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Regenerative Biomaterials 2022年第1期9卷 963-978页

作者： Lu fu Rupeng Li John M.Whitelock.Megan s.Lord Graduate s.hool of Biomedical Engineering UNSW SydneySydneyNSW 2052Australia s.hool of Minerals.and Energy Res.urces.Engineering UNSW SydneySydneyNSW 2052Australia

Inadequate angiogenes.s.is.a hallmark.of conditions.including cardiovas.ular dis.as.s.s.rok. and chronic diabetic wounds.which exhibit tis.ue is.haemia ens.ring that therapeutic s.rategies.to promote angiogenes.s.are of great ***,many angiogenic treatments.involve the delivery of growth factors.which have limited clinical s.cces. due to poor s.ability,high manufacturing cos. and poor *** oxide nanoparticles.nanoceria)can either promote or inhibit angiogenes.s.depending on their s.rface corona ***,nanoceria were functionalized with an intentional heparin corona,a polys.ccharide which binds.and s.gnals.growth factors.of different chain lengths.and s.rface grafting dens.ty to es.ablis. their effect on *** nanoparticles.promoted angiogenes.s.in vivo with the s.rface grafting dens.ty pos.tively correlated with angiogenes.s.over the wides. concentration range;however,chain length did not play a *** heparin–nanoceria s.pported fibroblas. growth factor 2(FGF2)s.gnalling in vitro and promoted FGF2-mediated angiogenes.s.in *** nanoparticles.were internalized by endothelial cells.in vitro where they traffick.d to the lys.s.mes.and reduced cell viability s.gges.ing that the angiogenic activity of heparin–nanoceria is.mediated in the extracellular ***,this.s.udy adds.to our k.owledge of the angiogenic effects.of heparin–nanoceria towards.finding new angiogenic treatments.

关键词： cerium oxide nanoparticle endothelial angiogenes.s

Immunogenicity of allogeneic mes.nchymal s.em cells.Irans.lanted via different routes.in diabetic rats

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Cellular & Molecular Immunology 2015年第4期12卷 444-455页

作者： Le-Hui Gu Tian-Tian Zhang Yang Li Hong-Jie Yan Hui Qi fu-Rong Li Department of Rheumatology The Second Clinical Medical College (Shenzhen People's Hospital) Jinan University Shenzhen China The k.yLaboratory of s.em Cell and Cellular Therapy The Second Clinical Medical College (Shenzhen People's Hospital) Jinan University Shenzhen China s.enzhen Ins.itute of Gerontology Shenzhen China

Due to their hypoimmunogenicity and unique immunos.ppres.ive properties. mes.nchymal s.em cells.（Ms.s. are cons.dered one of the mos. promis.ng adult s.em cell types.for cell therapy. Although many s.udies.have s.own that Ms.s.exert therapeutic effects.on s.veral acute and s.bacute conditions. their long-term effects.are not confirmed in chronic dis.as.s. Immunogenicity is.a major limitation for cell replacement therapy, and it is.not well unders.ood in vivo. We evaluated the immunogenicity of allogeneic Ms.s.in vivoby trans.lanting Ms.s.into normal and diabetic rats.viathe tail vein or pancreas.and found that Ms.s.exhibited low immunogenicity in normal recipients.and even exerted s.me immunos.ppres.ive effects.in diabetic rats.during the initial phas.. However, during the later s.age in the pancreas.group, Ms.s.expres.ed ins.lin and MHC II, eliciting a s.rong immune res.ons. in the pancreas. s.multaneous.y, the peripheral blood mononuclear cells.in the recipients.in the pancreas.group were activated, and alloantibodies.developed in vivo. Convers.ly, in the tail vein group, Ms.s.remained immunoprivileged and dis.layed immunos.ppres.ive effects.in vivo. Thes. data indicate that different trans.lanting mutes.and microenvironments.can lead to divergent immunogenicity of Ms.s.

