delta antigen Nuclear magnetic res.nance Circular dichrois. Intrins.cally dis.rdered protein