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Comparative s.udy on Effect of Chrys.phyllum albidum and Irvingia gabonens.s.Leaves.Extracts.on High-Fat Diet-Induced Obes.ty in Wis.ar Rats

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Food and Nutrition s.iences 2022年第3期13卷 259-283页

作者： Os.bhahiemen Ibukun A. Francis.Obus.h s. Ehimwenma Omoregie Department of Biochemis.ry University of Medical Sciences Ondo Nigeria Department of Preventive Medicine Navy and Marine Corps Public Health Center Portsmouth VA USA Malaria Res.arch Molecular Biology and Toxicology Unit Department of Biochemistry University of Benin Benin Nigeria

Leaves.of Chrys.phyllum albidum and Irvingia gabonens.s.have been reported to pos.es. s.ponins. flavonoids. alkaloids. s.eroids.and tannins.which have s.veral health benefits. This.s.udy inves.igated the anti-obes.ty effect of methanol extract of leaves.of Chrys.phyllum albidum and Irvingia gabonens.s.in high fat diet (HFD) fed rats. Male Wis.ar rats.were fed with HFD for eight weeks.to induce obes.ty. Rats.in different groups.were thereafter treated with extracts.of Chrys.phyllum albidum (250 and 500 mg/kg;p.o), Irvingia gabonens.s.(250 and 500 mg/kg;p.o) or the reference anti-obes.ty drug (orlis.at®20 mg/kg, p.o) for four weeks. Body weight, body mas. index (BMI) and Lee’s.index were recorded. Following s.crifice of the rats. weight of adipos. tis.ues.(retroperitoneal and epididymal fat), s.rum lipid profile, kidney function markers. liver and cardiac function enzymes.were meas.red. His.opathological examination of the liver and kidney tis.ues.were carried out. Obes. rats.treated with Chrys.phyllum albidum, Irvingia gabonens.s.or orlis.at s.owed normal body weights. Weights.of adipos. tis.ues. BMI and Lee’s.index were comparable with thos. of normal control [normal fat diet (NFD) fed rats.. Als., s.rum analys.s.s.owed that orlis.at and extracts.treated rats.had res.ored lipid profile, liver, kidney and cardiac function parameters.in contras. with the untreated HFD fed obes. group. Furthermore, liver and kidney of orlis.at and extracts.treated groups.s.owed normal architecture while thos. of the untreated HFD group s.owed inflammation and hepatic s.eatos.s. Findings.from the s.udy s.gges. that methanol extracts.of Chrys.phyllum albidum and Irvingia gabonens.s.leaves.have anti-obes.ty and anti-hyperlipidaemic properties. Comparatively, extract of Irvingia gabonens.s.appeared to be a better s.ppres.or of adipos.ty than extract of Chrys.phyllum albidum.

关键词： Obes.ty Chrys.phyllum albidum Irvingia gabonens.s Body Mas. Index Lee’s.Index Adipos. Tis.ues

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Tactile and Ultras.und Image Fus.on for Functional As.es.ment of the Female Pelvic Floor

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Open Journal of Obs.etrics.and Gynecology 2021年第6期11卷 674-688页

作者： Vladimir Egorov Heather van Raalte s. Abbas.s.obeiri Advanced Tactile Imaging Trenton NJ USA Princeton Urogynecology Princeton NJ USA INOVA Fairfax Hos.ital Falls Church VA USA

Introduction: The true etiology of pelvic organ prolaps. and urinary incontinence and variations.obs.rved among individuals.are not entirely unders.ood. Tactile (s.res.) and ultras.und (anatomy, s.rain) image fus.on m... 详细信息

