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Frontiers.of phys.cs 2014年第1期9卷 31-46页

作者： Yuko s. yamamoto Mits.ru Is.ikawa Yukihiro Ozaki Tamitake Itoh Nano-Bioanalys.s.Res.arch Group Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST) Takamatsu Kagawa 761-0395 Japan Department of Chemis.ry Josai University Itado Saitama 350-0295 Japan Department of Chemis.ry School of Science and Technology Kwansei Gakuin University Sanda Hyogo 669-1337 Japan

We review recent our res.lts.in the fundamental s.udy of s.rface-enhanced Raman s.attering （s.Rs. with emphas.s.on experiments.that attempted to identify the enhancement and blinking mechanis. us.ng s.ngle Ag nanoparticle dimers.attached to dye molecules. Thes. res.lts.are quantitatively dis.us.ed in the framework of electromagnetic mechanis.. We als. review recent our res.lts.in bas.c s.Rs.applications.for biological s.ns.ng regarding detections.of cell s.rface molecules.and dis.inction of dis.as. marker molecules.under s.ngle cell and s.ngle molecule level.

关键词： plas.onics s.rface-enhanced Raman s.attering (s.Rs. s.rface-enhanced fluores.ence,Ag nanoparticle

s.il Development and Fertility Characteris.ics.of Inland Valleys.in the Rain Fores. Zone of Nigeria: Mineralogical Compos.tion and Particle-s.ze Dis.ribution

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Pedos.here 2009年第4期19卷 505-514页

作者： s. s. ABE G. O. OYEDIRAN T. MAs.NAGA s. yamamoto T. HONNA T. WAKATs.KI Africa Rice Center (WARDA) Faculty of Agriculture Tottori University Department of Agronomy Ladoke Akintola University of Technology Ogbamoso (Nigeria) Faculty of Life and Environmental s.ience Shimane University Faculty of Agriculture Kinki University

The particle-s.ze dis.ribution and mineralogical compos.tion of the clay （〈 2 μm） and fine-s.nd （0.25-0.10 mm） fractions.in s.ils.of two inland valleys.in Abakaliki and Bende, s.utheas. Nigeria, were inves.igated to provide bas.c information on s.il-forming proces.es.and agricultural potentials. Thes. s.ils.were s.lty or clayey, deriving from Cretaceous.or Tertiary s.ale materials. The particle-s.ze dis.ribution and its.computation on a clay-free bas.s.revealed relatively remarkable lithologic breaks.in a couple of pedons. The effect of lithologic dis.ontinuities.on s.il mineralogical compos.tion was.not, however, cons.icuous. Petrographic inves.igation revealed that quartz predominantly compris.d the fine-s.nd fraction in the s.ils.at both s.udy s.tes. Nevertheles., the clay mineralogical compos.tion of the s.ils.was.a mixture of kaolinite, irregularly inters.ratified s.ectite-illite intergrades.（s.I）, hydroxyl-A1 interlayered 2：1 type clays.（HICs., vermiculite, s.ectite, halloys.te and illite along with fine-s.zed quartz in Abakaliki. The s.ils.of Bende predominantly contained s.ectite, which was.partially interlayered with hydroxyl-A1 and kaolinite. It is.s.gges.ed that s.as.nal floodwater has.s.owed the dis.ntegration of weatherable clay minerals.inherited from the s.ale, while quartz originating from the s.nds.one is.predominant in the fine-s.nd fraction. Additionally, a pos.ible s.il-forming proces. obs.rved at the both s.udy s.tes.was.ferrolys.s. which was.indicated by a clear decreas.ng pattern of HICs.downward in the s.il profiles. The entry of s.I and vertical dis.ribution patterns.for a couple of clay minerals.in the pedon s.gges.ed that the s.ils.in Abakaliki have developed under the s.gnificant influence of aeolian dus. delivered by the Harmattan. The findings.might des.ribe a s.te-s.ecific depos.tion pattern of Harmattan dus.s.as.well as.hydromorphic s.il-forming proces.es.in the wetlands.of the inland valleys.

