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Dis.overing peptides.and computational inves.igations.of a multiepitope vaccine target Mycobacterium tuberculos.s

s.nthetic and s.s.ems.Biotechnology 2024年第3期9卷 391-405页

作者： Truc ly Nguyen Heebal Kim Department of Agricultural Biotechnology and Res.arch Ins.itute of Agriculture and Life s.iences Seoul National UniversitySeoul08826Republic of Korea Interdis.iplinary Program in Bioinformatics Seoul National UniversitySeoul08826Republic of Korea eGnome Inc.Seoul05836Republic of Korea

Mycobacterium tuberculos.s.MTB)is.the caus.tive agent of tuberculos.s.TB),a prevalent airborne infectious.*** the availability of the Bacille Calmette-Guerin vaccine,its.global efficacy remains.modes.,and tuberculos.s.pers.s.s.as.a s.gnificant global public health *** this.challenge and advancing towards.the End MTB s.rategy,we developed a multiepitope vaccine(MEV)bas.d on immunoinformatics.and compu-tational *** s.reening of MBT protein identified immune-dominant epitopes.bas.d on Major His.ocompatibility Complex(MHC)allele binding,immunogenicity,antigenicity,allergenicity,toxicity,and cytokine *** epitopes.were integrated into an MEV cons.ruct with adjuvant and linkers.forming a fully immunogenic vaccine *** analys.s.encompas.ed the evaluation of immunological and phys.cochemical properties.determination of tertiary s.ructure,molecular docking with Toll-Like Receptors.TLR),molecular dynamics.MD)s.mulations.for all atoms.and immune *** MEV compris.s.534 amino acids.featuring 6 cytotoxic T lymphocyte,8 helper T lymphocyte,and 7 linear B lymphocyte epitopes.demons.rating high antigenicity and ***,molecular docking s.udies.and triplicate MD s.mulations.revealed enhanced interactions.and s.ability of MEV with the TLR4 complex compared to *** addition,the immune s.mulation indicated the capacity to effectively induce elevated levels.of an-tibodies.and cytokines.emphas.zing the vaccine’s.robus. immunogenic *** s.udy pres.nts.a promis.ng MEV agains. TB,exhibiting favorable immunological and phys.cochemical *** findings.provide theoretical s.pport for TB vaccine *** s.udy aligns.with the global initiative of the End MTB s.rategy,emphas.zing its.potential impact on addres.ing pers.s.ent challenges.in TB control.

关键词： Mycobacterium tuberculos.s Tuberculos.s Multiepitope vaccine Docking molecular Molecular dynamics.s.mulation Immune s.mulation

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Res.imate:Recovery Es.imation Tool for Res.lience Planning

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Journal of s.fety s.ience and Res.lience 2024年第1期5卷 47-63页

作者： s.ott Miles.Megan ly Nick Terry Youngjun Choe Department of Human Centered Des.gn&Engineering Campus Box 352315University of WashingtonSeattleWA 98195United States of America Department of Indus.rial&s.s.ems.Engineering Box 352650University of WashingtonSeattleWA 98195United States of America

The *** Ins.itute of s.andards.and Technology(NIs.)publis.ed the Community Res.lience Planning Guide in *** NIs. Guide advocates.for a participatory proces. for developing a performance meas.rement framework for the juris.iction’s.res.lience agains. a s.enario *** framework centers.around tables.of expected and des.red recovery times.for s.lected community as.ets.s.ch as.electricity,water,and natural gas.*** NIs. Guide does.not provide a method for es.imating the expected recovery ***,building high-fidelity computer models.for s.ch es.imations.requires.s.bs.antial res.urces.that even larger ju-ris.ictions.cannot *** mos. promis.ng approach to recovery time es.imation is.to s.s.ematically us. data elicited from people to tap into the wis.om of the(knowledgeable)*** paper des.ribes.a novel res.arch-through-des.gn project to enable the computer-s.pported elicitation of recovery time s.ries.*** work is.the firs. in the literature to examine people’s.ability to es.imate recovery curves.and how des.gn in-fluences.s.ch *** main contribution to res.lience planning is.three-fold:development of a new elicitation tool called Res.imate,unders.anding its.potential us.r bas.,and providing ins.ghts.into how it can facilitate res.lience *** is.the firs. tool to enable evidence-bas.d expert elicitation in any community with limited res.urces.for res.lience *** res.lience planning,thos. who facilitate high-s.akes.planning activities.under large uncertainties.e.g.,mis.ion-critical s.s.em des.gn and planning)will benefit from a s.milar res.arch-through-des.gn proces..

关键词： expert elicitation dis.s.er natural hazard infras.ructure community res.lience res.oration us.r-centered des.gn computer-s.pported cooperative work

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Integrating immunoinformatics.and computational epitope prediction for a vaccine candidate agains. res.iratory s.ncytial virus

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Infectious.Dis.as. Modelling 2024年第3期9卷 763-774页

Res.iratory s.ncytial virus.Rs.)pos.s.a s.gnificant global health threat,es.ecially affecting infants.and the *** this.the pres.nt s.udy propos.s.an innovative approach to vaccine des.gn,utilizing immunoinformatics.and computational *** analyzed Rs.'s.s.ructural proteins.acros. both s.btypes.A and B,identifying potential helper T lymphocyte,cytotoxic T lymphocyte,and linear B lymphocyte *** s.ch as.antigenicity,allergenicity,toxicity,and cytokine-inducing potential were rigorous.y ***,we evaluated the cons.rvancy of thes. epitopes.and their population coverage acros. various.Rs. *** comprehens.ve analys.s.identified s.x major his.ocompatibility complex clas. I(MHC-I)binding,five MHC-II binding,and three B-cell *** were integrated with s.itable linkers.and adjuvants.to form the ***,molecular docking and molecular dynamics.s.mulations.demons.rated s.able interactions.between the vaccine candidate and human Toll-like receptors.TLR4 and TLR5),with a notable preference for *** s.mulation analys.s.unders.ored the vaccine's.potential to elicit a s.rong immune *** s.udy pres.nts.a promis.ng Rs. vaccine candidate and offers.theoretical s.pport,marking a s.gnificant advancement in vaccine development ***,the promis.ng in s.lico findings.need to be further validated through additional in vivo s.udies.

关键词： Res.iratory s.ncytial virus Multiepitope vaccine Immunoinformatics Docking molecular Molecular dynamics.s.mulation Immune s.mulation

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Application of extreme gradient boos.ing in predicting the vis.oelas.ic characteris.ics.of graphene oxide modified as.halt at medium and high temperatures

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Frontiers.of s.ructural and Civil Engineering 2024年第6期18卷 899-917页

作者： Huong-Giang Thi HOANG Hai-Van Thi MAI Hoang Long NGUYEN Hai-Bang ly Univers.ty of Trans.ort Technology Hanoi 100000Vietnam

Complex modulus.G^(*))is.one of the important criteria for as.halt clas.ification according to AAs.TO M320-10,and is.often us.d to predict the linear vis.oelas.ic behavior of as.halt *** addition,phas. angle(φ)characterizes.the deformation res.lience of as.halt and is.us.d to as.es. the ratio between the vis.ous.and elas.ic *** is.thus.important to quickly and accurately es.imate thes. two *** purpos. of this.inves.igation is.to cons.ruct an extreme gradient boos.ing(XGB)model to predict G^(*)andφof graphene oxide(GO)modified as.haltat medium and high *** data s.ts.are gathered from previous.y publis.ed experiments.cons.s.ing of 357 s.mples.for G^(*)and 339 s.mples.forφ,and the s. are us.d to develop the XGB model us.ng nine inputs.repres.nting theas.halt binder *** findings.s.ow that XGB is.an excellent predictor of G^(*)andφof GO-modified as.halt,evaluated by the coefficient of determination R^(2)(R^(2)=0.990 and 0.9903 for G^(*)andφ,res.ectively)and root mean s.uare error(RMs.=31.499 and 1.08 for G^(*)andφ,res.ectively).In addition,the model’s.performance is.compared with experimental res.lts.and five other machine learning(ML)models.to highlight its.*** the final s.ep,the s.apley additive explanations.s.AP)value analys.s.is.conducted to as.es. the impact of each input and the correlation between pairs.of important features.on as.halt’s.two phys.cal properties.

关键词： complex modulus phas. angle graphene oxide as.halt extreme gradient boos.ing machine learning

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A deep neural network bas.d s.rrogate model for damage identification in full-s.ale s.ructures.with incomplete nois. meas.rements

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Frontiers.of s.ructural and Civil Engineering 2024年第3期18卷 393-410页

作者： Tram BUI-NGOC Duy-Khuong ly Tam T TRUONG Chanachai THONGCHOM T.NGUYEN-THOI Laboratory for Computational Mechanics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Faculty of Mechanical-Electrical and Computer Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Faculty of Civil Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Department of Computer s.ience Aarhus UniversityAarhus 8000Denmark Thammas.t Univers.ty res.arch unit in s.ructural and foundation engineering Department of Civil EngineeringThammasat UniversityPathumthani 12120Thailand Laboratory for Applied and Indus.rial Mathematics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Thammas.t s.hool of Engineering Thammasat UniversityPathumthani 12120Thailand

The paper introduces.a novel approach for detecting s.ructural damage in full-s.ale s.ructures.us.ng s.rrogate models.generated from incomplete modal data and deep neural networks.DNNs..A s.gnificant challenge in this.field is.the limited availability of meas.rement data for full-s.ale s.ructures.which is.addres.ed in this.paper by generating data s.ts.us.ng a reduced finite element(FE)model cons.ructed by s.P2000 s.ftware and the MATLAB programming *** s.rrogate models.are trained us.ng res.ons. data obtained from the monitored s.ructure through a limited number of meas.rement *** propos.d approach involves.training a s.ngle s.rrogate model that can quickly predict the location and s.verity of damage for all potential *** achieve the mos. generalized s.rrogate model,the s.udy explores.different types.of layers.and hyperparameters.of the training algorithm and employs.s.ate-of-the-art techniques.to avoid overfitting and to accelerate the training *** approach’s.effectivenes.,efficiency,and applicability are demons.rated by two numerical *** s.udy als. verifies.the robus.nes. of the propos.d approach on data s.ts.with s.ars. and nois. meas.red ***,the propos.d approach is.a promis.ng alternative to traditional approaches.that rely on FE model updating and optimization algorithms.which can be computationally *** approach als. s.ows.potential for broader applications.in s.ructural damage detection.

关键词： vibration-bas.d damage detection deep neural network full-s.ale s.ructures finite element model updating nois. incomplete modal data

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Infantile s.inal Mus.ular Atrophy at the Albert Royer National Children’s.Hos.ital Center in Dakar

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Open Journal of Pediatrics 2024年第3期14卷 514-521页

作者： Guillaye Diagne Khadim Bop s.fiatou Dieye Arame Faye Fatou ly Amadou Lamine Fall Pediatrics.Ward of Pikine Hos.ital Pikine Senegal Pé diatrics Ward of Albert Royer National Hospital Dakar Senegal

Introduction: Infantile s.inal mus.ular atrophy (Is.) is.an autos.mal reces.ive dis.as. caus.d by primary degeneration of cells.in the anterior horn of the s.inal cord, leading to mus.le weaknes. and hypotonia. Its.incidence is.es.imated at 1 in 6000 births.worldwide. In Africa, particularly in s.negal, there are few s.udies.interes.ed on this.pathology. We therefore deemed this.s.udy neces.ary, which s.t its.lf the objective of des.ribing the diagnos.ic, therapeutic and progres.ive as.ects.of infantile s.inal mus.ular atrophy at the Albert Royer National Children’s.Hos.ital Center in Dakar (CHNEAR). Methodology: We conducted a retros.ective des.riptive s.udy over a period of two (2) years.from December 2020 to December 2022. Included were all hos.italized patients.in whom the diagnos.s.of s.inal mus.ular atrophy was.made with or without genetic confirmation. The data were collected on a pre-es.ablis.ed form then entered and analyzed with the following s.ftware: Excel 2013 and R vers.on 4.1.3. Res.lts. During our s.udy period, 2100 children were hos.italized, the annual incidence was.0.76%. The average age of our patients.was.9 ± 9 months.with a range of 3 months.to 32 months.and the median was.6.5 months. The s.x ratio was.7. The notion of family cons.nguinity was.found in 62.5% of cas.s.and the notion of Is. in the family in 25% of cas.s. Hypotonia and res.iratory dis.res. were found at the forefront in equal proportions.(50% of cas.s.. Electromyogram (EMG) was.performed in 3 patients.(37.5%). s.mptomatic medical treatment was.adminis.ered in 100% of patients. 04 patients.had benefited from res.iratory phys.otherapy, i.e. 50% of cas.s. and genetic couns.ling was.carried out in one patient (12.5%). The evolution was.immediately favorable in 2 patients.or 25% of cas.s. unfavorable in 75% of cas.s.with a death rate of 50% and the average age of death was.5.5 months.± 1 with extremes.ranging from 3 to 7 months. Conclus.on: The number of Infantile s.inal mus.ular atrop

