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Prognostic Factors in Geriatric Patients with Metastatic Colon Cancer

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Journal of Cancer Therapy 2019年第10期10卷 779-788页

作者： Kenji Ina Megumi Kabeya Shu Yuasa Yuko Kato Satoshi Kayukawa Takae Kataoka ryuichi Furuta Department of Medical Oncology Nagoya Memorial Hospital Nagoya Japan Department of Phamacy Nagoya Memorial Hospital Nagoya Japan Medical Social Work Consultation Room Nagoya Memorial Hospital Nagoya Japan Department of Clinical Oncology Nagoya Memorial Hospital Nagoya Japan.

Backgrounds: Colorectal cancer is an important contributor to cancer morbidity and mortality. Given that many older adult patients often have concomitant diseases and impairments in organ function, they are at increased risk for chemotherapy toxicity. Therefore, it is important to identify prognostic factors in older patients undergoing chemotherapy. Methods: We performed a retrospective chart review of colorectal cancer patients treated at Nagoya Memorial Hospital between 2012 and 2017 and selected those who received chemotherapy for metastatic colon cancer. Overall survival was calculated from the beginning of chemotherapy until death or the most recent follow-up date. We used the Kaplan-Meier method to plot survival curves and performed a statistical comparison using a log-rank test. In addition, multivariate analysis was performed using stepwise Cox proportional hazards models. Finally, a comprehensive geriatric assessment was conducted for older patients. The chart review was approved by the ethics committee of Nagoya Memorial Hospital. Results: The overall survival of metastatic colon cancer patients was not markedly different between patients aged ≥ 65 years of age (N = 37). Neither lesion site nor the RAS status affected survival, whereas the usage of three kinds of cytotoxic agents prolonged longevity. In a multivariate analysis of patients ≥ 65 years of age, the only independent prognostic factor for survival was the functional capacity, as measured by the Tokyo Metropolitan Institute of Gerontology (TMIG) index of competence. Conclusions: A combination of the comprehensive geriatric assessment and TMIG index was useful for predicting the longevity in patients with metastatic colon cancer ≥ 65 years of age.

关键词： Metastatic Colon Cancer Chemotherapy Comprehensive Geriatric Assessment TMIG Index of Competence

Gastrointestinal stromal tumor presenting with prominent calcification

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World Journal of Gastroenterology 2012年第39期18卷 5645-5648页

作者： Naoki Izawa Takeshi Sawada ryuichi Abiko Daisuke Kumon Mami Hirakawa Mika Kobayashi Nobuyuki Obinata Masahito Nomoto Tadateru Maehata Shun-ichi Yamauchi Takefumi Kouro Takashi Tsuda Satoshi Kitajima Hiroshi Yasuda Keiichi Tanaka Ichiro Tanaka Masahiro Hoshikawa Masayuki Takagi Fumio Itoh Division of Gastroenterology and Hepatology St.Marianna University School of MedicineKawasaki 216-8511Japan Division of Gastroenterological and General Surgery St.Marianna University School of MedicineKawasaki 216-8511Japan Department of Pathology St.Marianna University School of MedicineKawasak 216-8511Japan

We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism.

关键词： Gastrointestinal stromal tumor Calcifica-tion Stomach Computed tomography Imatinib me-sylate

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FF型汽车变速器齿轮的制造技术(一)

世界汽车 1985年第5期 10-15页

作者： ryuichi TSUKAMOTO 朱宝琼

近年来人们已注意到汽车齿轮在制造技术上的显著变化,那就是在生产上需要提供一种柔性制造系统,用以制造多品种的齿轮而不降低原有的产量。主要由数控机床组成的这种系统,虽然具有很高的柔性,但仍然存在一个投资效益问题。解决的办法是... 详细信息

近年来人们已注意到汽车齿轮在制造技术上的显著变化,那就是在生产上需要提供一种柔性制造系统,用以制造多品种的齿轮而不降低原有的产量。主要由数控机床组成的这种系统,虽然具有很高的柔性,但仍然存在一个投资效益问题。解决的办法是要建立“一序一机”型生产线。即以最少的工序、最短的时间生产出齿轮来获取高效益。它必须通过平衡每一工序的生产能力和集多序为一序的办法才能达到。这样,除剃齿工序仍须从质量和柔性两方面加以慎重考虑外,滚压、齿端倒角和部分车工序均可由精锻取而代之。此外,切齿刀具近期也有了显著进展。如表面镀锡、粉末高速钢、CBN(立方氮化硼)磨料等均已投入使用,因此,切齿和磨齿能力已得到了尽可能的提高。

关键词：齿轮鼓形渐开线花键剃齿刀齿轮刀具 FF 汽车

Long-Term Prognosis and Predictive Risk Factors for Polyvascular Disease in Patients with Peripheral Arterial Disease

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World Journal of Cardiovascular Diseases 2022年第1期12卷 50-64页

作者： Kuniki Nakashima Hisao Kumakura ryuichi Funada Yae Matsuo Kimimasa Sakata Akiko Ichikawa Toshiya Iwasaki Shuichi Ichikawa Department of Cardiovascular Surgery Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular Hospital) Gunma Japan Department of Cardiovascular Medicine Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular Hospital) Gunma Japan Department of Nephrology Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular Hospital) Gunma Japan

Background: The aim of the current study was to assess fifteen-year life expectancy, cardiovascular events, fate of the limb, and risk factors with or without polyvascular disease in patients with Peripheral Arterial Disease (PAD). Methods: We conducted a prospective cohort study in 1019 PAD patients. The endpoints were Cardiovascular or Cerebrovascular Death (CCVD), All-Cause Death (ACD), Major Adverse Cardiovascular Events (MACE), and Cardiovascular and/or Limb Events (CVLE). Results: The patients who died were 539 (52.9%) during follow-up periods. The rate of CCVD was 50.5% (n = 272). In multiple regression analysis, the number of affected arteries had correlations with estimated Glomerular Filtration Rate (eGFR), HDL-cholesterol, Ankle Brachial Pressure Index (ABI), and diabetes (p cholesterol, and diabetes (p

The Best Choice to Achieve Zero Complications after Pancreatoduodenectomy

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Surgical Science 2011年第2期2卷 45-51页

作者： Shinji Osada Hisashi Imai Yoshiyuki Sasaki Itaru Yasufuku ryuichi Asai Yoshihisa Tokumaru Takuji Sakuratani Kazuhiro Yoshida 不详

Pancreatoduodenectomy (PD) has been performed commonly, but the occurrence of pancreatic fistula (PF) is a critical trigger of complications, which are potentially life threatening, and is also associated with markedly prolonged hospitalization. Many techniques have been proposed for connecting the pancreatic stump with the gastrointestinal tract, stomach vs. jejunum, etc. Among the risk factors for PF, such as general patient factors or disease-related factors, the most important is the texture of the remnant pancreas. Surgical technique might be one improvable aspect that can reduce the pancreatic leakage rate, therefore;various methods of managing the pancreatic remnant have been studied. Methods of reconstruction between the remnant pancreas and the intestine include end-to-side with/without duct-to-mucosa anastomosis or end-to-end invagination styles, has been argued. Here, we review several trials for safety and methods of treating the pancreatic stump after PD, and demonstrate our experiences.

关键词： Pancreatoduodenectomy Reconstruction Pancreatojejunostomy Pancreatic Fistula Pancreatoenteric Anastomosis

Analysis of Emotions Using Multimodal Data: A Case Study

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Journal of Biosciences and Medicines 2023年第12期11卷 54-68页

作者： Toshiya Akiyama Kyoko Osaka Hirokazu Ito ryuichi Tanioka Allan Paulo Blaquera Leah Anne Christine Bollos Tetsuya Tanioka Graduate School of Health Sciences Tokushima University Tokushima Japan Department of Psychiatric Nursing Nursing Course of Kochi Medical School Kochi University Kochi Japan Department of Nursing Art and Sciences Tokushima University Tokushima Japan Department of Physical Therapy Hiroshima Cosmopolitan University Hiroshima Japan Department of Nursing Outcomes Management Institute of Biomedical Sciences Tokushima University Tokushima Japan

In this case study, we hypothesized that sympathetic nerve activity would be higher during conversation with PALRO robot, and that conversation would result in an increase in cerebral blood flow near the Broca’s area. The facial expressions of a human subject were recorded, and cerebral blood flow and heart rate variability were measured during interactions with the humanoid robot. These multimodal data were time-synchronized to quantitatively verify the change from the resting baseline by testing facial expression analysis, cerebral blood flow, and heart rate variability. In conclusion, this subject indicated that sympathetic nervous activity was dominant, suggesting that the subject may have enjoyed and been excited while talking to the robot (normalized High Frequency < normalized Low Frequency: 0.22 ± 0.16 < 0.78 ± 0.16). Cerebral blood flow values were higher during conversation and in the resting state after the experiment than in the resting state before the experiment. Talking increased cerebral blood flow in the frontal region. As the subject was left-handed, it was confirmed that the right side of the brain, where the Broca’s area is located, was particularly activated (Left < right: 0.15 ± 0.21 < 1.25 ± 0.17). In the sections where a “happy” facial emotion was recognized, the examiner-judged “happy” faces and the MTCNN “happy” results were also generally consistent.

关键词： Humanoid Robots Multimodal Data Emotion Analysis

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日本松香松节油工业的状况

国外林业 1990年第3期 45-47页

作者： ryuichi Kohzu 汪宗莲

很久以前,日本没有生产脂松香的松树和生产木浆浮油的针叶树,只能生产少量的香松节油,作为天然树脂或油使用。从第二次世界大战以来,由于经济的高度发展,松香松节油工业也随之发展起来。日本的树脂制造商大约从1950年开始生产地

关键词：松香浮油乳化剂松节油萜类化合物松香树脂日本

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热带西太平洋海表温度的季节内变化

暴雨灾害 1992年第2期24卷 25-28页

作者： ryuichi Kawamura 陈贸

热带西太平洋海表温度(SST)具有明显的季节内(30天-60天)变化,它与热带对流活动有着同一时间尺度的耦合关系,位相相差10天-20天.在向东传播的30天-60天振荡以东地区SST异常偏高,海气反馈系统显示出非常明显的30天-60天振荡.同时,也发现... 详细信息

热带西太平洋海表温度(SST)具有明显的季节内(30天-60天)变化,它与热带对流活动有着同一时间尺度的耦合关系,位相相差10天-20天.在向东传播的30天-60天振荡以东地区SST异常偏高,海气反馈系统显示出非常明显的30天-60天振荡.同时,也发现具有30天-60天时间尺度位相差海气耦合,在1981年北半球夏季期间在热带西太平洋表现较弱,这一年正是1982年-1983年厄尔尼诺南方涛动(ENSO)事件的前一年.

关键词：海表温度热带西太平洋南方涛动 ENSO 海气时间尺度反馈系统热带印度洋距平位相差

Arbuscular Mycorrhizal Fungal Community Structure in Soybean Roots: Comparison between Kanagawa and Hokkaido, Japan

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Advances in Microbiology 2011年第1期1卷 13-22页

作者： Katsunori Isobe Kohei Maruyama Singo Nagai Masao Higo Tomiya Maekawa Gaku Mizonobe Rhae A. Drijber ryuichi Ishii 不详

The objectives of this study were to determine arbuscular mycorrhizal fungi (AMF) community structure in colonized roots of soybean cultivated from Kanagawa and Hokkaido in Japan and to relate the community structure to environmental conditions, which included soil type, preceding crops, and soil chemical properties. The average number of AMF OTU (operational taxonomic unit) colonizing soybean roots collected from Kanagawa and Hokkaido was 11.2 and 5.8, respectively, a significant difference. Moreover, AMF from the family Gigasporasera was not identified in soybean roots collected from Hokkaido, suggesting that AMF in the family Gigasporasea is absent or rare in the soybean fields of sampled in Hokkaido. We postulate that the soil type, preceding crops or soil chemical properties are not the underlying factor differentiating AMF community structure colonizing in soybean roots between Kanagawa and Hokkaido. Instead we conclude that temperature and phosphate absorption coefficient are the determining factors of AMF OTU in this study.

关键词： AM Fungi Colonization Community Structure Soybean