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A harmonis.tion approach to traditional Chines. medicine regis.ration in As.an countries

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Journal of Traditional Chines. Medical s.iences 2024年第2期11卷 143-147页

作者： Vivian s.w.chan Fung Independent s.holar 2 Woodward PlaceSt IvesNSW 2075Australia

The traditional Chines. medicine(TCM)indus.ry is.critical to not only for public health but als. for economic *** to the European Union(EU)directives.under the EU framew.rk for(traditional)herbal medicinal products.herbal medicines.w.th long his.ory of us. can be regis.ered in ***,there is.a condition in this.directive in w.ich only thos. that have at leas. 10e15 years.in the EU market are accepted for regis.ration and/or marketing *** author opinion,the condition of 10-15 years.of us. in EU countries.s.t w.thin the EU regulatory framew.rk is.w.th cons.deration of the genetic differences.w.ich can res.lt in variation in advers. drug res.ons.s.among different w.rld *** this.concept in mind,it is.reas.nable to project the principal of the EU directive to the As.an countries.w.ere TCM is.*** like China,s.ngapore,Japan and s.uth Korea that have w.ll es.ablis.ed drug regis.ration framew.rk are in bes. pos.tion in executing the bes. practice and facilitate harmonization of regis.ration for TCM w.thin the ***,the regis.ration proces. its.lf allow.0}more s.fety and efficacy data to be collected s.s.emically before and after product regis.ration/marketing *** are valuable information for future drug *** therapeutic value of TCM is.limitles.,it has.been left out in the EU regulatory framew.rk,and the opportunity for it to be expanded and carried forw.rd in modern medicines.is.s.adow.d by the limited number of TCM that are qualified to be regis.ered under the EU regulatory *** early es.ablis.ment of a harmonized ris.-bas.d regis.ration proces. for TCM in As.an countries.is.*** w.ll s.rengthen the databas. to s.bs.antiate the his.ory of s.fe us. and further pres.rving and expanding the therapeutic values.of TCM w.thin and beyond the As.an region.

关键词： Traditional Chines. medicines Population genetic Harmonization Regis.ration As.an countries

s.ructural engineering of antimicrobials.for optimal broad-s.ectrum activity

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Green Chemical Engineering 2024年第4期5卷 473-482页

作者： Arunmozhiaras. Armugam Diane s.w.Lim s.ti Nurhanna Riduan s.ook Pui chan Jerome As.gan Yugen Zhang Ins.itute of Bioengineering and Bioimaging Ins.itute of s.s.ainability for Chemicals Energy and Environment(ISCE2) Agency for Science Technology and Research (A*STAR) Diploma in Biomedical s.ience School of Chemical and Life SciencesSingapore Polytechnic

Antimicrobial materials.are a crucial component in eradicating and managing the s.read of infectious.*** are expected to act on a broad-s.ectrum of microbes. including emerging pathogens.w.ich could caus. the next Dis.as. X. Herein, w. reas.es.ed a s.ries.of antimicrobial imidazolium polymers.on our s.elves.and uncovered extended functionality through dual modes.of action. By redes.gning their s.ructures. a truly broads.ectrum antimicrobial material w.th optimized activity agains. bacteria(G +ve, G-ve) and fungi, as.w.ll as.enveloped and non-enveloped virus.s.w.s.developed. w. demons.rated that the imidazolium polymer exhibits.dual modes.of function agains. microbes. targeting the microbial membrane and binding DNA. The latter DNA binding affinity w.s.found to be key agains. non-enveloped virus.s. w.th this.ins.ght, w. des.gned s.all molecule compounds.that exhibited optimum broad-s.ectrum antimicrobial activity and excellent efficacy agains. Es.APE group of pathogens.that are res.ons.ble for s.me of the deadlies. nos.comial infections.w.rldw.de. Our res.lts.could als. s.ed light on the des.gn of broad-s.ectrum antimicrobial compounds.agains. Dis.as. X.

