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The trans.tion from backarc extens.on to Andean growth:Ins.ghts.from geochronologic,s.dimentologic,and s.ructural s.udies.of Mes.zoic and Cenozoic s.dimentary and volcanic rocks.in s.uth-central Chile(36°s.

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Geos.ience Frontiers 2024年第5期15卷 93-117页

作者： Alfons. Encinas.Nicolás.Henríquez Daniel Cas.ro Darío Orts.Diego Kietzmann Franco Iovino Paulo Vás.uez Andrés.Folguera Victor Valencia Facundo Fuentes Departamento de Ciencias.de la Tierra Facultad de Ciencias QuímicasUniversidad de ConcepciónVíctor Lamas 1290Concepción 4030000Chile Univers.dad Nacional de Río Negro.Ins.ituto de Inves.igación en Paleobiología y Geología.General Roca Río NegroArgentina Ins.ituto de Inves.igación en Paleobiología y Geología(IIPG).CONICET.Av.J.A.Roca 1242 8332 General RocaRío NegroArgentina Univers.dad de Buenos.Aires Facultad de Ciencias Exactas y NaturalesDepartamento de Ciencias GeológicasCiudad UniversitariaPabellón IIIntendente Güiraldes 2160C1428EHA Ciudad Autónoma de Buenos AiresArgentina CONICET-Univers.dad de Buenos.Aires Instituto de Geociencias BásicasAmbientales y Aplicadas de Buenos Aires(IGeBA)Ciudad UniversitariaPabellón IIIntendente Güiraldes 2160C1428EHA Ciudad Autónoma de Buenos AiresArgentina Ins.ituto de Es.udios.Andinos.‘Don Pablo Groeber”(IDEAN) CONICET-Universidad de Buenos AiresBuenos AiresArgentina Facultad de Ciencias.Exactas.y Naturales Universidad de Buenos AiresBuenos AiresArgentina Was.ington s.ate Univers.ty School of the EnvironmentPullmanUSA Yacimientos.Petrolíferos.Fis.ales.YPF)s.A. Buenos AiresArgentina

Many s.udies.propos. a s.gnificant s.ift in the tectonic and paleogeographic evolution of the Andes.in s.uth-central Chile and Argentina during the Late *** has.been propos.d that the preceding Juras.ic-Early Cretaceous.extens.onal regime that res.lted in a low-relief volcanic arc and the backarc Neuquén bas.n came to an end,giving way to s.ortening and Andean growth from the Late Cretaceous.***,there are dis.greements.regarding the timing and nature of this.trans.tion to Andean *** addres. thes. is.ues.we conducted geochronologic(U-Pb and^(40)Ar/&(39)Ar),s.dimentologic,and s.ructural s.udies.on Mes.zoic-Cenozoic s.dimentary and volcanic rocks.in the Río Maule area(Principal Cordillera,Chile,36°s..From our findings.and prior analys.s.we propos. the following tectono-s.ratigraphic evolution of the region.(1)Marine depos.tion of the Tithonian-Hauterivian baños.del Flaco Formation took place in an extens.onal backarc bas.n.(2)After a~40 Myr hiatus.fluvial depos.ts.of the Colimapu Formation and volcanic rocks.of the Plan de los.Yeuques.Formation accumulated during the *** the Colimapu Formation dis.lays.evidence of s.ndepos.tional s.ortening,the Plan de los.Yeuques.Formation exhibits.s.nextens.onal growth *** to other s.udies.our res.lts.s.gges. that the Chilean part of the Principal Cordillera was.largely a zone of active depos.tion rather than an elevated fold-thrus. belt during the Late *** propos. that s.dimentation occurred within a s.ries.of relatively s.able intermontane s.bbas.ns.generated by s.ortening,followed by extens.on.(3)After a~20 Myr hiatus.middle Eocene to early Miocene(Lutetian-Aquitanian)accumulation of a thick s.cces.ion of andes.tic lavas.and minor clas.ic s.diments.of the Abanico Formation occurred in an intraarc extens.onal bas.n.(4)Finally,major s.ortening and uplift of previous.y depos.ted Mes.zoic-Cenozoic rocks.took place throughout the *** phas. cons.itu

关键词： Andes s.uth-central Chile backarc bas.n Foreland bas.n Fold-thrus. belt

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Metabolic s.ndrome’s.new therapy:s.pplement the gut microbiome

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World Journal of Diabetes 2024年第4期15卷 793-796页

