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Com.ining ability of Egyptian cotton(Gos.ypium.barbadens. L.)reveals.genetic potential for im.roved yield and fiber quality

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Journal of Cotton Res.arch 2024年第2期7卷 109-122页

作者： Abdelghany Ahm.d m. El-Banna Aly A.A. Lam.om.s.bhi F El-s.rady Gawhara A. s.lam. Ehab A.A. Ren Honglei s.aibu Abdulwahab s. Yehia Waleed m.B. Crop s.ience Departm.nt Faculty of AgricultureDamanhour UniversityDamanhour 22516Egypt Plant Production Departm.nt Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Agricultural Botany Departm.nt Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Heilongjiang Academ. of Agricultural s.iences Soybean Research InstituteHarbin 150086China Departm.nt of Agronom. Bayero University KanoKano 700001Nigeria Cotton Breeding Departm.nt Cotton Research InstituteAgriculture Research CenterGizaEgypt

Background As.the m.s. widely cultivated fiber crop,cotton production depends.on hybridization to unlock the yield potential of current varieties.A deep unders.anding of genetic dis.ection is.crucial for the cultivation of enhanced hybrid plants.with des.red traits.s.ch as.high yield and fine fiber *** this.s.udy,the general com.ining ability(GCA)and s.ecific com.ining ability(s.A)of yield and fiber quality of nine cotton parents.s.x lines.and three tes.ers.and eighteen F1 cros.es.produced us.ng a line×tes.er m.ting des.gn were *** The res.lts.revealed s.gnificant effects.of genotypes.parents.cros.es.and interactions.between parents.and cros.es.for m.s. of the s.udied ***,the effects.of both additive and non-additive gene actions.played a notably s.gnificant role in the inheritance of m.s. of the yield and fiber quality *** F1 hybrids.of(Giza 90×Aus.)×Giza 86,Uzbekis.an 1×Giza 97,and Giza 96×Giza 97 dem.ns.rated s.perior perform.nce due to their favorable integration of high yield attributes.and prem.um.fiber quality *** analys.s.revealed that lint yield has.the highes. pos.tive direct effect on s.ed cotton yield,while lint percentage s.owed the highes. negative direct effect on s.ed cotton *** com.onent analys.s.identified s.ecific parents.and hybrids.as.ociated with higher cotton yield,fiber quality,and other agronom.c *** This.s.udy provides.ins.ghts.into identifying potential s.ngle-and three-way cros. hybrids.with s.perior cotton yield and fiber quality characteris.ics.laying a foundation for future res.arch on im.roving fiber quality in cotton.

关键词： Gos.ypium.barbadens. L. Com.ining ability s.ed cotton yield Fiber quality Clus.er analys.s Path analys.s

3-Dim.ns.onal Kinem.tic Com.aris.n of Arm.m.vem.nts.between an Individual with NGLY1 Deficiency and a Neurotypical Individual

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Cas. Reports.in Clinical m.dicine 2024年第4期13卷 122-146页

作者： Charles.s. Layne Chris.opher A. m.laya Brock Futrell Dacia m.rtinez Diaz Chris.ian Alfaro Hannah E. Gus.afs.n s.bhalaks.m. Chandras.karan Rhea m. Phatak Bernhard s.ter Departm.nt of Health and Hum.n Perform.nce University of Houston Houston TX USA Center for Neurom.tor and Biom.chanics.Res.arch University of Houston Houston TX USA Center for Neuro Engineering and Cognitive s.ience University of Houston Houston TX USA Departm.nt of Com.uter s.ience and Engineering Texas A&M University College Station TX USA Blue Bird Circle Rett Center Texas Children&#8217s Hospital Houston TX USA Baylor College of m.dicine Houston TX USA

NGLY1 Deficiency is.an ultra-rare autos.m.l reces.ively inherited dis.rder. Characteris.ic s.m.tom.0}include am.ng others. developm.ntal delays. m.vem.nt dis.rders. liver function abnorm.lities. s.izures. and problem.0}with tear form.tion. m.vem.nts.are hyperkinetic and m.y include dys.etric, choreo-athetoid, m.oclonic and dys.onic m.vem.nt elem.nts. To date, there have been no quantitative reports.des.ribing arm.m.vem.nts.of individuals.with NGLY1 Deficiency. This.report provides.quantitative inform.tion about a s.ries.of arm.m.vem.nts.perform.d by an individual with NGLY1 Deficiency and an aged-m.tched neurotypical participant. Three categories.of arm.m.vem.nts.were tes.ed: 1) open ended reaches.without s.ecific end point targets.2) goal-directed reaches.that included gras.ing an object;3) picking up s.all objects.from.a table placed in front of the participants. Arm.m.vem.nt kinem.tics.were obtained with a cam.ra-bas.d m.tion analys.s.s.s.em.and “initiation” and “m.intenance” phas.s.were identified for each m.vem.nt. The com.ination of the two phas.s.was.labeled as.a “com.lete” m.vem.nt. Three-dim.ns.onal analys.s.techniques.were us.d to quantify the m.vem.nts.and included hand trajectory pathlength, joint m.tion area, as.well as.hand trajectory and joint jerk cos.. Thes. techniques.were required to fully characterize the m.vem.nts.becaus. the NGLY1 individual was.unable to perform.m.vem.nts.only in the prim.ry plane of progres.ion ins.ead producing m.tion acros. all three planes.of m.vem.nt. The individual with NGLY1 Deficiency was.unable to pick up objects.from.a table or effectively com.lete m.vem.nts.requiring cros.ing the m.dline. The s.cces.fully com.leted m.vem.nts.were analyzed us.ng the above techniques.and the res.lts.of the two participants.were com.ared s.atis.ically. Alm.s. all com.aris.ns.revealed s.gnificant differences.between the two participants. with a notable exception of the 3D initiation area as.a percentage of the com.lete m.vem.nt. The s.ati

关键词： NGLY1 Deficiency Developm.ntal Dis.rders Kinem.tics 3 Dim.ns.onal Analys.s

Effect of s.ecial types.of bread with s.lect herbal com.onents.on pos.prandial glucos. levels.in diabetic patients

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World Journal of Diabetes 2024年第4期15卷 664-674页

作者： Dras.o m.Gos.iljac s.djan s.Popovic Ves.a Dim.trijevic-s.eckovic s.s. m.Ilic Jelena A Jevtovic Dragan m.Nikolic Ivan A s.ldatovic Clinic for Endocrinology Diabetes and Metabolic DiseasesUniversity Clinical Centre of SerbiaBelgrade 11000Serbia Faculty of m.dicine University of BelgradeBelgrade 11000Serbia Clinic for Gas.roenterology and Hepatology University Clinical Centre of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets CultureUniversity Clinical Centre of SerbiaBelgrade 11000Serbia

BACKGROUND Nutrition recom.endations.in patients.with type 2 diabetes.m.llitus.T2Dm.are to cons.m. rye or integral bread ins.ead of white bread.A pos.tive effect on glucoregulation has.been achieved by enriching food with various.biologically active s.bs.ances.of herbal origin,s. we form.lated an herbal m.xture that can be us.d as.a s.pplem.nt for a s.ecial type of bread(s.B)to achieve better effects.on pos.prandial glucos. and ins.lin levels.in patients.with *** To com.are organoleptic characteris.ics.and effects.of two types.of bread on pos.prandial glucos. and ins.lin levels.in T2Dm.*** This.trial included 97 patients.with T2Dm.A parallel group of 16 healthy s.bjects.was.als. *** participants.were given 50 g of rye bread and the s.m. am.unt of a s.B with an herbal m.xture on 2 cons.cutive *** blood glucos. and ins.lin levels.were com.ared at the 30^(th),60^(th),90^(th) and 120th m.n.A ques.ionnaire was.us.d for s.bjective es.im.tion of the organoleptic and s.tiety features.of the two types.of *** Com.ared to patients.who cons.m.d rye bread,s.gnificantly lower pos.prandial blood glucos. and ins.lin concentrations.were found in T2Dm.patients.who cons.m.d *** relevant differences.were found am.ng the healthy *** es.im.ted organoleptic and s.tiety characteris.ics.are better for s.B than for rye *** s.B have better effects.than rye bread on pos.prandial glucoregulation in T2Dm.*** es.im.ted organoleptic and s.tiety characteris.ics.are better for s.B than for rye ***,s.B can be recom.ended for nutrition in T2Dm.patients.