关键词： Broad-s.ectrum Antimicrobial Polyimidazolium s.ructure-function Membrane active

s.m-to-Real: A Performance Comparis.n of PPO, TD3, and s.C Reinforcement Learning Algorithms.for Quadruped w.lking Gait Generation

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Journal of Intelligent Learning s.s.ems.and Applications 2024年第2期16卷 23-43页

作者： James.w. Mock s.res. s. Muknahallipatna Department of Electrical Engineering and Computer s.ience University of Wyoming Laramie WY USA

The performance of the s.ate-of-the-art Deep Reinforcement algorithms.s.ch as.Proximal Policy Optimization, Tw.n Delayed Deep Determinis.ic Policy Gradient, and s.ft Actor-Critic for generating a quadruped w.lking gait in a virtual environment w.s.pres.nted in previous.res.arch w.rk titled “A Comparis.n of PPO, TD3, and s.C Reinforcement Algorithms.for Quadruped w.lking Gait Generation”. w. demons.rated that the s.ft Actor-Critic Reinforcement algorithm had the bes. performance generating the w.lking gait for a quadruped in certain ins.ances.of s.ns.r configurations.in the virtual environment. In this.w.rk, w. pres.nt the performance analys.s.of the s.ate-of-the-art Deep Reinforcement algorithms.above for quadruped w.lking gait generation in a phys.cal environment. The performance is.determined in the phys.cal environment by trans.er learning augmented by real-time reinforcement learning for gait generation on a phys.cal quadruped. The performance is.analyzed on a quadruped equipped w.th a range of s.ns.rs.s.ch as.pos.tion tracking us.ng a s.ereo camera, contact s.ns.ng of each of the robot legs.through force res.s.ive s.ns.rs. and proprioceptive information of the robot body and legs.us.ng nine inertial meas.rement units. The performance comparis.n is.pres.nted us.ng the metrics.as.ociated w.th the w.lking gait: average forw.rd velocity (m/s., average forw.rd velocity variance, average lateral velocity (m/s., average lateral velocity variance, and quaternion root mean s.uare deviation. The s.rengths.and w.aknes.es.of each algorithm for the given tas. on the phys.cal quadruped are dis.us.ed.

关键词： Reinforcement Learning Reality Gap Pos.tion Tracking Action s.aces Domain Randomization

Effect of s.ray Rails.on Takeoff Performance of Amphibian Aircraft

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w.rld Journal of Engineering and Technology 2024年第1期12卷 117-140页

作者： s.ham s. Bahulekar Alberto w. Mello Embry-Riddle Aeronautical Univers.ty Daytona Beach Florida USA

Amphibian aircraft have s.en a ris. in popularity in the recreational and utility s.ctors.due to their ability to take off and land on both land and w.ter, thus.s.rving a myriad of purpos.s. s.ch as.aerobatics. s.rveillance, and firefighting. s.ch s.aplanes.mus. be aerodynamically and hydrodynamically efficient, particularly during the takeoff phas.. Naval architects.have long employed innovative techniques.to optimize the performance of marine ves.els. including incorporating s.ray rails.on hulls. This.res.arch paper is.dedicated to a comprehens.ve inves.igation into the potential utilization of s.ray rails.to enhance the takeoff performance of amphibian aircraft. s.veral s.ray rail configurations.obtained from naval res.arch w.re s.mulated on a bare s.amax M22 amphibian hull to obs.rve an approximate 10% - 25% decreas. in w.ter res.s.ance at high s.eeds.alongs.de a 3% reduction in the takeoff time. This.s.udy s.rves.as.a motivation to improve the des.gn of the reference airplane hull and a platform for detailed inves.igations.in the future to improve modern amphibian des.gn.

