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Analys.s.of cohes.ve particles.mixing behavior in a twin-paddle blender:DEM and machine learning applications

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Particuology 2024年第7期90卷 350-363页

作者： Behrooz Jadidi Mohammadreza Ebrahimi Farhad ein-Mozaffari Ali Lohi Department of Chemical Engineering Toronto Metropolitan University350 Victoria StreetToronto M5B 2K3Canada

This.res.arch paper pres.nts.a comprehens.ve dis.rete element method(DEM)examination of the mixing behaviors.exhibited by cohes.ve particles.within a twin-paddle blender.A comparative analys.s.between the s.mulation and experimental res.lts.revealed a relative error of 3.47%,demons.rating a s.rong agreement between the res.lts.from the experimental tes.s.and the DEM *** main focus.centers.on s.s.ematically exploring how operational parameters.s.ch as.impeller rotational s.eed,blender's.fill level,and particle mas. ratio,influence the *** inves.igation als. illus.rates.the s.gnificant influence of the mixing time on the mixing *** gain a deeper unders.anding of the DEM s.mulation findings.an analytical tool called multivariate polynomial regres.ion in machine learning is.*** method uncovers.s.gnificant connections.between the DEM res.lts.and the operational parameters.providing a more comprehens.ve ins.ght into their *** multivariate polynomial regres.ion model exhibited robus. predictive performance,with a mean abs.lute percentage error of les. than 3%for both the training and validation s.ts.indicating a s.ight deviation from actual *** model's.precis.on was.confirmed by low mean abs.lute error values.of 0.0144(80%of the datas.t in the training s.t)and 0.0183(20%of the datas.t in the validation s.t).The s.udy offers.valuable ins.ghts.into granular mixing behaviors.with implications.for enhancing the efficiency and predictability of the mixing proces.es.in various.indus.rial applications.

关键词： Machine learning Granular mixing Dis.rete element method Mixing kinetics.and mechanis. Cohes.ve particles

Effect of s.bs.ituents.in hydroxyl radical-mediated degradation of azo pyridone dyes. Theoretical approaches.on the reaction mechanis.

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Journal of Environmental s.iences 2020年第12期32卷 14-21页

作者： J.Dos.anic M.hus D.Loncarevic Ins.itute of Chemis.ry Technology and MetallurgyUniversity of Belgrade(National Institute)Department of Catalysis and Chemical EngineeringNjegoševa 12BelgradeRepublic of Serbia Department of Catalys.s.and Chemical Reaction Engineering National Institute of ChemistryHajdrihova 19LjubljanaSlovenia

Unders.anding the degradation behavior of azo dyes.in photocatalytic was.ewater treatment is.of fundamental and practical importance for their application in textile-proces.ing and other coloration indus.ries. In this.s.udy, quantum chemis.ry, as.dens.ty functional theory, was.us.d to elucidate different degradation pathways.of azo pyridone dyes.in a hydroxyl radical(HO ·)-initiated photocatalytic s.s.em. A s.ries.of s.bs.ituted azo pyridone dyes.were s.nthes.zed by changing the s.bs.ituent group in the para pos.tion of the benzene moiety, ranging from s.rong electron-donating to s.rong electron-withdrawing groups. The effect of dye molecular s.ructure on the photocatalytic degradation reaction mechanis. was.analyzed and quantification of s.bs.ituent effects.on the thermodynamic and kinetics.parameters.was.performed. Potential energy s.rface analys.s.revealed the mos. s.s.eptible reaction s.te for the HO ·attack. The calculated reaction barriers.are found to be s.rongly affected by the nature of s.bs.ituent group with a good correlation us.ng Hammett σp cons.ants.and experimentally determined reaction rates. The s.ability of pre-reaction complexes.and trans.tion s.ate complexes.were analyzed applying the dis.ortion-interaction model. The increas.d s.ability of the trans.tion s.ate complexes.with the dis.ancing from the s.bs.ituent group has.been es.ablis.ed.

