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Inflammas.me links.traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as.

Neural Regeneration Res.arch 2025年第6期20卷 1644-1664页

作者： Gabriela s.plovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja andrew Reis.er Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas.Kobeis.y Department of s.rgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological s.rgery and the Miami Project to Cure Paralys.s University of Miami Miller School of MedicineMiamiFLUSA Divis.on of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neuros.rgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemis.ry and Biochemis.ry Texas Tech UniversityLubbockTXUSA Morehous. s.hool of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as. are three dis.inct neurological dis.rders.that s.are common pathophys.ological mechanis.s.involving neuroinflammation. One s.quela of neuroinflammation includes.the pathologic hyperphos.horylation of tau protein, an endogenous.microtubule-as.ociated protein that protects.the integrity of neuronal cytos.eletons. Tau hyperphos.horylation res.lts.in protein mis.olding and s.bs.quent accumulation of tau tangles.forming neurotoxic aggregates. Thes. mis.olded proteins.are characteris.ic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as. and can lead to downs.ream neuroinflammatory proces.es. including as.embly and activation of the inflammas.me complex. Inflammas.mes.refer to a family of multimeric protein units.that, upon activation, releas. a cas.ade of s.gnaling molecules.res.lting in cas.as.-induced cell death and inflammation mediated by the releas. of interleukin-1β cytokine. One s.ecific inflammas.me, the NOD-like receptor protein 3, has.been propos.d to be a key regulator of tau phos.horylation where it has.been s.own that prolonged NOD-like receptor protein 3 activation acts.as.a caus.l factor in pathological tau accumulation and s.reading. This.review begins.by des.ribing the epidemiology and pathophys.ology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as.. Next, we highlight neuroinflammation as.an overriding theme and dis.us. the role of the NOD-like receptor protein 3 inflammas.me in the formation of tau depos.ts.and how s.ch tauopathic entities.s.read throughout the brain. We then propos. a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's.dis.as. as.inflammas.medependent pathologies.that exis. along a temporal continuum. Finally, we dis.us. potential therapeutic targets.that may intercept this.pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's.dis.as. cas.as.-1 chronic traumatic encephalopathy inflammas.mes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptos.s tauopathy traumatic brain injury

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Morphology and efficiency enhancements.of PTB7-Th:ITIC nonfullerene organic s.lar cells.proces.ed via s.lvent vapor annealing

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journal of Energy Chemis.ry 2019年第10期28卷 148-156页

作者： Robert s. Gurney Wei Li Yu Yan Dan Liu andrew j. Pears.n Tao Wang s.hool of Materials.s.ience and Engineering Wuhan University of TechnologyWuhan 430070HubeiChina s.ate Key Laboratory of s.licate Materials.for Architectures Wuhan University of TechnologyWuhan 430070HubeiChina Cavendis. Laboratory University of CambridgeJ. J. Thomson AvenueCambridge CB3 0HEUK

The nanos.ale morphology within the photoactive layer of organic s.lar cells.is.critical in determining the power convers.on efficiency (PCE). Here, we draw attention to the roles.of molecular arrangement, and domain s.ze in improving performance, which can be tuned by s.bjecting the photovoltaic materials.to s.lvent vapor annealing (s.A). In our PTB7-Th:ITIC devices. the PCE can be improved by expos.ng the device to s.lvent vapor for 60 s.after s.lution cas.ing. The s.lvent vapor prolongs.reorganizational time and increas.s.molecular ordering and domain s.ze/phas. s.paration, which are s.b-optimal in pris.ine PTB7-Th:ITIC blend films. This.improved morphology res.lts.in better charge mobility, reduced recombination, and ultimately an improved PCE from 7.1% to 7.9% when us.ng Cs. as.the annealing s.lvent. This.s.mple s.A technique can be applied to a range of OPV s.s.ems.where the molecular ordering is.inferior within the as.cas. photoactive layer.

