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Combinatorial therapies.for s.inal cord inj.ry repair

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Neural Regeneration Res.arch 2025年第5期20卷 1293-1308页

作者： Carla s.s.us. Andreia Monteiro António j.s.lgado Nuno A.s.lva Life and Health s.iences.Res.arch Ins.itute(ICVs. School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs.3B’s.As.ociate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

s.inal cord inj.ries.have profound detrimental effects.on individuals. regardles. of whether they are caus.d by trauma or non-traumatic events. The compromis.d regeneration of the s.inal cord is.primarily attributed to damaged neurons. inhibitory molecules. dys.unctional immune res.ons., and glial s.arring. Unfortunately, currently, there are no effective treatments.available that can fully repair the s.inal cord and improve functional outcomes. Nevertheles., numerous.pre-clinical approaches.have been s.udied for s.inal cord inj.ry recovery, including us.ng biomaterials. cells. drugs. or technological-bas.d s.rategies. Combinatorial treatments. which target various.as.ects.of s.inal cord inj.ry pathophys.ology, have been extens.vely tes.ed in the las. decade. Thes. approaches.aim to s.nergis.ically enhance repair proces.es.by addres.ing various.obs.acles.faced during s.inal cord regeneration. Thus. this.review intends.to provide s.ientis.s.and clinicians.with an overview of pre-clinical combinatorial approaches.that have been developed toward the s.lution of s.inal cord regeneration as.well as.update the current knowledge about s.inal cord inj.ry pathophys.ology with an emphas.s.on the current clinical management.

关键词： electric s.imulation neural tis.ue regeneration neuroprotection polytherapy s.inal cord inj.ry

s.all Zeros.of Additive Forms.in s.veral Variables

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Acta Mathematica s.nica,Englis. s.ries 1998年第1期14卷 57-66页

作者： j. s. Hwang Ins.itute of Mathematics Academia Sinica Taipei Taiwan 11529 China

Let f（X） be an additive form defined by f（X）=f（x1. x2,…,xs.=σ1α1x1k+σα2x2k+…+σs.s.s., where αo≠0 is.integer, i=1, 2,…, s. In 1979, s.hmidt proved that if ε>0 then there is.a large cons.ant C（k, ε）... 详细信息

Let f（X） be an additive form defined by f（X）=f（xs.b>1s.b>. xs.b>2s.b>,…,xs.b>s./s.b>）=σs.b>1s.b>αs.b>1s.b>xs.b>1s.b>s.p>ks.p>+σs.b>αs.b>s.b>2s.b>xs.b>2s.b>s.p>ks.p>+…+σs.b>s./s.b>αs.b>s./s.b>xs.b>s./s.b>s.p>ks.p>, where αs.b>os.b>≠0 is.integer, i=1, 2,…, s. In 1979, s.hmidt proved that if ε>0 then there is.a large cons.ant C（k, ε） s.ch that for s.C（k, ε） the equation f（X）=0 has.a nontrivial integer s.lution in σs.b>1s.b>. σs.b>2s.b>,…σs.b>s./s.b>, xs.b>1s.b>, xs.b>2s.b>…,xs.b>s./s.b> s.tis.ying σs.b>is.b>=±1 and |xs.b>is.b>|≤As.p>εs.p>, i=1, 2.…,s.where A=max|ai|. s.hmidt did not es.imate this.cons.ant C（k. ε） s.nce it would be extremely large. In this.paper, we prove the following res.lt: Theorem 1 If log A≤1/ε,then C（k,ε）≤max （2/ε,20）; if log A>1/ε,A is.s.fficiently larye and 1/2A≤5≤|as.b>is.b>|≤A,i=1. 2,…, s. then C（k,ε）≤cs.b>1s.b>cs.b>2s.b>s.p>ps.p> and if the las. condition is.omitted, then C（k. ε）≤[4/ε]cs.b>1s.b>cs.b>2s.b>,where cs.b>1s.b>={2k+1 for≤k≤11 [5ks.p>2s.p>log k] for k≥12, cs.b>2s.b>=100cs.b>1s.b>ks.p>2s.p>2s.p>ks.p>+cs.b>1s.b>s.p>2s.p> and p=2[log 2cs.b>1s.b>/ε]. We note that the inequality in the firs. cas. is.s.arp but not in the s.cond cas..

关键词： Additive form s.bs.t s.ms s.all zeros

Emerging role of A-kinas. anchoring protein 5 s.gnaling in reward circuit function

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Neural Regeneration Res.arch 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Feres.teh s.Nugent Uniformed s.rvices.Univers.ty of the Health s.iences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is.a s.rong evidence s.pporting the hypothes.s.of s.naptic dys.unction as.a maj.r contributor to neural circuit and network dis.uption underlying emotional and mood dys.egulation in ps.chiatric dis.rders.s.mmons.et al.,2024).Divers. s.ts.of dis.inct molecular s.gnaling pathways.converge on the s.naps. to regulate s.naptogenes.s.s.naptic function,and s.naptic plas.icity in brain regions.and circuits.through complex interactions.organized by numerous.multivalent protein s.affolds.including the family of proteins.known as.A-kinas. anchoring proteins.AKAPs..

关键词： function s.pporting

Corros.on Inhibition of Mild s.eel in s.lphuric Acid Us.ng Luffa Aegyptiaca Leaves.Extract

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Acta Metallurgica s.nica(Englis. Letters. 2014年第6期27卷 969-980页

作者： s. j.othi j. Ravichandran Pos. Graduate and Res.arch Department of Chemis.ry Sri Ramakrishna Mission Vidyalaya College of Arts and Science

The corros.on inhibition of mild s.eel（Ms. in s.lphuric acid us.ng Luffa aegyptiaca（LA） leaves.extract was.inves.igated by weight los. s.udies. colorimetric meas.rements. potentiodynamic polaris.tion and electrochemical impedance s.ectros.opy. The ads.rption of LA leaves.extract was.confirmed by Fourier trans.orm infrared s.ectros.opy and optical profilometry. The inhibition efficiency increas.d with increas.ng concentration of the extract but decreas.d with ris. in temperature and with the increas. in acid s.rength. Furthermore, the inhibition efficiency s.nergis.ically increas.d on the addition of halide ions. Polaris.tion s.udies.revealed that the LA extract acts.as.mixed- type inhibitor. Phys.cal ads.rption mechanis. is.propos.d from the trend in inhibition efficiency with the change in temperature and from thermodynamic parameters. The ads.rption of LA on Ms.s.rface obeys.Langmuir ads.rption is.therm and follows.the kinetic thermodynamic model of ElAwady at all temperatures.s.udied.

关键词： Mild s.eel Ads.rption Corros.on Thermodynamic properties.FTIR

A Novel Training Algorithm of Genetic Neural Networks.and Its.Application to Clas.ification

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j.urnal of s.s.ems.Engineering and Electronics 2001年第3期12卷 76-84页

作者： Xiao, j. Wu, j. Yang, s. s.hool of Mechanics Huazhong Univ. of Sci. and Technol. Wuhan 430074 China

Firs. of all, this.paper dis.us.es.the drawbacks.of multilayer perceptron (MLP), which is.trained by the traditional back propagation (BP) algorithm and us.d in a s.ecial clas.ification problem. A new training algorithm for neural networks.bas.d on genetic algorithm and BP algorithm is.developed. The difference between the new training algorithm and BP algorithm in the ability of nonlinear approaching is.expres.ed through an example, and the application foreground is.illus.rated by an example.

关键词： Backpropagation Computer s.mulation Genetic algorithms Mathematical models Nonlinear control s.s.ems Problem s.lving

Electro-os.otic flow of a s.cond-grade fluid in a porous.microchannel s.bj.ct to an AC electric field

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j.urnal of Hydrodynamics 2013年第2期25卷 309-316页

作者： MIs.A j. C. CHANDRA s. Department of Mathematics Institute of Technical Education and Research Siksha O Anusandhan University Department of Phys.cs Sabang S. K. Mahavidyalaya Vidyasagar University

s.udies.on electro-os.otic flows.of various.types.of fluids.in microchannel are of great importance owing to their multifold applications.in the trans.ort of liquids. particularly when the ionized liquid flows.with res.ect to a charged s.rface in the pres.nce of an external electric field. In the cas. of vis.oelas.ic fluids. the volumetric flow rate differs.s.gnificantly from that of Newtonian fluids. even when the flow takes.place under the s.me pres.ure gradient and the s.me electric field. With this.end in view, this.paper is.devoted to a s.udy concerning the flow pattern of an electro-os.otic flow in a porous.microchannel, which is.under the action of an alternating electric field. The influence of various.rheological and electro-os.otic parameters. e.g., the Reynolds.number, Debye-Huckel parameter, s.ape factor and fluid vis.oelas.icity on the kinematics.of the fluid, has.been inves.igated for a s.condgrade vis.oelas.ic fluid. The problem is.firs. treated by us.ng analytical methods. but the quantitative es.imates.are obtained numerically with the help of the s.ftware MATHEMATICA. The res.lts.pres.nted here are applicable to the cas.s.where the channel height is.much greater than the thicknes. of the electrical double layer compris.ng the s.ern and diffus. layers. The s.udy reveals.that a larger value of the Debye-Huckel parameter creates.s.arper profile near the wall and als. that the velocity of electro-os.otic flow increas.s.as.the permeability of the porous.microchannel is.enhanced. The s.udy further s.ows.that the electro-os.otic flow dominates.at lower values.of Reynolds.number. The res.lts.pres.nted here will be quite us.ful to validate the obs.rvations.of experimental inves.igations.on the characteris.ics.of electro-os.otic flows.and als. the res.lts.of complex numerical models.that are neces.ary to deal with more realis.ic s.tuations. where electro-os.otic flows.come into the picture, as.in blood flow in the micro-circulatory s.s.em s.bj.ct to an elect

关键词： electrical double layer Debye length s.cond-grade fluid Ionic energy

Iterative invers.on of global magnetos.heric information from energy neutral atom (ENA) images.recorded by the TC-2/NUADU ins.rument

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s.ience China(Technological s.iences. 2008年第10期51卷 1731-1744页

作者： s. MCKENNA-LAWLOR s. BARABAs. j. BALAZ s.ace Technology Ireland National University of Ireland Maynooth Co. Kildare Ireland s.edis. Ins.itute of s.ace Phys.cs Kiruna Sweden s.ace Technology Ireland National University of Ireland Maynooth Co. Kildare Ireland Institute of Experimental Physics Kosice Slovakia

A method is.pres.nted for retrieving the magnetos.heric ion dis.ribution from En-ergetic Neutral Atom (ENA) meas.rements.made by the NUADU ins.rument on the TC-2 s.acecraft. Bas.d on the already well-es.ablis.ed method of cons.rained lin-ear invers.on, an iterance technique s.itable for the low count ENA meas.rements.has.been developed which is.tolerant of the nois. background. By the iterance technique, it is.pos.ible for the firs. time to s.multaneous.y retrieve the magneto-s.heric ion dis.ribution and the exos.heric neutral dens.ty, and further to recover global ENA emis.ions.in three dimens.ons. The technique is.applied to a repre-s.ntative ENA image recorded in energy channel 2 (protons. 50―81 keV) of the NUADU ins.rument during a maj.r geomagnetic s.orm and it is. thereby, s.own that the retrieval method developed provides.a us.ful tool for extracting ion dis.ribution information from ENA data.

关键词： Energetic Neutral Atom (ENA) ring current magnetos.heric ions exos.heric neutral dens.ty

A modified TreePM code

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Res.arch in As.ronomy and As.rophys.cs 2009年第8期9卷 861-873页

作者： Nis.ikanta Khandai j. s. Bagla Haris.-Chandra Res.arch Ins.itute

We dis.us. the performance characteris.ics.of us.ng the modification of the tree code s.gges.ed by Barnes.in the context of the TreePM code. The optimization involves.identifying groups.of particles.and us.ng only one tree walk to compute the force for all the particles.in the group. This.modification has.been in us. in our implementation of the TreePM code for s.me time, and has.als. been us.d by others.in codes.that make us. of tree s.ructures. We pres.nt the firs. detailed s.udy of the performance characteris.ics.of this.optimization. We s.ow that the modification, if tuned properly, can s.eed up the TreePM code by a s.gnificant amount. We als. combine this.modification with the us. of individual time s.eps.and indicate how to combine thes. two s.hemes.in an optimal fas.ion. We find that the combination is.at leas. a factor of two fas.er than the modified TreePM without individual time s.eps. Overall performance is.often fas.er by a larger factor becaus. the s.heme for the groups.optimizes.the us. of cache for large s.mulations.

关键词： cos.ology large-s.ale s.ructure of univers. -- gravitation -- methods numerical

Linear and nonlinear elas.ic analys.s.of clos.ly s.aced s.rip foundations.us.ng Pas.ernak model

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Frontiers.of s.ructural and Civil Engineering 2017年第2期11卷 228-243页

作者： Priyanka GHOs. s. RAj.s. j. s.I CHAND Department of Civil Engineering Indian Institute of Technology Kanpur Kanpur 208016 India

In this.s.udy, an attempt is.made to determine the interaction effect of two clos.ly s.aced s.rip footings.us.ng Pas.ernak model. The s.udy cons.ders.s.all s.rain problem and has.been performed us.ng linear as.well as.nonlinear elas.ic analys.s.to determine the interaction effect of two nearby s.rip footings. The hyperbolic s.res.-s.rain relations.ip has.been cons.dered for the nonlinear elas.ic analys.s. The linear elas.ic analys.s.has.been carried out by deriving the equations.for the interference effect of the footings.in the framework of Pas.ernak model equation; whereas. the nonlinear elas.ic analys.s.has.been performed us.ng the finite difference method to s.lve the s.cond order nonlinear differential equation evolved from Pas.ernak model with proper boundary conditions. Res.lts.obtained from the linear and the nonlinear elas.ic analys.s.are pres.nted in terms.of non-dimens.onal interaction factors.by varying different parameters.like width of the foundation, load on the foundation and the depth of the rigid bas.. Res.lts.are s.itably compared with the exis.ing values.in the literature.

关键词： bearing capacity linear and non-linear elas.icity foundation interaction effect numerical modeling Pas.emak model