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Impact of sex on the outcomes of deceased donor liver transplantation

World Journal of Transplantation 2024年第1期14卷 120-129页

作者： Oya M Andacoglu Isabel s Dennahy Nicole c Mountz Luisa Wilschrey Arzu Oezcelik Division of Transplantation and Advanced Hepatobiliary surgery University of UtahSalt Lake CityUT 84112United States Department of surgery University of EssenEssen D-45122Germany Department of surgery The University of Oklahoma Health Sciences CenterOklahoma CityOK 73117United States Department of surgery University of Oklahoma College of MedicineOklahoma CityOK 73117United States

BAcKGROUND Data examining the impact of sex on liver transplant(LT)outcomes are *** is clear that further research into sex-related differences in transplant patients is necessary to identify areas for *** of these differences may help to identify specific areas of focus to improve on the organ matching process,as well as the peri-and post-operative care of these *** To utilize data from a high-volume Eurotransplant center to compare characteristics of male and female patients undergoing liver transplant and assess association between sex-specific variables with short-and long-term post-transplant *** A retrospective review of the University of Essen’s transplant database was performed with collection of baseline patient characteristics,transplant-related data,and short-term *** of these data were made with shapiro-Wilk,Mann-Whitney U,χ2 and Bonferroni tests applied where appropriate.A P value ofs accepted as statistically *** Of the total 779 LT recipients,261(33.5%)were *** patients suffered higher incidences of acute liver failure and lower incidences of alcohol-related or viremic liver disease(P=0.001).Female patients were more likely to have received an organ from a female donor with a higher donor risk index score,and as a high urgency offer(all Pseline characteristics of male and female recipients were also significantly *** multivariate hazard regression analysis,recipient lab-Model for End-stage Liver Disease score and donor cause of death were associated with long-term outcomes in ***-operative diagnosis of hepatocellular carcinoma,age at time of listing,duration of surgery,and units transfused during surgery,were associated with long-term outcomes in *** of complications was associated with long-term outcomes in both *** survival was similar in both males and females;however,when stratified by age,females<50 y

关键词： Liver transplant Outcomes survival Peri-and post-operative care

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superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime s.Rosa Duque samuel M.s.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.Tsang sara chaothai Tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam sau Man chan Wilfred H.s.Wong Issan Y.s.Tam Masashi Mori sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina school of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(sARs-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** spike protein(s)immunoglobulin G(IgG),s-receptor-binding domain(RBD)IgG,s IgG Fcγreceptor IIIa(FcγRIIIa)-binding,sNM[sum of individual(s),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),sNM-specific IL-2^(+)cD8^(+),s-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,s-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,s IgG avidity,s IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated sARscoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

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Paleo-Mesoarchean sedimentary record in the Dharwar craton,India:Implications for Archean ocean oxygenation

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Geoscience Frontiers 2024年第1期15卷 126-154页

作者： G.Harshitha c.Manikyamba M.santosh cheng-Xue Yang A.Keshav Krishna V.V.sesha sai I.Panduranga reddy csIR-National Geophysical Research Institute(NGRI) Uppal RoadHyderabad 500007India Department of Geology Osmania UniversityHyderabad 500007India school of Earth science and Resources China University of GeosciencesBeijing 100083China Department of Earth science University of AdelaideAdelaide SA5005Australia Yonsei Frontier Lab Yonsei UniversitySeoul 03722Republic of Korea Geological survey of India State UnitNagpurIndia

