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Artificial intelligence analysis of videos to augment clinical assessment:an overview

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Neural Regeneration Research 2024年第4期19卷 717-718页

作者： David c.Wong stefan Williams University of Leeds Leeds Teaching Hospitals Trust LeedsUK

Observation is a fundamental part of the practice of clinical *** of movement is particularly important for the *** such as Parkinson’s disease,multiple sclerosis,stroke,epilepsy,and many others affect a person’s movement in characteristic *** some conditions,changes in the patient’s voice can be included in this-changes in sound caused by changes in the movements of *** clinician’s detection of a characteristic abnormality,and their judgment of its severity,plays a central role in both diagnosis and the assessment of prognosis or response to ***,that practice depends upon a limited resource of experienced *** addition,these experts are limited by human visual judgment,which cannot reliably or precisely detect and measure small or subtle changes in movement(Williams et al.,2023).

关键词： clinical epilepsy diagnosis

Apoer2/Lrp8:the undercover cop of synaptic homeostasis

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Neural Regeneration Research 2024年第12期19卷 2563-2564页

作者： Gordon c.Werthmann Joachim Herz Department of Molecular Genetics and center for Translational Neurodegeneration Research University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Neuroscience Department of Neurology University of Texas southwestern Medical center at Dallas DallasTXUSA

Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric *** this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.

关键词： homeostasis ApoE Alzheimer

There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of sport and Health science 2024年第4期13卷 521-536页

作者： Helder s.Lopes Marina c.Waiteman Liliam B.Priore Neal R.Glaviano David M.Bazett-Jones Ronaldo V.Briani Fabio M.Azevedo school of science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA school of Exercise and Rehabilitation sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,cINAHL,sPORTDiscus,and Web of science)were searched from inception to september *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(sMD)=-0.76,95%confidence interval(95%cI):-1.32 to-0.21)and concentric contractions(sMD=-0.97,95%cI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(sMD=-0.48,95%cI:-0.82 to-0.14),concentric(sMD=-1.07,95%cI:-2.08 to-0.06),and eccentric contractions(sMD=-0.59,95%cI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(sMD=-0.76,95%cI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

Nonaqueous potassium-ion full-cells:Mapping the progress and identifying missing puzzle pieces

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Journal of Energy chemistry 2024年第6期93卷 384-399,I0010页

作者： Badre Larhrib Louiza Larbi Lénaïc Madec Universite de Pau et des Pays de l’Adour E2S UPPACNRSIPREMPauFrance Universitéde Haute-Alsace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde strasbourg F-67081 StrasbourgFrance Réseau sur le stockage Electrochimique de l’Energie CNRS FR3459AmiensFrance Institut des Matériaux Jean Rouxel(IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This review addresses the growing interest for potassium-ion full-cells(KIFcs)in view of the transition from potassium-ion half-cells(KIHcs)toward commercial K-ion batteries(KIBs).It focuses on the key parameters of KIFcs such as the electrode/electrolyte interfaces challenge,major barriers,and recent advancements in *** strategies for enhancing KIFc performance,including interfaces co ntrol,electrolyte optimization,electrodes capacity ratio,electrode material screening and electrode design,are *** review highlights the need to evaluate KIBs in full-cell configurations as half-cell results are strongly impacted by the K metal *** also emphasizes the importance of understanding solid electrolyte interphase(sEI)formation in KIFcs and explores promising nonaqueous as well as quasiand all-solid-state electrolytes *** review thus paves the way for practical,cost-effective,and scalable KIBs as energy storage systems by offering insights and guidance for future research.

关键词： K-ion full-cells Potassium-ion batteries cross-talk solid-state batteries Potassium reactivity Electrolyte design Electrode design

Quantitative and qualitative subgenomic RNA profiles of sARs-coV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOc-D614G

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Virologica sinica 2024年第2期39卷 218-227页

作者： Zigui chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes s.Y.Leung chit chow siaw shi Boon Wendy c.s.Ho Maggie Haitian Wang Renee Wan Yi chan Albert Martin Li David shu cheong Hui Paul Kay sheung chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey club school of Public Health and Primary care Faculty of MedicineThe Chinese University of Hong KongHong KongChina stanley Ho centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The sARs-coV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOc)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOcD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUc¼0.91,95%cI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： coronavirus sARs-coV-2 Omicron BA.2 Non-VOc-D614G RNA-seq subgenomic RNA(sgRNA)

Isochrone Fitting of Galactic Globular clusters—Ⅵ.High-latitude clusters NGc 5024 (M53),NGc 5053,NGc 5272 (M3),NGc 5466,and NGc7099 (M30)

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Research in Astronomy and Astrophysics 2024年第6期24卷 170-190页

作者： G.A.Gontcharov s.s.savchenko A.A.Marchuk c.J.Bonatto O.s.Ryutina M.Yu.Khovritchev V.B.Il'in A.V.Mosenkov D.M.Poliakov A.A.smirnov central(Pulkovo)Astronomical Observatory Russian Academy of SciencesPulkovskoye chaussee 65/1St.Petersburg 196140Russia saint Petersburg state University Universitetskij pr.28St.Petersburg 198504Russia special Astrophysical Observatory Russian Academy of Sciences369167 Nizhnij ArkhyzRussia Departamento de Astronomia Instituto de FísicaUFRGSAv.Bento Gonçalves9500Porto AlegreRSBrazil saint Petersburg University of Aerospace Instrumentation Bol.Morskaya ul.67ASt.Petersburg 190000Russia Department of Physics and Astronomy Brigham Young UniversityN283 ESCProvoUT 84602USA

We fit various color–magnitude diagrams(cMDs) of the high-latitude Galactic globular clusters NGc 5024(M53),NGc 5053,NGc 5272(M3),NGc 5466,and NGc 7099(M30) by isochrones from the Dartmouth stellar Evolution Database and Bag of stellar Tracks and Isochrones for α–enrichment [α/Fe] = +*** the cMDs,we use data sets from Hubble space Telescope,Gaia,and other sources utilizing,at least,25 photometric filters for each *** obtain the following characteristics with their statistical uncertainties for NGc 5024,NGc 5053,NGc 5272,NGc 5466,and NGc 7099,respectively:metallicities [Fe/H] =-1.93 ± 0.02,-2.08 ± 0.03,-1.60 ± 0.02,-1.95 ± 0.02,and-2.07 ± 0.04 dex with their systematic uncertainty 0.1 dex;ages 13.00 ± 0.11,12.70 ± 0.11,11.63 ± 0.07,12.15 ± 0.11,and 12.80 ± 0.17 Gyr with their systematic uncertainty 0.8 Gyr;distances(systematic uncertainty added) 18.22 ± 0.06 ± 0.60,16.99 ± 0.06 ± 0.56,10.08 ± 0.04 ± 0.33,15.59 ±0.03 ± 0.51,and 8.29 ± 0.03 ± 0.27 kpc;reddenings E(B-V) = 0.023 ± 0.004,0.017 ± 0.004,0.023 ± 0.004,0.023 ± 0.003,and 0.045 ± 0.002 mag with their systematic uncertainty 0.01 mag;extinctions AV= 0.08 ± 0.01,0.06 ± 0.01,0.08 ± 0.01,0.08 ± 0.01,and 0.16 ± 0.01 mag with their systematic uncertainty 0.03 mag,which suggest the total Galactic extinction AV= 0.08 across the whole Galactic dust to extragalactic objects at the North Galactic *** horizontal branch morphology difference of these clusters is explained by their different metallicity,age,mass-loss efficiency,and loss of low-mass members in the evolution of the core-collapse cluster NGc 7099 and loose clusters NGc 5053 and NGc 5466.

关键词： (stars:)Hertzsprung Russell and c-M diagrams (IsM:)dust extinction (Galaxy:)globular clusters:general (Galaxy:)globular clusters:individual(NGc 5024,NGc 5053,NGc 5272,NGc 5466,NGc7099)

Decomposition solutions and Bäcklund transformations of the B-type and c-type Kadomtsev-Petviashvili equations

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communications in Theoretical Physics 2024年第6期76卷 34-44页

作者： Xiazhi Hao s Y Lou college of science Zhejiang University of TechnologyHangzhou 310014China school of Physical science and Technology Ningbo UniversityNingbo 315211China

This paper introduces a modified formal variable separation approach,showcasing a systematic and notably straightforward methodology for analyzing the B-type Kadomtsev-Petviashvili(BKP)*** the application of this approach,we successfully ascertain decomposition solutions,Bäcklund transformations,the Lax pair,and the linear superposition solution associated with the aforementioned ***,we expand the utilization of this technique to the c-type Kadomtsev-Petviashvili(cKP)equation,leading to the derivation of decomposition solutions,Bäcklund transformations,and the Lax pair specific to this *** results obtained not only underscore the efficacy of the proposed approach,but also highlight its potential in offering a profound comprehension of integrable behaviors in nonlinear ***,this approach demonstrates an efficient framework for establishing interrelations between diverse systems.

关键词： decomposition solution Backlund transformation Lax pair linear superposition solution

combined Effect of Outdoor Time and Other Modifiable Factors on Myopia Incidence Among children and Adolescents—9 PLADs,china,2020

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china cDc weekly 2024年第9期6卷 151-156,I0001,I0002页

作者： Panliang Zhong Yunfei Liu Ning Ma Jiajia Dang Di shi shan cai Ziyue chen Yanhui Dong Peijin Hu Jun Ma Patrick W.c Lau Randall s.stafford Yi song Institute of child and Adolescent Health School of Public HealthPeking UniversityNational Health Commission Key Laboratory of Reproductive HealthBeijingChina Department of sport Physical Education&HealthHong Kong Baptist UniversityKowloon TongHong Kong Special Administrative RegionChina Department of Medicine Stanford Prevention Research CenterStanford University School of MedicineStanfordCAUnited States

summary What is already known about this topic?Myopia has been identified as a significant emerging challenge and policy priority among children and adolescents in china by the Ministry of Education and seven other *** research has been conducted to investigate the collective impact of outdoor time and other modifiable factors on the incidence of myopia.

关键词： Incidence collective policy

IgE-Mast cell mediated allergy: a sensor of food quality

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signal Transduction and Targeted Therapy 2024年第1期9卷 8-9页

作者： christopher c.Udoye Rudolf A.Manz Institute for systemic Inflammation Research University of LübeckLübeckGermany

In two recent studies published in Nature,Florsheim et *** Plum et *** that allergic-specific reactions induced by immunoglobulin(Ig)E mediated mast cell activation is crucial for the timely induction of antigen-avoidance behaviour.1,2 These studies prove the concept that allergic sensitization triggers the formation of avoidance behaviour and define the underlying molecular mechanism.

关键词： allergic mechanism