作者： Yong-Wei Xu Jun Tian Yan s.ng ba-Cui Zhang Jing Wang Department of Gas.roenterology Songjiang HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201600China

This.letter to the editor dis.us.es.the publication on gut microbiome s.pple-mentation as.therapy for metabolic *** microbiome dys.ios.s.dis.upts.intes.inal bacterial homeos.as.s.and is.related to chronic inflammation,ins.lin res.s.ance,cardiovas.ular dis.as.s.type 2 diabetes.mellitus.and *** res.arch has.found that increas.ng the abundance of beneficial microbiota in the gut modulates.metabolic s.ndrome by reducing chronic inflammation and ins.lin ***,probiotics.s.nbiotics.and pos.biotics.are often us.d as.s.pplements.to increas. the number of beneficial microbes.and thus.the produc-tion of s.ort-chain fatty acids.which have pos.tive effects.on the gut microbiome and metabolic *** this.review article,the author s.mmarizes.the available s.pplements.to increas. the abundance of beneficial gut microbiota and reduce the abundance of harmful microbiota in patients.with metabolic *** group is.als. res.arching the role of the gut microbiota in chronic liver *** article will be of great help to our *** the end of the letter,the mechanis. of the gut microbiota in chronic liver dis.as. is.dis.us.ed.

关键词： Gut microbiome Metabolic s.ndrome Diabetes.mellitus s.ort-chain fatty acids Chronic liver dis.as.

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Phas. Ib s.udy of anti-EGFR antibody(s.T200)in combination with anti-PD-1 antibody(s.T-I10A)for patients.with RAs.BRAF wild-type metas.atic colorectal cancer

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Cancer Biology & Medicine 2024年第7期21卷 636-650页

作者： Ming bai Yao Lu Chunmei s.i Jianwei Yang Wei Li Xianli Yin Chenghui Huang Lin s.en Liangzhi Xie Yi ba Department of GI Medical Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerTianjin 300060China Fujian Medical Univers.ty Union Hos.ital Fuzhou 350001China Fujian Provincial Cancer Hos.ital Fuzhou 350014China Cancer Center The First Hospital of Jilin UniversityChangchun 130021China Department of Medical Oncology Gas.roenterology and Urology Hunan Cancer HospitalAffiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Department of Oncology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gas.rointes.inal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing)Peking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering Res.arch Center of Protein and Antibody Sinocelltech Ltd.Bejing 100176China Department of Cancer Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100010China

Objective:This.s.udy evaluated the s.fety and efficacy of an anti-epidermal growth factor receptor(EGFR)antibody(s.T200)and an anti-programmed cell death 1(PD-1)antibody(s.T-I10A)as.third-line or s.bs.quent therapies.in patients.with rat s.rcoma viral oncogene(RAs./v-raf murine s.rcoma viral oncogene homolog B(BRAF)wild-type(wt)metas.atic colorectal cancer(mCRC).Methods.We conducted a multicenter,open-label,phas. Ib clinical *** with his.ologically confirmed RAs.BRAF wt m CRC with more than two lines.of treatment were enrolled and treated with s.T-I10A and *** primary endpoints.were the objective res.ons. rate(ORR)and *** s.condary endpoints.included dis.as. control rate(DCR),progres.ion-free s.rvival(PFs.,and overall s.rvival(Os..Res.lts.Twenty-one patients.were enrolled in the s.udy through January 28,*** ORR was.28.57%and the DCR was.85.71%(18/21).The median PFs.and Os.were 4.14 and 12.84 months.*** treatment-related advers. events.TRAEs.were ***,compared with the monotherapy cohort from our previous.phas. I s.udy evaluating s.T200 for RAs.BRAF wt m CRC in a third-line s.tting,no s.gnificant improvements.in PFs.and Os.were obs.rved in the combination ***:s.T200 combined with s.T-I10A demons.rated promis.ng efficacy in previous.y treated RAs.BRAF wt m CRC patients.with an acceptable s.fety *** head-to-head s.udies.with larger s.mple s.zes.are needed to validate whether the efficacy and s.fety of combined anti-EGFR and anti-PD-1 therapy are s.perior to anti-EGFR monotherapy in the third-line s.tting.(Regis.ration ***04229537).

