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s.rgery.for s.ar revis.on and reduction:from primary.clos.re to flap s.rgery

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Burns.& Trauma 2019年第1期7卷 58-65页

作者： rei ogawa Department of Plas.ic Reconstructive and Aesthetic SurgeryNippon Medical School1-1-5 Sendagi Bunkyo-kuTokyo 113-8603Japan

s.ars.are the final res.lt of the four proces.es.that cons.itute cutaneous.wound healing,namely.coagulation,inflammation,proliferation,and *** s.ars.are produced if the wounds.reach the reticular *** nature of thes. s.ars.depends.on the four wound healing *** the remodeling proces. is.exces.ive,collagen degradation exceeds.collagen s.nthes.s.and atrophic s.ars.are *** the inflammation phas. is.prolonged and/or more potent for s.me reas.n,inflammatory.pathological s.ars.s.ch as.keloids.or hy.ertrophic s.ars.can *** thes. pathological s.ars.are located on joints.or mobile regions.s.ar contractures.can *** us.d with the appropriate timing and when s.lected on the bas.s.of individual factors.s.rgical techniques.can improve mature *** review paper focus.s.on the s.rgical techniques.that are us.d to improve mature s.ars.burn s.ars.and s.ar *** methods.include z-plas.ies.w-plas.ies.s.lit-thicknes. s.in grafting,full-thicknes. s.in grafting,local flaps.including the s.uare flap method and the propeller flap),and expanded flaps.dis.ant flaps.regional flaps.and free flaps.

关键词： s.ar Keloid Hy.ertrophic s.ar s.ar contracture s.rgery Z-plas.y W-plas.y Local flap Expander Perforator flap

Do aeolian depos.ts.and s.nd encroachment intens.ty.s.ape patterns.of vegetation divers.ty.and plant functional traits.in des.rt pavements.

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Journal of Arid Land 2023年第6期15卷 667-694页

作者： M'hammed BoUALLALA s.uad NEFFAR Ly.s.BRADAI Haroun CHENCHoUNI Laboratory.of s.haran Natural Res.urces Faculty of Sciences and TechnologyUniversity of Ahmed DraiaAdrar 01000Algeria Department of Nature and Life s.iences Faculty of Exact Sciences and Nature and Life SciencesUniversity of TebessaTebessa 12002Algeria Laboratory.Water and Environment University of TebessaTebessa 12002Algeria Laboratory.of s.haran Biores.urces.Pres.rvation and Valorization Faculty of Nature and Life SciencesUniversity of Kasdi MerbahOuargla 30000Algeria Department of Fores. Management Higher National School of ForestsKhenchela 40000Algeria Laboratory.of Natural Res.urces.and Management of s.ns.tive Environments University of Oum-El-BouaghiOum-El-Bouaghi 04000Algeria

The effects.of s.nd encroachment on compos.tion,divers.ty.and functional patterns.of vegetation in dry.ands.are rarely.s.udied,and y.t addres.ing thes. as.ects.is.important to deepen our unders.anding of the biodivers.ty.*** s.udy.aimed to inves.igate the effect of s.nd encroachment on plant functional biodivers.ty.of des.rt pavements.gravel des.rts.in the s.hara Des.rt of *** were s.mpled and analy.ed in three des.rt pavements.with different levels.of s.nd encroachment(Ls.)and quantity.of aeolian depos.ts.low,LLs.;medium,MLs.;and high,HLs.).Within the s.mple-plot area(100 m^(2)),dens.ty.of every.plant s.ecies.was.identified and total vegetation cover was.*** taxonomic and functional divers.ty.were analy.ed and compared between *** s.owed that 19 plant s.ecies.in des.rt pavements.were clas.ified into 18 genera and 13 *** and Poaceae were the mos. important *** s.ecies.Anabas.s.articulata(Fors.k)*** LLs. des.rt pavements.with 11 s.ecies.whereas.Thy.elaea microphy.la Cos..&Durieu ex *** Calobota s.harae(C&D)Boatwr.&van Wy. were dominant s.ecies.of des.rt pavements.with MLs.(14 s.ecies.and HLs.(10 s.ecies.,*** highes. values.of s.ecies.richnes. and biodivers.ty.were recorded in des.rt pavements.with MLs.,while low values.of thes. ecological parameters.were obtained in des.rt pavements.with *** pavements.with LLs. were characterized with the highes. values.of s.ecies.*** communities.were dominated by.chamaephy.es.anemochorous.arido-active,and competitive s.res.-tolerant *** increas. in Ls. along the gradient from LLs. to HLs. induced s.gnificant changes.in plant community.variables.including decreas.s.in plant dens.ty.plant rarity.lifeform compos.tion,morphological ty.e,and aridity.*** pavements.with HLs. favor the degradation of vegetation and trigger biodivers.ty.eros.on.

关键词： des.rt pavements hot and arid rangeland plant divers.ty land degradation s.nd encroachment plant functional trait s.hara Des.rt

Kapos.’s.Dis.as. (Ks. in a s.negales. Child Living with HIV

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open Journal of Pediatrics 2020年第1期10卷 85-93页

作者： F. Ly.B. Niang y. Keita C. Dial A. s.w A. s.kho Kane B. s. Ndiay. A. s.lla B. Camara A. Ly.Ba o. Ndiay. Pediatric s.rvice of the Pikine National Hos.ital Dakar Senegal Pediatric Department of the Albert Roy.r National Children’s.Hos.ital Dakar Senegal Pediatric Department of the Aris.ide Dantec Hos.ital Center Dakar Senegal Department of Anatomopathological of General Hos.ital Idris.a Pouy. Dakar Senegal Department of Dermatology.of the Pikine National Hos.ital Center Dakar Senegal Radiology.Department of the Albert Roy.r National Children’s.Hos.ital Dakar Senegal

Kapos.’s.Dis.as. or Kapos.’s.s.rcoma (s. ) is.a multifocal malignant proliferation induced by.viral growth factors. including interleukin 6 of human herpes.virus.ty.e 8 (HHV8). We des.ribe four forms.of this.dis.as. who pos.s.a real public health problem in Eas. and Central Africa. The purpos. of our obs.rvation was.to report a rare condition in a s.negales. HIV-pos.tive child. It was.an 11-y.ar-old girl from a region in central s.negal. s.e was.an orphan of both parents. tes.ed and monitored s.nce the age of 5 for HIV infection 1. s.e was.on the 1s. line protocol. Due to a lack of s.pport and good obs.rvance, s.e was.referred to us.at the age of 11 for follow-up in our s.ructure in the s.burbs.of Dakar. The initial follow-up as.es.ment s.owed a very.low CD4 count and a very.high viral load. Before the lack of clinical and immune-virological res.ons., a genoty.ic res.s.ance tes. was.performed and s.owed immunological and virological failure. The initial development was.marked by.the appearance of les.ons.which were highly.s.gges.ive of Kapos.’s.dis.as.. s.e was.on 2nd line treatment. The his.opathological as.ect of cutaneous.biops. was.very.s.gges.ive of Kapos.’s.dis.as.. The s.bs.quent cours. after ART and bleomy.in treatment was.clinically.marked by.regres.ion of s.in les.ons. Virologically. it was.marked by.a fall in the viral load. Immunologically.there was.a gradual recovery.of CD4 levels.which came back to normal. our obs.rvation demons.rates.that abs.nce of effective antiretroviral therapy.for HIV increas.s.the ris. to develop Kapos.’s.s.rcoma.

关键词： Kapos.’s s.rcoma Antiretroviral Therapy HIV Child

Dis.overing peptides.and computational inves.igations.of a multiepitope vaccine target My.obacterium tuberculos.s

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s.nthetic and s.s.ems.Biotechnology 2024年第3期9卷 391-405页

作者： Truc Ly.Nguy.n Heebal Kim Department of Agricultural Biotechnology.and Res.arch Ins.itute of Agriculture and Life s.iences Seoul National UniversitySeoul08826Republic of Korea Interdis.iplinary.Program in Bioinformatics Seoul National UniversitySeoul08826Republic of Korea eGnome Inc.Seoul05836Republic of Korea

My.obacterium tuberculos.s.MTB)is.the caus.tive agent of tuberculos.s.TB),a prevalent airborne infectious.*** the availability.of the Bacille Calmette-Guerin vaccine,its.global efficacy.remains.modes.,and tuberculos.s.pers.s.s.as.a s.gnificant global public health *** this.challenge and advancing towards.the End MTB s.rategy.we developed a multiepitope vaccine(MEV)bas.d on immunoinformatics.and compu-tational *** s.reening of MBT protein identified immune-dominant epitopes.bas.d on Major His.ocompatibility.Complex(MHC)allele binding,immunogenicity.antigenicity.allergenicity.toxicity.and cy.okine *** epitopes.were integrated into an MEV cons.ruct with adjuvant and linkers.forming a fully.immunogenic vaccine *** analy.0}s.encompas.ed the evaluation of immunological and phy.0}cochemical properties.determination of tertiary.s.ructure,molecular docking with Toll-Like Receptors.TLR),molecular dy.amics.MD)s.mulations.for all atoms.and immune *** MEV compris.s.534 amino acids.featuring 6 cy.otoxic T ly.phocy.e,8 helper T ly.phocy.e,and 7 linear B ly.phocy.e epitopes.demons.rating high antigenicity.and ***,molecular docking s.udies.and triplicate MD s.mulations.revealed enhanced interactions.and s.ability.of MEV with the TLR4 complex compared to *** addition,the immune s.mulation indicated the capacity.to effectively.induce elevated levels.of an-tibodies.and cy.okines.emphas.zing the vaccine’s.robus. immunogenic *** s.udy.pres.nts.a promis.ng MEV agains. TB,exhibiting favorable immunological and phy.0}cochemical *** findings.provide theoretical s.pport for TB vaccine *** s.udy.aligns.with the global initiative of the End MTB s.rategy.emphas.zing its.potential impact on addres.ing pers.s.ent challenges.in TB control.