关键词： Polymer s.lar cells Non-fullerene s.lvent vapor annealing

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Prognos.ic model of s.rvival outcomes.in non-s.all cell lung cancer patients.initiated on afatinib: pooled analys.s.of clinical trial data

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Cancer Biology & Medicine 2019年第2期16卷 341-349页

作者： As.ley M. Hopkins.Adel s.ahnam s.s.a Zhang Chris.s. Karapetis.andrew Rowland Michael j. s.rich Flinders.Centre for Innovation in Cancer Department of Clinical Pharmacology College of Medicine and Public Health Flinders University Adelaide 5042 Australia The Canberra Hos.ital Garran 2605 Australia

Objective: s.veral predictors.of s.rvival have been identified in EGFR-pos.tive non-s.all cell lung cancer(Ns.LC) patients.treated with firs. generation EGFR inhibitors. Prognos.ic models.of s.rvival outcomes.with afatinib have not been ***: A prognos.ic tool for overall s.rvival(Os./progres.ion free s.rvival(PFs. bas.d on pre-treatment clinicopathological factors.was.developed for EGFR-pos.tive advanced Ns.LC patients.treated with firs.-line afatinib us.ng penalis.d regres.ion of individual-participant data from LUX-Lung 3 and 6(n = 468). Favourable, intermediate and poor ris. groups.were identified and externally validated us.ng LUX-Lung 1(n = 390) and LUX-Lung 2(n = 129) trials.that initiated afatinib following previous.chemotherapy or EGFR inhibitor ***: Dis.riminative performance was.good in the development and validation cohorts. For patients.treated with firs.-line afatinib, the median Os.for the favourable, intermediate and poor ris. groups.were > 47.7, 29.3 and 16.4 months. res.ectively, and the median PFs.were 17.3, 13.2 and 8.3 months. res.ectively. The improvement in median Os.with afatinib us. compared to chemotherapy was.> 12.4 months.for the favourable ris. group, whereas.no Os.benefit was.apparent for the poor ris. group. The improvement in median PFs.with afatinib us. compared to chemotherapy was.10.2 months.for the favourable ris. group and 3.2 months.for the poor ris. ***: A prognos.ic tool was.developed and validated to identify favourable, intermediate and poor ris. groups.for Os.PFs.in EGFR-pos.tive advanced Ns.LC patients.treated with afatinib. The prognos.ic groups.can inform the likely abs.lute Os.PFs.benefit expected from afatinib compared to chemotherapy in firs.-line treatment.

关键词： Afatinib non-s.all cell lung cancer prognos.ic model

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The integrated us. of chemical ins.cticides.and the entomopathogenic nematode, s.einemema carpocaps.e （Nematoda： s.einernematidae）, for the control of s.eetpotato whitefly, Bemis.a tabaci （Hemiptera： Aleyrodidae）

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Ins.ct s.ience 2008年第5期15卷 447-453页

作者： andrew G. s. Cuthberts.n james.j. Mathers.Phil Northing Anthony j. Prickett Keith F. A. Waiters Central s.ience Laboratory Sand Hutton York YO41 1LZ UK

The integration of chemical ins.cticides.and infective juveniles.of the entomopathogenic nematode s.einernema carpocaps.e （Wes.er）（Nematoda： s.einernematidae）, to control s.cond ins.ars.of the s.eetpotato whitefly, Bemis.a tabaci Gennadius.（Hemiptera： Aleyrodidae） was.inves.igated. Us.ng a s.nd bioas.ay, the effects.of direct expos.re of s. carpocaps.e for 24 h to field rate dilutions.of four ins.cticides.（s.iromes.fen, thiacloprid, imidacloprid and pymetrozine） on infectivity to Galleria mellonella larvae were tes.ed. Although all chemicals.tes.ed, except s.iromes.fen, produced acceptable nematode infectivity rates. they were all s.gnificantly les. than the water control. The effect of ins.cticide treatment （dry res.dues.of s.iromes.fen, thiacloprid and pymetrozine and s.il drench of imidacloprid） on the efficacy of the nematode agains. B. tabaci was.als. inves.igated. Nematodes.in combination with thiacloprid and s.iromes.fen gave higher B. tabaci mortality （86.5% and 94.3% res.ectively） compared to us.ng nematodes.alone （75.2%） on tomato plants. There was.no s.gnificant difference in B. tabaci mortality when us.ng the chemicals.imidacloprid, pymetrozine and s.iromes.fen in conjunction with nematodes.compared to us.ng the chemicals.alone. However, us.ng thiacloprid in combination with the nematodes.produced s.gnificantly higher B. tabaci mortality than us.ng the chemical alone. The integration of s. carpocaps.e and thes. chemical agents.into current integrated pes. management programmes.for the control of B. tabaci is.dis.us.ed.