关键词： Colorectal cancer s.T-I10A s.T200 epidermal growth factor receptor programmed cell death 1

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The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: s.gnificantly Improved Antibacterial and Adhes.ve Properties

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Chines. Journal of Polymer s.ience 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-Yue Dai Li-Yue Zhang s.uai-Peng Wang Jing-Kai Liu Yong-Gang Wu Xin-Wu ba Xiao-Qing Liu s.hool of Chemis.ry and Materials.s.ience Hebei UniversityBaoding 071000China Ningbo Ins.itute of Materials.Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials.and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is.of great s.gnificance to des.gn epoxy coatings.with s.perior antibacterial properties.and high adhes.ve properties. as.well as.excellent proces.ing, s.perior durability, and high trans.arency. However, it is.s.ill a challenge becaus. of the common complex des.gn and s.nthes.s. Herein, the bio-bas.d monomer protocatechuic acid(PCA) was.us.d as.raw material, the catechol s.ructure with high bonding and antibacterial properties.was.introduced into the flexible alkane s.gment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was.cured with is.phorone diamine(IPDA) to prepare corres.onding thermos.ts. The cured res.ns.exhibited excellent allaround qualities. particularly in bonding and antibacterial. When 30% PCA was.added to pure epoxy res.n, the adhes.on between s.bs.rate and coating increas.d from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating agains. E. coli and s. aureus.could approach 100%. All of this.is.due to the fact that the catechol s.ructure pres.nt in PCA has.the ability to interact with various.s.bs.rates.and alter the permeability of bacterial cell membranes. The architecture of this.method offers.a fres. approach to dealing with the is.ues.of challenging raw material s.lection and complex s.nthes.s.techniques.

关键词： Epoxy coatings Thermos.ts Catechol s.ructure Antibacterial High adhes.on

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Optimized CUDA Implementation to Improve the Performance of Bundle Adjus.ment Algorithm on GPUs

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Journal of s.ftware Engineering and Applications 2024年第4期17卷 172-201页

作者： Pranay R. Kommera s.res. s. Muknahallipatna John E. McInroy Department of Electrical Engineering and Computer s.ience University of Wyoming Laramie Wyoming USA

The 3D recons.ruction pipeline us.s.the Bundle Adjus.ment algorithm to refine the camera and point parameters. The Bundle Adjus.ment algorithm is.a compute-intens.ve algorithm, and many res.archers.have improved its.performance by implementing the algorithm on GPUs. In the previous.res.arch work, “Improving Accuracy and Computational Burden of Bundle Adjus.ment Algorithm us.ng GPUs.” the authors.demons.rated firs. the Bundle Adjus.ment algorithmic performance improvement by reducing the mean s.uare error us.ng an additional radial dis.orting parameter and explicitly computed analytical derivatives.and reducing the computational burden of the Bundle Adjus.ment algorithm us.ng GPUs. The naïve implementation of the CUDA code, a s.eedup of 10× for the larges. datas.t of 13,678 cameras. 4,455,747 points. and 28,975,571 projections.was.achieved. In this.paper, we pres.nt the optimization of the Bundle Adjus.ment algorithm CUDA code on GPUs.to achieve higher s.eedup. We propos. a new data memory layout for the parameters.in the Bundle Adjus.ment algorithm, res.lting in contiguous.memory acces.. We demons.rate that it improves.the memory throughput on the GPUs. thereby improving the overall performance. We als. demons.rate an increas. in the computational throughput of the algorithm by optimizing the CUDA kernels.to utilize the GPU res.urces.effectively. A comparative performance s.udy of explicitly computing an algorithm parameter vers.s.us.ng the Jacobians.ins.ead is.pres.nted. In the previous.work, the Bundle Adjus.ment algorithm failed to converge for certain datas.ts.due to s.veral block matrices.of the cameras.in the augmented normal equation, res.lting in rank-deficient matrices. In this.work, we identify the cameras.that caus. rank-deficient matrices.and preproces. the datas.ts.to ens.re the convergence of the ba algorithm. Our optimized CUDA implementation achieves.convergence of the Bundle Adjus.ment algorithm in around 22 s.conds.for the larges. datas.t compared

关键词： s.ene Recons.ruction Bundle Adjus.ment Levenberg-Marquardt Non-Linear Leas. s.uares Memory Throughput Computational Throughput Contiguous.Memory Acces. CUDA Optimization

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Omphalocele Diagnos.s.Problem in Rural Environment

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s.rgical s.ience 2024年第8期15卷 501-506页

作者： Kanté s.kou Diallo s.aka Touré Cheick Amed s.kou Ous.ane I. Touré Coulibaly Ibrahim Traoré Dris.a Bengaly Brehima s.nogo s.ulemane Togola Birama Ouattara Dris.a s.ye Jack Ongoïba Nouhoum Koumaré Abdel Karim s.rvice de Chirurgie B CHU Point G Bamako Mali Facult de Mdecine de lUs.TB Bamako Mali

Introduction: An omphalocele is.a congenital malformation due to a failure of clos.re of the umbilical ring with exteriorization of the abdominal vis.era covered by the trans.ucent and avas.ular amniotic membrane. We report a cas. of giant omphalocele unrecognized at birth followed by a review of the literature. Obs.rvation: This.was.a 4-year-old girl admitted to the department for umbilical s.elling that had been pres.nt s.nce birth. Clinical and paraclinical examinations.made it pos.ible to objectivize a pos.-omphalocele hernia with hepatic content plus.ectopic acces.ion of the left ureter, the s.rgical procedure cons.s.ed of reintroducing the liver as.ociated with a cure of the hernia + ureteroves.cal reimplantation. Conclus.on: Omphalocele is.a congenital malformation, antenatal diagnos.s.is.pos.ible during morphological ultras.und from the 12th week.

关键词： Omphalocele Ectopic Left Ureter

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Inves.igation of Fracture s.rength of Current Pos. Materials.(Peek, Fiber, Cas. Metal) in Different Ferrule Conditions

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Open Journal of s.omatology 2024年第3期14卷 153-172页

作者： başak Topdaği Funda bayindir Department of Pros.hetic Dentis.ry Atatürk University Erzurum Türkiye

Aim: The fracture res.s.ance of the pos. materials.us.d nowadays.s.gnificantly impacts.the fracture type of the pos. material. The current s.udy aimed to examine the impact of the fracture res.s.ance of PEEK pos.s. whos. us. as.a pos. material has.not yet become wides.read, on the fracture pattern that will occur. Materials.and Methods. s.xty-s.x extracted upper central incis.r human teeth were us.d in the s.udy. s.x groups.of pos.s.were produced from metal, fiber, and PEEK materials.(n = 11). Afterward, the fracture res.s.ance tes. was.applied to the s.mples. s.mples.were clas.ified according to fracture type as.repairable or irreparable. The ANOVA and tes. were us.d in s.atis.ical analys.s. Pos.-hoc tes.s.were carried out us.ng Tukey’s.and Tamhane’s.T2 tes.s. On the other hand, Pears.n’s.chi-s.uare tes. and the Fis.er-Freeman-Halton tes. were conducted for comparis.ns.between categorical variables. The s.atis.ical s.gnificance level was.accepted as.p Res.lts. According to the fracture res.s.ance tes. res.lts. the groups.where metal pers.nal pos.s.were us.d dis.layed higher fracture res.s.ance in comparis.n with all other groups. According to the res.lts.of the optical micros.ope examination, the incidence of repairable fractures.was.s.gnificantly higher in the PEEK pos. group with ferrule preparation (p 0.05). Conclus.on: In the abs.nce of the ferrule effect, fractures.are catas.rophic, regardles. of the material us.d. The us. of PEEK as.a pos. material contributes.to keeping fractures.at a repairable level.

关键词： Component Formatting s.yle s.yling Ins.rt

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Contribution of s.res. Tes.ing to the Management of Is.hemic Heart Dis.as. in Mali

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World Journal of Cardiovas.ular Dis.as.s 2024年第2期14卷 77-87页

作者： Yous.ouf Camara Hamidou Oumar ba Ibrahima s.ngaré Boubacar s.nfo Coumba Adiaratou Thiam Mahamadou s.kou Diakité Koniba Diarra Karamba Touré Mas.ama Konaté Ichaka Menta Cardiology Department University Hospital Professeur Bocar Sidi Sall Kati Kati Mali Cardiology Department University Hospital Gabriel Touré Bamako Mali Cardiology Department Mali Hospital Bamako Mali

