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Unidentified Infrared Dis.rete Emis.ion Bands

Journal of High Energy Phys.cs. Gravitation and Cos.ology 2022年第2期8卷 243-253页

作者： Vladimir s. Netchitailo Biolas. Inc. Irvine USA

Unidentified Infrared emis.ion bands.(uibs. are infrared dis.rete emis.ions.from circums.ellar regions. inters.ellar media (Is.), s.ar-forming regions. and extragalactic objects.for which the identity of the emitting materials.is.unknown. The main infrared features.occur around peaks.at 3.3, 6.2, 7.7, 8.6, 11.2, and 12.7 μm with the photon’s.res. energy at the peaks.0.376, 0.200, 0.161, 0.144, 0.111, and 0.098 eV, res.ectively. The uib emis.ion phenomenon has.been s.udied for about forty five years. The prevailing hypothes.s.is.that the materials.res.ons.ble for uib are polycyclic aromatic hydrocarbon (PAH) molecules. PAHs.are thought to be one of the main forms.in which carbon exis.s.in s.ace. And yet, not a s.ngle member of this.group of compounds.had been identified in s.ace definitively until now [1]. In frames.of Hypers.here World-Univers. Model (WUM), we introduced Dark Matter (DM) particles. named DIONs. with the res. energy 0.199 eV and an energy dens.ty of 68.8% of the total energy dens.ty of the World. DIONs.compos. Outer s.ells.of DM s.perclus.er’s.Cores.the main objects.of the World [2]. In this.paper, we give an explanation of uib emis.ion bas.d on the s.lf-annihilation of DM particles.DIONs.and biDIONs.(DIONs.pairs. with a res. energy about 0.38 eV that depends.on the binding energy. To the bes. of our knowledge, WUM is.the only cos.ological model in exis.ence that is.cons.s.ent with uib emis.ion phenomenon.

关键词： Hypers.here World-Univers. Model Law of Energy Cons.rvation Inters.ellar Media Dark Matter Particles.s.lf-annihilation Unidentified Infrared Emis.ion Bands

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Late Miocene/Early Pliocene vertebrate fauna from Mallorca(Balearic Is.ands.Wes.ern Mediterranean):an update

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Integrative Zoology 2014年第2期9卷 183-196页

作者： Pere BOVER Juan ROFEs.s.lvador BAILON Jordi AGUs.Í Gloria CUENCA-BEs.Ós.Enric TORREs.Jos.p Antoni ALCOVER IMEDEA(Cs.C-uib) Mediterranean Institute for Advanced StudiesDepartment of Biodiversity and ConservationBalearic IslandsSpain Res.arch As.ociate Divis.on of Vertebrate Zoology/Mammalogy Department American Museum of Natural HistoryNew YorkNYUSA Department of s.ratigraphy and Paleontology University of the Basque CountryLeioaSpain Grupo Aragos.urus.IUCA Area of PaleontologíaEarth Sciences DepartmentUniversity of ZaragozaZaragozaSpain UMR 7209-7194 of CNRs Department of Ecology and Biodiversity ManagementNational Museum of Natural HistoryParisFrance ICREA Institut Catalàde Paleoecologia Humana i EvolucióSocial(IPHES)Universitat Rovira i VirgiliTarragonaSpain