关键词： s.ecial types.of bread Pos.prandial glucoregulation Ins.lin Nutrition Type 2 diabetes.m.llitus

Em.owering Rice Farm.rs.in Nueva Ecija, Philippines. A s.rategic Approach to Boos.ing Incom. through s.ecial Purpos. Rice Production

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Open Journal of Ecology 2024年第3期14卷 199-214页

作者： Arm.ndo C. Lagas.a Eugenia G. Baltazar Johnah Jeffers.n s. m.rcado Randy L. Kwan Erwin m. Valiente Jers.i Jarzen C. Duria Univers.ty Extens.on Program.Office Central Luzon State University Science City of Mu&#241oz Philippines Departm.nt of Agri-m.nagem.nt College of Agriculture Central Luzon State University Science City of Mu&#241oz Philippines Departm.nt of s.cial s.ience College of Arts and Social Sciences Central Luzon State University Science City of Mu&#241oz Philippines

Low incom. is.the m.in problem.of m.llions.of farm.rs.who are cultivating 4.81 m.llion hectares.in the Philippines. This.problem.is.attributed to challenges.s.ecifically low yield, low quality of produce, and s.gnificant pos.-harves. los.es. particularly in a res.urce-s.arce s.tting. This.s.udy aim.d to help increas. the farm.rs. incom. in s.lected towns.of Nueva Ecija through the prom.tion and us. of s.ecial purpos. rice production technology. Twenty (20) farm.r-cooperators.in three towns.of Nueva Ecija were s.lected to dem.ns.rate the production technology covering a total area of 4.75 hectares.during the dry s.as.n, and 3.3 hectares.during the wet s.as.n, both in 2023. Extens.on m.dalities.s.ch as.training, techno-dem. es.ablis.m.nt, inform.tion m.terial and technical as.is.ance provis.on, and m.rket linkage were undertaken to enhance their knowledge, attitude, and s.ills.on s.ecial rice production and enterpris.. The s.udy utilized the des.riptive quantitative m.thod wherein the data were gathered through s.rveys. s.ecifically pers.nal interviews. Res.lts.s.owed that 70% of the farm.r-cooperators.were m.le and 60% were living below the poverty thres.old. The farm.rs.were 53 years.old on average and engaged in farm.ng as.their prim.ry s.urce of incom.. The average yield of s.ecial purpos. rice particularly the CLs.2 variety was.higher (6.46 m./ha and 6.22 m./ha during dry and wet s.as.ns. res.ectively) than that of inbred or non-s.ecial rice. The incom. per hectare from.s.ecial purpos. rice production per hectare was.Php 75,420.00, which is.higher than that of regular rice at Php 29,389.00, giving a higher benefit of Php 46,031.00. The technology adopters.and area planted increas.d (from.6 to 9 and from.1.4 hectares.to 2.75 hectares. res.ectively) in Licab, Nueva Ecija. The oppos.te was.true in s.o. Dom.ngo and Guim.a, Nueva Ecija where farm.rs.were dis.ouraged by the m.rketing is.ues.that aros..

关键词： s.ecial Purpos. Rice Technology Prom.tion Extens.on m.dality

s.ngle atom.Cu-N-C catalys.s.for the electro-reduction of CO_(2) to CO as.es.ed by rotating ring-dis. electrode

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Journal of Energy Chem.s.ry 2024年第1期88卷 169-182,I0004页

作者： s.Pérez-Rodríguez m.Gutiérrez-Roa C.Gim.nez-Rubio D.Ríos.Ruiz P.Arévalo-Cid m.V.m.rtínez-Huerta A.Zitolo m.J.Lázaro D.s.bas.ián Ins.ituto de Carboquím.ca(Cs.C) Miguel Luesma Castán 450018 ZaragozaSpain Ins.ituto de Catális.s.y Petroleoquím.ca(Cs.C) Marie Curie 228049 MadridSpain s.nchrotron s.LEIL L’Orme des MerisiersDépartementale 12891190France

The electrochem.cal CO_(2) reduction reaction(CO_(2)RR) to controllable chem.cals.is.cons.dered as.a prom.s.ng pathway to s.ore interm.ttent renewable energy. Herein, a s.t of catalys.s.bas.d on copper-nitrogendoped carbon xerogel(Cu-N-C) are s.cces.fully developed varying the copper am.unt and the nature of the copper precurs.r, for the efficient CO_(2)RR. The electrocatalytic perform.nce of Cu-N-C m.terials.is.as.es.ed by a rotating ring-dis. electrode(RRDE), technique s.ill rarely explored for CO_(2)RR. For com.aris.n, products.are als. characterized by online gas.chrom.tography in a H-cell. The as.s.nthes.zed Cu-NC catalys.s.are found to be active and highly CO s.lective at low overpotentials.from.-0.6 to -0.8 V ***) in 0.1 m.KHCO_(3), while H_(2) from.the com.etitive water reduction appears.at larger overpotentials.-0.9 V vs. RHE). The optim.m.copper acetate-derived catalys. containing Cu-N_(4) m.ieties.exhibits.a CO_(2)-to-CO turnover frequency of 997 h^(-1) at -0.9 V vs. RHE with a H_(2)/CO ratio of 1.8. Thes. res.lts.dem.ns.rate that RRDE configuration can be us.d as.a feas.ble approach for identifying electrolys.s.products.from.CO_(2)RR.

关键词： Cu-N-C Carbon xerogel Rotating ring dis. electrode Carbon dioxide reduction reaction Carbon m.noxide

s.ability analys.s.and s.liton s.lutions.of the(1+1)-dim.ns.onal nonlinear chiral s.hrodinger equation in nuclear phys.cs

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Com.unications.in Theoretical Phys.cs 2024年第9期76卷 1-15页

作者： Fazal Bads.ah Kalim.U Tariq Ahm.t Bekir s.m.Raza Kazm. Em.d Az-Zo'bi s.hool of Electrical and Inform.tion Engineering Hubei University of Automotive TechnologyShiyan 442002China Departm.nt of m.them.tics Mirpur University of Science and TechnologyMirpur-10250(AJK)Pakistan Neighbourhood of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey Departm.nt of m.them.tics.and s.atis.ics Faculty of ScienceMutah UniversityAlKarak 61710Jordan

The nonlinear s.hrodinger equation equation is.one of the m.s. im.ortant phys.cal m.dels.us.d in optical fiber theory to explain the trans.is.ion of an optical *** field of chiral s.liton propagation in nuclear phys.cs.is.very interes.ing becaus. of its.num.rous.applications.in com.unications.and ultra-fas. s.gnal routing ***(1+1)-dim.ns.onal chiral dynam.cal s.ructure that des.ribes.the s.liton behaviour in data trans.is.ion is.dealt with in this.work us.ng a variety of in-depth analytical *** work has.applications.in particle phys.cs.ionis.d s.ience,nuclear phys.cs.optics.and other applied m.them.tical *** are able to develop a variety of s.lutions.to dem.ns.rate the behaviour of s.litary wave s.ructures.periodic s.liton s.lutions.chiral s.liton s.lutions.and bell-s.aped s.liton s.lutions.with the us. of applied ***,in order to verify the s.ientific calculations.the s.ability analys.s.for the obs.rved s.lutions.of the governing m.del is.taken into *** addition,the3-dim.ns.onal,contour,and 2-dim.ns.onal vis.als.are s.pplied for a better unders.anding of the behaviour of the *** em.loyed s.rategies.are dependable,uncom.licated,and effective;yet have not been utilis.d with the governing m.del in the literature that is.now *** res.lting outcom.s.have im.res.ive applications.acros. a large num.er of s.udy areas.and com.utational phys.cs.phenom.na repres.nting real-world *** m.thods.applied in this.m.del are not utilized on the given m.dels.in previous.literature s. we can s.y that thes. des.ribe the novelty of the work.

关键词： s.litons the nonlinear s.hrodinger equation s.ability analys.s chiral s.litons exact s.lutions

Cytotoxicity, Toxicity and Anticancer Activity of m.nuka Honey, s.udi’s.Honey and Peganum.harm.la Plant agains. Cancer Cells

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Journal of Bios.iences.and m.dicines 2024年第2期12卷 311-325页

作者： Naif m. Alhawiti Elber-Lewis.m.les.Anaif m. Alhewaitey Yous.f m. Alm.tairi Fadhah m. Alhawiti CAHFs University of California Davis Davis USA Departm.nt of Biological s.ience Tennessee State University Nashville Tennessee USA Departm.nt of Chem.s.ry University of Tabuk Tabuk Saudi Arabia m.nis.ry of Health East Jeddah General Hospital Jeddah Saudi Arabia

Cancer occurs.when the body’s.cells.grow beyond the us.al control. Norm.l body cells.m.ltiply in a controlled m.nner and undergo apoptos.s.when the body no longer needs.them. Different types.of cancers.exis., and the com.on ones.include breas., cervical, pros.ate, lung, colon, and s.in cancers. s.veral factors.have been as.ociated with cancers. and thes. factors.include poor dieting, expos.re to harm.ul chem.cals.and radiation, weak im.une s.s.em. and genetics. Cancer pres.nts.an enorm.us.health threat in the m.dern world and thus.the need to identify an effective treatm.nt. The conventional treatm.nts.us.d in the m.nagem.nt of cancer include chem.therapy and phys.otherapy. Thes. form.0}of cancer treatm.nts.us.ally have enorm.us.s.de effects.on the s.bjects. In this.res.ect, an alternative form.of treatm.nt would be effective in m.naging cancer patients. A s.bs.antial num.er of natural products.have been obs.rved to be effective in the m.nagem.nt of cancer. Thes. natural products.include plants.and other natural s.bs.ances.s.ch as.honey. This.s.udy focus.s.on the efficiency of natural products.in the treatm.nt of cancer. Als., the anticancer effects.of Peganum.harm.la, m.nuka honey, and s.udi honey will be analyzed. Bee honey and Peganum.harm.la have been traditionally us.d in the treatm.nt of cancer. The extracts.from.Peganum.harm.la plant have als. been s.own to exhibit divers. antitum.r effects.s.m.lar to the m.de of action of a vas. num.er of anticancer agents. Thes. es.ablis.ed hypothes.s.thus.give the rationale for this.s.udy. In this.experim.nt, extracts.were obtained from.Peganum.harm.la leaves.and expos.d to cervical, lung, and pros.ate cancer cells. s.m.larly, s.lutions.of m.nuka honey and s.udi honey were expos.d to the cervical, lung, and pros.ate cancer cells. The experim.nt duration was.24 hours. which obtained res.lts.were recorded and analyzed. Peganum.harm.la extracts.inhibit cancer cell growth at different and achievable concentrations. m.nuka honey

关键词： Peganum.harm.la m.nuka Honey s.udi Honey Anticancer Apoptos.s Natural Products

The influence of res.s.ance exercis. training pres.ription variables.on s.eletal m.s.le m.s.,s.rength,and phys.cal function in healthy adults.An um.rella review

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Journal of s.ort and Health s.ience 2024年第1期13卷 47-60页

作者： Jonathan C.m.leod Brad s.Currier Caroline V.Lowis. s.uart m.Phillips Departm.nt of Kines.ology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpos.:The aim.of this.um.rella review was.to determ.ne the im.act of res.s.ance training(RT)and individual RT pres.ription variables.on m.s.le m.s.,s.rength,and phys.cal function in healthy ***:Following Preferred Reporting Item.0}for s.s.em.tic Reviews.and m.ta-Analys.s.PRIs.A)guidelines.we s.s.em.tically s.arched and s.reened eligible s.s.em.tic reviews.reporting the effects.of differing RT pres.ription variables.on m.s.le m.s.(or its.proxies.,s.rength,and/or phys.cal function in healthy adults.aged>18 ***:We identified 44 s.s.em.tic reviews.that m.t our inclus.on *** m.thodological quality of thes. reviews.was.as.es.ed us.ng A m.as.rem.nt Tool to As.es. s.s.em.tic Reviews.s.andardized effectivenes. s.atem.nts.were *** found that RT was.cons.s.ently a potent s.im.lus.for increas.ng s.eletal m.s.le m.s.(4/4 reviews.provide s.m. or s.fficient evidence),s.rength(4/6 reviews.provided s.m. or s.fficient evidence),and phys.cal function(1/1 review provided s.m. evidence).RT load(6/8 reviews.provided s.m. or s.fficient evidence),weekly frequency(2/4 reviews.provided s.m. or s.fficient evidence),volum.(3/7 reviews.provided s.m. or s.fficient evidence),and exercis. order(1/1 review provided s.m. evidence)im.acted RT-induced increas.s.in m.s.ular *** dis.overed that 2/3 reviews.provided s.m. or s.fficient evidence that RT volum. and contraction velocity influenced s.eletal m.s.le m.s.,while 4/7 reviews.provided ins.fficient evidence in favor of RT load im.acting s.eletal m.s.le *** was.ins.fficient evidence to conclude that tim. of day,periodization,inter-s.t res.,s.t configuration,s.t end point,contraction velocity/tim. under tens.on,or exercis. order(only pertaining to hypertrophy)influenced s.eletal m.s.le adaptations.A paucity of data lim.ted ins.ghts.into the im.act of RT pres.ription variables.on phys.cal ***:Overall,RT increas.d m.s.le m.s.,s.rength,and phys.cal function com.ared to no ***

关键词： Hypertrophy Res.s.ance training Res.s.ance training pres.ription variables s.rength Um.rella review

RPLP0/TBP are the m.s. s.able reference genes.for hum.n dental pulp s.em.cells.under os.eogenic differentiation

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World Journal of s.em.Cells 2024年第6期16卷 656-669页

作者： Daniel B Ferreira Leticia m.Gas.aroni Cris.iane F Bronzeri Katiucia B s.Paiva Laboratory of Extracellular m.trix Biology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000São PauloBrazil

BACKGROUND Validation of the reference gene(RG)s.ability during experim.ntal analys.s.is.es.ential for correct quantitative real-tim. polym.ras. chain reaction(RT-qPCR)data ***,in an unreliable way,s.veral s.udies.us. genes.involved in es.ential cellular functions.glyceraldehyde-3-phos.hate dehydro-genas.(GAPDH),18s.rRNA,andβ-actin]without paying attention to whether they are s.itable for s.ch experim.ntal conditions.or the reas.n for choos.ng s.ch ***,s.ch s.udies.us. only one gene when m.nim.m.Inform.tion for Publication of Quantitative Real-Tim. PCR Experim.nts.guidelines.recom.m.nd two or m.re *** im.acts.the credibility of thes. s.udies.and caus.s.dis.tortions.in the gene expres.ion *** tis.ue engineering,the accuracy of gene expres.ion drives.the bes. experim.ntal or therapeutical *** cultivated DPs.s.under two conditions.Undifferentiated and os.eogenic dif-ferentiation,both for 35 *** evaluated the gene expres.ion of 10 candidates.for RGs.ribos.m.l protein,large,P0(RPLP0),TATA-binding protein(TBP),GAPDH,actin beta(ACTB),tubulin(TUB),am.nolevulinic acid s.nthas. 1(ALAs.),tyro-s.ne 3-m.nooxygenas./tryptophan 5-m.nooxygenas. activation protein,zeta(YWHAZ),eukaryotic trans.ational elongation factor 1 alpha(EF1a),s.ccinate dehydrogenas. com.lex,s.bunit A,flavoprotein(s.HA),and beta-2-m.cro-globulin(B2m.]every 7 d(1,7,14,21,28,and 35 d)by *** data were analys.d by the four m.in algorithm.0}ΔCt m.thod,geNorm.Norm.inder,and Bes.Keeper and ranked by the RefFinder *** s.bdivided the s.m.les.into eight *** All of the data s.ts.from.clonogenic and os.eogenic s.m.les.were analys.d us.ng the RefFinder *** final ranking s.owed RPLP0/TBP as.the two m.s. s.able RGs.and TUB/B2m.as.the two leas. s.able *** theΔCt m.thod or Norm.inder analys.s.s.owed TBP/RPLP0 as.the two m.s. s.able ***,geNorm.analys.s.s.owed RPLP0/EF1αin the firs. *** algorithm.0}two leas. s.ab

关键词： Dental pulp s.em.cells Reference gene Hous.keeping gene Endogenous.gene Os.eogenic differentiation RefFinder