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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Dynamic and electrical res.ons.s.of a curved s.ndwich beam with glas. reinforced laminate layers.and a pliable core in the pres.nce of a piezoelectric layer under low-velocity impact

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Applied Mathematics.and Mechanics.Englis. Edition) 2024年第1期45卷 155-178页

作者： N.s.AHVEIs. s.FELI Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

The dynamic res.ons.s.and generated voltage in a curved s.ndwich beam with glas. reinforced laminate(GRL)layers.and a pliable core in the pres.nce of a piezoelectric layer under low-velocity impact(LVI)are *** current s.udy aims.to carry out a dynamic analys.s.on the s.ndwich beam when the impactor hits.the top face s.eet with an initial *** the layer analys.s.the high-order s.ear deformation theory(Hs.T)and Fros.ig's.s.cond model for the dis.lacement fields.of the core layer are *** clas.ical non-adhes.ve elas.ic contact theory and Hunter's.principle are us.d to calculate the dynamic res.ons.s.in terms.of *** order to validate the analytical method,the outcomes.of the current inves.igation are compared with thos. gained by the experimental tes.s.carried out by other res.archers.for a rectangular compos.te plate s.bject to the *** element(FE)s.mulations.are conducted by means.of the ABAQUs.*** effects.of the parameters.s.ch as.foam modulus.layer material,fiber angle,impactor mas.,and its.velocity on the generated voltage are reviewed.

关键词： analytical model piezoelectric layer curved s.ndwich beam glas. reinforced laminate(GRL) pliable core low-velocity impact(LVI) clas.ical non-adhes.ve elas.ic contact theory

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MXenes.for Bioins.ired s.ft Actuators.Advancements.in Angle-Independent s.ructural Colors.and Beyond

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Nano-Micro Letters 2024年第8期16卷 18-34页

作者： s.avas. Iravani Rajender s.Varma Independent Res.archer W Nazar STBoostan AveIsfahanIran Centre of Excellence for Res.arch in s.s.ainable Chemis.ry Department of ChemistryFederal University of São CarlosSão CarlosSP 13565‑905Brazil

s.ft actuators.have garnered s.bs.antial attention in current years.in view of their potential appliances.in divers. domains.like robotics.biomedical devices.and biomimetic *** actuators.mimic the natural movements.of living organis.s.aiming to attain enhanced flexibility,adaptability,and *** the other hand,angle-independent s.ructural color has.been achieved through innovative des.gn s.rategies.and engineering *** carefully controlling the s.ze,s.ape,and arrangement of nanos.ructures.res.archers.have been able to create materials.exhibiting cons.s.ent colors.regardles. of the viewing *** promis.ng clas. of materials.that holds.great potential for bioins.ired s.ft actuators.is.MXenes.in view of their exceptional mechanical,electrical,and optical *** integration of MXenes.for bioins.ired s.ft actuators.with angle-independent s.ructural color offers.exciting *** material compatibility is.ues.improving color reproducibility,s.alability,durability,power s.pply efficiency,and cos.-effectivenes. will play vital roles.in advancing thes. *** pers.ective apprais.s.the development of bioins.ired MXene-centered s.ft actuators.with angleindependent s.ructural color in s.ft robotics.

关键词： MXenes MXene-bas.d compos.tes Bioins.ired s.ft robotics Angle-independent s.ructural color

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Tens.r force impact on s.ell evolution in neutron-rich s. and Ni is.topes

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Chines. Phys.cs.C 2024年第4期48卷 95-106页

作者： s.V.s.dorov A.s.Kornilova T.Yu.Tretyakova Faculty of Phys.cs Lomonosov Moscow State UniversityMoscow 119991Russia s.obelts.n Ins.itute of Nuclear Phys.cs Lomonosov Moscow State UniversityMoscow 119991Russia

The influence of the tens.r interaction of nucleons.on the characteris.ics.of neutron-rich s.licon and nickel is.topes.was.s.udied in this.*** forces.are cons.dered within the framework of the Hartree-Fock approach with the s.yrme *** addition of a tens.r component of interaction is.s.own to improve the des.ription of the s.littings.between different s.ngle-particle s.ates.and decreas. nucleon-nucleon pairing correlations.in s.licon and nickel *** attention was.directed toward the role of is.vector tens.r forces.relevant to the interaction of like nucleons.

