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AUFFINDUNG VON REIs IN EINER TONsCHERBE AUs EINER ETWA FNFTAUsEND-JHRIGEN CHINEsIsCHEN sIEDLUNG.

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地质学报 1929年第4期 382-384+386-389页

作者： Von G. EDMAN E. sderberg Die Pharmakognostische Abteilung des Pharmaceutischen Institutes und der Bergianische Garten in stockholm Die Pharmakognostische Abteilung des Pharmaceutischen Institutes und der Bergianische Garten in stockholm

Von Professor GUNNAR ANDERssON aufgefordert, haben wir versucht, Pflanzenreste in einigen von ihm (1923) gemachten Funden aus neolithischen und aeneolithischen siedlungen in China zu identifizieren. Unter diesem Mater... 详细信息

关键词： der NFTAUsEND-J AUFFINDUNG VON REIs IN EINER TONsCHERBE AUs EINER ETWA F HRIGEN CHINEsIsCHEN sIEDLUNG

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

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Translational Neurodegeneration 2021年第3期10卷 502-517页

作者： Fadi Rofo Jos Buijs Ronny Falk Ken Honek Lars Lannfelt Anna M.Lilja Nicole G.Metzendorf Tobias Gustavsson Dag sehlin Linda söderberg Greta Hultqvist Protein Drug Design Faculty of PharmacyUppsala University75124 UppsalaSweden Department of Immunology Genetics and PathologyUppsala University75185 UppsalaSweden Ridgeview Instruments 75237 UppsalaSweden BioArctic AB 11251 StockholmSweden Department of Public Health and Caring sciences Uppsala University75185 UppsalaSweden

Background:Amyloid-β(Aβ)immunotherapy is a promising therapeutic strategy in the fght against Alzheimer’s disease(AD).A number of monoclonal antibodies have entered clinical trials for *** of them have failed due to the lack of efcacy or side-efects,two antibodies are currently in phase 3,and one has been approved by *** soluble intermediate aggregated species of Aβ,termed oligomers and protofbrils,are believed to be key pathogenic forms,responsible for synaptic and neuronal degeneration in ***,antibodies that can strongly and selectively bind to these soluble intermediate aggregates are of great diagnostic and therapeutic ***:We designed and recombinantly produced a hexavalent antibody based on mAb158,an Aβprotofbrilselective *** humanized version of mAb158,lecanemab(BAN2401),is currently in phase 3 clinical trials for the treatment of *** new designs involved recombinantly fusing single-chain fragment variables to the N-terminal ends of mAb158 ***-time interaction analysis with LigandTracer and surface plasmon resonance were used to evaluate the kinetic binding properties of the generated antibodies to Aβ*** ELIsA setups were applied to demonstrate the binding strength of the hexavalent antibody to Aβaggregates of diferent ***,the ability of the antibodies to protect cells from Aβ-induced efects was evaluated by MTT ***:Using real-time interaction analysis with LigandTracer,the hexavalent design promoted a 40-times enhanced binding with avidity to protofbrils,and most of the added binding strength was attributed to the reduced rate of ***,ELIsA experiments demonstrated that the hexavalent design also had strong binding to small oligomers,while retaining weak and intermediate binding to monomers and insoluble *** hexavalent antibody also reduced cell death induced by a mixture of soluble Aβ***:We provide a new antibody design with i

关键词： Multivalent antibodies Alzheimer’s disease Aβ Avidity Oligomers Protofbrils

Body awareness therapy: A new strategy for relief of symptoms in irritable bowel syndrome patients

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World Journal of Gastroenterology 2007年第23期13卷 3206-3214页

作者： EM Eriksson IE Mller RH sderberg HT Eriksson GK Kurlberg Departments of surgery Sahlgrenska University Hospital/stra Gteborg Sweden Departments of Medicine Sahlgrenska University Hospital/stra Gteborg Sweden

AIM: To compare irritable bowel syndrome (IBs) pa- tients with apparently healthy persons and to evaluate body awareness therapy, which is a physiotherapeutic remedy focusing on normalising tensions in the body, for the treatment of IBs with the hypothesis that altered body tension is associated with the syndrome. METHODs: Twenty-one IBs patients received body awareness therapy two hours weekly for 24 wk. At base- line as well as after 12 and 24 wk, they underwent ex- aminations including resource oriented body examination in combination with body awareness scale evaluation and f illed in gastrointestinal and psychological symptom questionnaires. saliva cortisol was analysed. A group of 21 apparently healthy persons underwent the same ex- aminations once. REsULTs: Compared to the apparently healthy group, IBs patients scored higher at baseline for gastrointestinal and psychological symptoms. They showed more often alterations in normal body tension patterns, as well as deviating cortisol slopes in saliva. After 24 wk of body awareness therapy, their gastrointestinal and psychologi- cal symptoms were reduced overall. somatic symptoms decreased in parallel with depressive symptoms. Whole body pain score decreased, coping ability as well as bio- chemical stress markers improved. CONCLUsION: IBs patients scored higher for gastroin- testinal and psychological symptoms, and presented with altered biochemical stress markers. Their body tension deviated compared to healthy controls. Furthermore,body awareness therapy gave relief of both somatic com- plaints, psychological symptoms and normalised body tension. These findings indicate that distorted tension constitutes an important part of the symptoms in IBs.

关键词：急性肠综合症疼痛考的索物理疗法应激

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电动弓型锯床锯切过程锯条的磨损及磨损机理

河北冶金 1992年第6期 42-45,10页

作者： s.sderberg 岑玮吴立志

一、引言电动弓型锯的锯切过程是一种周期性的金属切削过程。其所用锯条的磨损情况是较为复杂的。过去,Thompson等人曾对锯屑的形成及锯切参数与锯条磨损间的关系做过理论性的探索。本文则着重通过锯切实验,研究不同锯齿材料对锯条磨损... 详细信息

一、引言电动弓型锯的锯切过程是一种周期性的金属切削过程。其所用锯条的磨损情况是较为复杂的。过去,Thompson等人曾对锯屑的形成及锯切参数与锯条磨损间的关系做过理论性的探索。本文则着重通过锯切实验,研究不同锯齿材料对锯条磨损抗力的影响,提出了锯切不同钢料时锯条的磨损机理。二、实验 1、工件材料及锯齿材料工件材料为φ100mm圆钢。

关键词：锯床切断锯条磨损机理

DMI——直流电动机发展过程中的一个新里程碑

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国外内燃机车 2001年第6期 17-20页

作者： Christer sderberg 聂向雷瑞士

ABB电机公司最近推出了一种新型、中等尺寸的直流电动机 ,它在一系列重要领域都具有明显优异的性能。许多以前被认为互相排斥的主要性能现在综合在同一台机器中。DMI新电动机系列使用户可以同时利用大功率、宽速度范围、高转矩、小直径... 详细信息

ABB电机公司最近推出了一种新型、中等尺寸的直流电动机 ,它在一系列重要领域都具有明显优异的性能。许多以前被认为互相排斥的主要性能现在综合在同一台机器中。DMI新电动机系列使用户可以同时利用大功率、宽速度范围、高转矩、小直径、高过载能力或低转动惯量的优点 ,而不必再放弃任何一种重要性能。这一改进十分重要 ,足以证明DMI开辟了直流电机技术的新纪元。

关键词：直流电动机开发方法结构性能换流余量 DMI ABB电机公司

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氨基末端脑钠尿肽前体与脑卒中风险的关系

中华高血压杂志 2019年第5期27卷 409-409页

作者：刘莉叶鹏 Di Castelnuovo A Veronesi G Costanzo s Zeller T schnabel RB de Curtis A salomaa V Borchini R Ferrario M Giampaoli s Kee F s?s?s?derberg s Niiranen T Kuulasmaa K de Gaetano G Donati MB Blankenberg s Iacoviello L 不详

氨基末端脑钠尿肽前体(N-terminal pro-B-type natriuretic peptide,NT-proBNP)是心房颠动的危险因素,是用于检测心力衰竭的心脏功能标志物。鉴于心脏功能障碍与脑卒中之间的关系,NT-proBNP是脑卒中风险的候选标志物。该研究旨在评估NT-... 详细信息

氨基末端脑钠尿肽前体(N-terminal pro-B-type natriuretic peptide,NT-proBNP)是心房颠动的危险因素,是用于检测心力衰竭的心脏功能标志物。鉴于心脏功能障碍与脑卒中之间的关系,NT-proBNP是脑卒中风险的候选标志物。该研究旨在评估NT-proBNP与脑卒中的相关性。方法:基于欧洲联盟心血管病风险评估研究的生物标志物,研究人员分析了来自6个社区队列无脑卒中的58173名参与者(50%男性;平均年龄52岁)数据。NT-proBNP测量在欧洲心血管病风险评估中心生物标志物实验室中进行。主要观察结果是脑卒中和脑卒中的亚型(缺血/出血)。结果显示,在随访7.9年(中位数)期间,共观察到1550例脑卒中事件(1176例为缺血性)。NT-proBNP四分位数增加与脑卒中风险增加相关(调整风险因素和心脏病后行多因素Cox回归分析显示趋势P<0.01)。

关键词：风险评估脑卒中脑钠尿肽 NT-proBNP 前体 N-terminal 心脏功能障碍生物标志物

酒精摄入、心脏生物标志物和心房颤动风险与不良结局

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中华高血压杂志 2021年第2期29卷 103-103页

作者：陈嘉睿(译) 练桂丽((审校) Csengeri D sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo s s s?s?derberg s Jensen sM Vartiainen E Donati MB Magnussen C Camen s Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T salomaa V Iacoviello L schnabel RB 不详

酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类... 详细信息

酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。

关键词：氨基末端脑钠肽前体酒精摄入心血管病危险因素生物标记物心房颤动饮酒方式不良结局生物标志物