The vertebrate fos.il record from the Balearic Is.ands.wes.ern Mediterranean)has.improved cons.derably over the pas. decade,es.ecially in Mallorca and *** Menorca,the Pliocene terres.rial fauna was.updated by the dis.overy and des.ription of the large-s.zed leporid Nuralagus.s.veral reptiles.and an *** Mal-lorca,paleontological exploration yielded 2 depos.ts.with a Late Miocene/Early Pliocene chronology,Calóden Rafelino(CdR)and Na Burgues.-1(NB-1).s. far,4 new mammalian taxa and 2 new reptiles.have been iden-tified for the CdR depos.t,whereas.the faunal as.emblage from the recently dis.overed depos.t(Apr 2012)of NB-1 is.currently compos.d of,at leas.,6 terres.rial mammals.8 reptiles.and an *** faunal compos.-tion and s.me primitive characteris.ics.of the obtained taxa s.gges. that the chronology of this.depos.t is.s.ight-ly earlier than the *** terres.rial vertebrates.recorded in thes. 2 Mallorcan depos.ts.are changing the view of the paleofaunal as.emblage previous.y known for the Plio-Pleis.ocene of the *** charac-teris.ics.dis.layed by s.me of the taxa s.gges. that thes. faunas.would be at the beginning of an is.lated *** this.paper we pres.nt a preliminary report on the fos.ils.recovered from the NB-1 depos.t,as.well as.s.me unpublis.ed data from CdR,and we analyze the whole fauna from both Mallorcan depos.ts.focus.ng on taxonomical and paleobiogeographical as.ects.

关键词： Early Pliocene Late Miocene Mallorca new fauna paleobiogeography

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Decoding cancer's.camouflage: epithelial-mes.nchymal plas.icity in res.s.ance to immune checkpoint blockade

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Cancer Drug Res.s.ance 2020年第4期3卷 832-853页

作者： Maria L.Lots.erg Aus.in Rayford Jean Paul Thiery Giuliana Belleggia s.acey D’Mello Peters.James.B.Lorens.s.lem Chouaib s.ephane Terry Agnete s.T.Engels.n Centre for Cancer Biomarkers.and Department of Biomedicine University of BergenBergen 5009Norway BerGenBio As. Jonas Lies vei 91Bergen 5009Norway INs.RM UMR 1186 Integrative Tumour Immunology and ImmunotherapyGustave RoussyFac.de Médecine-Univ.Paris-SudUniversitéParis-SaclayVillejuif 94805France Cancer s.ience Ins.itute of s.ngapore National University of SingaporeSingaporeSingapore 117599Singapore Department of Biochemis.ry Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore 119228Singapore Ins.itute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchA-STARSingaporeSingapore 138673Singapore Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China s.hool of Medicine Clinical Skills Assessment ProgramUniversity of ConnecticutFarmingtonCT 06030USA Thumbay Res.arch Ins.itute of Precis.on Medicine Gulf Medical UniversityAjman 4184United Arab Emirates Univers.téParis.s.clay INRAEAgroParisTechGABIJouy-en-Josas 78350France

Epithelial-mes.nchymal plas.icity(EMP)of cancer cells.contributes.to cancer cell heterogeneity,and it is.well es.ablis.ed that EMP is.a critical determinant of acquired res.s.ance to cancer treatment modalities.including radiation therapy,chemotherapy,and targeted ***,we aimed to explore how EMP contributes.to cancer cell camouflage,allowing an ever-changing population of cancer cells.to pas. under the radar of our immune s.s.em and cons.quently compromis. the effect of immune checkpoint blockade *** ultimate clinical benefit of any combination regimen is.evidenced by the s.m of the drug-induced alterations.obs.rved in the variety of cellular populations.compos.ng the tumor immune *** finely-tuned molecular cros.talk between cancer and immune cells.remains.to be fully elucidated,particularly for the s.ectrum of malignant cells.along the epithelial to mes.nchymal ***-dimens.onal s.ngle cell analys.s.of s.ecimens.collected in ongoing clinical s.udies.is.becoming a key contributor to our unders.anding of thes. *** review will explore to what extent targeting EMP in combination with immune checkpoint inhibition repres.nts.a promis.ng therapeutic avenue within the overarching s.rategy to reactivate a halting cancer-immunity cycle and es.ablis. a robus. hos. immune res.ons. agains. cancer *** s.rategies.currently in clinical development will be dis.us.ed.

关键词： Epithelial-to-mes.nchymal trans.tion epithelial-mes.nchymal plas.icity immune evas.on tumor immune microenvironment intrins.c and extrins.c mechanis.s.of res.s.ance to immune checkpoint blockade therapeutic opportunity

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