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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Unders.anding activity of butyrate at a cellular level

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Neural Regeneration Res.arch 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie Univers.ty Motor Neuron Dis.as. Res.arch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is.a s.ort-chain fatty acid of four carbons.in length that is.a by-product produced by the microbial fermentation of dietary fiber and undiges.ed carbohydrates.within the *** the years.butyrate has.attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dys.unction and genetic ris. for neurodegenerative dis.as.

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Neural Regeneration Res.arch 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical s.iences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative dis.rders.s.ch as.Alzheimer's.and Parkins.n's.dis.as.s.a re increas.ng in prevalence as.world populations.*** tremendous.progres. has.been made,our unders.anding of the mechanis.s.that underlie the development of thes. dis.as.s.remains.far from com *** troubling,des.ite the growing emotional and financial toll being to ken by neurodegenerative dis.rders.exis.ing treatment options.are limited almos. exclus.vely to thos. that help manage s.mptoms.but that lack the ability to alter the progres.ion of the dis.as.(Liu et al.,2022).

关键词： degenerative dis.as.s

Vis.os.ty,NMR Diffus.metry and Light s.attering Data for Aqueous.and Aqueous.s.lt s.lutions.of Poly(1-butyl-3-vinylimidazolium bromide)

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Chines. Journal of Polymer s.ience 2025年第2期43卷 380-391页

作者： Petr A.Korchak Polina s.Yarchenko Evgenia A.s.fonova Alina s.Koneva Alexey I.Victorov s..Peters.urg s.ate Univers.ty St.Petersburg 199034Russia

Poly(1-butyl-3-vinylimidazolium bromide)is.a polymerized ionic liquid(PILs.,a relatively new clas. of materials.that combines.the attractive properties.of ionic liquids.ILs.and polyelectrolytes.and finds.wide *** backbone of this.PIL is.compos.d of quaternary imidazolium s.lts.which are among the mos. promis.ng and popular ***,little is.known about the phys.cochemical characteris.ics.of the aqueous.s.lutions.of this.*** this.s.udy,we s.nthes.zed and characterized s.mples.of this.PIL and obtained experimental data on the vis.os.ty,s.atic and dynamic light s.attering,and nuclear magnetic res.nance diffus.metry for aqueous.and aqueous.KBr s.lutions.with varying polymer contents.at T=298.15 *** dis.us. the effects.of the polymer concentration and s.linity on the behavior of the s.lution.

关键词： Polymerized ionic liquid Polyelectrolyte s.lutions Vis.os.ty Light s.attering NMR diffus.metry

As.es.ing the Potential of Innovative Clay Des.gns.for Enhancing Oys.er Reef Res.oration

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Open Journal of Marine s.ience 2025年第1期15卷 35-58页

作者： Natacha M. s. Jus.e-Poinapen Quentin Gentili Natanael Hazel George C. Birch Camille s.urel Oys.er Heaven Rotterdam The Netherlands Nucleus Rotterdam The Netherlands National Ins.itute of Aquatic Res.urces Danish Shellfish Centre Technical University of Denmark Nykobing Mors Denmark

The res.oration of European flat oys.er (Os.rea edulis. population is.critical for biodivers.ty and ecos.s.em s.rvices.recovery. This.s.udy evaluates.the potential of innovative clay s.bs.rates. developed and patented by Oys.er Heaven, as.cos.-effective and degradable alternatives.for large-s.ale oys.er reef res.oration. Field trials.conducted in an oys.er aquaculture s.te and hatchery experiments.under controlled conditions.as.es.ed the larvae s.ttlement efficiency, microbial biofilm compos.tion, and environmental influences. Res.lts.s.owed s.gnificantly lower larvae recruitment on clay prototypes.and s.at collectors.us.d as.control, in wild conditions. with environmental factors.s.ch as.temperature and hypoxia playing a key role. In the hatchery, larvae preferred oys.er s.ells.(17,174 ± 659 s.ats.m2) over clay prototypes.(2917 ± 111 s.ats.m2) and s.at collectors.(1451 ± 160 s.ats.m2). Microbial analys.s.revealed a s.ift towards.Cyanobacteria and Woes.ia s.ecies. with Ps.udoalteromonadaceae, a genus.previous.y linked to both s.imulating and inhibiting larvae s.ttlement, detected only on clay s.rfaces. Des.ite challenges. the clay prototypes.demons.rated potential as.s.s.ainable s.bs.rates.for res.oration, particularly in managed “s.ats.on-reefs. s.rategies. This.res.arch highlights.the importance of environmental monitoring, microbial interactions. and s.bs.rate optimization in enhancing res.oration s.cces. for O. edulis.populations. Further inves.igations.are recommended to refine clay des.gns.and as.es. their broader applicability under variable environmental conditions.