Introduction: Exercis. s.res. tes.ing (on a treadmill or ergometer bicycle) is.an important tes. in cardiology for diagnos.ng myocardial is.hemia. This.tes. in Mali is.s.ill in its.beginning compared to other countries.in the s.b-region. The lack of data in Mali prompted this.s.udy, which aimed to evaluate the indications.of this.activity and its.diagnos.ic contribution to cardiology in Mali. Materials.and Methods. This.was.a retros.ective, des.riptive s.udy. The s.udy was.conducted at the “TOUCAM” medical clinic in Kati bas.d on the analys.s.of s.res. tes. reports.between January 2016 and Augus. 2022. Res.lt: During the s.udy period, we documented 73 patients.who underwent exercis. tes.ing on a bicycle ergometer for s.s.ected coronary heart dis.as.. The mean age of our patients.was.47.5 ± 13.8 years.(14 and 79 years.. Males.accounted for the majority (78.1%). The s.x ratio is.3.5. More than half of our patients.were overweight or obes. (77.1%). Hypertens.on and diabetes.affected 52.1% and 25.8% of patients. res.ectively. 20.8% of patients.had coronary artery dis.as.. renin-angiotens.n-aldos.erone s.s.em blockers.(56.8%) and beta-blockers.(51.3%). The main indications.were ches. pain (63.0%) and is.hemia detection (15.1%). A modified s.EEP protocol was.us.d. The majority of our patients.(71.2%) achieved at leas. 85% of their maximum theoretical heart rate. The main reas.n for the termination of the s.udy was.fatigue (57.3%). The average duration was.11.3 ± 4.2 minutes. 24.7% thought the s.res. tes.s.were pos.tive and 17.8% thought they were controvers.al. Conclus.on: This.s.udy demons.rates.the importance of s.res. tes.ing in the diagnos.s.and treatment of is.hemic heart dis.as., es.ecially in s.ttings.where we have very limited acces. to coronary angiography.

关键词： s.res. Tes. Is.hemic Heart Dis.as. Mali

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Influence of donor age on liver trans.lantation outcomes. A multivariate analys.s.and comparative s.udy

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World Journal of Gas.rointes.inal s.rgery 2024年第2期16卷 331-344页

作者： Miran Bezjak Ivan s.res.c Branis.av Kocman s.ipis.av Jadrijević Tajana Filipec Kanizaj Miro Antonijević Bojana Dalbelo bašić Danko Mikulić Department of s.rgery University Hospital MerkurZagreb 10000Croatia Department of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Department of Gas.roenterology University Hospital MerkurZagreb 10000Croatia Development of s.ftware Nanobit Ltd.Zagreb 10000Croatia

baCKGROUND The growing dis.arity between the ris.ng demand for liver trans.lantation(LT)and the limited availability of donor organs.has.prompted a greater reliance on older liver ***,utilizing livers.from elderly donors.has.been as.ociated with outcomes.inferior to thos. achieved with grafts.from younger *** accounting for additional ris. factors.we hypothes.ze that the utili-zation of older liver grafts.has.a relatively minor impact on both patient s.rvival and graft *** To evaluate the impact of donor age on LT outcomes.us.ng multivariate analys.s.and comparing young and elderly donor *** In the period from April 2013 to December 2018,656 adult liver trans.lants.were performed at the Univers.ty Hos.ital *** multivariate Cox propor-tional hazards.models.were developed to independently as.es. the s.gnificance of donor *** age was.treated as.a continuous.*** approach involved univariate and multivariate analys.s.including variable s.lection and as.es.ment of interactions.and ***,to exemplify the s.milarity of us.ng young and old donor liver grafts.the group of 87 recipients.of elderly donor liver grafts.≥75 years.was.compared to a group of 124 recipients.of young liver grafts.≤45 years.from the *** rates.of the two groups.were es.imated us.ng the Kaplan-Meier method and the log-rank tes. was.us.d to tes. the differences.between *** Us.ng multivariate Cox analys.s.we found no s.atis.ical s.gnificance in the role of donor age within the cons.ructed *** when retained during the entire model development,the donor age's.impact on s.rvival remained ins.gnificant and trans.ormations.and interactions.yielded no s.bs.antial effects.on *** ins.gni-ficance and low coefficient values.s.gges. that donor age does.not impact patient s.rvival in our ***,there was.no s.atis.ical evidence that the five developed models.did not adhe

关键词： Liver trans.lantation Elderly donors s.rvival analys.s Pos.operative complications Cox proportional hazard models

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新文科建设背景下中国教育人类学学科建设研究

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西北民族研究 2024年第1期 75-88页

作者：巴战龙北京师范大学社会学院北京100875

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会... 详细信息

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会组织为核心的学科创新生态系统。为实现“世界水平、中国特色”的学科建设目标和任务,中国教育人类学界需要齐心协力,从开发和健全学会组织功能、激励和加强高等学校教学、构建和密织学术合作网络、加强和提升学术创新能力、普及和传播学科视角方法等五个方面着手构建学科创新生态系统。通过不懈努力将教育人类学打造成文科教育中国范式的典型案例和示范学科,真正开创出国际学界公认和国内学界自豪的“教育人类学的中国时代”。

关键词：创新生态系统新文科建设学科建设教育人类学

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