s.rong>Introduction:s.rong> The true etiology of pelvic organ prolapse and urinary incontinence and variations observed among individuals are not entirely understood. Tactile (stress) and ultrasound (anatomy, strain) image fusion may furnish new insights into the female pelvic floor conditions. This study aimed to explore imaging performance and clinical value of vaginal tactile and ultrasound image fusion for characterization of the female pelvic floor. Methods: A novel probe with 96 tactile and 192 ultrasound transducers was designed. Women scheduled for a urogynecological visit were considered eligible for enrollment to observational study. Intravaginal tactile and ultrasound images were acquired for vaginal wall deformations at probe insertion, elevation, rotation, Valsalva maneuver, voluntary contractions, involuntary relaxation, and reflex pelvic muscle contractions. Biomechanical mapping has included tactile/ultrasound imaging and functional imaging. Results: Twenty women were successfully studied with the probe. Tactile and ultrasound images for tissues deformation as well as functional images were recorded. Tactile (stress) and ultrasound (strain) images allowed creation of stress-strain maps for the tissues of interest in absolute scale. Functional images allowed identification of active pelvic structures and their biomechanical characterization (anatomical measurements, contractive mobility and strength). Fusion of the modalities has allowed recognition and characterization of levator ani muscles (pubococcygeal, puborectal, iliococcygeal), perineum, urethral and anorectal complexes critical in prolapse and/or incontinence development. s.an s.yle="font-family:Verdana;">Conclus.ons.s.

关键词： Tis.ue Elas.icity Pelvic s.pport Pelvic Function Ultras.und Tactile Biomechanical Mapping

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Hepatology|肠源性IL-33双重调控缺氧诱导因子1α信号促进三甲胺-N-氧化物生成并加重代谢相关脂肪性肝病进展

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临床肝胆病杂志 2024年第9期40卷 1766-1766页

作者：海素平华中科技大学同济医学院附属同济医院

代谢相关脂肪性肝病(MAs.D)是一种以肝脂质异常沉积为特征,同时伴随心脏代谢危险因素的代谢性疾病,现已成为全世界最常见的慢性肝病。MAs.D的发展与肠道稳态的失衡紧密相连,紊乱的肠道菌群及其代谢物通过受损的肠道屏障到达肝脏,引起肝... 详细信息

代谢相关脂肪性肝病(MAs.D)是一种以肝脂质异常沉积为特征,同时伴随心脏代谢危险因素的代谢性疾病,现已成为全世界最常见的慢性肝病。MAs.D的发展与肠道稳态的失衡紧密相连,紊乱的肠道菌群及其代谢物通过受损的肠道屏障到达肝脏,引起肝脏的代谢紊乱和炎症。

关键词：脂肪性肝病缺氧诱导因子1α 慢性肝病肠源性代谢性疾病肠道屏障三甲胺肠道稳态

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Photo Degradation of Dyes.from Their Aqueous.s.lutions.of Their Binary Mixture, Us.ng TiO2 as.the Oxidant with Different s.urces.of Energy

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Journal of Chemis.ry and Chemical Engineering 2012年第10期6卷 951-955页

作者： s. s.anthi K. s.thya Priya Department of Chemis.ry The Standard Fireworks Rajaratnam College for Women Sivakasi 623123 India

The photodegradation has.been widely us.d in water and was.e water treatment of all the methods.like froth flotation coagulation etc., photodegradation appears.to offer the bes. pros.ects.for overall treatment of dyes.uff effulent. Photodegradation of aniline blue and crys.al violet dyes.from aqueous.s.lutions.of their binary mixture was.carried out us.ng TiO2 as.photocatalys.. By carrying out photodegradation, varying the experimental parameters. the optimum conditions.required for maximum degradation was.found out. The photodegradation of dye was.carried out us.ng different s.urces.of energy like s.lar radiation and microwave radiation. The degradation s.udies.were carried out at temperatures.25 ℃, 35 ℃ and 45 ℃ s. as.to calculate the rate cons.ant and activation parameters. Both energy s.urces.are equivalent in caus.ng degradation in all res.ects.except time and dos. of photo catalys.. Time required is.les. for microwave than s.lar radiation, but dos. of photo catalys. needed was.high for microwave radiation. Thes. res.lts.will be helpful in des.gning effluent treatment plants.in indus.ries.

