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Health 2014年第18期6卷 2408-2415页

作者： sébastien champion Bernard A. Gaüzère David Vandroux Bruno J. Bouchet Didier Drouet Yannick Lefort Réanimation Polyvalente CHU de la Réunion H&ocirc pital Félix Guyon Saint Denis France

Objective: Prognostic analysis of 249 patients admitted for cardiogenic shock (Cs) of various origins. Background: Little is known about prognosis of Cs from non-ischemic cardiomyopathy. Methods: Retrospective monocentric study of patients referred to an ICU during 2 years. Results: Despite aggressive management including intra-aortic balloon pump (31%), extra-renal replacement therapy (36%), extra-corporeal life support (8%), and catecholamine infusion (97%), in-hospital mortality was 46%. Toxic Cs or Cs related to deficiency carried a better outcome (mortality 5%). Post-myocardial infarction or post-cardiac arrest Cs was associated with higher mortality. In the multivariate analyses, only sAPs II (OR 1.037;1.013 - 1.056;p = 0.0001), pulmonary hypertension (OR 4.8;1.3 - 17;p = 0.02), extra-renal replacement therapy (OR 2.9;1.3 - 6;p = 0.006), and dobutamine infusion (OR 0.44;0.2 - 0.96;p = 0.04) were significantly associated with in-hospital mortality. Conclusion: Dobutamine infusion was associated with a better outcome. Higher sAPs II, pulmonary hypertension, and extra-renal replacement therapy were associated with increased in-hospital mortality.

关键词： Cardiogenic shock Myocardial Infarction Catecholamine Pulmonary Hypertension Dobutamine Critically Ill

A New simulation of Track structure of Low-Energy Electrons in Liquid Water:Considering the Condensed-Phase Effect on Electron Elastic scattering

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Chinese Physics Letters 2016年第9期33卷 35-38页

作者：刘玮谭震宇 C.champion school of Electrical Engineering Shandong University Centre d 'Etudes Nucleaires de Bordeaux Gradignan Universite de Bordeaux

A new Monte Carlo simulation of the track structure of low-energy electrons （〈10keV） in liquid water is presented. The feature of the simulation is taken into consideration of the condensed-phase effect of liquid water on electron elastic scattering with the use of the champion model, while the dielectric response formalism incorporating the optical-data model developed by Emfietzoglou et al. is applied for calculating the electron inelastic scattering. The spatial distributions of energy deposition and inelastic scattering events of low-energy electrons with different primary energies in liquid water are calculated and compared with other theoretical evaluations. The present work shows that the condensed-phase effect of liquid water on electron elastic scattering may be of the influence on the fraction of absorbed energy and distribution of inelastic scattering events at lower primary energies, which also indicate potential effects on the DNA damage induced by low-energy electrons.

关键词： of as in A New simulation of Track structure of Low-Energy Electrons in Liquid Water:Considering the Condensed-Phase Effect on Electron Elastic scattering for CCPI on is

Positron Characteristics in Cadmium and Zinc Chalcogenides

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Communications in Theoretical Physics 2016年第5期65卷 617-621页

作者： N.Bouarissa Z.Rouabah C.champion Laboratory of Materials Physics and its Applications University of M’sila Laboratoire Materiaux et systemes Electroniques Universite de Bordj-Bou-Arreridj Universite de Bordeaux 1 CNRS/IN2P3 Centre d’Etudes Nucleaires de Bordeaux-Gradignan (CENBG)

Electron energy levels and positron states have been calculated for cadmium and zinc chalcogenide compounds within the pseudo-potential approach and the independent particle ***,the present contribution deals with the electron and positron chemical potentials allowing the calculation of the positron affinity to different materials of interest and hetero-structures formed by these ***,we here determine the positron diffusion constant by means of the positron deformation *** attempt has been made to scale positron affinity and diffusion constant with the lattice constant and the band gap energy,*** scaling is found to be not *** information gathered by the present study is of prime importance for a better understanding of positron trapping at interfaces and precipitates and should be useful in slow positron beam experiments.

关键词：硫族化合物电子特性慢正电子束晶格常数锌镉能级计算材料构成

Microstructural evolution of a recycled aluminum alloy deformed by equal channel angular pressing process

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International Journal of Minerals,Metallurgy and Materials 2012年第11期19卷 1016-1022页

作者： Thabet Makhlouf Atef Rebhi Jean-Philippe Couzinié Yannick champion Nabil Njah Applied Metallurgy Laboratory Faculty of SciencesUniversity of SfaxBP.1171 (3000) Sfax Institut de Chimie et des Matériaux Paris-Est (ICMPE) CNRS 2-8 rue Henri Dunant 94320 Thiais

The microstructural evolution of a recycled aluminum alloy after equal channel angular pressing （ECAP） up to four passes was investigated using X-ray diffxaction （XRD） analysis and transmission electron microscopy （TEM）. Microhardness tests were performed to determine the associated changes in mechanical properties. An ultrafine-grained material has been obtained with a microstructure showing a mixture of highly strained crystallites. A high density of dislocations was achieved as a result of severe plastic deformation （sPD） through the die. Changes in mechanical behavior are also revealed after ECAP due to strain hardening. Thermal analysis and TEM micrographs ob- tained after annealing indicate the succession of the recovery, recrystallization, and grain growth phenomena. Moreover, the energy stored during ECAP may be related to the dislocation density introduced by sPD. We finally emphasize the role played by the precipitates in this alloy.

关键词： aluminum alloys equal channel angular pressing (ECAP) microstructural evolution precipitates

Periodic interstellar scintillation variations of PsRs J0613-0200 and J0636+5128 associated with the Local Bubble shell

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中国科学:物理学、力学、天文学英文版 2023年第11期66卷 221-232页

作者： Yulan Liu Robert A.Main Joris P.W.Verbiest Ziwei Wu Krishnakumar M.Ambalappat Jiguang Lu David J.champion Ismael Cognard Lucas Guillemot Kuo Liu James W.Mc Kee Nataliya Porayko Golam.M.shaifullah Gilles Theureau National Astronomical Observatories Chinese Academy of SciencesBeijing100101China Fakultät für Physik Universität BielefeldBielefeld33501Germany Max-Planck-Institut für Radioastronomie Bonn53121Germany Florida space Institute University of Central FloridaOrlandoFL32826USA station de radioastronomie de Nançay Observatoire de ParisNançay18330France Laboratoire de Physique et Chimie de l’Environnement et de l’Espace Universitéd’OrléansOrléans45071France E.A.Milne Centre for Astrophysics University of HullHullHU67RXUK Centre of Excellence for Data science Artificial Intelligence and ModellingUniversity of HullHullHU67RXUK Dipartimento di Fisica“G.Occhialini” Universitàdi Milano-BicoccaMilano20126Italy INAF-Osservatorio Astronomico di Cagliari Selargius(CA)09047Italy INFN Sezione di Milano-BicoccaMilano20126Italy

Annual variations of interstellar scintillation can be modelled to constrain parameters of the ionized interstellar *** a pulsar is in a binary system,then investigating the orbital parameters is possible through analysis of the orbital variation of *** observations carried out from 2011 to 2020 by the European Pulsar Timing Array radio telescopes,PsRs J0613-0200and J0636+5128 show strong annual variations in their scintillation velocity,while the former additionally exhibits an orbital *** theory and Markov-chain-Monte-Carlo methods are used to interpret these periodic *** assume a thin and anisotropic scattering screen model,and discuss the mildly and extremely anisotropic scattering *** J0613-0200is best described by mildly anisotropic scattering,while PsR J0636+5128 exhibits extremely anisotropic *** measure the distance,velocity,and degree of anisotropy of the scattering screen for our two pulsars,finding that scattering screen distances from Earth for PsRs J0613-0200 and J0636+5128 are 316_(-20)^(+28)pc and 262_(-38)^(+96)pc,*** positions of these scattering screens are coincident with the shell of the Local Bubble towards both *** associations add to the growing evidence of the Local Bubble shell as a dominant region of scattering along many sightlines.

关键词： pulsar interstellar scintillation ionized interstellar medium

Impact of colorectal cancer screening participation in remote northern Canada:A retrospective cohort study

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World Journal of Gastroenterology 2020年第48期26卷 7652-7663页

作者： Heather A smith Andrew D scarffe Nicole Brunet Cait champion Kami Kandola Alisha Tessier Robin Boushey Craig Kuziemsky Department of surgery University of OttawaOttawa K1Y4E9OntarioCanada Telfer school of Management University of OttawaOttawa K1N6N5OntarioCanada Faculty of Medicine University of OttawaOttawa K1Y4E9OntarioCanada Department of surgery Northern Ontario School of MedicineSudbury P3E2C6OntarioCanada Department of Health and social services Government of the Northwest TerritoriesYellowknife X1A1P5Northwest TerritoriesCanada Department of surgery Stanton Territorial Health AuthorityYellowknife X1A0H1Northwest TerritoriesCanada Division of General surgery University of OttawaOttawa K1H 8L6OntarioCanada Office of Research services MacEwan UniversityEdmonton T5J4S2AlbertaCanada

BACKGROUND screening provides earlier colorectal cancer(CRC)detection and improves *** remains poorly understood if these benefits are realized with screening guidelines in remote northern populations of Canada where CRC rates are nearly twice the national average and access to colonoscopy is *** To evaluate the participation and impact of CRC screening guidelines in a remote northern *** This retrospective cohort study included residents of the Northwest Territories,a northern region of Canada,age 50-74 who underwent CRC screening by a fecal immunohistochemical test(FIT)between January 1,2014 to March 30,*** assess impact,individuals with a screen-detected CRC were compared to clinically-detected CRC cases for stage and location of CRC between *** assess participation,we conducted subgroup analyses of FIT positive individuals exploring the relationships between signs and symptoms of CRC at the time of screening,wait-times for colonoscopy,and screening *** sample Welch t-test was used for normally distributed continuous variables,Mann-Whitney-Wilcoxon Tests for data without normal distribution,and Chi-square goodness of fit test for categorical variables.A P value ofs considered to be statistically *** 6817 fecal tests were completed,meaning an annual average screening rate of 25.04%,843(12.37%)were positive,629 individuals underwent a follow-up colonoscopy,of which,24.48%had advanced neoplasia(AN),5.41%had *** were no significant differences in stage,pathology,or location between screen-detected cancers and clinically-detected *** assessing participation and screening outcomes,we observed 49.51%of individuals referred for colonoscopy after FIT were ineligible for CRC screening,most often due to signs and symptoms of *** were more likely to have AN if they had signs and symptoms of cancer at the time of screening,waited over 180 d for colonoscopy,or were indigenous[

关键词： Gastroenterology Rural health services Public health Colorectal neoplasms Early detection of cancer Northwest Territories

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig s Anderson sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C sandset Jeffrey L saver Angela shone Aloysius Niroshan siriwardena Joanna M Wardlaw Nikola sprigg Philip M Bath stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance service NHs Trust NottinghamUK stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK stroke Research in stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRs)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRs,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(sD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRs>2107(18%),Glasgow Coma scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** Is ALREADY KNOWN ON THIs TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction

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Asian Journal of Andrology 2008年第1期10卷 14-22页

作者： Travis D. strong Milena A. Gebska Arthur L. Bumett Hunter C. champion Trinity J. Bivalacqua The Brady Urological Institute Department of Urology Johns Hopkins Hospital Baltimore MD 21287 USA Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD 21287 USA

Erectile dysfunction （ED） commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 （PDE-5） inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.

关键词： erectile dysfunction endothelial-specific gene endothelial dysfunction gene therapy

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西门子奥钢联的中厚板轧机技术与能力

钢铁 2006年第4期41卷 88-90页

作者： N.champion 西门子奥钢联

西门子奥钢联是快速发展的亚洲特别是中国钢铁市场上中厚板轧机的一家主要供应商,合同包括较小的自动化包、设备包直至新建设备的总承包。结合鞍钢4.3 m中厚板机架、沙钢5.0 m宽厚板轧机、南钢板卷轧机等中国项目实例描述西门子奥钢联... 详细信息

西门子奥钢联是快速发展的亚洲特别是中国钢铁市场上中厚板轧机的一家主要供应商,合同包括较小的自动化包、设备包直至新建设备的总承包。结合鞍钢4.3 m中厚板机架、沙钢5.0 m宽厚板轧机、南钢板卷轧机等中国项目实例描述西门子奥钢联中厚板轧机技术的主要特点。

关键词：中厚板轧机板卷轧机自动化

WLAN-log-based superspreader detection in the COVID-19 pandemic

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High-Confidence Computing 2021年第1期1卷 2-11页

作者： Cheng Zhang Yunze Pan Yunqi Zhang Adam C.champion Zhaohui shen Dong Xuan Zhiqiang Lin Ness B.shroff Department of Computer science and Engineering The Ohio State UniversityUSA Department of Electrical and Computer Engineering The Ohio State UniversityUSA Virtual Kare LLC USA

Identifying“superspreaders”of disease is a pressing concern for society during pandemics such as *** represent a group of people who have much more social contacts than *** widespread deployment of WLAN infrastructure enables non-invasive contact tracing via people’s ubiquitous mobile *** technology offers promise for detecting *** this paper,we propose a general framework for WLAN-log-based superspreader *** our framework,we first use WLAN logs to construct contact graphs by jointly considering human symmetric and asymmetric ***,we adopt three vertex centrality mea-surements over the contact graphs to generate three groups of superspreader ***,we leverage sEIR simulation to determine groups of superspreaders among these candidates,who are the most critical individuals for the spread of disease based on the simulation *** have implemented our framework and evaluate it over a WLAN dataset with 41 million log entries from a large-scale *** evaluation shows superspread-ers exist on university *** change over the first few weeks of a semester,but stabilize throughout the rest of the *** data also demonstrate that both symmetric and asymmetric contact tracing can dis-cover superspreaders,but the latter performs better with daily contact ***,the evaluation shows no consistent differences among three vertex centrality measures for long-term(i.e.,weekly)contact graphs,which necessitates the inclusion of sEIR simulation in our *** believe our proposed framework and these results can provide timely guidance for public health administrators regarding effective testing,intervention,and vaccination policies.

关键词： superspreader detection WLAN logs Contact tracing Network analysis COVID-19 pandemic