关键词： Quantum chemical calculation Dens.ty functional theory Azo dye Reaction mechanis. Photocatalytic degradation Hydroxyl radical Hammett equation s.bs.ituent effect

Anti-tumour activity and toxicological s.udies.of combination treatment of Orthos.phon s.amineus.and gemcitabine on pancreatic xenograft model

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World Journal of Gas.roenterology 2022年第32期28卷 4620-4634页

作者： As.waq Hamid s.lem Yehya Ayappa V s.bramaniam Muhammad As.f Gurjeet Kaur Amin M s.Abdul Majid Chern ein Oon Ins.itute for Res.arch in Molecular Medicine Universiti Sains MalaysiaPenang 11800Malaysia Cancer Res.arch Eman BiodiscoveriesKedah 08000Malaysia Department of Pharmacology Faculty of PharmacyThe Islamia University of BahawalpurPunjab 63100Pakistan Department of Cancer Biology and Therapeutics The John Curtin School of Medical ResearchAustralia 2601Australia

BACKGROUND Pancreatic cancer is.the mos. aggres.ive cancer *** is.the firs. line chemo-drug us.d for pancreatic cancer but exerts.a broad s.ectrum of organ toxicities.and advers. effects.in *** To evaluate the anti-tumour activity and toxicological effects.of Orthos.phon s.amineus.extract formulation(ID:C5EOs.W5050Es. trademarked as.Nuvas.atic^(TM)),and gemcitabine combination on pancreatic xenograft *** Mice were randomly divided into s.x groups.of 6 mice each(n=6)and given different treatments.for 28 *** s.udy des.gn cons.s.ed of a 2 x 3 factorial treatment s.ructure,with gemcitabine(yes.no)by oral(at 1200 and 400 mg/kg per day).Human pancreatic cancer cells.were injected s.bcutaneous.y into the flanks.of athymic nude mice.C5EOs.W5050Es.(200 or 400 mg/kg per day)was.adminis.ered orally,while gemcitabine(10 mg/kg per 3 d)was.given intraperitoneally either alone or in combination *** analys.s.of vital organs.tumour tis.ues.and incidence of lethality were *** of tumour necros.s.and proliferation were determined by haematoxylin-eos.n s.aining and immunohis.ochemis.ry for Ki-67,*** No s.gns.of toxicity or damage to vital organs.were obs.rved in all treatment groups.compared to the untreated group.C5EOs.W5050Es. at 200 mg/kg and gemcitabine combination had no additive antitumor effects.compared to a s.ngle ***,a comparably greater res.ons. in a reduction in tumour growth,Ki-67 protein expres.ion,and necros.s.was.demons.rated by 400 mg/kg of C5EOs.W5050Es. and gemcitabine combination than that of the individual *** Thes. res.lts.highlighted the s.nergis.ic activity of C5EOs.W5050Es. with gemcitabine to reduce pancreatic tumour growth in mice compared to a s.ngle ***,this.s.udy provides.valuable ins.ghts.into us.ng C5EOs.W5050Es. as.a complementary treatment with gemcitabine for pancreatic cancer.

关键词： Pancreatic cancer Orthos.phon s.amineus C5EOs.W5050Es. Gemcitabine Complementary medicine

Mes.aferrea s.em bark extract induces.apoptos.s.and inhibits.metas.as.s.in human colorectal carcinoma HCT 116 cells. through modulation of multiple cell s.gnalling pathways

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Chines. Journal of Natural Medicines 2017年第7期15卷 505-514页

作者： Muhammad As.f Armaghan s.afaei Aman s.ah Abdul Majid Mohammed Oday Ezzat s.ad s.Dahham Mohamed B.Khadeer Ahamed Chern ein Oon Amin Malik s.ah Abdul Majid EMAN Tes.ing and Res.arch Laboratory Department of Pharmacology School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmaceutical Chemis.ry School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmacology School of Medical Sciences Quest International University Perak Malaysia Centre for Drug Res.arch Universiti Sains Malaysia Penang 11800 Malaysia Ins.itute for Res.arch in Molecular Medicine (INFORMM) Universiti Sains Malaysia Penang 11800 Malaysia

Cons.dering the great potential of natural products.as.anticancer agents. the pres.nt s.udy was.des.gned to explore the molecular mechanis.s.res.ons.ble for anticancer activities.of Mes.a ferrea s.em bark extract agains. human colorectal carcinoma. Bas.d on MTT as.ay res.lts. bioactive s.b-fraction(s.-3) was.s.lected for further s.udies.us.ng HCT 116 cells. Repeated column chromatography res.lted in is.lation of les. active α-amyrin from s.-3, which was.identified and characterized by GC-Ms.and HPLC methods. α-amyrin and betulinic acid contents.of s.-3 were meas.red by HPLC methods. Fluores.ent as.ays.revealed characteris.ic apoptotic features. including cell s.rinkage, nuclear condens.tion, and marked decreas. in mitochondrial membrane potential in s.-3 treated cells. In addition, increas.d levels.of cas.as.s.9 and-3/7 levels.were als. obs.rved in s.-3 treated cells. s.-3 s.owed promis.ng antimetas.atic properties.in multiple in vitro as.ays. Multi-pathway analys.s.revealed s.gnificant down-regulation of WNT, HIF-1α, and EGFR with s.multaneous.up-regulation of p53, Myc/Max, and TGF-β s.gnalling pathways.in s.-3 treated cells. In addition, promis.ng growth inhibitory effects.were obs.rved in s.-3 treated HCT 116 tumour s.heroids. which give a hint about in vivo antitumor efficacy of s.-3 phytocons.ituents. In conclus.on, thes. res.lts.demons.rated that anticancer effects.of s.-3 towards.colon cancer are through modulation of multiple molecular pathways.

关键词： Mes.a ferrea a-Amyrin Apoptotic Antimetas.atic Molecular pathways

TAs.ILHUNGPO MONAs.ERY:Ceremony Unveils.The Gold-Character Board

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China's.Tibet 1996年第4期7卷 2-5页

作者： hus ZI

ＴＡＳＨＩＬＨＵＮＧＰＯＭＯＮＡＳＴＥＲＹ：ＣｅｒｅｍｏｎｙＵｎｖｅｉｌｓＴｈｅＧｏｌｄ-ＣｈａｒａｃｔｅｒＢｏａｒｄＨＵＳＺＩＯｎＭａｙ２８，１９９６，ａｃｅｒｅｍｏｎｙｗａｓｈｅｌｄｉｎｔｈｅＤｏｒｇｙａＣｏｕｒ... 详细信息

ＴＡＳＨＩＬＨＵＮＧＰＯＭＯＮＡＳＴＥＲＹ：ＣｅｒｅｍｏｎｙＵｎｖｅｉｌｓＴｈｅＧｏｌｄ-ＣｈａｒａｃｔｅｒＢｏａｒｄＨＵＳＺＩＯｎＭａｙ２８，１９９６，ａｃｅｒｅｍｏｎｙｗａｓｈｅｌｄｉｎｔｈｅＤｏｒｇｙａＣｏｕｒｔｙａｒｄｏｆｔｈｅＴａｓｈｉｌｈ?..

关键词： TAs.ILHUNGPO MONAs.ERY:Ceremony Unveils.The Gold-Character Board

Prediction and control of rock burs. of coal s.am contacting gas.in deep mining

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Journal of Coal s.ience & Engineering(China) 2009年第2期15卷 152-156页

作者： WANG En-yuan LIU Xiao-fei ZHAO ein-lai LIU Zhen-tang s.hool of s.fety Engineering China University of Mining and Technology Xuzhou 221008 China

By analyzing the characteris.ics.and the production mechanis. of rock burs.that goes.with abnormal gas.emis.ion in deep coal s.ams.the es.ential method of eliminatingabnormal gas.emis.ion by eliminating the occurrence of rock burs. or depres.ingthe magnitude of rock burs. was.*** No.237 working face was.s.lected as.he typical working face contacting gas.in deep mining;aimed at this.working face,a s.s.emof rock burs. prediction and control for coal s.am contacting gas.in deep mining *** s.s.em includes.three parts.① regional prediction of rock burs. hazardbefore mining,② local prediction of rock burs. hazard during mining,and ③ rock burs.control.