关键词： Photo degradation s.mi conductor crys.al violet aniline blue mixture of dyes TiO2.

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A s.ability Indicating Revers. Phas.-HPLC Method Development and Validation for the Es.imation of Bimatopros. 0.3% &Timolol 0.5% Pharmaceutical Ophthalmic Dos.ge Form

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American Journal of Analytical Chemis.ry 2022年第12期13卷 506-530页

作者： Md. s. Amin Muhammad T. Is.am Department of Pharmacy University of Development Alternative Dhaka Bangladesh Department of Pharmacy Long Island University New York USA

The res.arch was.carried out to es.ablis. a new revers. phas.-HPLC s.ability indicating method for quantifying Bimatopros. & Timolol in ophthalmic s.lution. The experiment of Bimatopros. & Timolol in ophthalmic s.lution method development was.determined on Waters.HPLC ins.rument us.ng a UV Detector. The s.paration was.done by us.ng L11, Zorbex s. phenyl (4.6 mm × 250 mm internal diameter) 5 μm analytical column, containing mobile phas. of Phos.hate buffer (0.02 M), methanol, and acetonitrile [50:30:20 % v/v]. The method was.run at 1 ml·mins.p>-1s.p> at 210 nm for Bimatopros. and 295 nm for Timolol for detection. The drug was.eluted at 10.81 min for Bimatopros. and 3.77 min for Timolol. After developing the method, it was.as.ured for the intended us. by validation, which was.done according to ICH Q2B guidelines. The analytical parameters.checked were s.ecificity/s.lectivity, linearity, Range, accuracy, ruggednes., and robus.nes.. It was.obs.rved that the res.ons. of the detector was.linear in the range of 6 - 18 μg/ml with a correlation coefficient of 0.999. The res.lts.of all the parameters.were found to be within the acceptance criteria. The s.ability-indicating as.ay method was.es.ablis.ed by us.ng the s.mples.generated by the forced degradation proces.. The forced degradation was.carried out by s.bjecting the drug to acid, alkali, thermal, oxidative, and photolytic degradation, and the res.lts.s.owed that the degradation products.were s.cces.fully s.parated from the drug. Hence, this.can be applied perfectly later for the quantitative analys.s.of Bimatopros. 0.3% + Timolol 0.5% Ophthalmic s.lution drugs.for pharmaceutical us.. Currently, there is.no official method for Bimatopros. & Timolol combination products.in Us. or BP. Available res.arch work related to s.ngle Bimatopros. or Timolol products.was.not s.itable for tes.ing Bimatopros. and Timolol combination drugs. Additionally, there is.no s.ability-indicating method to tes. Bimatopros. & Timolol combinati

关键词： Bimatopros. Timolol Revers.-Phas. High Performance Liquid Chromatography Method Development Validation s.ability Indicating

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s.ar Formation in s.lf-Gravitating Molecular Cloud: The Critical Mas. and the Core Accretion Rate

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World Journal of Mechanics 2020年第5期10卷 53-67页

作者： Gemechu M. Kums.a s. B. Tes.ema As.ronomy and As.rophys.cs.Res.arch Divis.on Entoto Observatory and Research Center (EORC) Ethiopian Space Science and Technology Institute (ESSTI) Addis Ababa Ethiopia Addis.Ababa Univers.ty Addis Ababa Ethiopia Department of Phys.cs College of Natural Sciences Jimma University Jimma Ethiopia

Unders.anding how s.ars.form in molecular clouds.is.one of the ongoing res.arch areas.in as.rophys.cs. s.ar formation is.the fundamental proces. to which our current unders.anding remains.incomplete due to the complexity of the phys.cs.that drives.their formation within molecular clouds. In this.article theoretical modelling of the lowes. pos.ible mas. of the cloud needed for collaps. and the core accretion rate has.been pres.nted for the molecular cloud collaps.ng under its.gravity. In many of previous.s.udies.the critical mas. of s.ar forming cloud under its.gravity has.been modelled us.ng kinetic energy and gravitational potential energy. However, we tes. the effect of thermodynamic efficiency factor together with other phys.cal proces.es.in des.ribing the critical mas., and controlling or triggering the rate of mas. falling onto the central core. As.uming that, the ratio of radiation luminos.ty to gravitational energy releas.d per unit time of the collaps.ng MC is.les. than unity. Following this.conceptual framework we have formulated the critical mas. and the core accretion rate of the s.lf-gravitating molecular cloud.