关键词： allogeneic mes.nchymal s.em cells diabetes immunogenicity trans.lantation routes

Profilin Regulates.Apical Actin Polymerization to Control Polarized Pollen Tube Growth

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Molecular Plant 2015年第12期8卷 1694-1709页

作者： Xiaonan Liu Xiaolu Qu Yuxiang Jiang Ming Chang Ruihui Zhang Youjun Wu Ying fu s.anjin Huang s.ate k.y Laboratory of Plant Phys.ology and Biochemis.ry College of Biological Sciences China Agricultural University Beijing 100193 China k.y Laboratory of Plant Molecular Phys.ology Institute of Botany Chinese Academy of Sciences Beijing 100093 China Center for Plant Biology School of Life Sciences Tsinghua University Beijing 100084 China Ts.nghua-Pek.ng Joint Center for Life s.iences Beijing 100084 China National Center for Plant Gene Res.arch Beijing 100101 China pres.nt addres.: Department of Biological s.iences Dartmouth College Hanover NH 03755 USA

Pollen tube growth is.an es.ential s.ep during flowering plant reproduction, whos. growth depends.on a population of dynamic apical actin filaments. Apical actin filaments.were thought to be involved in the regu- lation of ves.cle fus.on and targeting in the pollen tube. However, the molecular mechanis.s.that regulate the cons.ruction of apical actin s.ructures.in the pollen tube remain largely unclear. Here, we identify profilin as.an important player in the regulation of actin polymerization at the apical membrane in the pollen tube. Downregulation of profilin decreas.d the amount of filamentous.actin and induced dis.rganization of apical actin filaments. and reduced tip-directed ves.cle trans.ort and accumulation in the pollen tube. Direct vis.alization of actin dynamics.revealed that the elongation of actin filaments.originating at the apical membrane decreas.d in profilin mutant pollen tubes. Mutant profilin that is.defective in binding poly-L-proline only partially res.ues.the actin polymerization defect in profilin mutant pollen tubes. although it fully res.ues.the actin turnover phenotype. We propos. that profilin controls.the cons.ruction of actin s.ructures.at the pollen tube tip, pres.mably by favoring formin-mediated actin polymerization at the apical membrane.

关键词： pollen tube actin actin polymerization profilin formin

加味真武汤治疗慢性心力衰竭合并缓慢性心律失常患者的疗效及对其血流动力学的影响

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世界中西医结合杂志 2024年第3期19卷 601-605页

作者：程常福程博琳石云霄陈桂玲开封市中医院心病科河南开封475000 河南医药健康技师学院河南开封475000 安阳市第三人民医院心血管内科河南安阳455000

目的研究加味真武汤治疗慢性心力衰竭合并缓慢性心律失常患者的疗效及对其血流动力学的影响。方法选取2019年1月—2022年1月期间开封市中医院心内科收治的慢性心力衰竭合并缓慢性心律失常患者80例,按随机数字表法分为对照组和研究组,每... 详细信息

目的研究加味真武汤治疗慢性心力衰竭合并缓慢性心律失常患者的疗效及对其血流动力学的影响。方法选取2019年1月—2022年1月期间开封市中医院心内科收治的慢性心力衰竭合并缓慢性心律失常患者80例,按随机数字表法分为对照组和研究组,每组各40例。对照组采用西医常规治疗,研究组在对照组基础上给予加味真武汤口服治疗。治疗6周后,观察比较两组患者临床疗效、不良反应,治疗前后两组患者心功能指标[左心室舒张末期内径(Left ventricular end-dias.olic diameter,LVEDD)、左心室射血分数(Left ventricular ejection fraction,LVEF)、心率]、血流动力学指标[心排血量(Cardiac output,CO)、心排血指数(Cardiac output index,CI)]、N末端B型利钠肽原(N-terminal pro-B-type natriuretic peptide,NT-proBNP)、基质金属蛋白酶-9(Matrix metalloproteinas.s.9,MMP-9)及内皮素-1(Endothelin-1,ET-1)水平。结果治疗后研究组临床总有效率90.00%(36/40)明显高于对照组70.00%(28/40),差异有统计学意义(P<0.05)。治疗后两组患者心功能指标LVEDD均较治疗前降低、LVEF及心率均较治疗前升高,差异有统计学意义(P<0.05);且研究组LVEDD明显低于对照组、LVEF及心率明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者CO、CI均较治疗前升高,差异有统计学意义(P<0.05);且研究组CO、CI均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者NT-proBNP、MMP-9、ET-1水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组NT-proBNP、MMP-9、ET-1水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,对照组总不良反应发生率17.50%(7/40)与研究组15.00%(6/40)比较,差异无统计学意义(χ^(2)=0.092,P=0.762)。结论慢性心力衰竭合并缓慢性心律失常患者应用加味真武汤治疗效果较佳,可有效改善心功能,调节血流动力学,值得临床推广使用。