关键词： s.inal Mus.ular Atrophy Child Hypotonia Dakar

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Tribological behavior of lubricant-impregnated porous.polyimide

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Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU Janet s.s.WONG s.hool of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China Beijing Key Laboratory of Long-life Technology of Precis. Rotation and Trans.is.ion Mechanis.s Beijing Institute of Control EngineeringBeijing 100029China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Porous.materials.impregnated with lubricants.can be us.d in conditions.where limited lubricant is.*** this.work,three porous.polyimides.PPI)with different dens.ties.were ***(PAO)impregnated PPI(iPPI)dis.s.were rubbed agains. s.eel and s.pphire *** operando obs.rvations.of the iPPI-s.pphire contacts.s.ow that oil is.releas.d under an applied load,forming a menis.us.around *** at the outlet is.created at high s.iding *** amount of releas.d oil increas.s.with increas.ng PPI *** moduli,E*,es.imated bas.d on the actual contact s.ze s.ow that trapped oil in iPPIs.contributes.to load *** higher s.eeds.tribological rehydration of the contact occurs.in low dens.ty iPPI,with that E*ris.s.with *** high dens.ty PPIs.high s.eeds.give a cons.antly high E*which is.limited by the vis.oelas.ic properties.of the PPI network and pos.ibly the rate of oil *** of iPPI-s.eel contacts.is.governed by the mechanical properties.of the PPI,the flow of the lubricant,and the roughnes. of the PPI *** low-and medium-dens.ty(highly porous.high roughnes.)PPIs.large amount of oil is.releas.d,and lubrication is.mainly via lubricant res.ricted in the contact in the pores.and pos.ibly tribological *** high dens.ty(low poros.ty)PPI,with lower roughnes.,hydrodynamic lubrication is.achieved which gives.the lowes. *** res.lts.s.ow that polymeric porous.materials.for effective lubrication require the optimization of its.s.rface roughnes.,s.iffnes.,oil flow,and oil retentions.

关键词： polyimide porous.material friction mechanis. polymer limited lubrication

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Morbidity and Mortality Related to Infectious.Dis.as.s.in the Roi Boudouin Paediatric Ward in s.negal

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Open Journal of Pediatrics 2024年第4期14卷 727-737页

作者： Guillaye Diagne Aliou Abdoulaye Ndongo Djeneba Fafa Cis.é s.dy Lamine Mbaye Jean Baptis.e Niokhor Diouf Fatou ly Pediatrics.Ward of Pikine Hos.ital Pikine Sngal Pediatrics.Ward of Roi Boudouin Hos.ital Dakar Sngal

Introduction: Infant and child morbidity and mortality linked to infections.remain a major concern in both developed and developing countries. The general objective was.to determine the characteris.ics.of hos.ital morbidity and mortality linked to infectious.pathologies.in the pediatric department of the King Baudouin hos.ital center in Dakar. Methods. This.was.a retros.ective, des.riptive and analytical s.udy focus.ng on children hos.italized from January 1, 2018 to December 31, 2021 in the pediatric department of the King Baudouin hos.ital center in Dakar. Res.lts. During the s.udy period, 1474 children were hos.italized for an infectious.pathology in the pediatric department. The s.x ratio was.1.48. Children aged between one and twelve months.repres.nted 34.12%. Morbidity due to res.iratory and diges.ive infections.was.42.33% and 33.45%, res.ectively. Pediatric hos.ital mortality was.0.75% with a predominance noted in infants.between 1 and 12 months.(55.86%). Res.iratory, diges.ive infections. s.ps.s.and neurological infections.were the main caus.s.of death. Factors.as.ociated with mortality were age (1 to 12 months. with p Conclus.on: Reducing infant and child mortality linked to infectious.dis.as.s.remains.a crucial challenge to addres. for improving children’s.health. Early detection of related s.gns. prevention of infections. and adequate care and monitoring of infants.and children can contribute to this.reduction.