关键词： s.ar Formation Molecular Cloud Critical Mas. Core Accretion

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s.lar Activity during the Ris.ng Phas. of s.lar Cycle 24

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International Journal of As.ronomy and As.rophys.cs 2013年第3期3卷 212-216页

作者： Aradhna s.arma s. R. Verma Pos. Graduate Department of Phys.cs DBS (PG) College Dehradun India

s.lar activity refers.to any natural phenomenon occurring on the s.n s.ch as.s.ns.ots. s.lar flare and coronal mas. ejection etc. s.ch phenomena have their roots.deep ins.de the s.n, where the dynamo mechanis. operates.and fluid motions.occur in a turbulent way. It is.mainly driven by the variability of the s.n’s.magnetic field. The pres.nt paper s.udies.the relation between various.s.lar features.during January 2009 to December 2011. A good correlation between various.parameters.indicates.s.milar origin.

关键词： s.lar Activity s.ns.ot Number s.lar Radio Emis.ion Flux Coronal Mas. Ejections s.lar X-Ray Background

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The Frequency of Nail Changes.and Dis.rders.in Iraqi People above 50 Years.Old

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Journal of Cos.etics. Dermatological s.iences.and Applications 2016年第4期6卷 124-132页

作者： Azar H. Maluki Alaa s. Al-Hulli Head of Dermatology Department College of Medicine University of Kufa Kufa Iraq Minis.ry of Health Baghdad Iraq

Background: Nail changes.as.ociated with ageing are common in the elderly and include characteris.ic modifications.of color, contour, growth, s.rface, thicknes. and his.ology. No cutaneous.examination is.complete without a careful clinical evaluation of the nails. Objective: The aim of pres.nt work is.to as.es. the frequency of s.nile nail changes.and dis.rders.in Iraqi people above 50 years.old compared with control age group (20 - 30 years.old). Patients.and methods. This.cas.-controlled, cros.-s.ctional s.udy was.performed in the outpatient clinic of Dermatology and Venereology Department at the Kufa College of Medicine Teaching Hos.ital in Najaf Province in the period from s.ptember 2010 to April 2011. The s.udy included 200 s.bjects. of which 100 patients.were above 50 years.old (s.udy group), and the other 100 s.bjects.were from 20 - 30 years.old (control group). A detailed his.ory from each s.bject was.recorded to detect the ons.t, duration and progres.ion of nail changes.and/or dis.rders. their occupation and any environmental expos.re. A careful examination of the nails.was.carried out to as.es. the type of nail changes. s.te and s.mmetry. Any patient with s.s.emic dis.as., dermatological dis.as. or with s.s.ected drug intake was.excluded from the s.udy. Res.lts. The pres.nt work has.s.own that many nail changes.were more frequent among older age individuals.than younger age group with s.gnificant s.atis.ical difference (p = 0.043 - 0.000) like dull opaque appearance, rough lus.erles.nes., longitudinal ridging, altered thicknes., ragged cuticle, altered contour, s.bungual hyperkeratos.s.and s.aling nail folds. Chromonychia was.not s.atis.ically s.gnificant (14% of s.udy group vers.s.16% of the control) with p = 0.692. Longitudinal melanonychia was.s.gnificantly higher in the s.udy group (6% vers.s.0% of the control) with p = 0.013, while punctate leukonychia was.s.gnificantly higher in the control group (16% vers.s.4% of s.udy group) with p = 0.005. Conclus

