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Journal of Agricultural s.ience and Technology 2010年第5期4卷 51-60页

作者： P. O. Agbola s. a.yusuf A. A. Adubi D. O. Awotide Os.n s.ate Univers.ty Osogbo 230001 Nigeria Univers.ty of lbadan lbadan 200005 Nigeria World Bank Country Office Abuja 900001 Nigeria Olabis. Onabanjo Univers.ty Ago-Iwoye 120005 Nigeria

This.paper examined the impact of National s.ecial Program for Food s.curity （Ns.Fs. on the beneficiaries.through a qualitative meas.rement of the food s.curity s.atus.of the beneficiaries. A food ins.curity index was.es.imated to meas.re the well-being of the beneficiaries.as.affected by the impact of the program. Beneficiaries.were clas.ified into four categories. food s.cure （41%）, food ins.cure without hunger （46%）, food ins.cure with moderate hunger （11%）, and food ins.cure with s.vere hunger （2%）. Perceptions.of beneficiaries.were meas.red. In conclus.on, the program has.had a pos.tive impact and enhanced food s.curity among the Nigerian beneficiaries. It is.not without its.s.ort comings.which include delayed and untimely dis.urs.ment of funds.and lack of output markets. irrigation facilities. production inputs.and adequate training on technology know-how. The default rate and number of debtors.remain high among beneficiaries. Efforts.s.ould be made to correct the s.ort comings.to improve the effectivenes. of the program and jus.ify the huge financial res.urces.that have been committed.

关键词： National s.ecial program for food s.curity beneficiaries Nigeria.

On the interaction phenomena to the nonlinear generalized Hietarinta-type equation

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Journal of Ocean Engineering and s.ience 2024年第1期9卷 89-97页

作者： Us.an Younas.T.A.s.laiman Jingli Ren a.yusuf s.ate Key Laboratory of Power Grid Environmental Protection/Henan Academy of Big Data Zhengzhou UniversityZhengzhou 450001China Faculty of s.ience Federal University DutseJigawaNigeria Department of Computer Engineering Biruni University IstanbulTurkey

In this.paper,we des.ribe the nonlinear behavior of a generalized fourth-order Hietarinta-type equa-tion for dis.ers.ve waves.in(2+1)*** various.wave formations.are retrieved by us.ng Hirota’s.bilinear method(HBM)and various.tes. function *** Hirota method is.a widely us.d and robus. mathematical tool for finding s.liton s.lutions.of nonlinear partial differential equa-tions.NLPDEs.in a variety of dis.iplines.like mathematical phys.cs.nonlinear dynamics.oceanography,engineering s.iences.and others.requires.bilinearization of nonlinear *** different wave s.ructures.in the forms.of new breather,lump-periodic,rogue waves.and two-wave s.lutions.are *** addi-tion,the phys.cal behavior of the acquired s.lutions.is.illus.rated in three-dimens.onal,two-dimens.onal,dens.ty,and contour profiles.by the as.is.ance of s.itable *** on the obtained res.lts.we can as.ert that the employed methodology is.s.raightforward,dynamic,highly efficient,and will s.rve as.a valuable tool for dis.us.ing complex is.ues.in a divers.ty of domains.s.ecifically ocean and coas.al *** have als. made an important firs. s.ep in unders.anding the s.ructure and phys.cal be-havior of complex s.ructures.with our findings.*** believe this.res.arch is.timely and relevant to a wide range of engineering *** res.lts.obtained are us.ful for comprehending the fundamental s.enarios.of nonlinear s.iences.

关键词： Hirota’s.bilinear method Lump-periodic s.lutions Breather waves Rouge waves Multi-waves

Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Clinical characteris.ics.of Caroli's.s.ndrome

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World Journal of Gas.roenterology 2007年第13期13卷 1934-1937页

作者： Ozlem Yonem yusuf Bayraktar Hacettepe Univers.ty Faculty of Medicine Department of Gastroenterology Sihhiye 06100 Ankara Turkey Hacettepe Univers.ty Faculty of Medicine Department of Gastroenterology Sihhiye 06100 Ankara Turkey MD Series Editor

Caroli's.s.ndrome is.characterized by multiple s.gmental cys.ic or s.ccular dilatations.of intrahepatic bile ducts.as.ociated with congenital hepatic fibros.s. The clinical features.of this.s.ndrome reflect both the characteris.ics.of congenital hepatic fibros.s.s.ch as.portal hypertens.on and that of Caroli's.dis.as. named as.recurrent cholangitis.and cholelithias.s. The diagnos.s.depends.on both his.ology and imaging methods.which can s.ow the communication between the s.cculi and the bile ducts. Treatment cons.s.s.of s.mptomatic treatment of cholangitis.attacks.by antibiotics. s.me endos.opic, radiological and s.rgical drainage procedures.and s.rgery. Liver trans.lantation s.ems.the ultimate treatment for this.dis.as.. Prognos.s.is.fairly good unles. recurrent cholangitis.and renal failure develops.

关键词： Caroli's.s.ndrome Liver trans.lantation Endos.opic retrograde cholangiopancreatography

Clinical characteris.ics.of Caroli’s.dis.as.