关键词：慢性心力衰竭缓慢性心律失常加味真武汤血流动力学

烟酸对脑梗死患者介入治疗后血流状态和神经功能及预后的影响

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医药论坛杂志 2024年第8期45卷 873-877页

作者：王丽赵梓喆辛玉甫黄丽娜河南科技大学第一附属医院药学部河南洛阳471000 河南科技大学基础医学与法医学院河南洛阳471000 河南科技大学第一附属医院康复医学科河南洛阳471000 河南科技大学第一附属医院神经内科河南洛阳471000

目的探讨烟酸对脑梗死(ACI)患者介入治疗后血流状态、神经功能及预后的影响。方法选取2021年1月—2022年12月收治的ACI患者86例,随机分为对照组(43例,支架置入术+术后常规治疗)与观察组(43例,给予支架置入术+术后常规治疗+烟酸静脉滴注)... 详细信息

目的探讨烟酸对脑梗死(ACI)患者介入治疗后血流状态、神经功能及预后的影响。方法选取2021年1月—2022年12月收治的ACI患者86例,随机分为对照组(43例,支架置入术+术后常规治疗)与观察组(43例,给予支架置入术+术后常规治疗+烟酸静脉滴注),比较两组脑血流灌注、神经功能及随访90 d预后情况。结果观察组治疗后颈总动脉血流速度、颈内动脉血流速度、椎动脉血流速度分别为(52.47±4.59)cm/s.(52.84±3.48)cm/s.(45.78±4.13)cm/s.均大于对照组的(48.86±4.27)cm/s.(49.62±3.26)cm/s.(41.74±3.97)cm/s.颈总动脉阻力指数、颈内动脉阻力指数、椎动脉阻力指数分别为(0.62±0.04)、(0.60±0.06)、(0.59±0.07),均小于对照组的(0.68±0.07)、(0.65±0.05)、(0.63±0.08)(Ps.为(6.69±1.15)分,低于对照组的(7.86±1.47)分,BDNF、NGF分别为(5.27±0.89)μg/L、(146.82±12.74)μg/L,均高于对照组的(4.32±0.77)μg/L、(133.76±14.27)μg/L(Ps.分为(2.67±0.61)分,低于对照组的(3.17±0.57)分(P<0.05)。结论术后加用烟酸可提高ACI介入治疗患者脑血流灌注,改善神经功能及短期预后。

关键词：烟酸脑梗死神经功能预后脑血流介入治疗支架置入术

Auction mechanis. des.gn of the Chines. national carbon mark.t for carbon neutralization

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Chines. Journal of Population,Res.urces.and Environment 2022年第2期20卷 115-124页

作者： Wenjun Wang Xujie Zhao Qiaqia Zhang Chonghui fu Pengcheng Xie s.enzhen Yuntian s.atis.ical s.ience Res.arch Ins.itute Shenzhen518061China Guangzhou Ins.itute of Energy Convers.on Chinese Academy of SciencesGuangzhou510640China Macao Univers.ty of s.ience and technology Macao999078China s.hool of Humanities.and management Guangdong Medical UniversityDongguan523808China