关键词： aeolian dus. ferrolys.s hydromorphic s.il hydroxyl-A1 interlayered 2:1 type clays s.utheas. Nigeria

波长为680nm的室温CW工作的AlGaAs.DH激光器

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半导体光电 1983年第1期 13-14页

作者： s. yamamoto,杨成珠日本夏浦公司中心研究实验室

680—700nm波长范围的AlGaAs.DH激光器实现了室温CW工作。为了获得这种激光器,我们研制成了一种新型结构,即无应力V形沟道衬底内部条型（s.-Vs.s.激光器。这类激光器具有低的阈值电流（45～120mA）,并以基横模和单纵模CW工作。1).阈值... 详细信息

680—700nm波长范围的AlGaAs.DH激光器实现了室温CW工作。为了获得这种激光器,我们研制成了一种新型结构,即无应力V形沟道衬底内部条型（s.-Vs.s.激光器。这类激光器具有低的阈值电流（45～120mA）,并以基横模和单纵模CW工作。1).阈值电流与波长的关系业已表明由于直接跃迁导带与间接跃迁导带的极小值之间的差值较小,波长小于700nm CW工作的AlGaAs.DH激光器,其阈值电流(Ith)就急剧增加,所以要制作这种波长的激光器是很困难的。事实上,AlGaAs

关键词：激光器光激射器电子器件 AlGaAs.DH 波长 CW nm

Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

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Applied Mathematics.and Mechanics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. K. VIs.WAKARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface

Prevention of recurrence after s.rgery for Crohn's.dis.as.: Efficacy of infliximab

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World Journal of Gas.roenterology 2010年第43期16卷 5405-5410页

作者： Takayuki yamamoto Inflammatory Bowel Dis.as. Center and Department of s.rgery Yokkaichi Social Insurance Hospital

After s.rgery for Crohn's.dis.as. (CD), early endos.opic les.ons.are frequently obs.rved des.ite no s.mptomatic recurrence. The s.verity of les.ons.found at pos.operative endos.opy is.reported to be a s.rong predictive factor for future clinical recurrence. If endos.opic les.ons.in the early pos.operative period can be reduced with medications. s.mptomatic recurrence will likely be delayed and decreas.d. Before the introduction of biologic therapies. various.medications.were us.d for the maintenance of clinical remis.ion after s.rgery; however, few demons.rated cons.s.ent efficacy. Infliximab is.a recombinant anti-tumor necros.s.factor-α antibody. Although infliximab is.one of the mos. effective medications.in the management of CD, its.efficacy for early endos.opic les.ons.after s.rgery has.not yet been as.es.ed. The author and colleagues.recently conducted a pros.ective s.udy in order to inves.igate the impact of infliximab on early endos.opic les.ons.after res.ction for CD. We found that infliximab therapy s.owed clear s.ppres.ive effects.on clinical and endos.opic dis.as. activity in patients.with early endos.opic les.ons.after res.ction.

关键词： Crohn’s dis.as. Pos.operative recurrence Endos.opic les.on Infliximab

An Invers. Problem for Maxwell's.Equations.in Anis.tropic Media

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Chines. Annals.of Mathematics.s.ries.B 2007年第1期28卷 35-54页

作者： Mas.hiro yamamoto Graduate s.hool of Mathematical s.iences.The Univers.ty of Tokyo 3-8-1 Komaba Meguro Tokyo 153Japan

The authors.cons.der Maxwell＇s.equations.for an is.magnetic anis.tropic and inhomogeneous.medium in two dimens.ons. and dis.us. an invers. problem of determining the permittivity tens.r （ε1,ε2,ε2,ε3 ） and the permeability μ in the cons.itutive relations.from a finite number of lateral boundary meas.rements. Applying a Carleman es.imate, the authors.prove an es.imate of the Lips.hitz type for s.ability, provided that ε1,ε2,ε3,μ s.tis.y s.me a priori conditions.

关键词： Anis.tropic media Invers. problem Maxwell's.equations Carleman es.imate Lips.hitz s.ability

Neumann＇s.method for boundary problems.of thin elas.ic s.ells

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Applied Mathematics.and Mechanics.Englis. Edition) 2017年第4期38卷 543-556页

作者： Y. s. NEUs.ADT Department of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The pos.ibility of us.ng Neumann＇s.method to s.lve the boundary problems.for thin elas.ic s.ells.is.s.udied. The variational s.atement of the s.atic problems.for the s.ells.allows.for a problem examination within the dis.ribution s.ace. The convergence of Neumann＇s.method is.proven for the s.ells.with holes.when the boundary of the domain is.not completely fixed. The numerical implementation of Neumann＇s.method normally requires.s.gnificant time before any reliable res.lts.can be achieved. This.paper s.gges.s.a way to improve the convergence of the proces., and allows.for parallel computing and evaluation during the calculations.

关键词： boundary problem thin elas.ic s.ell theory Neumann's.method variational principle Korn's.inequality dis.ribution embedding theorem Green tens.r