The early Archean oceans were marked by significant redox changes which have subsequently shaped the Earth’s *** chemical sediments of banded Iron and Manganese formations provide important geochemical proxies for these historical shifts in the redox conditions and to trace the ancient sedimentation patterns and *** this study,we investigate the proto-ore of the Archean Mn-formations of the sandur,chitradurga and shimoga greenstone belts of Dharwar craton of southern Peninsular India,which is geochemically characterised as quartz arenites,Mn-arenites,Fe-arenites,Mn-argillites and *** geochemical systematics suggest their deposition in shallow to deeper shelf in the Archean *** detrital zircon U-Pb systematics of Mn arenites and argillites indicate their maximum depositional age of 3230±52 Ma representing the oldest onset of sedimentation during the Paleo-Mesoarchean timeframe in the chitradurga Group of Dharwar *** detrital influx proxies suggest variations in sedimentation rates associated with the Archean transgressive-regressive cycles and fluctuating hydrodynamic conditions,together reflecting an increasing trend in the contributions of recycled sediment from sandur to chitradurga and shimoga greenstone *** available detrital zircon ages of the Mn arenites and argillites from these greenstone belts indicate a~600 Ma prolonged period of Mn deposition for which high-T hydrothermal fluids from Archean mid-oceanic ridges supplied the *** trace element compositions of the concordant detrital zircons suggest 3.3-3.1 Ga Dharwar basement TTG/granitoid source which is corroborated by the zircon crystallization temperatures of 690-820℃.The source-normalisedα-dose rates of the detrital zircons signify greater degrees of sediment transport and multi-cycle nature which correspond to the earliest episode of crustal growth in the Indian sub-continent associated with the Mesoarchean Ur supercontinent.T

关键词： Mn-arenites-argillites Dharwar craton Zircon U-Pb geochronology Passive margin sediments Ocean oxygenation

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Assessment of cO_(2)storage prospect based on physical properties of Rio Bonito Formation rock units

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Energy Geoscience 2024年第1期5卷 321-330页

作者： Richardson M.Abraham-A stephanie san Martín cañas Isabella F.s.Miranda colombo c.G.Tassinari Institute of Energy and Environment(IEE) University of São Paulo(USP)Brazil Research centre for Greenhouse Gas Innovation(RcGI) University of Sãao Paulo(USP)Brazil

The physical properties of the rock units associated with the Rio Bonito Formation are presented in this study with the focus on modelling reservoir quality based on petrophysics-derived parameters to evaluate cO_(2)storage *** involves the modelling of the reservoir depths,thicknesses,flow zone indicators(FZI),and effective permeability(Keff)and presenting the cO_(2)storage efficiency factors peculiar to the rock units of the study *** results presented by this study for the stated objectives are not quite common in the *** values range from 200 mD to higher than 2000 mD,and FZI values are generally above 1.0 mm and up to 13.0 mm within the portions covered by the drilled *** sandstone units recorded are up to 20 m thick in some *** Keff and FZI models indicate the sandstone reservoirs as permeable units to support the injection and circulation of cO_(2)within the potential reservoir units of the Rio Bonio Formation across são Paulo *** from some points in the southeastern part of the study location,where the Rio Bonito are delineated at depths less than 800 m(minimum cO_(2)storage depth based on best practices),other portions are deeper,ranging from 950 m to 3500 ***-bedded layers will affect the integrity of the rocks as cO_(2)storage tanks or reservoir seals/traps/overburden within the *** bed thicknesses are up to 20 m in some ***,hybrid cO_(2)reservoir units are feasible,especially in portions where thin siltstone layers are sandwiched between sandstone units to provide considerable thicknesses based on cO_(2)storage *** current study shows that useable areas considering reservoir thickness,depth,and other physical qualities will significantly control the cO_(2)storage efficiency of the study *** studies featuring a detailed geophysical exploration of the site to confirm the availability and saturations of preexisting fluid(hydrocarbon and water)are encouraged

关键词： Rio Bonito Effective permeability Fluid transmissibility cO_(2)storage prospect Reservoir quality Overburden integrity Flow zones

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伴有增殖型糖尿病视网膜病变的1型糖尿病孕妇的不良结局(英文)

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国际眼科杂志 2011年第9期11卷 1504-1507页

作者： c c T Helen I Tajunisah s c reddy 马来亚大学医学院眼科马来西亚吉兰丹国际医药大学临床医学院眼科马来西亚森美兰

目的:报道伴有增殖型糖尿病视网膜病变的糖尿病孕妇,在给予适当的治疗与随访后,产妇和胎儿的不良结局。方法:对患有 1 型糖尿病及增殖型糖尿病视网膜病变的四位年轻的糖尿病孕妇( 年龄 20 ～25 岁) ,进行随访观察。结果:孕妇的不良后果:... 详细信息

目的:报道伴有增殖型糖尿病视网膜病变的糖尿病孕妇,在给予适当的治疗与随访后,产妇和胎儿的不良结局。方法:对患有 1 型糖尿病及增殖型糖尿病视网膜病变的四位年轻的糖尿病孕妇( 年龄 20 ～25 岁) ,进行随访观察。结果:孕妇的不良后果: 流产 1 例,先兆子痫及早产 1 例,肾功能衰竭需要透析 1 例; 胎儿的不良后果: 新生儿死亡1 例,早产婴儿 1 例。结论:对于糖尿病孕妇出现增殖型视网膜病变时,妇产科医生应该给予紧密的随访。对于患有糖尿病的妇女,在其妊娠期间的产前检查与随访中,增殖型糖尿病视网膜病变应当作为疾病的评估之一。

关键词：妊娠 1型糖尿病增殖型糖尿病视网膜病变玻璃体积血

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synthesis of coral-like structures of Pr-Yb co-doped YIG: structural,optical, magnetic and antimicrobial properties

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Journal of Rare Earths 2024年第3期42卷 543-554,I0004页

作者： A.Fernandez Francisca P.Araujo Y.Guerra s.castro-Lopes J.Matilla-Arias Idglan s.de Lima Edson c.silva-Filho Josy A.Osajima F.Guerrero R.Pena-Garcia Federal University of Piau Graduate Program in Materials Science and EngineeringTeresinaPIBrazil Federal Rural University of Pernambuco Academic Unit of Cabo de Santo AgostinhoCabo de Santo AgostinhoPEBrazil Federal University of Piaui Department of PhysicTeresinaPBrazil Federal University of Pernambuco Graduate Program in Materials ScienceRecifePEBrazil University of Granma Departmentof Basic Sciences and Applied InformaticsFaculty of Technical SciencesBayamoCuba Federal University of Amazonas Department of PhysicManausAMBrazil Federal University of Pernambuco Department of PhysicRecifePEBrazil

coral-like structures of the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y ≤ 0.02) compound were synthesized using the sol-gel method. structural investigation certified the YIG cubic crystal structure formation, without any secondary phase. It is shown that, the relatively large ionic radius of the dopant cations results in an expansion of the lattice parameter, variations in the Iona-O-Iondangle, Iona-O,Iond-O and Ionc-O bond distances and decrease in the average crystallite size. Fourier transform infrared(FTIR) and Raman measurements are essential to testify the single-phase formation of YIG crystal structure and are observed changes in the stretching and vibrational modes, respectively. The morphological study, energy dispersive spectroscopy(EDs) spectra and textural properties show corallike structures, peaks associated with Pr^(3+) and Yb^(3+) atoms and the effect of dopants on surface area,diameter, and pore volume, respectively. The optical analysis from diffuse reflectance spectra witnessed an increase in the optical gap band, a decrease in Urbach energy and blue shift in the charge transfer,correlated with the expansion of the unit cell due to the dopant's insertion in the YIG structure. A typical ferrimagnetic behavior is exhibited by the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12)compound. The saturation magnetization(M_(s)), cubic anisotropy constant(K_(1)) and coercive field(H_(c)) increase with the Pr^(3+)cations content, as consequence of their magnetic nature and distribution around of Fe^(3+)ions due to the coexistence with the Yb^(3+). Finally, for the first time, antibacterial tests by mean of the direct contact method were performed for YIG co-doped with Pr^(3+)and Yb^(3+)and it is shown that, relatively high dosages of Pr^(3+) cations favored the activity against s. aureus, therefore, a new biological property for YIG doped with rare earths is presented.

关键词： Yttrium iron garnet(YIG) coral-like structures Rare earths Band gap energy Magnetic properties Antimicrobial properties

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Reversed-Phase-HPLc Assay Method for simultaneous Estimation of sorbitol, sodium Lactate, and sodium chlorides in Pharmaceutical Formulations and Drug solution for Infusion

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American Journal of Analytical chemistry 2024年第2期15卷 57-71页

作者： sreenivas Pippalla Venugopal Komreddy srinivasulu Kasa Vaishnavi chintala Poluri Venkata reddy Department of chemistry Sikkim Professional University Gangtok India Analytical Research & Development Hikma Pharmaceuticals USA Inc. Bedford USA Department of chemistry Osmania University Hyderabad India Analytical Research & Development Cambrex High Point High Point USA Department of Analytical chemistry Annamalai University Annamalai Nagar India

A rapid, straightforward, sensitive, efficient, and cost-effective reverse-phase high-performance liquid chromatographic method was employed for the simultaneous determination of sorbitol, sodium Lactate, and chlorides in a drug solution for infusion. sorbitol, sodium lactate, and chloride are all officially recognized in the UsP monograph. Assay methods are provided through various techniques, with titrations being ineffective for trace-level quantification. Alternatively, Ic, AAs, and IcP-Ms, though highly accurate, are costly and often unavailable to most testing facilities. When considering methods, it’s important to prioritize both quality control requirements and user-friendly techniques. A simple HPLc simultaneous method was developed for the quantification of chlorides, sorbitol, and sodium Lactate with a shorter run time. The separation utilized a shimpack scR-102(H) ion exclusion analytical column (7.9 mm × 300 mm, 7 μm), with a flow rate of 0.6 mL per min. The column compartment temperature was maintained at 40°c, and the injection volume was set at 10 μL, with detection at 200 nm. All measurements were conducted in a 0.1% solution of phosphoric acid. The analytical curves demonstrated linearity (r > 0.9999) in the concentration range of 0.79 to 3.8 mg per mL for sodium Lactate (sL), 0.16 to 0.79 mg per mL for sodium chloride (sc), and 1.5 to 7.2 mg per mL for sorbitol. Validation of the developed method followed the guidelines of the International conference on Harmonization (IcH Q2B) and UsP. The method exhibited precision, robustness, accuracy, and selectivity. In accelerated stability testing over 6 months, no significant variations were observed in organoleptic analysis and pH. consequently, the developed method is deemed suitable for routine quality control analyses, enabling the simultaneous determination of sodium Lactate, sodium chloride, and sorbitol in pharmaceutical formulations and infusions.

关键词： sorbitol sodium Lactate and chloride Assay Analytical Validation HPLc

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A global analysis of the introduction pathways and characteristics associated with non-native fish species introduction, establishment, and impacts

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Ecological Processes 2024年第2期 16-31页

作者： camille Bernery céline Bellard Franck courchamp sébastien Brosse Boris Leroy cNRs Agro Paris Tech Ecologie Systématique Evolution Université Paris-Saclay Unité Biologie des Organismes et Ecosystèmes Aquatiques (BOREA UMR 8067) Muséum National d’Histoire Naturelle Sorbonne Universités Université de Caen Normandie Université des Antilles CNRS IRD Laboratoire évolution & Diversité Biologique (EDB UMR5174) Université Paul Sabatier-Toulouse 3 CNRS IRD UPS

Background The invasion success of introduced freshwater fishes is influenced by many factors, including ecological, species, and socioeconomic characteristics. Most studies that document the importance of these characteristics are conducted at local scales and/or focus on a single step of the invasion process. In this study, we aim to determine the species characteristics, ecological characteristics, and socioeconomic characteristics of non-native freshwater fish invasions. Our assessment was done at the global scale and considers all three steps of the invasion(i.e., introduction, establishment, and impact). For this purpose, we applied generalized linear models to 20 variables collected for 307 non-native species and modeled them as a function of ecological characteristics(i.e., environmental features), species traits(i.e., functional and morphological), and socioeconomic characteristics(i.e., human use and introduction pathways). We considered the number of countries in which each species was introduced, established, or had ecological impacts as a proxy of invasion step success. We also explored the specifics of species introduced through the aquaculture and the ornamental fish trade *** We found that non-native freshwater fishes with broad diets, high parental care, and multiple introduction pathways are the most widely introduced and established worldwide. The number of countries with impacts reported was best explained by the type of introduction pathway(i.e., aquaculture or fisheries). Moreover, among non-native species introduced through aquaculture, those belonging to cypriniformes and having broad diets were the most widely introduced and established species. In contrast, the species introduced through the ornamental fish trade pathway belonged to various taxonomic orders but were mainly native to tropical *** considering several types of factors is important when analyzing the invasion success of freshwater fish and disentang

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comparison of trigeminal lateralization with differing stimulants

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World Journal of Otorhinolaryngology-Head and Neck surgery 2024年第1期10卷 66-69页

作者： Tiffany chen Nicolas s.Poupore Michael c.shih Thomas s.Edwards shaun A.Nguyen Zachary M.soler Rodney J.schlosser Department of Otolaryngology‐Head and Neck surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA

Trigeminal-specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory *** is unclear whether trigeminal sensitivity is similar across different transient receptor potential(TRP)receptors or if dysfunction of different receptors results in differing patient ***,a prospective cohort study was conducted,consisting of trigeminal lateralization testing with three different stimulants(eucalyptol,isothiocyanate,acetic acid),olfaction testing with sniffin'sticks,and measurement of various patient‐reported outcome measures(PROMs).A total of 50 participants were enrolled across the olfactory *** TDI score was 27.1±8.3(range 7.0–39.5)with 38%normosmic and 62%*** trigeminal lateralization scores out of 20 in the overall cohort were 16.18(2.78)for eucalyptol,14.94(3.49)for mustard oil,and 15.28(3.68)for *** showed a significant correlation with threshold scores of sniffin'sticks.A significant correlation was found between acetic acid and various *** of the lateralization scores of the trigeminal stimulants correlated to each other significantly and there was no correlation to *** lack of correlation suggests that the measured sensitivity of one type of TRP receptor may not translate to similar sensitivity of the other *** investigations with TRPV1 and TRPA1 agonists are needed to corroborate our findings.

关键词： chemosensory olfaction trigeminal TRP receptor

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Oncologic outcomes with and without amniotic membranes in robotic-assisted radical prostatectomy:A propensity score matched analysis

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Asian Journal of Urology 2024年第1期11卷 19-25页

作者： Jonathan Noël Daniel stirt Marcio covas Moschovas sunil reddy Abdel Rahman Jaber Marco sandri seetharam Bhat Travis Rogers subuhee Ahmed Anya Mascarenhas Ela Patel Vipul Patel Advent Health Global Robotics Institute CelebrationFLUSA University of central Florida college of Medicine OrlandoFLUSA Big and Open Data Innovation Laboratory University of BresciaItaly sUNY Upstate Medical University SyracuseNYUSA Kansas city University college of Medicine Kansas CityMOUSA Harvard University CambridgeMAUSA

Objective:Placement of human placenta derived grafts during robotic-assisted radical prostatectomy(RARP)hastens the return of continence and *** long-term impact on the oncologic outcomes remains to be *** objective was to determine the oncologic outcomes of patients with dehydrated human amnion chorion membrane(dHAcM)at RARP compared to a matched ***:In a referral centre,from August 2013 to October 2019,599 patients used dHAcM in bilateral nerve-sparing *** excluded patients with less than 12 months follow-up,simple prostatectomy,and unilateral *** with dHAcM(amnio group)were 529,and were propensity score matched 1:1 to 2465 patients without dHAcM(non-amnio group)and a minimum follow-up of 36 *** the time of RARP,dHAcM was placed around the neurovascular bundle in the amnio *** and categorical variables in matched groups was tested by two-sample Kolmogorov-smirnov test and Fisher's exact test *** measured were biochemical recurrence(BcR),adjuvant and salvage therapy ***:Propensity score matching resulted in two groups of 444 *** incidence functions for BcR did not show a difference between the groups(p=0.3).Patients in the non-amnio group required salvage therapy more frequently than the amnio group,particularly after partial nerve-sparing RARP(6.3%vs.2.3%,p=0.001).Limitations are the absence of prospective ***:The data suggest that using dHAcM does not have a negative impact on BcR in *** of cancer specific and overall survival will require follow-up study to increase our understanding of these grafts’impact on prostate cancer biology.

关键词： Prostatectomy Prostatecancer Robotic Oncology Outcome Allograft Biomaterial Dehydrated human amnionchorion membrane

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