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A priori, de novo mathematical exploration of gene expression mechanism via regression viewpoint with briefly cataloged modeling antiquity

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International Journal of Biomathematics 2017年第1期10卷 99-113页

作者： shaurya Jauhari s. A. m. rizvi Department of Computer scienceJamia miUia Islamia Jamia Nagar Okhla New Delhi Delhi 110025 India

Various algorithms have been devised to mathematically model the dynamic mecha- nism of the gene expression data. Gillespie＇s stochastic simulation （GssA） has been exceptionally primal for chemical reaction synthesis with future ameliorations. several other mathematical techniques such as differential equations, thermodynamic models and Boolean models have been implemented to optimally and effectively represent the gene functioning. We present a novel mathematical framework of gene expression, under~ taking the mathematical modeling of the transcription and translation phases, which is a detour from conventional modeling approaches. These subprocesses are inherent to every gene expression, which is implicitly an experimental outcome. As we foresee, there can be modeled a generality about some basal translation or transcription values that correspond to a particular assay.

关键词： Gene expression method of least squares microarray normal equations regression transcriptioni translation.

suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling:role of the ubiquitin proteasome system

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Cellular & molecular Immunology 2021年第1期18卷 162-170页

作者： Anil K.singh mahamudul Haque Kayla O'sullivan mukesh Chourasia madhu m.Ouseph salahuddin Ahmed Department of Pharmaceutical sciences Washington State University College of PharmacySpokaneWAUSA Center for Computational Biology and Bioinformatics Amity Institute of BiotechnologyAmity UniversityNoidaUttar PradeshIndia Department of Pathology Stanford University School of MedicineStanfordCAUSA Division of Rheumatology University of Washington School of MedicineSeattleWAUSA

monosodium urate(msU)crystals activate inflammatory pathways that overlap with interleukin-1β(IL-1β)***,the post-translational mechanisms involved and the role of signaling proteins in this activation are *** the present study,we investigated the intracellular signaling mechanisms involved in msU-induced activation of THP-1 macrophages and human nondiseased synovial fibroblasts(NLsFs)and the in vivo efficacy of an inhibitor of tumor grovArth factor-β(TGF-β)-activated kinase 1(TAK1),5Z-7-oxozeaenoI,in msU-induced paw inflammation in C57BL76 ***-1 macrophage activation with msU crystals(25-200 ng/ml)resulted in the rapid and sustained phosphorylation of interleukin-1 receptor-activated kinase 1(IRAK1 Thr^(209))and TAK1(Thr^(184/187))and their association with the E3 ubiquitin ligase *** the cellular level,msU inhibited the deubiquitinases A20 and UCHL2 and increased 20s proteasomal activity,leading to a global decrease in K^(63)-linked ubiquitination and increase in K^(48)-linked ubiquitination in THP-1 *** msU did not stimulate cytokine produaion in NLsFs,it significantly amplified IL-1β-induced IL-6,IL-8,and ENA-78/CXCL5 *** studies and mD simulations followed by TAK1 in vitro kinase assays revealed that uric acid molecules are capable of arresting TAK1 in an active-state conformation,resulting in sustained TAK1 kinase ***,msU-induced proinflammatory cytokine production was completely inhibited by 5Z-7-oxozeaenol but not IRAK1/4 or TRAF6 *** of 5Z-7-oxozeaenol(5 or 15 mg/kg;orally)significantly inhibited msU-induced paw inflammation in C57BL/6 *** study identifies a novel post-translational mechanism of TAK1 activation by msU and suggests the therapeutic potential of TAK1 in regulating msU-induced Inflammation.

关键词： monosodium urate crystals Gout TAK1 Ubiquitination 5Z-7-oxozeaenol

Comparison study of Two Commercial spectrometers for Heavy metal Analysis of Laser Induced Breakdown spectroscopy （LIBs）

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Photonic sensors 2014年第1期4卷 63-69页

作者： m.Arab N.Bidin Z.H.rizvi s.safie m.A.Alsaedi Advance Photonics science Institute Faculty of ScienceUniversiti Teknologi Malaysia81310Johor BahruJohorMalaysia

The purpose of this paper is to compare the performance of two spectrometers that are manufactured from the same company. In this work, heavy metals like lead Pb and copper Cu in the KBr matrix were analyzed using the laser induced breakdown spectroscopic technique. A Q-switched Nd：YAG laser with 90mJ per pulse operating at the fundamental wavelength of 1064nm and pulse duration of 10 ns was used to generate plasma at the focal region. The important experimental parameters such as the laser energy, integration time, distance between the lens and sample, distance and angle of the optical fiber from the target were optimized. Two spectrometers manufactured by Ocean Optics namely as maya2000Pro and UsB 4000 were employed for anlyzing the spectral lines. The experimental setup and conditions were remained the same for both experiments. The production of spectral lines from each of the interested elements was analyzed and compared with the NIsT （National Institute of standards and Technology） database. The sensitivity, repeatability and limit of detection for each of the systems are discussed in detail.

关键词： Heavy metal spectrometer LIBs LOD

Oviposition preference and larval performance of Epiphyas postvittana （Lepidoptera： Tortricidae） on Botrytis cinerea （Helotiales： sclerotiniaceae） infected berries of Vitis vinifera （Vitales： Vitaceae）

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Insect science 2016年第2期23卷 313-325页

作者： syed Z. m. rizvi Anantanarayanan Raman Warwick m. Wheatley Geoffrey Cook school of Agricultural & Wine sciences Graham Centre forAgricultural Innovation Charles Sturt University Orange NSW 2800 Austrafia

In this paper we tested the behavior of gravid Epiphyas postvittana in select- ing the most-appropriate site for oviposition thus benefitting offspring performance. Our hypothesis was built on Jaenike＇s preference-performance hypothesis （also referred to as the ＂mother-knows-the-best＂ hypothesis）. To test this, we used the interacting Epiphyas postvittana, its host Vitis vinifera, and the pathogenic microbe Botrytis cinerea system. Populations ofE. postvittana and B. cinerea often exist concurrently on 14. vinifera in Aus- tralasia and their interaction and mutual influence are currently being explored, although the suggestion presently is that the relationship between E. postvittana and B. cinerea is mutualistic. We tested the effect of volatiles from B. cinerea-infected berries and unin- fected （control） berries of V. vinifera on the oviposition behavior of E. postvittana. We also characterized the effects of B. cinerea infection on the berries of V. vinifera on the growth and development of E. postvittana. Contrary to the preference-performance hy- pothesis, oviposition choices made by gravid E. postvittana did not result in the best offspring survival, development, and performance. The preference for oviposition by E. postvittana was strongly influenced by the olfactory and tactile cues. she laid fewer eggs on B. cinerea-infected berries compared to uninfected berries of V. vinifera. The larvae of E. postvittana showed no preference to uninfected berries of V. vinifera. The larvae fed on B. cinerea-infected berries of V. vinifera showing greater survival rate, shorter time to pupation, greater pupal mass, and on becoming adults they laid more numbers of eggs than the larvae that were enabled to feed on uninfected berries. The larvae of E. postvittana transport the conidia of B. cinerea and transmit grey-mould disease to uninfected berries of V. vinifera.

关键词： larval development life-history performance light-brown apple moth ovipo-sition preference preference-performance hypothesis grapevine

Neurocysticercosis:A case report and brief review

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Asian Pacific Journal of Tropical medicine 2016年第1期9卷 98-100页

作者： syed A.A.rizvi Ayman m.saleh Hanns Frimpong Hussain m.Al mohiy Jasmin Ahmed Ronda D.Edwards sultan s.Ahmed College of Pharmacy Nora Southeastern University JAs medical management LLC Department of Basic medical sciences College of MedicineKing Saud Bin Abdulaziz University for Health SciencesNational Guard Health Affairs Radiological sciences Department College of Applied Medical SciencesKing Khalid University Herbert Wertheim College of medicine Florida International University school of medicine Spartan Health Science University

Neurocysticercosis(NCC) is one of the seven neglected endemic zoonoses targeted by the World Health *** is considered a common infection of the nervous system caused by the Tanenia solium and is known to be the primary cause of preventable epilepsy in many developing *** is commonly resulted by the ingestion of Tanenia solium eggs after consuming undercooked pork,or contaminated *** parasite can grow in the brain and spinal cord within the nervous system,causing severe headache and seizures beside other pathological *** and international travel to endemic countries has made this disease common in the United *** can be diagnosed with computed tomography and magnetic resonance imaging of the *** treatment of the NCC including cysticidal drugs(eg.,albendazole and praziquantel),and neurosurgical procedure,depending upon a the situation.A patient of Asian origin came to our clinic with complaints of dizziness,headaches and episodes seizures for the past twelve years without proper *** computed tomography and magnetic resonance imaging scans indicated multilobulated cystic mass in the brain with the suspicion of neurocysticercosis.

关键词： Neurocysticercosis Tanenia solium Epilepsy magnetic resonance imaging Computed Tomography

Do We Really Need to Adopt Electronic Banking?

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Do We Really Need to Adopt Electronic Banking?

mechanism of Infrared Detection and Transduction by Beetle melanophila Acuminata In memory of Jerry Wolken

International Conference on machine Learning and Computing（ICmLC 2009）

作者： Zaid Al-Baghdadi s.A.m.rizvi Halima sadia rizvi Dept. of Computer sc. J.M.I.New DelhiIndia Dept. of Economics J.M.I.New DelhiIndia

Today at the beginning of the third millennium with the huge information technology revolution in all life sectors and the banking sector is one of it,many of the banks in world adopted e-banking and convert them ordinary banking services to e-banking services and this growing in e-banking services mostly came from e-commerce growing which it is value estimated in hundreds billions of dollars and all this huge business needs a strong infrastructure of e-banking to manage all the money transactions and support e-commerce so the question is " Do We Really Need to Adopt Electronic Banking?,"in this paper we are trying to answer this question and highlight some of important points of it.

关键词： Internet Banking Electronic Banking Banking Technology

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Journal of Bionic Engineering 2011年第2期8卷 129-139页

作者： meir Israelowitz Jeong-Ah Kwon syed W. H. rizvi Christoph Gille Herb P. von schroeder Biomimetics Technologies Inc. 191 Ellis Avenue Toronto Ontario M6S 2X4 Canada Hillman Cancer Center Research Pavilion Floor 2 2.35 5117 Centre Avenue Pittsburgh PA 15213 USA Institute of Biochemistry CharitO Universiaitsmedizin Monbijourstr. 2 10117 Berlin Germany University of Toronto 399 Bathurst Street 2E Tolvnto ON M5T2SS Canada

The melanophila acuminata beetle is attracted to forest fires via a pair of infrared sensory organs composed of sensilla. Our histological work showed that each sensillum contains lipid layers surrounding a protein layer and a unique polysaccharide base that is associated with a neuron to each sensillum. Infrared microscopy showed that the protein region maximally absorbs infrared radiation at 3 ~tm wavelength and at 10 ~tm, which corresponds to the known radiation produced by forest fires at 3 ~tm. mathematical calculations showed that the physical properties of the sensilla are such that the expected temperature rise is insufficient for transduction of the infrared signal through mechanical means or as a thermal receptor as previously thought; hence the protein plays the pivotal role in perception of single photons and transmission of the signal within the sensilla.

关键词： sensory organs sensillum insect radiation fire

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAs detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht s.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.s. Acharya C. Adam Bourdarios L. Adamczyk s.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.s. Ahmed s. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy s. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali s. Ali s.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei s.P. Amor Dos santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders s.Y. Andrean A. Andreazza s. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal s.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin s. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai s. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos s. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten s. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay s. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-s. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAs Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAs Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAs *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAs JET QUARK GLUON TAGGING

Transitioning patients with inflammatory bowel disease from hospital-based to rapid home-based infliximab: A stepwise, safety and patient-orientated process towards sustainability

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World Journal of Gastroenterology 2020年第36期26卷 5437-5449页

作者： Anuj Bohra Qurat-Al-Ain rizvi Charlotte Yuen Yu Keung Abhinav Vasudevan Daniel R van Langenberg Department of Gastroenterology Eastern HealthBox Hill 3128VictoriaAustralia Eastern Health Clinical school Monash UniversityBox Hill 3128VictoriaAustralia

BACKGROUND Infliximab and other intravenous biologic infusions are increasingly used for chronic disorders like inflammatory bowel disease(IBD).Rapid infliximab and home-based infusions are attractive solutions to address resource and capacity issues for infusion centres,yet infliximab infusion reactions reportedly occur in up to 25%of patients with IBD,even at the manufacturers’recommended infusion duration of 2 *** To evaluate the safety,cost and patient satisfaction of transitioning from hospitalbased,standard 2 h to rapid home-based,30-min infliximab *** All patients receiving rapid infliximab infusions for IBD between 2014 to 2017(39 mo)were compared with those who received standard two-hour IFX infusions between 2005-2013(96 mo)at a single IBD ***(per-infusion and perindividual)including adverse drug reactions(ADR),duration(based on needledeparture time)and other clinical data were extracted from electronic medical *** logistical regression analysis assessed factors potentially associated with increased risk of ADRs to rapid *** primary outcome was the safety[as per relative risk(RR)of (ADR)of(1)rapid 30 m infusions(both hospital-and home-based)vs standard 2 h infliximab ***,relative cost per infusion and patient satisfaction and productivity were evaluated in rapid infusion recipients who transitioned to home-based *** Of 129 patients who received 1461 rapid IFX infusions(2014-2017)were compared with 169 patients who received 2214 standard IFX infusions(2005-2013).Within the rapid cohort,55(42.6%)were males,median age 42 years(range 18,86),114(84%)had Crohn’s disease(CD)with a median disease duration 5 years(0,36).median needle to departure time was higher in the standard than the rapid protocol group,108(70,253)vs 50(33,90)min,(Psion cost of$AUD 107.50 vs$49.77,respectively(both Ps no difference in median infusion duration or costs between rapi

关键词： Inflammatory bowel disease Infliximab safety Cost Therapy Drug reaction