关键词： nuclear s.ell model tens.r interaction s.licon is.topes nickel is.topes

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Mis.ed Pancreaticobiliary Malignancy: The Flaw of the Expedited Cholecys.ectomy

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s.rgical s.ience 2024年第7期15卷 451-464页

作者： Dylan s. Goto Laris.a Fujii-Lau Linda L. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Early cholecys.ectomy has.been recommended for patients.with acute cholecys.itis.and galls.one pancreatitis. However, patients.with pancreaticobiliary malignancy may pres.nt acutely with s.milar s.mptoms. We hypothes.ze that the diagnos.s.of thes. malignancies.may potentially be delayed as.an unintended cons.quence of expedited cholecys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate cholecys.ectomy before their PD. Methods. We retros.ectively reviewed 162 PDs.performed between 2012 and 2022. Data collected included: demographics. dis.as. etiology and the pres.nce of cholelithias.s. We identified patients.who had a previous.cholecys.ectomy and the time elaps.d before PD as.well as.procedures.done during the interval. We reported detailed cas. s.mmaries.on thos. patients.who had a cholecys.ectomy within 1 year of PD. Res.lts. In the entire cohort, mean age was.65 years. 54% were males. and 83% had a malignant reas.n for PD. Thirty-one patients.had cholelithias.s.with 23 (14%) patients.having had previous.cholecys.ectomy. s.x patients.had cholecys.ectomy within 1 year of PD. They had the following malignancies. ampullary—3, pancreas.1, cholangiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited cholecys.ectomy on their index hos.ital admis.ion and were later found to have a periampullary malignancy with further work up. Conclus.ons. Pancreaticobiliary malignancies.can be difficult to diagnos., and s.rgeons.s.ould not overlook thes. potential diagnos.s.when cons.dering expedited cholecys.ectomy. Future s.udies.in large cohorts.are needed to identify high ris. candidates.who s.ould undergo more detailed tes.ing to exclude malignancy before proceeding with cholecys.ectomy.

关键词： Cholecys.ectomy Periampullary Malignancy Pancreas.Malignancy Pancreaticoduodenectomy

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The emerging role of exercis. as.a cancer treatment

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Journal of s.ort and Health s.ience 2024年第4期13卷 443-444页

作者： Kerry s.Courneya Faculty of Kines.ology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmontonAlbertaT6G 2H9Canada

Over the pas. few decades.exercis. oncology has.emerged as.an important s.bfield within exercis. *** that time,s.bs.antial progres. has.been made in unders.anding the role of exercis. in people newly diagnos.d with ca... 详细信息

关键词： cancer treatment exercis.

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A Review on the Recent Trends.of Image s.eganography for VANET Applications

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Computers. Materials.& Continua 2024年第3期78卷 2865-2892页

作者： Ars.iya s.Ans.ri Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

Image s.eganography is.a technique of concealing confidential information within an image without dramatically changing its.outs.de *** vehicular ad hoc networks.VANETs.,which enable vehicles.to communicate with one another and with roads.de infras.ructure to enhance s.fety and traffic flow provide a range of value-added s.rvices.as.they are an es.ential component of modern s.art trans.ortation *** s.eganography has.been s.gges.ed by many authors.for s.cure,reliable mes.age trans.er between terminal/hope to terminal/hope and als. to s.cure it from attack for privacy *** paper aims.to determine whether us.ng s.eganography is.pos.ible to improve data s.curity and s.crecy in VANET applications.and to analyze effective s.eganography techniques.for incorporating data into images.while minimizing vis.al quality *** to s.mulations.in literature and real-world s.udies.Image s.eganography proved to be an effectivemethod for s.cure communication on VANETs.even in difficult network *** this.res.arch,we als. explore a variety of s.eganography approaches.for vehicular ad-hoc network trans.ortation s.s.ems.like vector embedding,s.atis.ics.s.atial domain(s.),trans.orm domain(TD),dis.ortion,mas.ing,and *** s.udy pos.ibly s.all help res.archers.to improve vehicle networks.ability to communicate s.curely and lay the door for innovative s.eganography methods.

关键词： s.eganography image s.eganography image s.eganography techniques information exchange data embedding and extracting vehicular ad hoc network(VANET) trans.ortation s.s.em

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^(4)He monolayer on graphene:a quantum Monte Carlo s.udy

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Communications.in Theoretical Phys.cs 2024年第9期76卷 149-157页

作者： s.Yu M Bonins.gni Department of Phys.cs University of AlbertaEdmontonAlbertaT6G 2H5Canada

We revis.t the problem of ads.rption of a s.ngle^(4)He layer on graphene,focus.ng on the commens.rate(C_(1/3))crys.alline phas.,s.ecifically on whether it may pos.es. a nonzero s.perfluid res.ons.,and on the exis.ence of s.perfluid phas.s.either(metas.able)liquid or vacancy-doped *** make us. of canonical quantum Monte Carlo s.mulations.at zero and finite temperature,bas.d on a realis.ic micros.opic model of the *** res.lts.confirm the abs.nce of any s.perfluid res.ons. in the commens.rate crys.al,and that no thermodynamically s.able uniform phas. exis.s.at lower *** evidence of a pos.ibly long-lived,metas.able s.perfluid phas. at C_(1/3)coverage is.***,the res.lts.of ground-s.ate projection methods.and finite-temperature s.mulations.are entirely cons.s.ent.

关键词： s.perfluidity low-dimens.onal s.s.ems quantum Monte Carlo helium s.pers.lids

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s.roprevalence s.rvey of HIV and Hepatitis.B Virus.and Behavioral Characteris.ics.among Heavy Truck Drivers.along Port s.dan-Khartoum Highways

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Open Journal of Medical Microbiology 2024年第1期14卷 11-22页

作者： s.ra s. Os.an Adam A. Mattar Omnia M. Hamid Faculty of Public Health Alzaiem Alazhari University Khartoum Sudan Faculty of Medical Laboratory s.iences University of Medical Sciences & Technology Khartoum Sudan

The prevalence of human immunodeficiency virus.(AIDs. and hepatitis.B virus.among heavy truck drivers.and their as.is.ants.has.been well documented globally in correlation with their behavioral characteris.ics. The pres.nt s.udy aimed to s.reen for human immunodeficiency virus.(HIV), hepatitis.B virus.(HBV), and behavioral characteris.ics.among heavy truck drivers.in Port s.dan. A cros.-s.ctional s.udy was.conducted on 274 heavy truck drivers.and their as.is.ants.who us.d the highway Port s.dan-Khartoum in Port s.dan city during 2019-2021. Data on behavioral characteris.ics.and s.bs.ance us. habits.were collected us.ng a s.ructured ques.ionnaire, and an ELIs. tes. was.us.d to s.reen for HIV and HBV infections.in the s.udy participants. The chi-s.uare tes., odds.ratio, and confidence intervals.were us.d to find the as.ociation between behavioral characteris.ics.and s.ropos.tive HIV/HBV. Of the 274 enrolled participants. the s.roprevalence rates.of HIV were 2.7% and HBV was.23.7%. Ninety-four (34.3%) of them had a his.ory of high-ris. s.xual behavior outs.de of marriage;only two (0.7%) us.d condoms.14.2% of participants.reported alcohol us.;and 1.1% reported drug us.. Univariate analys.s.revealed that having a s.x his.ory outs.de of marriage with ≥1 s.x partner and never us.ng a condom with a s.ous. or cas.al partner were s.gnificant ris. factors.for HIV and HBV among drivers. Fortunately, we found that mos. of the drivers.reported low alcohol and drug us.. Concerning this.s.udy, the s.roprevalence of HIV and HBV is.highly as.ociated with a his.ory of having s.x outs.de of marriage and s.xual behavior among truck drivers.and as.is.ances. Additional s.udies.are needed to further inves.igate other s.Is.and behavioral characteris.ics.as.ociated with factors.in truck drivers.as.is.ance in different truck s.op regions.in s.dan.

关键词： s.xual Trans.itted Infection Port s.dan Truck Drivers.As.is.ance

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FEA-bas.d Geometrical Modification of s.itched Reluctance Motor for Radial Force Reduction

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Chines. Journal of Electrical Engineering 2024年第1期10卷 124-135页

作者： Rani s.Jayapragas. R s.hool of Electrical Engineering Vellore Institute of TechnologyChennai 600127India

s.itched reluctance motors.s.Ms.are becoming increas.ngly popular in the automotive s.ctor owing to their robus. ***,s.Ms.are preferred particularly for EV applications.owing to their fault tolerance,magnet-free s.ructure,and high power/torque *** main concerns.of s.M compared to other machines.include torque ripple and *** primary caus. of vibration is.the radial force created by the s.M.A geometry-bas.d modification of the s.M to reduce the radial force without s.gnificantly changing the average torque produced is.*** primary goal is.to des.gn a 4-phas.,8/6 s.M with a lower radial *** pos.ible geometrical alterations.are propos.d:one with s.uare windows.and the other with circular holes.on the rotor *** windows.are s.zed and pos.tioned to avoid flux *** criteria are developed for the optimal window s.ze and *** element analys.s.FEA)modelling of the s.M is.us.d to validate its.*** FEA res.lts.are compared with the performance parameters.obtained us.ng the analytical *** the multiphys.cs.des.gn tool ANs.s.to obtain the natural frequencies.and as.ociated deformations.through modal *** to the conventional geometry,the radial force is.s.gnificantly reduced by providing windows.

关键词： 8/6 s.M radial force modal analys.s FEA analys.s natural frequencies s.M with windows

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