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Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

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Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano ryoji Ito Mamoru Ito Yutaka Kawakami Division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of Dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO *** cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T *** using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine

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Lithium-site substituted argyrodite-type Li_(6)PS_(5)I solid electrolytes with enhanced ionic conduction for all-solid-state batteries

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Science China(Technological Sciences) 2023年第7期66卷 2059-2068页

作者： GAO Ling XIE YuLin TONG Yan XU Miao YOU JiaLe WEI HuiPing YU XiangXiang XU SiQi ZHANG Yi CHE Yong TANG Ya SUZUKI Kota KANNO ryoji ZHAO GuoWei College of Chemistry and Chemical Engineering Huanggang Normal UniversityHuanggang 438000China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghai 200245China Shanghai Enpower Technology Co. Ltd.Shanghai 201802China Beijing Enpower Technology Co. Ltd.Beijing 102628China Department of Chemistry School of ScienceShanghai UniversityShanghai 200444China Research Center for All-Solid-State Battery Institute of Innovation ResearchTokyo Institute of TechnologyYokohama 226-8502Japan

Argyrodites,Li_(6)PS_(5)X(X=Cl,Br,I),have piqued the interest of researchers by offering promising lithium ionic conductivity for their application in all-solid-state batteries(ASSBs).However,other than Li_(6)PS_(5)Cl(651Cl)and Li_(6)PS_(5)Br(651Br),Li_(6)PS_(5)I(651I)shows poor ionic conductivity(10^(-7)S cm^(-1)at 298 K).Herein,we present Al-doped 651I with I^(-)/S^(2-)site disordering to lower activation energy(Ea)and improve ionic *** formed argyrodite-type solid solutions with a composition of(Li_(6–3x)Al_(x))PS_(5)I in 0≤x≤0.10,and structural analysis revealed that Al^(3+)is located at Li ***,the Al-doped samples contained anion I^(-)/S^(2-)site disorders in the crystal structures and smaller lattice parameters than the non-doped *** spectroscopy measurements indicated that Al-doping reduced the ionic diffusion barrier,Ea,and increased the ionic conductivity to 10^(-5)S cm^(-1);the(Li5.7Al0.1)PS5I had the highest ionic conductivity in the studied system,at 2.6×10^(-5)S cm^(-1).In a lab-scale ASSB,with(Li_(5.7)Al_(0.1))PS_(5)I functioned as a solid electrolyte,demonstrating the characteristics of a pure ionic conductor with negligible electronic *** evaluated ionic conduction is due to decreased Li+content and I^(-)/S^(2-)disorder ***-site cation doping enables an in-depth understanding of the structure and provides an additional approach to designing betterperforming SEs in the argyrodite system.

关键词： argyrodite Li6PS5I solid electrolytes ionic conductor ionic conductivity

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Evaluation of the Local Burning Velocity Using DNS Data of Turbulent Premixed Flames

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Natural Science 2014年第12期6卷 1030-1036页

作者： Kazuya Tsuboi ryoji Matsugi Eiji Tomita Graduate School of Natural Science and Technology Okayama University Okayama Japan

The local burning velocity, which is based on the consumption rate of the unburned mixture, is one of the dominant parameters in turbulent premixed flames. In this study, the evaluating method of the local burning velocity was investigated using DNS data of turbulent premixed flames with different Lewis numbers. The local burning velocity was evaluated by integrating the chemical reaction rates along normal to the flame surface within three kinds of integration ranges that were defined as follows: the range which is defined by the half length of normal to the flame surface between its certain point and the other point crossing the flame surface (Range 1);the range which is defined by the reaction progress variable that the chemical reaction rate along normal to a planer flame surface takes a half of the maximum value (Range 2);the range which is defined by the length of normal to the flame surface between its certain point and the point which has the extreme value of the reaction progress variable (Range 3). As a result, Range 1 and Range 2 were affected by the flame shapes greatly, since the quantities of the integration ranges fluctuated widely dependent on the variations of turbulent premixed flames. Under the conditions of the turbulent combustion in this study, Range 3, which is hardly affected by a flame shape, is considered to be appropriate to the evaluation of the local burning velocity.

关键词： Local Burning Velocity Integration Range Reaction Progress Variable Turbulent Premixed Flame Direct Numerical Simulation

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Appropriate kidney stone size for ureteroscopic lithotripsy:When to switch to a percutaneous approach

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World Journal of Nephrology 2015年第1期4卷 111-117页

作者： ryoji Takazawa Sachi Kitayama Toshihiko Tsujii Department of Urology Tokyo Metropolitan Ohtsuka HospitalTokyo 170-8476Japan

Flexible ureteroscopy(f URS) has become a more effective and safer treatment for whole upper urinary tract stones. Percutaneous nephrolithotomy(PNL) is currently the first-line recommended treatment for large kidney stones ≥ 20 mm and it has an excellent stone-free rate for large kidney stones. However, its invasiveness is not negligible considering its major complication rates. Staged f URS is a practical treatmentfor such large kidney stones because f URS has a minimal blood transfusion risk, short hospitalization and few restrictions on daily routines. However, as the stone size becomes larger, the stone-free rate decreases, and the number of operations required increases. Therefore, in our opinion, staged f URS is a practical option for kidney stones 20 to 40 mm. Miniaturized PNL combined with f URS should be considered to be a preferred option for stones larger than 40 mm. Moreover, URS is an effective treatment for multiple upper urinary tract stones. Especially for patients with a stone burden < 20 mm, URS is a favorable option that promises a high stone-free rate after a single session either unilaterally or bilaterally. However, for patients with a stone burden ≥ 20 mm, a staged operation should be considered to achieve stone-free status.

关键词： Ureteroscopy Lithotripsy Laser Kidney calculi Nephrostomy Percutaneous

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Localization of ATP-sensitive K^+ channel subunits in rat liver

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World Journal of Experimental Medicine 2019年第2期9卷 14-31页

作者： Ming Zhou Kiwamu Yoshikawa Hideo Akashi Mitsutaka Miura ryoji Suzuki Tao-Sheng Li Hiroshi Abe Yoshio Bando Department of Anatomy Akita University Graduate School of MedicineAkita 010-8543Japan Department of Cell Biology and Morphology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan TRUST A Long-Term Care Health FacilitySendai 980-0011Japan

BACKGROUND ATP-sensitive K^+(KATP)channels were originally found in cardiac myocytes by Noma in *** channels were formed by potassium ion-passing poreforming subunits(Kir6.1,Kir6.2)and regulatory subunits SUR1,SU2A and SUR2B.A number of cells and tissues have been revealed to contain these channels including hepatocytes,but detailed localization of these subunits in different types of liver cells was still *** To investigate the expression of KATP channel subunits in rat liver and their localization in different cells of the *** Rabbit anti-rat SUR1 peptide antibody was raised and purified by antigen immunoaffinity column *** of Sprague-Dawley rats were used for liver protein extraction for immunoblot analysis,seven of them were used for immunohistochemistry both for the ABC method and immunofluorescence *** of Wistar rats were used for the isolation of hepatic stellate cells(HSCs)and Kupffer cells for both primary culture and *** Immunoblot analysis showed that the five kinds of KATP channel subunits,***6.1,Kir6.2,SUR1,SUR2A,and SUR2B,were detected in *** staining showed that Kir6.1 and Kir6.2 were weakly to moderately expressed in parenchymal cells and sinusoidal lining cells,while SUR1,SUR2A,and SUR2B were mainly localized to sinusoidal lining cells,such as HSCs,Kupffer cells,and sinusoidal endothelial *** for SUR2A and SUR2B was expressed in the hepatocyte *** immunofluorescence staining further showed that the pore-forming subunits Kir6.1 and/or Kir6.2 colocalized with GFAP in rat liver sections and primary cultured *** KATP channel subunits also colocalized with CD68 in liver sections and primary cultured Kupffer *** SUR subunits colocalized with GFAP in liver sections and colocalized with CD68 both in liver sections and primary cultured Kupffer *** addition,five KATP channel subunits colocalized with SE-1 in si

关键词： ATP-sensitive K^+channel Liver Hepatic stellate cells Kupffer cells Sinusoidal endothelial cells Rat

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Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis

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World Journal of Gastroenterology 2012年第29期18卷 3883-3888页

作者： Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hirosh Matsubara Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura ryoji Miyahara Naoki Ohmiya Hidemi Goto Yoshiki Hirooka Department of Gastroenterology Nagoya University Graduate School of Medicine65 Tsuruma-choShowa-kuNagoya 466-8550Japan Department of Endoscopy Nagoya University Hospital65 Tsuruma-choShowa-kuNagoya 466-8550Japan

AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic *** 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for ***:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent ***-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic *** of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of *** one met level 1 findings of IDCP,but 3 patients met level 2 findings of *** 10 seronegative cases,2 cases were diagnosed with "definitive type 1 AIP",and 3 cases were diagnosed with "probable type 2 AIP" when considering both the level 2 histological findings and response to ***:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases.

关键词： Autoimmune pancreatitis Endoscopic ultrasound-guided fine needle aspiration Idiopathic duct centric pancreatitis Lymphoplasmacytic sclerosing pancreatitis Pancreatic cancer

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Dynamic Contact Problem for Slide Hinge

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Open Journal of Applied Sciences 2012年第4期2卷 82-86页

作者： Kazunori Shinohara ryoji Takaki Takeshi Akita Faculty of Engineering Chiba Institute of Technology Chiba Japan Institute of Space and Astronautical Science (ISAS) Japan Aerospace Exploration Agency (JAXA) Sagamihara Japan JAXA's Engineering Digital Innovation Center (JEDI) Japan Aerospace Exploration Agency (JAXA) Sagamihara Japan

Contact analysis can be either static or dynamic. In static contact analysis, the position on the contact surface is constant. In dynamic contact analysis, the position on the contact surface changes at every time step. In static contact analysis, the computing results (stress, strain, etc.) of contact states have been verified through the Hertz contact problem in literature. On the other hand, there has been insufficient research into dynamic contact analysis. The contact algorithm is insufficiently constructed in finite element model (FEM) discretization. The gap between two objects cannot be calculated accurately. A contact method is demanded for artificial parameters. Inappropriate setting of artificial parameters causes artificial numerical oscillations on the contact surface between objects. To develop a high-reliability satellite, we started the development of FEM contact-friction modeling techniques in this study. A dynamic contact method was realized by using the appropriate parameters required in the contact analysis. We verified the reproducibility of the physical behavior of the contact friction via numerical simulation techniques by using a computational model of the hinge joints.

关键词： FEM Contact Friction Stress Joints Structural Analysis Advance/FrontSTR Dynamic Contact Analysis Static Contact Analysis

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Lightning Induced Surge on the Distribution Lines in the House near by the Lightning Point

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Journal of Energy and Power Engineering 2012年第5期6卷 840-844页

作者： Aiko Takahara ryoji Oshiro Eiji Kaneko Graduate School of Electrical and Electronic Engineering University of the Ryukyus Okinawa 903-0213 Japan Toshiba Corporation Hamakawasaki Works Kawasaki 210-0862 Japan

Recently, a lightning surge is recognized as one of the biggest risks to the society. If the surges induced by lightning invade into low voltage distribution lines, there might be a possibility of giving some severe damages to the systems. Therefore, it is necessary to examine these induced phenomena. FDTD （finite difference time domain） method which treats objects as three-dimensional solid circuits is applied to analyze these induced phenomena. VSTL （Virtual Surge Test Lab.） is the surge analysis simulation program using FDTD method. In this paper, the lightning induced phenomena on the low voltage distribution line in the house are analyzed by using VSTL. In this paper, investigation results about induced surge when a lightning struck the point nearby the house, and about a suppressing effect of surges by comparing the results of analysis with and without SPD （surge protective device） are shown. As a result, it is confirmed that SPD is effective for suppressing lightning surge.

关键词： Lightning surge induced phenomena FDTD method distribution line VSTL.

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RAYLEIGH WAVE VELOCITY FOR FROST SUSCEPTIBLE VOLCANIC ASH DEPOSITS IN ASAMA VOLCANO

RAYLEIGH WAVE VELOCITY FOR FROST SUSCEPTIBLE VOLCANIC ASH DE...

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岩石力学与环境岩土工程国际会议

作者： ryoji Sakurada Hideo Miyaguchi Ichiro Kuroshima Akita National College of Technology Akita 011 Japan Civil Engineers Co. Ltd.Tokyo 110 Japan Mitsui Construction Co. Ltd.Tokyo 110 Japan

＜正＞In the regions covered with pyroclastic fall deposits,most of the frost-heave damages of road relates to hydrogeological conditions of a *** this study,emphasis is given to the effect of soil stratification on the frost damages of *** a geological exploration Rayleigh wave method was employed for the ashy deposits in the foot of Asama *** frost damages attributed to geological conditions can be summarized as following two forms:（1）Frost damages dominated by the thickly covered,high-heaving soils,（2）Frost damages dominated by drainage conditions of roadbed formed by low-heaving *** low-heaving soils easily become mid-heaving soils if once groundwater flows into the soils.

关键词： Rayleigh wave method frost heave volcanic ash

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Improvement of Water and Wastewater Treatment Process Using Various Sound Waves—A Consideration from the Viewpoint of Frequency

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Journal of Water Resource and Protection 2014年第15期6卷 1464-1474页

作者： Akira Hiratsuka Yugo Tomonaga Yoshiro Yasuda ryoji Tsujino Department of Civil Engineering Osaka Sangyo University Osaka Japan National Museum of Ethnology Osaka Japan University of Hyogo Kobe Japan SetsunanUniversity Osaka Japan

Application of sound waves is one of the novel techniques for the improvement of water treatment process. In this study, various sound waves such as 1) ultrasonic wave, 2) music box, and 3) windbell were irradiated to water and wastewater for removing contaminants such as nitrate, phosphorus and BOD/COD. As a result, a possibility of improvement of water and wastewater treatment process using sound waves with various frequencies was proposed.

关键词： Sound Waves (Frequency) Total Hardness (Ca2+ Mg2+) Nitrogen (N) Phosphorus (P) Water Treatment

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