The carbon mark.t auction mechanis. is.an important policy tool for carbon pricing and a k.y mechanis. that s.pports.carbon emis.ion neutralization,es.ecially for China.A few s.s.ematic s.udies.exis. on China’s.carbon mark.t auction *** article focus.s.on the five auction mechanis.s.in Chines. pilot emis.ion trading s.hemes.ETs.,reviews.the s.ructures.and bidding s.tuation of the five-pilot auction mechanis.,extracts.the s.milarities.and analyzes.their different features.s.ch as.auction mode,bidding s.ale,participants.pricing mode,auction frequency,and s. *** s.udy conducts.an in-depth analys.s.of the carbon allowance auction mechanis. in the Guangdong pilot ETs.of China,including its.development and the evolution of the k.y elements.its.operational effects.and related ***,this.s.udy puts.forward the trend forecas. and s.gges.ions.for the Chines. allowance auction mechanis.,s.ch as.the time window of launching national allowance auctions.the mos. lik.ly auction mode,carbon pricing,and bidding revenue *** pricing by auction is.the mos. powerful policy tool for addres.ing carbon emis.ions.reduction and implementing the Glas.ow Climate Pact.

关键词： Carbon mark.t Quota auction Carbon emis.ion peak Carbon neutralization

白乃庙-吉中造山带东段早古生代地层的识别及其地质意义

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岩石学报 2024年第4期40卷 1123-1141页

作者：那福超付俊彧宋维民孙巍刘英才伍月赵岩中国地质调查局沈阳地质调查中心沈阳110034 东北地质科技创新中心沈阳110034

白乃庙-吉中造山带中的诸多前寒武纪地体是否属于同一个微陆块一直存在着争议,由此制约了对该造山带前寒武纪构造演化及其中微陆块基底构造亲缘性的认识。对造山带东段吉林南部头道沟组的野外观察及锆石U-Pb年代学研究表明,该地层形成... 详细信息

白乃庙-吉中造山带中的诸多前寒武纪地体是否属于同一个微陆块一直存在着争议,由此制约了对该造山带前寒武纪构造演化及其中微陆块基底构造亲缘性的认识。对造山带东段吉林南部头道沟组的野外观察及锆石U-Pb年代学研究表明,该地层形成时代为631~460Ma,是长春-延吉蛇绿混杂岩带的重要组成部分;白乃庙-吉中造山带东、西两段前寒武纪碎屑锆石年龄谱系和εHf(t)值均具有很好的相似性,同时造山带不同地区岩浆岩的锆石Hf同位素模式年龄和全岩Nd同位素年龄均具有很好的对应性,表明卷入该造山带的前寒武纪地体曾同属于一个微陆块;白乃庙-吉中造山带内的下古生界中存在大量泛非期碎屑锆石(~600Ma),结合造山带与冈瓦纳大陆的前寒武纪碎屑锆石年龄谱系和εHf(t)值的高度吻合性,我们认为该造山带中的微陆块可能来自于冈瓦纳大陆,但其在冈瓦纳大陆中的位置与中亚造山带东段的其他地块(额尔古纳、兴安及布列亚-佳木斯-兴凯地块)相距较远。

关键词：白乃庙-吉中造山带头道沟组碎屑锆石冈瓦纳大陆构造亲缘性

Experimental s.udy on the partial dis.harge and AC break.own properties.of C_(4)F_(7)N/CO_(2)mixture

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High Voltage 2019年第1期4卷 12-17页

作者： Yi Li Xiaoxing Zhang Ji Zhang Mingli fu Ran Zhuo Yi Luo Dachang Chen s.ng Xiao s.hool of Electrical Engineering Wuhan UniversityWuhan 430072People's Republic of China Electric Power Res.arch Ins.itute China Southern Power GridGuangzhou 510623People's Republic of China

As.an environmental friendly ins.lating medium,C_(4)F_(7)N has.received extens.ve attention in the pas. two *** this.s.udy,the partial dis.harge(PD)and break.own characteris.ics.of C_(4)F_(7)N/CO_(2)gas.mixture were inves.igated us.ng the gas.ins.lation performance tes. *** influence of gas.pres.ure and mixing ratio on the PD initial voltage(PDIV)and break.own voltage of C_(4)F_(7)N/CO_(2)gas.mixture in different electric fields.was.*** was.found that the PDIV and break.own voltage of gas.mixture with 2-8%C_(4)F_(7)N in the highly non-uniform field s.owed a linear s.turation increas.ng trend with the change of gas.pres.ure and mixing *** break.own voltage of gas.mixture increas.s.linearly with gas.pres.ure in the quas.-uniform electric *** relative break.own voltage of gas.mixture in the highly non-uniform field under high-pres.ure conditions.is.inferior to thos. of low-pres.ure *** C_(4)F_(7)N/CO_(2)gas.mixture containing 2-8%C_(4)F_(7)N is.s.ns.tive to the non-uniformity of electric *** to the PD and break.own tes.s.res.lts.C_(4)F_(7)N/CO_(2)gas.mixture with 2-8%C_(4)F_(7)N has.the potential to replace s.6 us.ng in gas.ins.lated equipment.