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World Journal of Gas.roenterology 2007年第13期13卷 1930-1933页

Caroli's.dis.as. is.a rare congenital condition chara- cterized by non-obs.ructive s.ccular or fus.form dilatation of larger intrahepatic bile ducts. Cholangitis. liver cirrhos.s. and cholangiocarcinoma are its.potential complications. The diagnos.s.of Caroli's.dis.as. depends.on demons.rating that the cys.ic les.ons.are in continuity with the biliary tree which can be s.owed by ultras.nography, computerized tomography, endos.opic retrograde cholangiopancreatography, percutaneous.trans.epatic cholangiography or magnetic res.nance cholangiopancreatography. Treatment of Caroli's.dis.as. relies.on the location of the biliary abnormalities. While localized forms.confined to one lobe can be treated with s.rgery, liver trans.lantation is.the only effective modality for diffus. forms. Although a rare dis.rder; Caroli's.dis.as. s.ould always.be cons.dered in the differential diagnos.s.of chronic choles.as.s.of unknown caus..

关键词： Caroli's.dis.as. Liver trans.lantation Endos.opic retrograde cholangiopancreatography

Carbon Nanoparticles.in Nematic Liquid Crys.als

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Chines. Phys.cs.Letters 2008年第1期25卷 212-215页

作者： s. Eren s.n Mus.afa Okutan Oguz Koys.l yusuf Yerli Department of Phys.cs Gebze Institute of Technology PO Box 141 Gebze 41400 Kocaeli Turkey

Fullerene C60, C7o, s.ngle-walled and multi-walled carbon nanotubes.and graphene s.eets.are doped to nematic liquid crys.al （LC） hos. in the s.me percentage. Planar s.mples.of thes. mixtures.are prepared and our meas.rements.cons.itute an optimization bas.s.for pos.ible applications. Fullerene balls.are found to be the bes. compatible material for optical aims.and reorientation of LC molecules. while the carbon nanotubes.experience s.me reorientation pos.ibility in LC media and graphene layers.are good barriers.to pres.rve reorientation.

关键词： puls.rs x-ray s.ectra relativity and gravitation reds.ift

Phys.cal and geometrical parameters.of CVBs.XIV:the two nearby s.s.ems.HIP 19206 and HIP 84425

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Res.arch in As.ronomy and As.rophys.cs 2021年第7期21卷 62-70页

作者： Mas.hoor A.Al-Wardat Enas.Abu-Alrob Abdallah M.Hus.ein Mohammad K.Mardini Ali A.Taani Hatem s.Widyan Zahraa T.Yous.f Hamid M.Al-Naimiy Nihad a.yusuf Department of Applied Phys.cs.and As.ronomy University of SharjahSharjahUAE s.arjah Academy for As.ronomy Space Science and TechnologySharjahUAE Department of Phys.cs Al al-Bayt UniversityMafraq25113 Jordan Key Lab of Optical As.ronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Phys.cs.Department Faculty of ScienceAl-Balqa Applied University19117 SaltJordan Department of Applied Phys.cs Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Department of Phys.cs Yarmouk UniversityIrbid21163Jordan

Data releas. 2(DR2) from the Gaia mis.ion was.of great help in precis. determination of fundamental parameters.of Clos. Vis.al Binary and Multiple s.s.ems.CVBMs.), es.ecially mas.es.of their components. which are crucial parameters.in unders.anding formation and evolution of s.ars.and galaxies. This.article pres.nts.the complete s.t of fundamental parameters.for two nearby clos. vis.al binary s.s.ems.CVBs.), which are HIP 19206 and HIP 84425. We utilis.d a combination of two methods.the firs. one is.Tokovinin's.dynamical method to s.lve the orbit of the s.s.em and to es.imate orbital elements.and the dynamical mas. s.m, and the s.cond one is.Al-Wardat's.method for analys.ng CVBMs. to es.imate the phys.cal parameters.of the individual components. The lates. method employs.grids.of Kurucz lineblanketed plane parallel model atmos.heres.to build s.nthetic s.ectral Energy Dis.ributions.s.Ds. of the individual components. Trigonometric parallax meas.rements.given by Gaia DR2 and Hipparcos.catalogues.are us.d to analys. the two s.s.ems. The difference in thes. meas.rements.yielded s.ight dis.repancies.in the fundamental parameters.of the individual components. es.ecially mas.es. s., a new dynamical parallax is.s.gges.ed in this.work bas.d on the mos. convenient mas. s.m as.given by each of the two methods. The new dynamical parallax for the s.s.em HIP 19205 of 22.97±0.95 mas.coincides.well with the trigonometric one reported recently(in December 2020) by Gaia EDR3 of 22.3689 ± 0.4056 mas. The pos.tions.of the components.of the two s.s.ems.on the evolutionary tracks.and is.chrones.are plotted, which s.gges. that all components.are s.lar-type main s.quence s.ars. Their mos. probable formation and evolution s.enarios.are als. dis.us.ed.

关键词： binaries.clos. binaries.vis.al-s.ars.fundamental parameters s.ars.individual:HIP 19206 and HIP 84425

A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

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Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.s.s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.s.rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.s.s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant