检索结果-南通市图书馆

Acute hepatitis B of genotype H resulting in persistent infection

World Journal of Gastroenterology 2014年第11期20卷 3044-3049页

作者： Norie Yamada Ryuta Shigefuku ryuichi Sugiyama Minoru Kobayashi Hiroki Ikeda Hideaki Takahashi Chiaki Okuse Michihiro Suzuki Fumio Itoh Hiroshi Yotsuyanagi Kiyomi Yasuda Kyoji Moriya Kazuhiko Koike Takaji Wakita Takanobu Kato Department of Virology Ⅱ National Institute of Infectious DiseasesShinjyuku-KuTokyo 162-8640Japan Department of Internal Medicine Center for Liver DiseasesKiyokawa HospitalSuginamiTokyo 166-0004Japan Division of Gastroenterology and Hepatology Department of Internal MedicineSt. Marianna University School of MedicineKanagawa 216-8511Japan Department of Infectious Diseases Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Infection Control and Prevention Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan

A 47-year-old man presented with general fatigue and dark *** laboratory data showed increased levels of hepatic *** patient was positive for hepatitis B virus(HBV)markers and negative for antihuman immunodeficiency *** HBV-DNA titer was set to 7.7 log copies/*** patient was diagnosed with acute hepatitis *** HBV infection route was *** serum levels of hepatic transaminases decreased to normal ranges without any treatment,but the HBVDNA status was maintained for at least 26 mo,indicating the presence of persistent *** isolated HBV from the acute-phase serum and determined the genome sequence.A phylogenetic analysis revealed that the isolated HBV was genotype *** this patient,the elevated peak level of HBV-DNA and the risk alleles at human genome single nucleotide polymorphisms s3077and rs9277535 in the human leukocyte antigen-DP locus were considered to be risk factors for chronic *** case suggests that there is a risk of persistent infection by HBV genotype H following acute hepatitis;further cases of HBV genotype H infection must be identified and ***,the complete determination of the HBV genotype may be essential during routine clinical care of acute hepatitis B outpatients.

关键词： Acute hepatitis Chronic hepatitis Genotyping Hepatitis B virus Single nucleotide polymorphisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

FIR Filter Design Methods with Discrete Coefficients Using A New LP Relaxation with Triangle Inequalities

FIR Filter Design Methods with Discrete Coefficients Using A...

引用

第四届运筹学及其应用国际研讨会

作者： Rika Ito Tetsuya Fujie Kenji Suyama ryuichi Hirabayashi Faculty of Engineering Science University of Tokyo School of Economics and Business Administration Kobe University of Commerce

＜正＞In this paper,we propose new design methods for linear phase FIR filters with signed power-of-two（SP2） coefficients based on a semi-definite programming （SDP） relaxation *** proposed methods include a linear programming （LP） relaxation and a relaxation by adding triangle *** such the design problems are known as one of the NP-hard problems,these methods can solve the design problems in a low computational cost in comparison with a traditional SDP relaxation *** is shown by several numerical experiments that those method are superior to the simple SDP relaxation method.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A NEW HEURISTIC APPROACH FOR DESIGN OF FIR FILTERS WITH SP2 COEFFICIENTS IN A MIN-MAX SENSE

A NEW HEURISTIC APPROACH FOR DESIGN OF FIR FILTERS WITH SP2 ...

引用

第七届国际信号处理会议

作者： Rika ITO Tetsuya FUJIE Kenji SUYAMA ryuichi HIRABAYASHI Tokyo University of Science University of Hyogo Tokyo DENKI University MEJIRO University

Since FIR ?lters can easily obtain a linear phase property, it is great useful in many ?elds. In this paper, we consider de- sign problems of linear phase FIR ?lter with Signed Power of Two (SP2) c

关键词： FIR ?lter CSD coe?cients SP2 coef- ?cients allocation optimization

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Benefit Evaluation Approach of Consumer Side Energy Management Systems Focusing on Enterprise Productivity

Benefit Evaluation Approach of Consumer Side Energy Manageme...

引用

作者： Ken Kuroda Hideki Magori Tomiyasu Ichimura ryuichi Yokoyama Waseda University Fujitsu Limited

Energy management systems(EMSs) for electricity consumers which manage energy consumption and control some energy consuming equipment in consumer side are expected to be one of effective measures for optimized energy supply and utilization. On the other hand, it is difficult to clarify the benefit of EMS installation, because EMS does not reduce energy consumption only with its installation but improvement or optimization of energy usage in consumer side should be necessary. In addition, whereas advantages of EMS installation such as energy cost and CO2 emission reduction have been considered, negative(trade-off) factors of energy saving have not been discussed enough. This paper proposes a benefit evaluation approach of EMS and the EMS installation impact on enterprise productivity is considered. Also, simulations using Monte Carlo method are conducted and their results are discussed and evaluated.

关键词： Demand control energy management system Monte Carlo method work productivity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Relationships among Community Type, Peat Layer Thickness, Belowground Carbon Storage and Habitat Age of Mangrove Forests in Pohnpei Island, Micronesia

引用

Open Journal of Forestry 2015年第1期5卷 48-56页

作者： Kiyoshi Fujimoto Yukira Mochida Takao Kikuchi ryuichi Tabuchi Yasumasa Hirata Saimon Lihpai Faculty of Policy Studies Nanzan University Seto Japan Graduate School of Environmental and Information Sciences Yokohama National University Yokohama Japan Forestry and Forest Products Research Institute Tsukuba Japan Division of Forestry and Marine Enforcement Department of Land & Natural Resources Pohnpei State Government Kolonia The Federated States of Micronesia

This paper quantifies the relationships among community type, peat layer thickness and habitat age of the mangrove forests in Pohnpei Island, Micronesia and provides a discussion concerning the primary succession and the belowground carbon storage of the main mangrove community types. The ages of the habitat were estimated from a relationship between the thickness of the mangrove peat layer and the formative period, which was decided by calibrated radiocarbon ages. Mangrove communities in the coral reef type habitat were generally arranged in the following order, from seaward to landward: 1) the Rhizophora stylosa or Sonneratia alba community (I or II communities), 2) the typical subunit of the S. alba subcommunity of the Rhizophora apiculata— Bruguiera gymnorrhiza community (III(2)a subunit) and 3) the Xylocarpus granatum subunit of the same subcommunity of the same community (III(2)b subunit). Their habitat ages were estimated to be younger than 460 years, between 360 and 1070 years and between 860 and 2300 years, respectively. Based on these results and other evidences such as photosynthetic characteristics and pollen analysis derived from the previous studies, the primary succession was inferred to have progressed in the order mentioned above. Belowground stored carbon for the main community types in the coral reef type habitat were estimated to be less than 370 t C ha-1 for the I and the II communities, between 290 and 860 t C ha-1 for the III(2)a subunit and between 700 and 1850 t C ha-1 for the III(2)b subunit.

关键词： Mangrove Forest Community Type Habitat Age Belowground Carbon Storage Primary Succession

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical experience of hyperthermia for deep-seated malignant glioma

Clinical experience of hyperthermia for deep-seated malignan...

引用

中国医师协会神经外科医师分会首届全国代表大会

作者： Hideaki Takahashi ryuichi Tanaka Takeo Uzuka Igor Grinev Department of Neurosurgery Brain Research Institute Niigata University 1-757 Asahimachi-dori951-8585NiigataJAPAN Department of Neurosurgery Brain Research Institute Niigata University 1-757 Asahimachi-dori951-8585NiigataJAPAN Department of Neurosurgery Brain Research Institute Niigata University 1-757 Asahimachi-dori951-8585NiigataJAPAN Department of Neurosurgery Brain Research Institute Niigata University 1-757 Asahimachi-dori951-8585NiigataJAPAN

＜正＞Purpose We introduce our clinical experience with radio frequency （RF） interstitial hyperthermia for malignant glioma. From the preliminary experimental study to the prospect of the near future, we will dicuss. Material We retrospectively reviewed 76 patients. Fortythree primary malignant gliomas and 33 recurrent malignant gliomas were treated with thermoradiotherapy （60 Gy, conventionally fractionated external beam radiation）. These patients received no reductive surgery. Electrodes （RF antennas） were set into the tumor and thermistor catheter was placed through the tumor center with stereotactic procedure under local anesthesia. Hyperthermia was given by RF interstitial hyperthermia of 13. 56 MHz, and the tumor was heated by measuring the temperature at the tumor margin （Tt: temperature of target point）. Tumor response was evaluated according by follow - up CT scan. TTPs and survivals were estimated by Kaplan - Meier method. Result Tumor responses of primary malignant gliomas were CR in 10 cases and PR in 17 cases. The response rate （CR + PR / all） amounted to 62. 8%. These of recurrent cases were CR in 3 cases and PR 12 cases. The response rate amounted to 45. 5 % . In primary malignant gliomas, median survival was 18months. In comparison with control group （ n = 35）, it was 10 months longer. According to achieved temperature at the target point, these patients were divided in two groups. The first group was adequate heating group achieved Tt of 42 ℃at least and the second was inadequate heating group Tt of less than 42 ℃. The response rate of adequate heating group was 68% Comparing gliomas heated to a Tt ＞ 42 ℃and those heated to a Tt ＜ 42℃, Kaplan- Meier survival and TTP curves displayed improvement in adequate heating group. In adequate heating group, median TTP was 4months longer and median survival was 11 months longer than those of inadequate group. Conclusion RF interstitial hyperthermia resulted in a higher response rate for primary malignant gliomas.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Effects of puddling on percolation and rice yields in rainfed lowland paddy cultivation: Case study in Khammouane province, central Laos

引用

Agricultural Sciences 2013年第8期4卷 360-368页

作者： Yoichi Fujihara ryuichi Yamada Masato Oda Hideto Fujii Osamu Ito Junichi Kashiwagi Faculty of Bioresources and Environmental Sciences Ishikawa Prefectural University Nonoichi Japan Graduate School of Agriculture Hokkaido University Sapporo Japan Institute for Sustainability and Peace United Nations University Tokyo Japan Japan International Research Center for Agricultural Sciences Tsukuba Japan

We investigated the effects of puddling on percolation and rice yields in rainfed lowland paddy cultivation. We selected a study village in Khammouane province, central Laos, and set up non-puddling and puddling plots from high to low positions. Even when puddling was conducted carefully, the ponding water in the plots disappeared in the case of little rainfall. Further, percolatifons during the later periods of rice growth increased drastically. Therefore, it is difficult to overcome drought stresses only by conducting puddling. We also compared the water conditions in the non-puddling and puddling plots. In the puddling plots at high position and low position along a stream, the number of days without ponding water in the puddling plots was less than that in the non-puddling field in July, suggesting the possibility of a different transplanting date. We tried to estimate the effects of transplanting date on the rice yields and found that transplanting 15 days earlier leads to an increase of 0.5 t/ha in the rice yields. Moreover, the profits from the increased yields exceed the puddling costs considerably, leading to a definite increase in income. Because the transplanting date has no effects in the fields with high ground water, puddling is effective in paddy fields where ponding does not occur to a significant degree.

关键词： Rainfed Lowland Paddy Rice Puddling Percolation Yield Laos

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

引用

Acta Pharmaceutica Sinica B 2022年第10期12卷 3905-3923页

作者： Aneesh V.Karkhanis Gopalakrishnan Venkatesan ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto Jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan Department of Pharmacy Faculty of ScienceNational University of SingaporeSingapore 117543Singapore Department of Pharmacology Faculty of MedicineToho UniversityTokyo 143-8540Japan Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adverse effects(AEs)with poorly understood *** previously demonstrated that dronedarone inactivates CYP2J2 potently and irreversibly,disrupts AA-EET pathway leading to cardiac mitochondrial toxicity rescuable via EET *** this study,we investigated if mitigation of CYP2J2 inhibition prevents dronedarone-induced cardiac *** first synthesized a deuterated analogue of dronedarone(termed poyendarone)and demonstrated that it neither inactivates CYP2J2,disrupts AA-EETs metabolism nor causes cardiac mitochondrial toxicity in *** patch-clamp experiments demonstrated that pharmacoelectrophysiology of dronedarone is unaffected by ***,we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat(BTB)variability reflective of proarrhythmic *** contrast,poyendarone treatment yields significantly lower BTB variability compared to dronedarone in cardiomyocytes indicative of preserved CYP2J2 ***,poyendarone and dronedarone display similar antiarrhythmic properties in the canine model of persistent AF,while poyendarone substantially reduces beat-to-beat variability of repolarization duration suggestive of diminished proarrhythmic *** findings prove that deuteration of dronedarone prevents CYP2J2 inactivation and mitigates dronedarone-induced cardiac AEs.

关键词： Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids Mechanism-based inactivation Dronedarone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Changes in Alanine Aminotransferase/Aspartate Aminotransferase Ratio Are Associated with Changes in Insulin Resistance in Japanese Community-Dwelling Middle-Aged and Elderly Women

引用

Open Journal of Endocrine and Metabolic Diseases 2016年第6期6卷 159-166页

作者： ryuichi Kawamoto Daisuke Ninomiya Yoshihisa Kasai Tomo Kusunoki Nobuyuki Ohtsuka Teru Kumagi Masanori Abe Department of Community Medicine Ehime University Graduate School of Medicine Ehime Japan Department of Internal Medicine Seiyo Municipal Nomura Hospital Ehime Japan

Liver marker {e.g., alanine aminotransferase (ALT) and aspartate aminotransferase (AST)} levels independently predict insulin resistance. The aim of the present study is to examine how changes in liver markers are associated with changes in insulin resistance after exercise in Japanese community-dwelling adults. The participants were 76 women aged 67 ± 6 years from a rural village. Nordic walk (NW) exercise of 120 min per week was performed for 12 weeks. Before and at the end of the 12-week intervention, various confounding factors and insulin resistance {e.g., Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)} were measured. The baseline, follow-up, and changes in ALT/AST ratio (β = 0.390, P β = 0.393, P β = 0.321, P = 0.004, respectively) were each significantly and independently associated with HOMA-IR. When the data were further stratified by baseline and change in ASL/AST ratio, changes in HOMA-IR decreased more significantly in participants with baseline ASL/AST ratio ≥ 0.762 and change in ALT/AST ratio of < 0 than those with change in ALT/AST ratio of ≥ 0 (baseline ASL/AST ratio P = 0.002 and ASL/AST ratio ≥ 0.762, P = 0.047). This study is of interest because liver transaminase markers, which are inexpensive and routinely collected in clinical settings, may provide a simple and accurate enhancement to models currently used to identify subjects with changes in insulin resistance. These results suggest that a higher baseline and decreased change in ALT/AST ratio may be a predictor for decreased insulin resistance after a 12-week walking exercise in community-dwelling middle-aged and elderly women.

关键词： ALT/AST Ratio Insulin Resistance HOMA-IR Change Walking Exercise Women

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis

引用

World Journal of Gastroenterology 2009年第41期15卷 5193-5199页

作者： Mitsuteru Kitade Hitoshi Yoshiji ryuichi Noguchi Yasuhide Ikenaka Kosuke Kaji Yusaku Shirai Masaharu Yamazaki Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Masayoshi Sawai Motoyuki Yoshida Chie Morioka Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui Third Department of Internal Medicine Nara Medical University

AIM: To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH).METHODS: Twenty-eight patients with NASH and 11 with simple fatty liver disease (FL) were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18immunopositive cells, and homeostasis model assessment of IR (HOMA-IR), respectively. The correlations of these factors with NASH were ***: Significant development of hepatic neovascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18expression and HOMA-R were signifi cantly increased in NASH as compared with FL and healthy liver. Furthermore, CK-18 and HOMA-IR were also positively correlated with the degree of neovascularization. CONCLUSION: These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH.

关键词： Angiogenesis Cytokeratin-18 Fatty liver Insulin resistance Non-alcoholic steatohepatitis Liver fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：