关键词： entomopathogenic nematode infectivity ins.cticide res.due pes. management

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Multi-s.ale magnetic res.nance meas.rements.and validation of Dis.rete Element Model s.mulations

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Particuology 2011年第4期9卷 330-341页

作者： Chris.oph R. Müller Daniel j. Holland james.R. Third andrew j. s.derman john s. Dennis.Lynn F. Gladden Ins.itute of Energy Technology Department of Mechanical and Process Engineering Department of Chemical Engineering and Biotechnology University of Cambridge

This.s.ort review des.ribes.the capabilities.of magnetic res.nance （MR） to image opaque s.ngle- and two-phas. granular s.s.ems. s.ch as.rotating cylinders.and gas.fluidized beds.operated in different fluidization regimes. The unique capability of MR to not only image the s.lids. dis.ribution （voidage） but als. the velocity of the particulate phas. is.clearly s.own. It is.demons.rated that MR can provide meas.rements.over different length and time s.ales. With the MR equipment us.d for the s.udies.s.mmarized here, temporal and s.atial s.ales.range from s.b-millis.cond to hours.and from a few hundred micrometres.to a few centimetres. res.ectively. Bes.des.providing crucial data required for an improved unders.anding of the underlying phys.cs.of granular flows. multi-s.ale MR meas.rements.were als. us.d to validate numerical s.mulations.of granular s.s.ems. It is.s.own that predictions.of time-averaged properties. s.ch as.voidage and velocity of the particulate phas., made us.ng the Dis.rete Element Model agree very well with MR meas.rements.

关键词： Dis.rete Element Modelling Magnetic res.nance imaging Multis.aleGas.fluidized beds.Rotating cylinders

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Three-dimens.onal impact kinetics.with foot-s.rike manipulations. during running

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journal of s.ort and Health s.ience 2017年第4期6卷 489-497页

作者： andrew D. Nordin janet s. Dufek john A. Mercer Department of Kines.ology and Nutrition s.iences University of Nevada Las Vegas NV 89154 USA

Background: Lack of an obs.rvable vertical impact peak in fore/mid-foot running has.been s.gges.ed as.a means.of reducing lower extremity impact forces. although it is.unclear if impact characteris.ics.exis. in other axes. The purpos. of the inves.igation was.to compare three-dimens.onal(3 D) impact kinetics.among foot-s.rike conditions.in over-ground running us.ng ins.antaneous.loading rate–time ***: Impact characteris.ics.were as.es.ed by identifying peak loading rates.in each direction(medial–lateral(ML), anterior–pos.erior(AP),vertical, and 3 D res.ltant) following foot-s.rike ins.ructions.fore-foot, mid-foot, s.btle heel, and obvious.heel s.rike). Kinematic and kinetic data were analyzed among 9 male participants.in each foot-s.rike ***: Loading rate peaks.were obs.rved in each direction and foot-s.rike condition, differing in magnitude by direction(3 D res.ltant and vertical > AP > ML, p ≤ 0.031) and foot-s.rike: ML(fore-foot and mid-foot s.rike > obvious.heel s.rike, p ≤ 0.032), AP(fore-foot and mid-foot s.rikes.> s.btle-heel and obvious.heel s.rikes. p ≤ 0.023). In each direction, the firs. loading rate peak occurred later during heel s.rike running relative to fore-foot(p ≤ 0.019), with vertical and 3 D res.ltant impact durations.exceeding s.ear(ML and AP, p ≤ 0.007) in each ***: Loading rate–time as.es.ment identified contras.ing impact characteris.ics.in each direction and the 3 D res.ltant following foot-s.rike manipulations. with potential implications.for lower extremity s.ructures.in running.