关键词： s.aplane s.ray Rails Hull Optimization Take-Off Performance

Effect of Eu3+,Bi3+,and Li+ doping on lumines.ent property of GdNbO4

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Journal of Rare Earths 2024年第1期42卷 66-75页

作者： s.w.w. Y.s.Lee Department of Phys.cs.and Integrative Ins.itute of Bas.c s.iences Soongsil University

w. inves.igated the emis.ion properties.of Eu3+-doped GdNbO4-bas.d oxide phos.hors.aiming at improving the Eu3+emis.ion by codoping of Bi3+and Li+.Eu3+s.ngly doped,Eu3+and Bi3+doubly doped,and Eu3+,Bi3+,and Li+triply doped GdNbO4w.re prepared us.ng a high-temperature s.lid-s.ate reaction *** red-orange emis.ions.from Eu3+in the s.ngly doped s.mples.are s.gnificantly improved by the codoping of Bi3+,mainly due to the energy trans.er from Bi3+to Eu3+.The additional codoping of Li+is.found to increas. the Eu3+emis.ion *** improvement might be attributed to the increas. in the photolumines.ent quantum yield originating from larger grain s.zes.and better crys.allinity.A detailed analys.s.of the X-ray diffraction pattern and the as.mmetric ratio es.imated from the photolumines.ence s.ectra s.ow.that the local lattice environment around Eu3+in GdNbO4does.not change s.gnificantly w.th the codoping of Bi3+and Li+.Our res.lts.indicate that Li+doping is.a promis.ng w.y to improve the emis.ion properties.of rare-earth ion-doped GdNbO4phos.hors.

关键词： Eu 3+ GdNbO 4 Codoping of Li + Photolumines.ence s.ns.tizer Rare earths

s.perplas.icity of fine-grained Mg-10Li alloy prepared by s.vere plas.ic deformation and unders.anding its.deformation mechanis.s

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Journal of Magnes.um and Alloys 2024年第1期12卷 316-331页

作者： H.T.Jeong s.w.Lee w.J.Kim Department of Materials.s.ience and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The s.perplas.ic behavior and as.ociated deformation mechanis.s.of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)w.th a grain s.ze of 3.2μm,primarily compos.d of the BCCβphas. and a s.all amount of the HCPαphas.,w.re examined in a temperature range of 473 K to 623 *** micros.ructural refinement of this.alloy w.s.achieved by employing high-ratio differential s.eed *** bes. s.perplas.icity w.s.achieved at 523 K and at s.rain rates.of 10^(-4)-5×10^(-4)s.(-1),w.ere tens.le elongations.of 550±600%w.re *** the heating and holding s.age of the tens.le s.mples.prior to tens.le loading,a s.gnificant increas. in grain s.ze w.s.obs.rved at temperatures.above 573 ***,it w.s.important to cons.der this.effect w.en analyzing and unders.anding the s.perplas.ic deformation behavior and *** the inves.igated s.rain rate range,the s.perplas.ic flow.at low.s.rain rates.w.s.governed by lattice diffus.on-controlled grain boundary s.iding,w.ile at high s.rain rates.lattice diffus.on-controlled dis.ocation climb creep w.s.the rate-controlling deformation *** w.s.concluded that s.lute drag creep is.unlikely to *** the late s.ages.of deformation at 523 K,it w.s.obs.rved that grain boundary s.iding led to the agglomeration of theαphas.,res.lting in s.gnificant s.rain *** mechanis. maps.w.re cons.ructed forβ-Mg-Li alloys.in the form of 2D and 3D formats.as.a function of s.rain rate,s.res.,temperature,and grain s.ze,us.ng the cons.itutive equations.for various.deformation mechanis.s.derived bas.d on the data of the current tes.s.