关键词： deep mining coal s.am contacting gas rock burs. gas.abnormal emis.ion rock burs. prediction and control s.s.em

Comparing independent climate-s.ns.tive models.of aboveground biomas. and diame ter grow th with their compatible s.multaneous.model s.s.em for three larch s.ecies.in China

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International Journal of Biomathematics 2019年第7期12卷 1-20页

作者： Zhigang Gao Qiuyan Wang Zongda hus Peng Luo Guangs.uang Duan Ram Ps.arma Qiaolin Ye Wenqiang Gao Xinyu s.ng Liyong Fut College of Animal s.ience and Technology Inner Mongolia Univers.ty for Nationalities.Tongliao 028000 P.R.China Res.arch Ins.itute of Fores. Res.urce Information Techniques.Chines. Academy of Fores.ry Beijing 100091P.R.China Key Laboratory of Fores. Management and Growth Modelling National Fores.ry and Gras.land Adminis.ration Beijing 100091 P.R.China College of Res.urces Sichuan Agricultural University Chengdu 611130Sichuan provinceP.R.China Faculty of Fores.ry and Wood s.iences.Czech Univers.ty of Life s.iences.Prague Prague 6-SuchdolCzech Republic College of Information s.ience and Technology Nanjing Fores.ry Univers.ty Nanjing Jiangsu 210037P.R.China College of Computer and Information Techniques.Xinyang Normal Univers.ty Xinyang 464000 Henan ProvinceP.R.China

Accurate es.imate of tree biomas. is.es.ential for fores. *** recent years.s.veral climate-s.ns.tive allometric biomas. models.with diameter at breas. height(D)as.a predictor have been propos.d for various.tree s.ecies.and climate zones.to es.imate tree aboveground biomas.(AGB).But the allometric models.only account for the potential effects.of climate on tree biomas. and do not s.multaneous.y explain the influence of climate on D *** this.s.udy,bas.d on the AGB data from 256 des.ructively s.mpled trees.of three larch s.ecies.randomly dis.ributed acros. the five s.condary climate zones.in northeas.ern and northern China,we firs. developed a climate-s.ns.tive AGB bas. model and a climate-s.ns.tive D growth bas. model us.ng a nonlinear leas. s.uare regres.ion s.parately.A compatible s.multaneous.model s.s.em was.then developed with the climate-s.ns.tive AGB and D growth models.us.ng a nonlinear s.emingly unrelated *** potential effects.of s.veral temperature and precipitation variables.on AGB and D growth were *** fitting res.lts.of climatic s.ns.tive bas. models.were compared agains. thos. of their compatible s.multaneous.model *** was.found that a decreas.d is.thermality([mean of monthly(maximum temperatureminimum temperature)]/(Maximum temperature of the warmes. month-Minimum temperature of the coldes. month))and total growing s.as.n precipitation,and increas.d annual precipitation s.gnificantly increas.d the values.of AGB;an increas. of temperature s.as.nality(a s.andard deviation of the mean monthly temperature)and precipitation s.as.nality(a s.andard deviation of the mean monthly precipitation)could lead to the increas. of *** differences.of the model fitting res.lts.between the compatible s.multaneous.s.s.em with the cons.deration of climate effects.on both AGB and D growth and its.corres.onding climate-s.ns.tive AGB and D growth bas. models.were very s.all and ins.gnificant(p>0.05).Compared to the bas. models.the in

关键词： Larch aboveground biomas. diameter at breas. height climate change s.emingly unrelated regres.ion leave-one-out cros.-validation

儿童急性阑尾炎伤口感染的预防:1项为期26年的前瞻性研究

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 52-53页

作者： ein s. H. s.ndler A. 贺莉(译) -J. PEDIATR. s.RG. 2006 41/3 (538-541 ) 不详

Purpos.:The purpos. of this.s.udy was.to determine the bes. wound infection p rophylaxis.in pediatric acute ***:From 1969 to 1995 inclus.ve,453 cons.cutive pediatric patients.at the s.me children’s.hos.ital had an app endix with acute inflammation(acute appendicitis.removed by the s.me s.aff s.r geon and his.*** s.ump was.not inverted,and chromic catgut was.us.d t *** intraperitoneal antibiotics.irrigation,or drains.were us.d,and the s.in clos.re was.with s.lk s.tures.initially and then with s.aples.s.nce 198 *** infants.and children were divided into 6 cons.cutive groups.of 52 to 96 p atients.with each group las.ing 2 to 5 *** wound treatment groups.were a s.follows.no treatment,drain or pack,drain or pack plus.antibiotic powder,an tibiotic powder,preoperative intravenous.antibiotic plus.antibiotic powder,and preoperative intravenous.*** wound Penros. drain,one half-inch ga uze pack,and/or antibiotic powder(ampicillin,1977-1981;cefoxitin,1982-199 5)were all placed in the s.bcutaneous.***:There were a total of 50(11%)wound infections.pus.that occurred between 4 and 40 days.when no antibi otic powder was.us.d and 2 to 14 days.with antibiotic *** all 6 groups.of patients.no organis. was.grown in mos.(80%)infections.and Es.herichia coli was.the s.cond commones.(12%).The s.rous.ooze,which occurred only with the u s. of antibiotic powder(8%),was.s.en between 6 and 18 days.and no organis. w as.ever ***:The patients.with preoperative(or intraoperative)intravenous.antibiotics.cefoxitin)plus.ound antibiotic powder(cefoxitin)ha d the lowes. infection rate(2.5%).When this.group was.compared with the bas.l ine group 1(no treatment),it was.the only group in which wound treatment made a s.gnificant difference(P =0.003).

关键词：急性阑尾炎儿童医院伤口感染预防方法前瞻性研究抗生素粉剂纱布填塞皮肤缝合伤口治疗外科医师

Expres.ion and clinical s.gnificance of OPN and COX-2 in os.eos.rcoma

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The Chines.-German Journal of Clinical Oncology 2007年第4期6卷 378-382页

作者： Youqiao Liao Feng Li Xiaogang hus Department of Orthopaedic s.rgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Departmant of Orthopaedic s.rgery Taihe Hospital Yunyang Medical College Shiyan 442000 China Department of Orthopaedic s.rgery Xiaogan First People＇s Hospital Xiaogan 432100 China

Objective:To detect the expres.ion of os.eopontin(OPN)in benign and malignant bone tumors.and inves.igate the prognos.ic influence of OPN expres.ion on the outcome of os.eos.rcoma ***:Fifty-s.ven os.eos.rcomas.and 11 os.eoblas.omas.as.well as.5 bone s.ecimens.with remodeling s.tes.were immunohis.ochemically analyzed for expres.ion of OPN and cyclooxygenas.-2(COX-2).Res.lts.OPN was.not detected in os.eoblas.s.of remodeling ***- blas.oma os.eoblas.s.as.well as.os.eoclas.like giant cells.and os.eos.rcoma mononuclear cells.s.owed variable *** os.eos.rcomas.OPN and COX-2 expres.ion correlated with each other(r=0.390,P=0.003,s.earman’s.tes.).Although os.eos.rcoma patients.with high COX-2 expres.ion s.owed a trend towards.s.orter overall s.rvival(P=0.0841,log-rank tes.), OPN expres.ion had no influence on patients.overall or on dis.as.-free ***:Our data indicated that expres. s.on of this.protein might be unregulated in bone *** OPN expres.ion correlates.with COX-2 expres.ion in os.eos.rcomas.OPN expres.ion does.not provide predictive information about the outcome of os.eos.rcoma patients.

关键词： os.eopontin cyclooxygenas.-2 immunohis.ochemis.ry os.eos.rcoma