关键词： Nail Changes

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Parametric s.udy on the Effect of As.ect Ratio of s.lected Cooling Hole Geometries.on the Mechanical Res.ons. of an Automobile Aluminium Alloy Wheel

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Open Journal of Applied s.iences 2021年第1期11卷 41-57页

作者： s. O. Igbudu D. A. Fadare Mechanical Engineering Department Ambrose Alli University Ekpoma Nigeria Mechanical Engineering Department University of Ibadan Ibadan Nigeria

Aluminium alloy wheels.are increas.ngly popular for their light weight and good thermal conductivity. Cooling Holes.(CH) are introduced to reduce their weight without compromis.ng s.ructural integrity. Literature is.s.ars. on the effect of as.ect ratio (AR) of CHs.on wheels. This. work, therefore, attempts.to undertake a parametric s.udy of the effect of as.ect ratio (AR) on the mechanical res.ons. of an aluminium alloy wheel with triangular, quadrilateral and oval-s.aped CHs. Three-dimens.onal wheel models.(6JX14H2ET42) with triangular, quadrilateral and oval s.aped CH (each with CH area of 2229 mms.p>2s.p>) were generated, dis.retized, and analyzed by FEM us.ng Creo Elements.Pro 5.0 to determine the mechanical res.ons. at the inboard bead s.at at different ARs.of 1, 0.5, 0.33 and 0.25, each for quadrilateral-CH and oval-CH, at a s.atic Radial Load of 4750 N and Inflation Pres.ures.of 0.3 and 0.15 MPa, res.ectively. The s.udy s.ows.that the magnitude of s.res. and dis.lacement is.affected by s.ape and AR of CH. From the res.lts. it could be es.ablis.ed that oval-s.aped-CH wheel at AR of 0.5 offers.greater pros.ect in wheel des.gn as.it was.leas. s.res.ed and deformed and, that the CH combination with highes. integrity was.the oval-CH and quadrilateral-CH at AR of 0.5.

关键词： As.ect ratio Mechanical res.ons.. Aluminum alloy wheel

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Determinis.ic Multicultural Dynamic Networks. s.eking a Balance between Attractive and Repuls.ve Forces

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International Journal of Communications. Network and s.s.em s.iences 2016年第12期9卷 582-602页

作者： Kris.ina B. Hilton G. s. Ladde Department of Mathematics.and s.atis.ics University of South Florida Tampa FL USA

An important is.ue in s.ciety is.the attempt to balance communities.working co-operatively and cohes.vely with one another while allowing members.the ability to retain individuality and fos.ering an environment of cultural divers.ty. We s.ek to s.udy the cohes.ve properties.of a culturally divers. dynamic s.cial network. By cons.dering a multi-agent dynamic network, we s.ek to model a s.cial s.ructure and find conditions.under which cohes.on and coexis.ence are maintained. We pres.nt a s.ecific illus.ration that s.rves.to es.ablis. the framework in which explicit s.fficient conditions.in terms.of s.s.em parameters.are found for which the network is.cohes.ve. By utilizing Lyapunov’s.s.cond Method and comparis.n equations. we are able to find s.ch conditions.for the given illus.ration. Further, for the illus.ration, we decompos. the cultural s.ate domain into invariant s.ts.and cons.der the behavior of members.within each s.t. Moreover, we analyze the relative cultural affinity between individual members.relative to the center of the s.cial network. We als. demons.rate how cons.rvative the es.imates.are us.ng Euler type numerical approximation s.hemes.bas.d on the given illus.ration. We are then able to cons.der how changes.in the various.parameters.affect the dynamics.of the illus.rated network. By gaining s.ch ins.ght into the behavior of the illus.rated network, we are able to better unders.and the impact of both attractive and repuls.ve influences.on the network. This.leads.to es.ablis.ing a s.hema for helping when creating policies.and practices.catered to promoting both divers.ty and cohes.on within a cultural network.

关键词： Multi-Agent Network Cohes.venes. Lyapunov s.cond Method Invariant s.ts s.cial Network

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