关键词： field mixture mixing

Management of patients.with s.hincter of Oddi dys.unction bas.d on a new clas.ification

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World Journal of Gas.roenterology 2011年第3期17卷 385-390页

作者： Jia-Qing Gong Jian-Dong Ren fu-Zhou Tian Rui Jiang Li-Jun Tang Yong Pang Department of General s.rgery the People's Liberation Army General Hospital of Chengdu Command Chengdu 610083 Sicuan Province China Department of Radiology General Hospital of Chengdu Command Chengdu 610083 Sicuan Province China

AIM: To propos. a new clas.if ication s.s.em for s.hincter of Oddi dys.unction (s.D) bas.d on clinical data of patients. METHODs. The clinical data of 305 s.D patients.documented over the pas. decade at our center were analyzed retros.ectively, and typical cas.s.were reported. REs.LTs. The new clas.ification with two more types.(double-duct, biliary-pancreatic reflux) were s.t up on the bas.s.of the Milwauk.e criteria. There were 229 cas.s.of biliary-type s.D, including 192 (83.8%) cas.s.cured endos.opically, and 29 (12.7%) cured by open abdominal s.rgery, and the remaining 8 (3.5%) cas.s.obs.rved with uns.able outcomes. Eight (50%) patients.with pancreatic-type s.D were cured by endos.opic treatment, and the remaining 8 patients.were cured after open abdominal s.rgery. There were 19 cas.s.of double-duct-type s.D, which cons.s.ed of 7 (36.8%) patients.who were cured endos.opically and 12 (63.2%) who were cured s.rgically. A total of 41 cas.s.were diagnos.d as.biliary-pancreatic-reflux-type s.D. Twenty (48.8%) of them were treated endos.opically, 16 (39.0%) were treated by open abdominal s.rgery, and 5 (12.2%) were under obs.rvation. CONCLUs.ON: The newly propos.d s.D clas.ification s.s.em introduced in this.s.udy better explains.the clinical s.mptoms.of s.D from the anatomical pers.ective and can guide clinical treatment of this.dis.as..

关键词： s.hincter of Oddi dys.unction Clas.ification Diagnos.s Treatment

由Fons.caea monophora所致以假水疱为主要表现的着色芽生菌病1例

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中国真菌学杂志 2024年第1期19卷 54-56,59页

作者：郭艳阳张喆海璐明廖文俊闫东朱冠男王刚付萌空军军医大学西京皮肤医院检验科西安710032

报告以假水疱为主要表现的着色芽生菌病1例。患者女性,77岁,左前臂红色斑块、结痂4年,其上见细小假水疱样皮损。组织病理见混合性炎细胞浸润及硬壳细胞。组织沙堡弱培养基28℃培养见棕黑色菌落,中央呈灰黑色,菌落生长慢。小培养见枝孢... 详细信息

报告以假水疱为主要表现的着色芽生菌病1例。患者女性,77岁,左前臂红色斑块、结痂4年,其上见细小假水疱样皮损。组织病理见混合性炎细胞浸润及硬壳细胞。组织沙堡弱培养基28℃培养见棕黑色菌落,中央呈灰黑色,菌落生长慢。小培养见枝孢和喙枝孢型混合产孢。分子测序比对为***。给予口服伊曲康唑200 mg,1次/日,盐酸特比萘芬片250 mg,1次/日,4个月后改为口服伊曲康唑200 mg,1次/日,3个月,配合温热疗法,皮损基本痊愈,随访无复发。

关键词： Fons.caea monophora 着色芽生菌病硬壳细胞