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BIOCELL 2022年第5期46卷 1163-1167页

作者： YUKA ikeda NOZOMI NAGASE AI TSUJI KURUMI TANIGUCHI YASUKO KITAGISHI SATORU MATSUDA Department of Food Science and Nutrition Nara Women’s UniversityNara630-8506Japan

Stemness of cancer cells contains limitless self-renewal *** the purpose of proliferation,secretome might exert its effects via the paracrine *** microRNAs enclosed in the secretome of cancer stem cells could regulate the expression of anti-proliferative APRO family *** biological functions of APRO family proteins seems to be quite intricate,however,which might be a key modulator of microRNAs,then could regulate the proliferation of cancer *** addition to affecting proliferation/differentiation during cellular development,APRO family proteins might also play an imperious role on keeping homeostasis in healthy stem cells under a physiological ***,relationship between the microRNAs and the APRO family proteins has attracted much attention in the field of cancer research and regenerative ***,we have described the molecular mechanism behind this interplay that have a potential role in the future promising tools with targeting APRO family proteins for the medical applications.

关键词： Cancer Stem cell Secretome Proliferation APRO family microRNA

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基于学习的自校正控制算法

上海交通大学学报 2000年第5期34卷 638-641页

作者：袁向阳施颂椒 Masao ikeda 上海交通大学自动化系上海200030 日本大阪大学工学部

提出了一种基于学习的自校正控制算法 ,算法中包含一个自适应模型和多个固定模型 ,每一个模型都有一个相对应的控制器 .在每一采样时刻 ,将当前时段内具有最小预测误差的模型对应的控制器的输出作为控制输入 .在该算法中 ,自适应模型和... 详细信息

提出了一种基于学习的自校正控制算法 ,算法中包含一个自适应模型和多个固定模型 ,每一个模型都有一个相对应的控制器 .在每一采样时刻 ,将当前时段内具有最小预测误差的模型对应的控制器的输出作为控制输入 .在该算法中 ,自适应模型和自适应控制器的作用是确保闭环系统的稳定性和输出跟踪误差的渐近收敛性 ,而固定模型和固定控制器的作用是当被控对象的参数发生变化时 ,在自适应模型的参数估计收敛之前 ,暂时担当控制器的角色 ,以改善闭环系统的暂态响应 .文中证明了闭环系统的稳定性和输出跟踪误差的渐近收敛性 .仿真结果表明算法的有效性 .

关键词：自校正控制自学习暂态响应算法工业过程控制

Bioremediation of Bisphenol A by Glycosylation with Immobilized Marine Microalga <i>Amphidinium crassum</i><br>——Bioremediation of Bisphenol a by Immobilized Cells

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Advances in Chemical Engineering and Science 2011年第3期1卷 90-95页

作者： Kei Shimoda ryohei Yamamoto Hiroki Hamada 不详

Glycosylation of bisphenol A, which is an endocrine disrupting chemical, was investigated using immobilized marine microalga and plant cells from the viewpoint of bioremediation of bisphenol A. Immobilized marine microalga of Amphidinium crassum glucosylated bisphenol A to the corresponding glucoside. On the other hand, bisphenol A was glycosylated to its glucoside, diglycoside, gentiobioside, and gentiobiosylglucoside, which was a new compound, by immobilized plant cells of Catharanthus roseus.

关键词： Glycosylation Biosphenol A Amphidinium Crassum Catharanthus Roseus Immobilized Cells

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一类工作点可变线性系统的镇定控制器设计

上海交通大学学报 2000年第5期34卷 657-660页

作者：袁向阳施颂椒 Masao ikeda 上海交通大学自动化系上海200030 日本大阪大学工学部

对于一类工作点可变的线性系统 ,即被控系统表达为两个典型工作点上的传递函数矩阵的正则稳定的既约分解的线性内插 ,考虑其镇定控制器设计问题 .假设被控对象在典型工作点上的传递函数矩阵的既约分解组成一个集合 ,提出了镇定该集合的... 详细信息

对于一类工作点可变的线性系统 ,即被控系统表达为两个典型工作点上的传递函数矩阵的正则稳定的既约分解的线性内插 ,考虑其镇定控制器设计问题 .假设被控对象在典型工作点上的传递函数矩阵的既约分解组成一个集合 ,提出了镇定该集合的控制器的设计方法 .对于线性内插系数不可知的情形 ,提出了两种固定型镇定控制器的设计方法 ;对于线性内插系数可知的情形 ,提出了一种内插型镇定控制器设计方法 .文中将控制器的设计问题转化为 H∞ 控制问题 ,再转化为状态空间下的基于线性矩阵不等式 ( LMI)

关键词：线性系统工作点可变镇定控制器 LMI H∞控制

Temperature-dependent phonon spectra of magnetic random solid solutions

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npj Computational Materials 2018年第1期4卷 606-612页