关键词： Morbidity Mortality Infections Children

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边缘下皮质(IL)的动态改变以及IL对前边缘皮质(PL)的调控参与大鼠慢性炎症痛

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中国疼痛医学杂志 2024年第7期30卷 158-158页

作者：刘风雨(译) 北京大学神经科学研究所

慢性疼痛是临床的常见病。内侧前额叶皮质(medial prefrontal cortex,mPFC)参与慢性疼痛发病机制。前边缘皮质(prelimbic cortex,PL)是mPFC的一个核心亚区,介导慢性疼痛。边缘下皮质(IL)是mPFC的另一个亚区,也能够调控伤害性反应。神经... 详细信息

慢性疼痛是临床的常见病。内侧前额叶皮质(medial prefrontal cortex,mPFC)参与慢性疼痛发病机制。前边缘皮质(prelimbic cortex,PL)是mPFC的一个核心亚区,介导慢性疼痛。边缘下皮质(IL)是mPFC的另一个亚区,也能够调控伤害性反应。神经解剖学研究表明,IL深层的兴奋性锥体神经元通过支配PL深层的抑制性中间神经元,进而作用到PL局部的锥体神经元上,调控PL的功能。IL、PL以及IL-PL环路如何参与慢性疼痛的发病机制,不甚清晰。研究者采用完全弗氏佐剂(complete Freund's.adjuvant,CFA)建立的大鼠慢性炎症痛模型,结合体电生理记录和化学遗传学等方法,深入解析IL、PL及其环路在慢性疼痛中的作用。

关键词：中间神经元完全弗氏佐剂慢性疼痛神经解剖学锥体神经元大鼠发病机制

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Do aeolian depos.ts.and s.nd encroachment intens.ty s.ape patterns.of vegetation divers.ty and plant functional traits.in des.rt pavements.

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Journal of Arid Land 2023年第6期15卷 667-694页

作者： M'hammed BOUALLALA s.uad NEFFAR lyès.BRADAI Haroun CHENCHOUNI Laboratory of s.haran Natural Res.urces Faculty of Sciences and TechnologyUniversity of Ahmed DraiaAdrar 01000Algeria Department of Nature and Life s.iences Faculty of Exact Sciences and Nature and Life SciencesUniversity of TebessaTebessa 12002Algeria Laboratory Water and Environment University of TebessaTebessa 12002Algeria Laboratory of s.haran Biores.urces.Pres.rvation and Valorization Faculty of Nature and Life SciencesUniversity of Kasdi MerbahOuargla 30000Algeria Department of Fores. Management Higher National School of ForestsKhenchela 40000Algeria Laboratory of Natural Res.urces.and Management of s.ns.tive Environments University of Oum-El-BouaghiOum-El-Bouaghi 04000Algeria

The effects.of s.nd encroachment on compos.tion,divers.ty,and functional patterns.of vegetation in drylands.are rarely s.udied,and yet addres.ing thes. as.ects.is.important to deepen our unders.anding of the biodivers.ty *** s.udy aimed to inves.igate the effect of s.nd encroachment on plant functional biodivers.ty of des.rt pavements.gravel des.rts.in the s.hara Des.rt of *** were s.mpled and analyzed in three des.rt pavements.with different levels.of s.nd encroachment(Ls.)and quantity of aeolian depos.ts.low,LLs.;medium,MLs.;and high,HLs.).Within the s.mple-plot area(100 m^(2)),dens.ty of every plant s.ecies.was.identified and total vegetation cover was.*** taxonomic and functional divers.ty were analyzed and compared between *** s.owed that 19 plant s.ecies.in des.rt pavements.were clas.ified into 18 genera and 13 *** and Poaceae were the mos. important *** s.ecies.Anabas.s.articulata(Fors.k)*** LLs. des.rt pavements.with 11 s.ecies.whereas.Thymelaea microphylla Cos..&Durieu ex *** Calobota s.harae(C&D)Boatwr.&van Wyk were dominant s.ecies.of des.rt pavements.with MLs.(14 s.ecies.and HLs.(10 s.ecies.,*** highes. values.of s.ecies.richnes. and biodivers.ty were recorded in des.rt pavements.with MLs.,while low values.of thes. ecological parameters.were obtained in des.rt pavements.with *** pavements.with LLs. were characterized with the highes. values.of s.ecies.*** communities.were dominated by chamaephytes.anemochorous.arido-active,and competitive s.res.-tolerant *** increas. in Ls. along the gradient from LLs. to HLs. induced s.gnificant changes.in plant community variables.including decreas.s.in plant dens.ty,plant rarity,lifeform compos.tion,morphological type,and aridity *** pavements.with HLs. favor the degradation of vegetation and trigger biodivers.ty eros.on.

关键词： des.rt pavements hot and arid rangeland plant divers.ty land degradation s.nd encroachment plant functional trait s.hara Des.rt

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