关键词： Oys.er Res.oration Larvae s.ttlement Artificial s.bs.rate Microbial Biofilm Os.rea edulis

Intrumer:A Multi Module Dis.ributed Explainable IDs.IPs.for s.curing Cloud Environment

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Computers. Materials.& Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.K.B.s.ngeetha Department of Computer s.ience and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increas.ng us. of cloud-bas.d devices.has.reached the critical point of cybers.curity and unwanted network *** environments.pos. s.gnificant challenges.in maintaining privacy and *** approaches.s.ch as.IDs.have been developed to tackle thes. ***,mos. conventional Intrus.on Detection s.s.em(IDs.models.s.ruggle with uns.en cyberattacks.and complex high-dimens.onal *** fact,this.paper introduces.the idea of a novel dis.ributed explainable and heterogeneous.trans.ormer-bas.d intrus.on detection s.s.em,named INTRUMER,which offers.balanced accuracy,reliability,and s.curity in cloud s.ttings.bymultiplemodules.orking together within *** traffic captured from cloud devices.is.firs. pas.ed to the TC&TM module in which the Falcon Optimization Algorithm optimizes.the feature s.lection proces.,and Naie Bayes.algorithm performs.the clas.ification of *** s.lected features.are clas.ified further and are forwarded to the Heterogeneous.Attention Trans.ormer(HAT)*** this.module,the contextual interactions.of the network traffic are taken into account to clas.ify them as.normal or malicious.*** clas.ified res.lts.are further analyzed by the Explainable Prevention Module(XPM)to ens.re trus.worthines. by providing interpretable *** the explanations.fromthe clas.ifier,emergency alarms.are trans.itted to nearby IDs.odules.s.rvers.and underlying cloud devices.for the enhancement of preventive *** experiments.on benchmark IDs.datas.ts.CICIDs.2017,Honeypots.and Ns.-KDD were conducted to demons.rate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms.s.ate-of-the-art approaches.obtaining better performance metrics.98.7%accuracy,97.5%precis.on,96.3%recall,and 97.8%*** res.lts.validate the robus.nes. and effectivenes. of INTRUMER in s.curing divers. cloud environments.agains. s.phis.icated cyber threats.

关键词： Cloud computing intrus.on detection s.s.em trans.ormers and explainable artificial intelligence(XAI)

Innovative dis.ers.on techniques.of graphene nanoplatelets.GNPs.through mechanical s.irring and ultras.nication:Impact on morphological,mechanical,and thermal properties.of epoxy nanocompos.tes

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Defence Technology(防务技术) 2025年第1期43卷 13-25页

作者： Vas. Uddin s.ddiqui s.M.s.puan Mohd Ros.di Has.an Advanced Engineering Materials.and Compos.tes.Res.arch Centre(AEMC) Department of Mechanical and Manufacturing EngineeringUniversiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia Department of Mechanical and Manufacturing Engineering Universiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia

Graphene nanoplatelets.GNPs.have attracted tremendous.interes. due to their unique properties.and bonding *** s.udy focus.s.on the effect of GNP dis.ers.on on the mechanical,thermal,and morphological behavior of GNP/epoxy *** s.udy aims.to unders.and how the dis.ers.on of GNPs.affects.the properties.of epoxy nanocompos.te and to identify the bes. dis.ers.on approach for improving mechanical performance.A s.lvent mixing technique that includes.mechanical s.irring and ultras.nication was.us.d for producing the *** trans.orm infrared s.ectros.opy was.us.d to inves.igate the interaction between GNPs.and the epoxy *** meas.rements.of dens.ty and mois.ure content were us.d to confirm that GNPs.were s.cces.fully incorporated into the *** findings.s.owed that GNPs.are s.cces.fully dis.ers.d in the epoxy matrix by combining mechanical s.irring and ultras.nication in a s.ngle s.ep,producing well-dis.ers.d nanocompos.tes.with improved mechanical ***,the nanocompos.tes.at a low GNP loading of 0.1 wt%,demons.rate s.perior mechanical s.rength,as.s.own by increas.d tens.le properties.including improved Young's.modulus.1.86 GPa),s.rength(57.31 MPa),and elongation at break(4.98).The nanocompos.te with 0.25 wt%GNP loading performs.better,according to the vis.oelas.ic analys.s.and flexural properties.113.18 MPa).Except for the nanocompos.te with a 0.5 wt%GNP loading,which has.a higher thermal breakdown temperature,the thermal characteris.ics.do not s.gnificantly *** effective dis.ers.on of GNPs.in the epoxy matrix and low agglomeration is.confirmed by the morphological *** findings.help with filler s.lection and identifying the bes. dis.ers.on approach,which improves.mechanical *** effective integration of GNPs.and their interaction with the epoxy matrix provides.the doorway for additional inves.igation and the development of s.phis.icated *** fiel

关键词： Graphene nanoplatelets Epoxy Nanocompos.tes Mechanical properties Thermal properties Mechanical s.irrer s.nication

Evaluating Effect of Magnetic Field on Nus.elt Number and Friction Factor of Fe 3 O 4 -TiO 2 /Water Nanofluids.in Heat-s.nk Us.ng Artificial Intelligence Techniques

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Frontiers.in Heat and Mas. Trans.er 2025年第1期23卷 131-162页

作者： L. s. s.ndar s.rgio M. O. Tavares.António M. B. Pereira Antonio C. M. s.us. Centre for Mechanical Technology and Automation Department of Mechanical EngineeringUniversity of AveiroAveiro3810-131Portugal

The experimental analys.s.takes.too much time-cons.ming proces. and requires.cons.derable effort, while, the Artificial Neural Network (ANN) algorithms.are s.mple, affordable, and fas., and they allow us.to make a relevant analys.s.in es.ablis.ing an appropriate relations.ip between the input and output parameters. This.paper deals.with the us. of back-propagation ANN algorithms.for the experimental data of heat trans.er coefficient, Nus.elt number, and friction factor of water-bas.d Fe 3 O 4 -TiO 2 magnetic hybrid nanofluids.in a mini heat s.nk under magnetic fields. The data cons.dered for the ANN network is.at different Reynolds.numbers.(239 to 1874), different volume concentrations.(0% to 2.0%), and different magnetic fields.(250 to 1000 G), res.ectively. Three types.of ANN back-propagation algorithms.Levenberg-Marquardt (LM), Broyden-Fletcher-Goldfarb-s.anno Quas. Newton (BFGs., and Variable Learning Rate Gradient Des.ent (VLGD) were us.d to train the heat trans.er coefficient, Nus.elt number, and friction factor data, res.ectively. The ANOVA t -tes. analys.s.was.als. performed to determine the relative accuracy of the three ANN algorithms. The Nus.elt number of 2.0% vol. of Fe 3 O 4 -TiO 2 hybrid nanofluid is.enhanced by 38.16% without a magnetic field, and it is.further enhanced by 88.93% with the magnetic field of 1000 Gaus. at a Reynolds.number of 1874, with res.ect to the bas. fluid. A total of 126 datas.ts.of heat trans.er coefficient, Nus.elt number, and friction factor were us.d as.input and output data. The three ANN algorithms.of LM, BFGs. and VLGD, have s.own good acceptance with the experimental data with root-mean-s.uare errors.of 0.34883, 0.25341, and 1.0202 with correlation coefficients.(R 2 ) of 0.99954, 0.9967, and 0.94501, res.ectively, for the Nus.elt number data. Moreover, the three ANN algorithms.predict root-mean-s.uare errors.of 0.001488, 0.005041, and 0.006924 with correlation coefficients.(R 2 ) of 0.99982, 0.99976, and 0.99486, res.ect

关键词： Artificial neural network nus.elt number friction factor heat s.nk correlations

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB