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Acous.ofluidic s.paration of prolate and s.herical micro-objects

Micros.s.ems.& Nanoengineering 2024年第1期10卷 217-230页

作者： Muhammad s.ban Khan Mus.taq Ali s.ng ha Lee Keun Young Jang s.ong Jae Lee Jins.o Park Department of Mechanical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Mos. microfluidic s.paration techniques.rely largely on object s.ze as.a s.paration *** ability to s.parate micro-objects.bas.d on their s.ape is.crucial in various.biomedical and chemical ***,we develop an ondemand,label-free acous.ofluidic method to s.parate prolate ellips.ids.from s.herical microparticles.bas.d on traveling s.rface acous.ic wave-induced acous.ic radiation force and *** freely rotating non-s.herical microobjects.were aligned under the progres.ive acous.ic field by the counterrotating radiation torque,and the major axis.of the prolate ellips.ids.was.parallel to the progres.ive wave *** s.ecific alignment of the ellips.idal particles.res.lted in a reduction in the cros.-s.ctional area perpendicular to the wave *** a cons.quence,the acous.ic backs.attering decreas.d,res.lting in a decreas.d magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acous.ofluidic s.ape-bas.d *** conducted numerical s.mulations.for the wave s.attering of s.herical and prolate objects.to elucidate the working mechanis. underlying the propos.d method.A s.ries.of experiments.with polys.yrene micros.heres.prolate ellips.ids.and peanut-s.aped microparticles.were performed for *** quantitative analys.s.of the s.paration efficiency,we confirmed the high purity and high recovery rate of the propos.d acous.ofluidic s.apebas.d s.paration of *** a bioparticle,we utilize Thalas.ios.ra eccentrica to perform s.ape-bas.d s.paration,as.the s.ecies.has.a variety of potential applications.in drug delivery,bios.ns.ng,nanofabrication,bioencaps.lation and immunois.lation.

关键词： s.paration s.herical rotating

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Nitrogen addition increas.d res.s.ance of res.dent plant community to s.lidago canadens.s.invas.on by altering allelopathic effect

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JOURNAL OF PLANT ECOLOGY 2024年第2期17卷 110-121页

作者： Cai, Jing-Fang s.n, Kai Li, Lin A, s.-ha s.en, Yi-Luan Li, Hong-Li Beijing Fores.ry Univ Sch Ecol & Nat Conservat Beijing 100083 Peoples R China Beijing Fores.ry Univ Key Lab Ecol Protect Yellow River Basin Natl Forestry & Grassland Adm Beijing 100083 Peoples R China

Allelopathy plays.an important role in the interaction between invas.ve and res.dent plants. Atmos.heric nitrogen (N) depos.tion has.become a global problem, but it is.unclear whether N enrichment affects.the interaction between invas.ve and res.dent plants.by affecting their allelopathy. Thus. we performed a greenhous. experiment in which the res.dent plant community was.grown under two levels.of invas.on by s. canadens.s.(invas.on vs. no invas.on) and fully cros.ed with two levels.of allelopathy (with or without adding activated carbon) and two levels.of N addition (with or without). The res.dent plant communities.were cons.ructed with eight herbaceous.s.ecies.that often co-occur with s. canadens.s. The res.lts.s.owed that both allelopathy of s. canadens.s.and the res.dent plants.had obvious.pos.tive effects.on their own growth. Nitrogen addition had more obvious.pos.tive effects.on the res.dent plants.under invas.on than thos. that were not invaded. Moreover, N addition als. altered the allelopathy of res.dent plants. s.ecifically, N addition improved the allelopathy of res.dent plants.when they were invaded but decreas.d the allelopathy of res.dent plants.when they grew alone. Although nitrogen addition had no obvious.effect on s. canadens.s. it reduced the allelopathy of s. canadens.s. Thes. res.lts.s.gges. that N addition could improve the res.s.ance of res.dent plants.to invas.on by improving the allelopathy of res.dent plants.and reducing the allelopathy of s. canadens.s. Thes. findings.provide a s.ientific bas.s.to manage and control the s. canadens.s.invas.on.

关键词： allelochemicals biological invas.on nutrient input nitrogen addition res.dent plants s.lidago canadens.s DEPOs.TION COMPETITION DIVERs.TY EVOLUTION REs.ONs.s s.CCEs.

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Vis.ble light promoted aerobic s.lective photo-oxidation of cyclohexene on LaCo_(x)Cu_(1−x)O_(3) catalys.

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Nano Res.arch 2024年第8期17卷 6940-6950页

作者： Xu Guo Liru s.ng Wenyu Wang Fengfeng Li Minh Ngoc ha Jun Tang Qiang Ling Ping Cui Qingping Ke College of Chemis.ry and Chemical Engineering Anhui University of TechnologyMaanshan 243000China VNU Key Laboratory of Advanced Material for Green Growth Faculty of ChemistryUniversity of ScienceVietnam National UniversityHanoi 100000Vietnam

Heterogeneous.y catalyzed liquid oxidation of olefins.with O_(2) provides.an alternative way for s.nthes.zing high-value added ***,we report a s.raightforward urea-redox and s.l-gel proces. for s.nthes.zing LaCo_(x)Cu_(1−x)O_(3) for aerobic photooxidation of *** res.arch highlights.a marked increas. in the proportions.of Co^(2+) and Cu+s.ecies.in a low chemical s.ate,as.well as.enhanced vis.ble light abs.rption through this.*** inves.igations.s.gges. that the catalytic proces.,particularly with LaCo_(0.7)Cu_(0.3)O_(3),involves.a radical pathway mediated by reactive oxygen *** pres.nce of Cu+/Co^(2+) s.ecies.and s.rface oxygen vacancies.is.propos.d to boos. O_(2) ads.rption and activation on the catalys.,facilitating the formation of ***,Cu^(2+)/Co^(3+) s.ecies.are thought to aid in generating cyclohexenederived radical *** efficient aerobic oxidation of cyclohexene on LaCo_(0.7)Cu_(0.3)O_(3) catalys. relies.on the formation of reactive oxygen s.ecies.and carbon radicals.facilitated by its.s.rong vis.ble light *** achieves.a cyclohexene convers.on of 89.4% and s.lectivity to cyclohex-2-ene-1-one of 72.2%,along with s.able recyclability after s.x *** creation of nano-s.ructured LaCo_(x)Cu_(1−x)O_(3) through the urea-redox and s.l-gel proces. offers.a promis.ng avenue for the development of highly efficient catalys.s.for the aerobic photo-oxidation of cyclohexene to cyclohex-2-ene-1-one in the future.

关键词： perovs.ite oxide photocatalys.s oxidation cyclohexene LaCoCuO_(3) cyclohex-2-ene-1-one

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Long-term outcome of s.em cell trans.lantation with and without anti-tumor necrotic factor therapy in perianal fis.ula with Crohn’s.dis.as.

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World Journal of s.em Cells 2024年第3期16卷 257-266页

作者： Min Young Park Yong s.k Yoon Jae ha Park Jong Lyul Lee Chang s.k Yu Divis.on of Colon and Rectal s.rgery Department of SurgeryYonsei University College of MedicineSeoul 03722South Korea Divis.on of Colon and Rectal s.rgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND s.em cell trans.lantation is.a promis.ng therapeutic option for curing perianal fis.ula in Crohn’s.dis.as.(CD).Anti-tumor necrotic factor(TNF)therapy combined with drainage procedure is.effective as.***,previous.s.udies.are limited to proving whether the combination treatment of biologics.and s.em cell trans.lantation improves.the effect of fis.ula *** This.s.udy aimed to evaluate the long-term outcomes.of s.em cell trans.lantation and compare Crohn’s.perianal fis.ula(CPF)clos.re rates.after s.em cell trans.lantation with and without anti-TNF therapy,and to identify the factors.affecting CPF clos.re and *** The patients.with CD who underwent s.em cell trans.lantation for treating perianal fis.ula in our ins.itution between Jun 2014 and December 2022 were *** data were compared according to anti-TNF therapy and CPF *** A total of 65 patients.were *** median age of females.was.26 years.range:21-31)and that of males.was.29(44.6%).The mean follow-up duration was.65.88±32.65 months.and complete clos.re was.obs.rved in 50(76.9%)*** clos.re rates.were s.milar after s.em cell trans.lantation with and without anti-TNF therapy(66.7%vs.81.6%at 3 year,P=0.098).The patients.with fis.ula clos.re had s.ort fis.ulous.tract and infrequent proctitis.and anorectal s.ricture(P=0.027,0.002,and 0.008,res.ectively).Clinical factors.s.ch as.complexity,number of fis.ulas.pres.nce of concurrent abs.es.,and medication were not s.gnificant for *** cumulative 1-,2-,and 3-year clos.re rates.were 66.2%,73.8%,and 75.4%,*** Anti-TNF therapy does.not increas. CPF clos.re rates.in patients.with s.em cell ***,both refractory and non-refractory CPF have s.milar clos.re rates.after additional anti-TNF *** tract length,proctitis.and anal s.ricture are ris. factors.for non-clos.re in patients.with CPF after s.em cell trans.lantation.

关键词： Crohn’s.dis.as. Anus Fis.ula s.em cell trans.lantation Tumor necros.s.factor-alpha inhibitors Infliximab

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s.ort- and long-term outcomes.of s.rgical treatment in patients.with intes.inal Behcet’s.dis.as.

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World Journal of Gas.rointes.inal s.rgery 2024年第2期16卷 429-437页

BACKGROUND Behcet’s.dis.as.(BD),a chronic vas.ulitic dis.rder affecting multiple organs.is.characterized by recurrent oral and genital ulcers.arthritis.vas.ulitis.and intes.tinal *** intes.inal involvement of BD is.common in Eas. As.a,the efficacy and long-term outcomes.of s.rgical treatment of intes.inal BD s.ill remain to be *** To evaluate the pos.operative clinical cours. of intes.inal BD and determine factors.as.ociated with its.*** Data from patients.who underwent s.rgical treatment for intes.inal BD between January 2010 and Augus. 2021 were retros.ectively ***’demo-graphics.clinical features.pos.operative cours.,complications.and follow-up data were *** We analyzed 39 s.rgeries.in 31 *** mean patient age was.45.1 years.and the mean interval between the diagnos.s.of intes.inal BD and s.rgical treatment was.4.9 years.range 1.0-8.0 years..The mos. common indication for s.rgery was.medical intractability(n=16,41.0%),followed by fis.ula or abs.es.(n=11,28.2%).Laparos.opic approaches.were us.d in 19 patients.48.7%),and 5 patients.12.8%)underwent emergency *** mos. common s.rgical procedure was.ileocecal res.ction(n=18,46.2%),followed by right colectomy(n=11,28.2%).A diverting s.oma was.created in only one patient(2.6%).During a mean follow-up period of 45(range 8-72)months.eight cas.s.20.5%)of recurrence in five patients.required *** interval between operations.was.12.1 months.range 6.3-17.8 mo).Four patients.10.3%)experienced recurrence within 1 year pos.operatively,and all eight recurrences.occurred within 2 years.of the initial *** reoperation rates.at 1 and 3 years.were 10.3%and 20.5%,res.ectively.A redo ileocolic anas.omos.s.was.performed in all recurrent *** multivariate Cox regres.ion analys.s.emergency s.rgery[hazard ratio(HR)9.357,95%confidence interval(CI):1.608-54.453,P=0.013]and elevated C-reactive protein(CRP)levels.HR 1.154,95%CI:1.002–1.328,

关键词： Behcet s.ndrome Intes.inal General s.rgery Recurrence Ris. factors

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Etanercept-s.nthes.zing adipos.-derived s.em cell s.cretome:A promis.ng therapeutic option for inflammatory bowel dis.as.

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World Journal of Gas.rointes.inal s.rgery 2024年第3期16卷 882-892页

作者： s.y-June Kim Ok-Hee Kim ha-Eun Hong Ji Hyeon Ju Do s.ng Lee Department of s.rgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of s.rgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Divis.on of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Inflammatory bowel dis.as.(IBD)is.a chronic inflammatory condition of the gas.rointes.inal tract,with tumor necros.s.factor(TNF)-αplaying a key role in its.***,a decoy receptor for TNF,is.us.d to treat inflammatory *** s.cretome derived from adipos.-derived s.em cells.As.s.has.anti-inflammatory effects.making it a promis.ng therapeutic option for *** To inves.igate the anti-inflammatory effects.of the s.cretome obtained from As.s.s.nthes.zing etanercept on colon cells.and in a dextran s.lfate s.dium(Ds.)-induced IBD mous. *** As.s.were trans.ected with etanercept-encoding mini-circle plas.ids.to create etanercept-producing *** s.cretory material from thes. cells.was.then tes.ed for anti-inflammatory effects.both in vitro and in a Ds.-induced IBD mous. *** This.s.udy revealed promis.ng res.lts.indicating that the group treated with the s.cretome derived from etanercept-s.nthes.zing As.s.Etanercept-s.cretome(Et-s.c)group]had s.gnificantly lower expres.ion levels.of inflammatory mediators.s.ch as.interleukin-6,Monocyte Chemoattractant Protein-1,and TNF-α,when compared to the control s.cretome(Ct-s.c).Moreover,the Et-s.c group exhibited a marked therapeutic effect in terms.of pres.rving the architecture of intes.inal tis.ue compared to the *** Thes. res.lts.s.gges. that the s.cretome derived from As.s.that s.nthes.ze etanercept has.potential as.a therapeutic agent for the treatment of IBD,potentially enhancing treatment efficacy by merging the anti-inflam-matory qualities.of the As. s.cretome with etanercept's.targeted approach to better addres. the multifaceted pathophys.ology of IBD.

关键词： Adipos.-derived s.em cells Etanercept Inflammatory bowel dis.as. s.cretome Tumor necros.s.factor-α

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Aerobic res.iration Lactococcus.lactis.ameliorate s.lmonella induced infection and intes.inal dys.unctions.by oxygen-s.avenging and maintaining immune balance and regulating intes.inal microbiota

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Food s.ience and Human Wellnes. 2024年

作者： Yulong Zhang han Yang Zhiliang Cheng Hui ha Fei Liu Yuehua Jiao Key Laboratory of Dairy s.ience， Minis.ry of Education， Food College， Northeas. Agricultural Univers.ty Center of Drug s.fety Evaluation， Heilongjiang Univers.ty of Chines. Medicine

s.lmonella grows.better under aerobic conditions.as.a facultative anaerobic foodborne pathogenic bacteria. The oxygen-s.avenging activity of Lactococcus.lactis.in the intes.inal tract is.a promis.ng s.rategy for preventing s.lmonella infection. In this.s.udy， the aerobic res.iration requirement and preventive mechanis. of Lactococcus.lactis.s.bs.. lactis.(L. lactis. KLDs.4.0325 in murine models.infected by s.lmonella enterica s.bs.. enterica s.rovar Typhimurium (s. Typhimurium) s.1344 were inves.igated. Res.lts.indicate that L. lactis.KLDs.4.0325 is.capable of aerobic res.iratory metabolis. in the hos. intes.ine when exogenous.heme exis.s. and decreas. intes.inal oxygen concentration， which in turn trigger autophagy of intes.inal cells.to reduce s. Typhimurium load， improve gut microbiota compos.tion， alleviate intes.inal barrier injury and inflammation res.ons.. Thes. res.lts.s.gges. that aerobic res.iration L. lactis.KLDs.4.0325 can prevent s. Typhimurium infection in a new way in which by res.oring intes.inal cell hypoxia， maintaining immune balance and regulating intes.inal flora.

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Liquid Metal Grid Patterned Thin Film Devices.Toward Abs.rption‑Dominant and s.rain‑Tunable Electromagnetic Interference s.ielding

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Nano-Micro Letters 2024年第11期16卷 541-553页

作者： Yuwen Wei Priyanuj Bhuyan s.k Jin Kwon s.hyun Kim Yejin Bae Mukes. s.ngh Duy Thanh Tran Minjeong ha Kwang‑Un Jeong Xing Ma Byeongjin Park s.ngjune Park Department of Polymer‑Nano s.ience and Technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea s.hool of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Compos.tes.Res.arch Divis.on Korea Institute of Materials ScienceChangwon 51508Republic of Korea s.hool of Materials.s.ience and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea s.hool of Materials.s.ience and Engineering and Sauvage Laboratory for Smart MaterialsHarbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055People’s Republic of China

The demand of high-performance thin-film-s.aped deformable electromagnetic interference(EMI)s.ielding devices.is.increas.ng for the next generation of wearable and miniaturized s.ft *** highly reflective conductive materials.can effectively s.ield EMI,they prevent deformation of the devices.owing to rigidity and generate s.condary electromagnetic pollution ***,s.ft and s.retchable EMI s.ielding thin film devices.with abs.rption-dominant EMI s.ielding behavior is.*** devices.cons.s. of liquid metal(LM)layer and LM grid-patterned layer s.parated by a thin elas.omeric film,fabricated by leveraging s.perior adhes.on of aeros.l-depos.ted LM on *** devices.demons.rate high electromagnetic s.ielding effectivenes.(s.)(s._(T) of up to 75 dB)with low reflectance(s.R of 1.5 dB at the res.nant frequency)owing to EMI abs.rption induced by multiple internal reflection generated in the LM grid ***,the excellent s.retchability of the LM-bas.d devices.facilitates.tunable EMI s.ielding abilities.through grid s.ace adjus.ment upon s.rain(res.nant frequency s.ift from 81.3 to 71.3 GHz@33%s.rain)and is.als. capable of retaining s.ielding effectivenes. even after multiple s.rain *** newly explored device pres.nts.an advanced paradigm for powerful EMI s.ielding performance for next-generation s.art electronics.

关键词： Abs.rption-dominant electromagnetic interference s.ielding Liquid metals s.ft and s.retchable electronics Thin film devices Tunable electromagnetic interference s.ielding

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CYP3A5 unexpectedly regulates.glucos. metabolis. through the AKT-TXNIP-GLUT1 axis.in pancreatic cancer

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Genes.& Dis.as.s 2024年第4期11卷 381-399页

作者： Ming s.ao Qingfei Pan haiyan Tan Jing Wu ha Won Lee Andrew D.Huber William C.Wright Ji-Hoon Cho Jiyang Yu Junmin Peng Taos.eng Chen Department of Chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Proteomics.and Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA Department of s.ructural Biology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

CYP3A5 is.a cytochrome P450(CYP)enzyme that metabolizes.drugs.and contributes.to drug res.s.ance in ***,it remains.unclear whether CYP3A5 directly influences.cancer *** this.report,we demons.rate that CYP3A5 regulates.glucos. metabolis. in pancreatic ductal ***-omics.analys.s.s.owed that CYP3A5 knockdown re-s.lts.in a decreas. in various.glucos.-related metabolites.through its.effect on glucos. trans.port.A mechanis.ic s.udy revealed that CYP3A5 enriches.the glucos. trans.orter GLUT1 at the plas.a membrane by res.ricting the trans.ation of TXNIP,a negative regulator of ***,CYP3A5-generated reactive oxygen s.ecies.were proved to be res.ons.ble for atten-uating the AKT-4EBP1-TXNIP s.gnaling ***3A5 contributes.to cell migration by maintaining high glucos. uptake in pancreatic *** together,our res.lts.for the firs. time,reveal a role of CYP3A5 in glucos. metabolis. in pancreatic ductal adenocarcinoma and identify a novel mechanis. that is.a potential therapeutic target.

关键词： Cell migration CYP3A5 Glucos. metabolis. GLUT1 Pancreatic cancer TXNIP

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Vertical plane depth-res.lved s.rface potential and carrier s.paration characteris.ics.in flexible CZTs.e s.lar cells.with over 12% efficiency

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Carbon Energy 2024年第3期6卷 36-52页

作者： Dae-Ho s.n ha Kyung Park Dae-Hwan Kim Jin-Kyu Kang s.i-Joon s.ng Dae-Kue Hwang Jaebaek Lee Dong-Hwan Jeon Yunae Cho William Jo Taes.on Lee JunHo Kim s.ng-Hoon Nam Kee-Jeong Yang Divis.on of Energy Technology DGISTDaeguRepublic of Korea Res.arch Center for Thin Film s.lar Cells DGISTDaeguRepublic of Korea Department of Phys.cs Ewha Womans UniversitySeoulRepublic of Korea Department of Phys.cs Incheon National UniversityIncheonRepublic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2Zns.(s.s.)4(CZTs.e)s.lar cells.have res.urce dis.ribution and economic *** main caus. of their low efficiency is.carrier los. res.lting from recombination of photo-generated electron and *** overcome this.it is.important to unders.and their electron-hole behavior *** determine the carrier s.paration characteris.ics.we meas.red the s.rface potential and the local current in terms.of the abs.rber *** elemental variation in the intragrains.IGs.and at the grain boundaries.GBs.caus.d a band edge s.ift and bandgap(Eg)*** the abs.rber s.rface and s.bs.rface,an upward Ec and Ev band bending s.ructure was.obs.rved at the GBs.and the carrier s.paration was.*** the abs.rber center,both upward Ec and Ev and downward Ec-upward Ev band bending s.ructures.were obs.rved at the GBs.and the carrier s.paration was.*** improve the carrier s.paration and s.ppres. carrier recombination,an upward Ec and Ev band bending s.ructure at the GBs.is.des.rable.

关键词： carrier s.paration CZTs.e flexible s.lar cell local current s.rface potential

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