关键词： Magnes.um-lithium alloy s.perplas.icity s.vere plas.ic deformation Grain s.ze Grain grow.h

A Preliminary Comparative s.udy on the Centering Algorithms.for Cas.iniIs. NAC Images

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Res.arch in As.ronomy and As.rophys.cs 2024年第10期24卷 58-65页

作者： T.Liang Q.-F.Zhang G.-M.Liu w.-H.Zhu C.-s.w.ng Department of Computer s.ience Jinan UniversityGuangzhou 510632China s.no-French Joint Laboratory for As.rometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China s.hool of Computer s.ience Guangdong University of EducationGuangzhou 510303China

Obtaining high precis.on is.an important cons.deration for as.rometric s.udies.us.ng images.from the Narrow.Angle Camera(NAC)of the Cas.ini Imaging s.ience s.bs.s.em(Is.).s.lecting the bes. centering algorithm is.key to enhancing as.rometric *** this.s.udy,w. compared the accuracy of five centering algorithms.Gaus.ian fitting,the modified moments.method,and three point-s.read function(Ps.)fitting methods.effective Ps.(ePs.),Ps.Ex,and extended Ps.(x Ps.)from the Cas.ini Imaging Central Laboratory for Operations.CICLOPs.).w. as.es.ed thes. algorithms.us.ng 70 Is. NAC s.ar field images.taken w.th CL1 and CL2 filters.acros. different s.ellar *** ePs. method cons.s.ently demons.rated the highes. accuracy,achieving precis.on below.0.03 pixels.for s.ars.of magnitude *** to the previous.y cons.dered bes.,the modified moments.method,the e Ps. method improved overall accuracy by about 10%and 21%in the s.mple and line directions.***,the xPs. model provided by CICLOPs.had low.r precis.on than the ***,the ePs. exhibits.an improvement in meas.rement precis.on of 23%and 17%in the s.mple and line directions.res.ectively,over the *** dis.repancy might be attributed to the xPs. focus.ng on photometry rather than *** findings.highlight the neces.ity of cons.ructing Ps. models.s.ecifically tailored for as.rometric purpos.s.in NAC images.and provide guidance for enhancing as.rometric meas.rements.us.ng thes. Is. NAC images.

关键词： methods.analytical techniques.image proces.ing s.ars.imaging as.rometry

Protected s.multaneous.quantum remote s.ate preparation s.heme by w.ak and revers.l meas.rements.in nois. environments

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

w. dis.us. a quantum remote s.ate preparation protocol by w.ich tw. parties. Alice and Candy, prepare a s.ngle-qubit and a tw.-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.know. to Alice w.ile the tw.-qubit s.ate w.ich is.a non-maximally entangled Bell s.ate is.know. to Candy. The three parties.are connected through a s.ngle entangled s.ate w.ich acts.as.a quantum channel. w. firs. des.ribe the protocol in the ideal cas. w.en the entangled channel under us. is.in a pure s.ate. After that, w. cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.ow. to occur w.th the increment in the nois. parameter. This.is.s.ow. by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, w. s.ow.that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of w.ak and revers.l meas.rements. w. als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce w.ich w. require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments w.ak and revers.l meas.rements

轴重和频率对激光修复316L不锈钢涂层在铁路车轮踏面制动中摩擦学性能的影响

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表面工程与再制造 2024年第2期24卷 51-52页

作者： Li s. Xiao Q. Yang w. Yang C. w.ng Y. s.ate Key Laboratory of Performance Monitoring and Protecting of Rail Trans.t Infras.ructure East China Jiaotong University Nanchang 330013 China s.hool of Mechatronics.and Vehicle Engineering East China Jiaotong University Nanchang 330013 China Railw.y Indus.ry Key Laboratory of Intelligent Operation and Maintenance of Rolling s.ock East China Jiaotong University Nanchang 330013 China

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用Ms.HT1000高温磨损试验机进行磨损实... 详细信息

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用Ms.HT1000高温磨损试验机进行磨损实验。然后,分析不同制动条件对修复试样在室温和高温下摩擦磨损性能的影响。

关键词：激光修复铁路车轮局部损伤磨损实验车轮踏面磨损试验机服役性能踏面制动