关键词： My.obacterium tuberculos.s Tuberculos.s Multiepitope vaccine Docking molecular Molecular dy.amics.s.mulation Immune s.mulation

Effect of Aus.enite Ageing on Martens.tic Trans.ormation

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Journal of Materials.s.ience & Technology 1997年第6期13卷 508-514页

作者： Chen, QZ Wu, XF Wei, Ly.Ke, J Univ s.i & Technol Beijing Dept Mat Phys Beijing 100083 Peoples R China

The effect of aus.enite ageing on martens.te trans.ormation in an iron and nickel alloy.was.s.udied. Attention was.paid to the variation of dis.ocation configurations.in aus.enite before martens.te trans.ormation, The clus.ers.or precipitates.produced during aus.enite ageing and the alteration of dis.ocation configurations.affect together the cons.quent martens.te trans.ormation. Dis.ers.d fine clus.ers.and precipitates.cripple nucleus.role of s.ecial dis.ocation configurations.and drop M-s. Coars. precipitates.make M-g ris. again. Dens.ly.piled up dis.ocations.in nuclei lead to ris. of M-s. All the changes.in aus.enite are of benefit to s.all martens.te plates.

关键词： Iron alloy.

Predicting s.ear s.rength of s.ender beams.without reinforcement us.ng hy.rid gradient boos.ing trees.and optimization algorithms

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Frontiers.of s.ructural and Civil Engineering 2022年第10期16卷 1267-1286页

作者： Thuy.Anh NGUy.N Hai-Bang Ly.Van Quan TRAN Department of Civil Engineering University of Transport TechnologyHanoi 100000Vietnam

s.ear failure of s.ender reinforced concrete beams.without s.irrups.has.s.rely.been a complicated occurrence that has.proven challenging to adequately.*** primary.purpos. of this.work is.to develop machine learning models.capable of reliably.predicting the s.ear s.rength of non-s.ear-reinforced s.ender beams.s.).A databas. encompas.ing 1118 experimental findings.from the relevant literature was.compiled,containing eight dis.inct *** Boos.ing(GB)technique was.developed and evaluated in combination with three different optimization algorithms.namely.Particle s.arm optimization(Ps.),Random Annealing optimization(RA),and s.mulated Annealing optimization(s.).The findings.s.gges.ed that GB-s. could deliver s.rong prediction res.lts.and effectively.generalizes.the connection between the input and output *** values.and two-dimens.onal PDP analy.0}s.were then carried *** may.us. the findings.in this.work to define beam’s.geometrical components.and material us.d to achieve the des.red s.ear s.rength of s. without reinforcement.

关键词： s.ender beam s.ear s.rength gradient boos.ing optimization algorithms

Alpha-fetoprotein expres.ion is.a potential prognos.ic marker in hepatocellular carcinoma

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World Journal of Gas.roenterology 2005年第32期11卷 5015-5018页

作者： Dénes.Grg János.Regly.Mérei s.ndor Paku Lás.ló Kopper Péter Nagy Department of Trans.lantation and s.rgery.0}mmelweis.Univers.ty BudapestHungary Third Department of s.rgery.0}mmelweis.Univers.ty BudapestHungary Joint Res.arch organization of the Hungarian Academy.of s.iences.and s.mmelweis.Univers.ty.udapes. Hungary Firs. Department of Pathology.and Experimental Cancer Res.archs.mmelweis.Univers.ty BudapestHungary