作者： Yuji ikeda Fritz Körmann Biswanath Dutta Abel Carreras Atsuto Seko Jörg Neugebauer Isao Tanaka Department of Materials Science and Engineering Kyoto UniversityKyoto 606-8501Japan Center for Elements Strategy Initiative for Structural Materials(ESISM) Kyoto UniversityKyoto 606-8501Japan Max-Planck-Institut für Eisenforschung GmbH D-40237 DüsseldorfGermany Department of Materials Science and Engineering Delft University of TechnologyMekelweg 22628 CD DelftNetherlands Precursory Research for Embryonic Science and Technology(PRESTO) Japan Science and Technology Agency(JST)Kawaguchi 332-0012Japan Center for Materials Research by Information Integration National Institute for Materials Science(NIMS)Tsukuba 305-0047Japan Nanostructures Research Laboratory Japan Fine Ceramics CenterNagoya 456-8587Japan

A first-principles-based computational tool for simulating phonons of magnetic random solid solutions including thermal magnetic fluctuations is *** method takes fluctuations of force constants due to magnetic excitations as well as due to chemical disorder into *** developed approach correctly predicts the experimentally observed unusual phonon hardening of a transverse acoustic mode in Fe–Pd an Fe–Pt Invar alloys with increasing *** peculiar behavior,which cannot be explained within a conventional harmonic picture,turns out to be a consequence of thermal magnetic *** proposed methodology can be straightforwardly applied to a wide range of materials to reveal new insights into physical behaviors and to design materials through computation,which were not accessible so far.

关键词： magnetic random phonon

Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment

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World Journal of Gastroenterology 2023年第40期29卷 5566-5581页

作者： Aitoshi Hoshimoto Atsushi Tatsuguchi ryohei Hamakubo Takayoshi Nishimoto Jun Omori Naohiko Akimoto Shu Tanaka Shunji Fujimori Tsutomu Hatori Akira Shimizu Katsuhiko Iwakiri Department of Gastroenterology Nippon Medical SchoolTokyo 113-8603Japan Department of Analytic Human Pathology Nippon Medical SchoolTokyo 113-8603Japan Department of Pathology Nippon Medical SchoolChiba Hokusoh HospitalChiba 270-1694Japan

BACKGROUND Comprehensive genomic analysis has shown that small bowel adenocarcinoma(SBA)has different genomic profiles from gastric and colorectal ***,it is essential to establish chemotherapeutic regimens based on SBA *** expression of programmed cell death-ligand 1(PD-L1)and programmed cell death-ligand 2(PD-L2)in SBA is not fully ***-PD-L1/PD-1 therapy uses tumor-infiltrating lymphocytes(TILs);therefore,the status of TILs in the tumor microenvironment(TME)may influence their *** ratio of FoxP3+to CD8+T cells has been reported to be useful in predicting the prognosis of digestive system *** To investigate the clinicopathological significance of PD-L1/2 expression according to the status of TILs in SBA *** We performed immunohistochemical analysis for PD-L1,PD-L2,CD8,FoxP3,and DNA mismatch repair(MMR)proteins using formalin-fixed,paraffin-embedded tissues from 50 patients diagnosed with primary *** immunoreactivities of PD-L1 and PD-L2 were determined separately in tumor cells and tumor-infiltrating immune cells throughout the tumor center and invasive margins,and finally evaluated using the combined positive score(CPS).We assessed CD8+and FoxP3+T cells in the intratumoral and tumor-surrounding ***,we calculated and summed the ratio of FoxP3 to CD8+T cell ***-related cell densities were graded as low or *** results were compared with clinicopathological factors and patient *** distribution of cancer-specific survival(CSS)was estimated using the Kaplan–Meier method,and the log-rank test was used to test for significant differences in CSS.A Cox proportional hazard model was also used to assess the effect of tumor variables on *** PD-L1 expression was positive in 34%in tumor cells(T-PD-L1)and 54%in tumor-infiltrating immune cells(I-PDL1)of the cases examined.T-PD-L2 was positive in 34%and I-PD-L2 was positive in 42%of the ***-L1

关键词： Small bowel adenocarcinoma Programmed cell death-ligand 1 Programmed cell death-ligand 2 Tumor microenvironment Tumor-infiltrating lymphocytes Regulatory T-cells

CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 75-80页

作者： Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka ikeda Mitsugu Sekimoto Shoji Nakamori Department of Surgery National Hospital Organization Osaka National Hospital

Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from ***: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December *** patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate ***: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL.

关键词： Pancreatic cancer CA19-9 Para-aortic lymph node

Stability of pyrrolidone derivatives against γ-ray irradiation

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Science China Chemistry 2012年第9期55卷 1739-1745页

作者： NOGAMI Masanobu SUGIYAMA Yuichi KAWASAKI Takeshi HARADA Masayuki KAWATA Yoshihisa MORITA Yasuji KIKUCHI Toshiaki ikeda Yasuhisa Research Laboratory for Nuclear Reactors Tokyo Institute of Technology2-12-1-N1-34O-okayamaMeguro-kuTokyo 152-8550Japan Japan Atomic Energy Agency Tokai-muraNaka-gunIbaraki 319-1195Japan Mitsubishi Materials Corporation 1002-14MukoyamaNaka-shiIbaraki 311-0102Japan

To evaluate the stability of N-alkylated pyrrolidone derivatives （NRPs）, which are supposed to be used as precipitants for U（VI） and Pu（IV, VI） species in HNO3 media, under irradiation environment, some candidate NRPs were irradiated by γ-ray. Irradia- tion to HNO3 solutions up to 6 mol dm-3 （= M） containing 2 M N-n-butyl-2-pyrrolidone （NBP）, one of NRPs with lower hy- drophobicity, has revealed that the residual ratios of NBP in the samples of HNO3 up to 3 M decreased identically and linearly. Approximately 20% of NBP was found to be degraded after the irradiation at 1 MGy. It was also found that the decrease in the precipitation ratio of UOf＋（P.R., %） was gentle and that the P.R. values were relatively in accordance with the residual ratios of NBP. On the other hand, the degradation of the samples irradiated in 6 M HNO3 was found more distinguished. It was pro- posed from the analyses of degraded compounds that the degradation of NBP in HNO3 by γ-ray irradiation started from the cleavage of the pyrrolidone ring by the addition of oxygen atom originating from HNO3, followed by the formation of chain compounds by the successive addition of oxygen, leading to the generation of oxalic acid and acetic acid. The stability of other NRPs in 3 M HNO3 was evaluated to be nearly identical with that of NBP except lower P.R. values of the samples containing NRPs with higher hydrophobicity irradiated at more than 0.5 MGy.

关键词： pyrrolidone derivatives precipitants γ-ray irradiation HNO3 U(VI)

Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the tongue exhibiting characteristic fluorine-18 deoxyglucose accumulation on positron emission tomography–computed tomography: A case report

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World Journal of Clinical Cases 2020年第9期8卷 1666-1673页

作者： Hiroaki Shimamoto Yuka Hirota Yoshihisa Kashima Naoya Kinoshita Misaki Yokokawa Tohru ikeda Hiroyuki Harada Oral and Maxillofacial Surgery Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo 113-8549Japan Human Pathology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo 113-8549Japan Oral Pathology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyo 113-8549Japan

BACKGROUND Granulocyte colony-stimulating factor(G-CSF)is a cytokine produced in inflammatory environments that induces differentiation and proliferation of neutrophils in bone *** report a rare case of aggressive G-CSFproducing squamous cell carcinoma of the tongue exhibiting fluorine-18 deoxyglucose(FDG)accumulation in primary lesion,metastatic lymph nodes,spleen,and bone marrow on positron emission tomography–computed tomography(PET/CT).CASE SUMMARY We report a 58-year-old female with a rapid enlarged lingual mass with partial *** test results from the initial examination revealed a leukocyte count of 21380/μ*** PET/CT,extensive FDG accumulation was observed in the tongue and bilateral cervical lymph nodes,with elevated FDG accumulation in the spleen and bone marrow although no distant metastases were *** performed partial glossectomy and bilateral neck *** staining with G-CSF antibodies on biopsy specimen and resected samples revealed that both specimens were G-CSF *** is a rare case of G-CSF producing tongue carcinoma with elevated FDG accumulation in the spleen and bone *** In patients with the tongue cancer and hyperleukocytosis,where FDG accumulations in the spleen and bone marrow are observed using PET/CT and when these accumulations are not caused by metastasis,G-CSF-producing tumors,with associated poor prognosis,should be considered.

关键词： Tongue cancer Granulocyte colony-stimulating factor Hyperlukocytosis Positron emission tomograph Case report

The Relationship among Stress Response, Weight Management, and Physical Exercise in Japanese University Students

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Journal of Sports Science 2016年第3期4卷 163-169页

作者： Tomoko ikeda Takahiro ikeda Osamu Aoyagi Faculty of Children's Studies Nishi-Kyushu University Saga-shi Saga 840-0806 Japan School of Human and Social Sciences Fukuoka Prefectural University Tagawa Fukuoka 825-8585 Japan Faculty of Sports and Health Science Fukuoka University Jonan-ku Fukuoka 814-0180 Japan

The aim of the present study was to investigate the relationship between stress response, gender, weight management, and physical exercise among Japanese university students. The participants were 411 university students （169 males, 242 females）. All participants completed the Stress Response Scale and the European Health and Behavior Survey. T-test results showed that scores of females were consistently higher than those of males （P 〈 0.05）. In the chi-square test, the proportion of females managing their weight （75.3%） was significantly higher than that of males （42.9%）. In multiple regression analysis, the group managing their weight showed a higher stress score, and the group doing physical exercise showed a lower stress score. These results show that weight management through physical exercise reduces mental stress, making it the most beneficial method of weight management for the mental and physical wellbeing of youths.

关键词： Health behavior physical activity Stress Response Scale youth.