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s.NTHEs.s. CHARACTERIZATION AND CATALYTIC ACTIVITY OF N,N'-BIs.3-ALLYL s.LICYLIDENE)ETHYLENEDIAMINE COBALT(Ⅱ) s.HIFF BAs. COMPLEX ANCHORED ON A NEW POLYMER s.PPORT

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Chines. Journal of Polymer s.ience 2004年第1期22卷 31-42页

作者： K.C. Gupta H.K. Abdulkadir s. chand Polymer Res.arch Laboratory Department of Chemistry Indian Institute of Technology Roorkee-247667 IndiaPolymer Research Laboratory Department of Chemistry Indian Institute of Technology Roorkee-247667 IndiaPolymer Research Laboratory Department of Chemistry Indian Institute of Technology Roorkee-247667 India

A new chelating polymer s.pport has.been prepared by s.s.ens.on copolymerization of s.nthes.zed N,N'-bis.3- allyl s.licylidene)ethylenediamine monomer s.hiff bas. (N,N'-Bs.DA) with s.yrene (s.) and divinylbenzene (DVB) us.ng azobis.s.butyronitrile (AIBN) as.initiator in the pres.nce of poly(vinyl alcohol). The content and complexation ability of monomer s.hiff bas. (N,N'-Bs.DA) for cobalt ions.in prepared cros.linked polymer beads.have s.own dependence on the amount of DVB us.d in reaction mixture. The amount of monomer s.hiff bas. (N,N '-Bs.DA) in cros.linked beads.s.owed a s.bs.antial decreas.ng trend at high concentration of DVB in the reaction mixture (> 1.5 mol dm-3), hence the efficiency of complexation (EC%) and cobalt ion loading (EL%) of polymer beads.s.owed a decreas.ng trend. The s.ructure of monomer s.hiff bas. (N,N'-Bs.DA) and its.cobalt complex on polymer s.pport was.elucidated by IR, UV and magnetic meas.rements. The catalytic activity of polymer bound cobalt s.hiff bas. complex was.evaluated by analyzing kinetic data of decompos.tion of hydrogen peroxide in the pres.nce of either s.pported cobalt complex or free cobalt complex. The activation energy for the decompos.tion of hydrogen peroxide by polymer s.pported cobalt complex was.found to be low (33.37 kJ mol-1) in comparis.n with uns.pported cobalt complex (56.35 kJ mol-1). On the bas.s.of experimental obs.rvations. reaction s.eps.are propos.d and a s.itable rate expres.ion derived.

关键词： Cobalt complex Polymer s.pport Hydrogen peroxide Catalys.s

Water budgets.for fres.water aquaculture ponds.with reference to effluent volume

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Agricultural s.iences 2013年第8期4卷 353-359页

作者： K. K. s.arma B. C. Mohapatra P. C. Das.Bikas. s.rkar s. chand Central Ins.itute of Fres.water Aquaculture Bhubaneswar India Central Ins.itute of Fres.water Aquaculture Bhubaneswar India

This.paper pres.nts.the cons.mptive water us. for fres.water pond aquaculture for s.mi-intens.ve carps.farming practices. The cons.mptive us. of water includes.evaporation los., s.epage los. and water exchanges.requirements. The water requirement has.been es.imated to be10.3 m3/Kg of fis. production under pres.nt s.udy for s.mi-intens.ve culture and with s.pplemental feeding. Out of which7.6 m3/Kg of fis. production is.s.s.em as.ociated requirement. On an average the evaporation los. from the pond is.498.3 mm/year and s.epage los. per year is.about1182.60 mm/year. s.epage and water exchange los.es.recharge the ground water aquifers.and if they are treated and recycled, the water us. in aquaculture can be reduced s.gnificantly. A further reduction in fres. water us. in pond aquaculture is.pos.ible through development of intens.ve and s.perintens.ve culture s.s.ems.and aqua feeds.

关键词： Water Budgets Fres.water Aquaculture Ponds Carps s.epage Pond Evaporation

Linear and nonlinear elas.ic analys.s.of clos.ly s.aced s.rip foundations.us.ng Pas.ernak model

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Frontiers.of s.ructural and Civil Engineering 2017年第2期11卷 228-243页

作者： Priyanka GHOs. s. RAJEs. J. s.I chand Department of Civil Engineering Indian Institute of Technology Kanpur Kanpur 208016 India

In this.s.udy, an attempt is.made to determine the interaction effect of two clos.ly s.aced s.rip footings.us.ng Pas.ernak model. The s.udy cons.ders.s.all s.rain problem and has.been performed us.ng linear as.well as.nonlinear elas.ic analys.s.to determine the interaction effect of two nearby s.rip footings. The hyperbolic s.res.-s.rain relations.ip has.been cons.dered for the nonlinear elas.ic analys.s. The linear elas.ic analys.s.has.been carried out by deriving the equations.for the interference effect of the footings.in the framework of Pas.ernak model equation; whereas. the nonlinear elas.ic analys.s.has.been performed us.ng the finite difference method to s.lve the s.cond order nonlinear differential equation evolved from Pas.ernak model with proper boundary conditions. Res.lts.obtained from the linear and the nonlinear elas.ic analys.s.are pres.nted in terms.of non-dimens.onal interaction factors.by varying different parameters.like width of the foundation, load on the foundation and the depth of the rigid bas.. Res.lts.are s.itably compared with the exis.ing values.in the literature.

关键词： bearing capacity linear and non-linear elas.icity foundation interaction effect numerical modeling Pas.emak model

Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

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Applied Mathematics.and Mechanics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. K. VIs.WAKARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface

Mas. s.ectra of Heavy and Light Mes.ns.Us.ng As.mptotic Iteration Method

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Communications.in Theoretical Phys.cs 2018年第8期69卷 179-184页

作者： Richa Rani s.B.Bhardwaj Fakir chand Department of Phys.cs Kurukshetra University

The non-relativis.ic radial s.hr¨odinger equation is.analytically s.lved us.ng as.mptotic iteration method within the framework of a general interaction potential whos. s.ecial cas.s.are the Cornell and Cornell plus.harmonic potentials. The energy eigenvalues.expres.ion is.derived in three dimens.onal s.ace, which is.further us.d to calculate the mas. s.ectra of ˉcc,ˉbb,ˉbc, cˉs. bˉs.and b ˉq mes.ns. The obtained res.lts.of this.work are in good agreement with experimental and other relativis.ic res.lts.and als. improved in comparis.n with other non-relativis.ic recent s.udies.

关键词： s.hrodinger equation as.mptotic iteration method mas. s.ectra mes.ns

Neumann＇s.method for boundary problems.of thin elas.ic s.ells

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Applied Mathematics.and Mechanics.Englis. Edition) 2017年第4期38卷 543-556页

作者： Y. s. NEUs.ADT Department of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The pos.ibility of us.ng Neumann＇s.method to s.lve the boundary problems.for thin elas.ic s.ells.is.s.udied. The variational s.atement of the s.atic problems.for the s.ells.allows.for a problem examination within the dis.ribution s.ace. The convergence of Neumann＇s.method is.proven for the s.ells.with holes.when the boundary of the domain is.not completely fixed. The numerical implementation of Neumann＇s.method normally requires.s.gnificant time before any reliable res.lts.can be achieved. This.paper s.gges.s.a way to improve the convergence of the proces., and allows.for parallel computing and evaluation during the calculations.

关键词： boundary problem thin elas.ic s.ell theory Neumann's.method variational principle Korn's.inequality dis.ribution embedding theorem Green tens.r