关键词： Fore-foot Heel s.rike Loading rate Mid-foot Overground Res.ltant

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Bio-Imitation of Mexican Migration Routes.to the Us. with s.ime Mould on 3D Terrains

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journal of Bionic Engineering 2013年第2期10卷 242-250页

作者： andrew Adamatzky Genaro j Martinez Department of Computer s.iences University of the West of England Bristol BS16 1QY UK Es.uela s.perior de Computo Instituto Politecnico Nacional Mexico

Plas.odium ofPhys.rum polycephalum （P. polycephalum） is.a large s.ngle cell vis.ble by an unaided eye. It s.ows.s.phis.icated behavioural traits.in foraging for nutrients.and developing an optimal trans.ort network of protoplas.ic tubes.s.anning s.urces.of nutrients. When placed in an environment with dis.ributed s.urces.of nutrients.the cell computes. an optimal graph s.anning the nutrients.by growing a network of protoplas.ic tubes. P. polycephalum imitates.development ofman-made trans.ort networks.of a country when configuration of nutrients.repres.nts.major urban areas. We employed this.feature of the s.ime mould to imitate mexican migration to Us.. The Mexican migration to Us. is.the World＇s.larger migration s.s.em. We bio-phys.cally imitated the migration us.ng s.ime mould P. poIycephalum. In laboratory experiments.with 3D Nylon terrains.of Us. we imitated development of migratory routes.from Mexico-Us. border to ten urban areas.with high concentration of Mexican migrants. From res.lts.of laboratory experiments.we extracted topologies.of migratory routes. and highlighted a role of elevations.in s.aping the human movement networks.

关键词： biomimetics bio-ins.ired computing migration routes s.ime mould

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Bemis.a tabaci： The current s.tuation in the UK and the pros.ect of developing s.rategies.for eradication us.ng entomopathogens

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Ins.ct s.ience 2011年第1期18卷 1-10页

作者： andrew G. s. Cuthberts.n Lis. F. Blackburn Dominic P. Eyre Raymond j.C. Cannon judith Miller Phil Northing The Food and Environment Res.arch Agency Sand Hutton York UK

The s.eetpotato whitefly, Bemis.a tabaci （Gennadius. （Hemiptera： Aleyrodidae） remains.a s.rious.threat to crops.worldwide. The damaging B-biotype is.of s.ecific economic concern becaus. it is.an effective vector of over 111 virus.s.from s.veral fam- ilies. particularly geminivirus.s. Bemis.a tabaci is.regularly intercepted on plants.coming into the UK where it is.s.bjected to a policy of eradication. The UK maintains.Protective Zone s.atus.agains. this.pes.. A main pathway of entry of B. tabaci into the Protected Zone involves.propagating material, es.ecially Poins.ttia （Euphorbia pulcherrima）. With increas.d ins.cticide res.s.ance continuous.y being recorded, B. tabaci is.becoming more difficult to control/eradicate. Recent res.arch involving both entomopathogenic nematodes.and fungi is.s.owing much potential for the development of control programs.for this.pes.. Both the nematode s.einernemafeltiae and the fungus.Lecanicillium mus.arium have been s.own to be mos. effective agains. s.cond ins.ar B. tabaci. Fine-tuning of the environmental conditions.required has.als. increas.d their efficacy. The entomopathogens.have als. s.own a high level of compatibility with chemical ins.cticides. all increas.ng their potential to be incorporated into control s.rategies.agains. B. tabaci.

关键词： biocontrol entomopathogenic nematodes entomopathogenic fungi ins.cticide res.s.ance whitefly

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An in s.tu monitoring campaign of a hard rock pillar at great depth within a Canadian mine

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journal of Rock Mechanics.and Geotechnical Engineering 2020年第3期12卷 427-448页

作者： Bradley Forbes.Nicholas.Vlachopoulos.Mark s.Diederichs.andrew j.Hyett Allan Punkkinen Department of Geological s.iences.and Geological Engineering Queen’s UniversityKingstonOntarioK7L 3N6Canada Department of Civil Engineering Royal Military College of CanadaKingstonOntarioK7K 7B4Canada YieldPoint Inc. KingstonOntarioK7M 4W9Canada Normet Canada Ltd. LivelyOntarioP3Y 0B3Canada

A recent res.arch campaign at a Canadian nickel-copper mine involved ins.rumenting a hard rock s.ll drift pillar with an array of multi-point rod extens.meters.dis.ributed optical fibre s.rain s.ns.rs.and borehole pres.ure cells.BHPCs..The ins.rumentation s.anned acros. a 15.24 m lengthwis. s.gment of the relatively mas.ive granitic pillar s.tuated at a depth of 2.44 km within the *** May 2016 and March 2017,the pillar’s.dis.lacement and pres.ure res.ons. were meas.red and correlated with mining activities.on the s.me level as.the pillar,including:(1)mine-by of the pillar,(2)footwall drift development,and(3)ore body s.oping *** dis.lacements.of the pillar,the extens.meters.provided high temporal res.lution(logged hourly)and the optical fibre s.rain s.ns.rs.provide high s.atial res.lution(meas.red every 0.65 mm along the length of each s.ns.r).The combination of s.ns.ng techniques.allowed centimetre-s.ale rock mas. bulking near the pillar s.dewalls.to be dis.inguis.ed from micros.rain-s.ale fracturing towards.the core of the ***,the influence and extent of a mine-s.ale s.his.os. s.ear zone trans.cting the pillar was.*** converting meas.red rock mas. dis.lacement to velocity,a proces. was.demons.rated which allowed mining activities.inducing dis.lacements.to be categoris.d by time-duration and cumulative *** over half of the analys.d mining activities.dis.lacements.were determined to prolong for over an hour,predominately res.lting in s.bmillimetre cumulative dis.lacements.but in s.me cas.s.multi-centimetre cumulative dis.lacements.were *** time-dependent behaviour was.more pronounced within the vicinity of the plumb s.ear *** meas.rements.were als. us.d to as.es. s.lected s.pport member load and elongation mobilis.tion per mining *** was.found that a combined s.atic load and elongation capacity of reinforcing members.was.es.ential to maintaining excavation s.ability,while

关键词： Hard rock pillar Rockburs. Rock mas. bulking Dis.ributed optical fibre s.rain s.ns.ng Extens.meter In s.tu monitoring High s.res. Dynamic s.pport

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Teles.is.ic waves.reveal anis.tropic poroelas.ic res.ons. of was.ewater dis.os.l res.rvoir

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Earth and Planetary Phys.cs 2021年第6期5卷 547-558页

作者： andrew j Barbour Nicholas.M Beeler u.s.geological s.rvey earthquake science centerusa

Connecting earthquake nucleation in bas.ment rock to fluid injection in bas.l,s.dimentary res.rvoirs.depends.heavily on choices.related to the poroelas.ic properties.of the fluid-rock s.s.em,thermo-chemical effects.*** cons.raints.on thes. parameters.outs.de of laboratory s.ttings.are rare,and it is.commonly as.umed that the rock layers.are *** the Arbuckle was.ewater dis.os.l res.rvoir in Os.ge County,Oklahoma,high-frequency formation pres.ure changes.and collocated broadband ground velocities.meas.red during the pas.ing of large teles.is.ic waves.s.ow a poroelas.ic res.ons. of the res.rvoir that is.both azimuthally variable and anis.tropic;this.includes.evidence of s.atic s.ifts.in pres.ure that pres.mably relate to changes.in local *** azimuthal dependence in both the s.atic res.ons. and s.ear coupling appears.related to tectonic s.res. and s.rain indicators.s.ch as.the orientations.of the maximum horizontal s.res. and faults.and *** dynamic s.rains.from a nearby borehole s.rainmeter,we s.ow that the ratio of s.ear to volumetric s.rain coupling is.0.41 which implies.a mean s.empton's.coefficient of A=0.24 over the plaus.ble range of the undrained Pois.on's.*** thes. obs.rvations.are made at relatively low confining pres.ure and differential s.res.,we s.gges. that the hydraulically conductive fracture network is.a primary control on the coupling between pore pres.ure diffus.on and elas.ic s.res.es.in res.ons. to natural or anthropogenic s.urces.

关键词： poroelas.icity dynamic s.rain anis.tropy was.ewater dis.os.l Oklahoma induced s.is.icity

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