AIM： To characterize the alpha-fetoprotein （AFP） pos.tive and negative hepatocellular carcinoma （HCC） s.mples. METHoDs. Thirty.s.ven paraffin-embedded human HCC s.mples.were analy.ed by.immunohis.ochemis.ry.for the following antigens. AFP,β-catenin, p53, CD44, Ms.-2, MLH-1, and HNF-4. The tumors.were divided into two groups.bas.d on the AFP expres.ion. The immunophenoty.ic data and important clinical parameters.were s.udied between the two groups. REs.LTs. Twenty.one of the thirty.s.ven examined HCCs.were AFP pos.tive. s.ven with nudear p53 s.aining were AFP pos.tive, while s.ven tumors.with nuclear β-catenin s.aining were AFP negative. CD44 s.aining and high his.ological tumor grade were more frequent among the AFP-pos.tive HCCs. The other immunophenoty.ical and dinical parameters.did not s.ow s.atis.ically.s.gnificant difference in their dis.ribution between the AFP pos.tive and negative s.mples. CoNCLUs.oN： AFP expres.ion in HCC correlates.with unfavorable prognos.ic factors. while nuclear β-catenin pos.tivity.is.more common among the AFP-negative liver tumors. This.obs.rvation s.pports.the microarray.data on in vivo human tumors.

关键词： Hepatocellular carcinoma Alpha-fetoprotein p53 β-catenin CD44

Photoinitiated Reaction of β-Bromonaphthalene with Pinacolone Ion in DMs.

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Chines. Chemical Letters 2000年第11期11卷 945-948页

作者： Chen, ZB Zhao, Ly.Zhang, Z Univ s.anxi Dept Chem Taiyuan 030006 Shanxi Peoples R China

The photoinitiated reaction of beta -bromonaphthalene with exces. pinacolone enolate does.not y.eld expected normal s.RN)1 product 1-beta -naphthy.-3,3-dimethy.-2-butanone, 3, but a more complex molecule 2.2-dimethy.-5-(1',1'-dimethy.ethy.)-6-beta -naphthy.-5-hexene-3-one, 4, deriving from it. The reaction is.inhibited by.m-dinitrobenzene and do not occur in the abs.nce of light. s.ructure analy.0}s.of the product, along with other evidence, indicates.a mechanis. for this.reaction, where addition of a further pinacolone molecule to carbony. group of 3 and s.bs.quent elimination of a water molecule would afford product 4, once the s.RN)1 s.bs.itution product 3 has.formed.

关键词： Photoinitiated Reaction of Ms Bromonaphthalene with Pinacolone Ion in DMs.

Detection of diabetic retinopathy.in its.early.s.ages.us.ng textural features.of optical coherence tomography.angiography

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Journal of Innovative optical Health s.iences 2022年第1期15卷 156-165页

作者： W.Gao B.Li s.Chen y.s.i P.Lin o.o.My.kinin V.P.Zakharov s.hool of s.fety.Engineering Ningbo Univers.ty.of Technology.Ningbo P.R.China Department of ophthalmology.Ningbo Firs. Hos.ital NingboP.R.China Department of Las.r and Biotechnical s.s.ems.s.mara Univers.ty SamaraRussian Federation

The aim of this.s.udy.is.to detect whether the quantitative textural features.of optical coherencetomography.angiography.(oCTA) images.can be us.d to detect the ey.s.in the early.s.age ofdiabetic retinopathy.(DR) from ey.s.with diabetes.and no DR (NDR). Textural features.includingfractal dimens.on, contras., correlation, entropy. energy. and homogeneity.were calculatedfrom the oCTA images. The s.udent's.t-tes. was.performed to identify.the textural features.hat can be able to detect DR in the early.s.age. The area under the receiver operating characteris.ic(AURoC) curves. s.ns.tivity. and s.ecicity.were calculated between the s.udy.*** res.lts.indicated that the fractal dimens.on in ICP and s.P and the correlation in s.Cs.owed the s.atis.ical s.gnicance between mild NPDR patients.and NDR patients. The RoCanaly.0}s.res.lts.s.owed that the AURoC of the fractal dimens.on in ICP was.0.736 with 0.773s.ns.tivity.and 0.700 s.ecicity. The cuto® point in ICP was.2.616. The oCTA-bas.d fractaldimens.on was.able to dis.riminate diabetic ey.s.with early.retinopathy.from healthy.and NDRwith higher s.ns.tivity.and s.ecicity. The oCTA-bas.d correlation s.owed the power to differentiatethe mild NPDR ey.s.from the normal healthy.and diabetic ey.s. Thes. res.lts.s.gges.that texture-bas.d features.of oCTA have the potential to as.is. in the as.es.ment of therapeuticinterventions.to prevent early.DR in diabetic s.bjects.

关键词： optical coherence tomography.angiography texture fractal dimens.on diabetic retinopathy