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Chemical and Genetic Diversity of Some Ligularia Species (Compositae) in Northwestern Yunnan and Southwestern Sichuan of China

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复旦学报（自然科学版） 2005年第5期44卷 742-743页

作者： Chiaki Kuroda ryo Hanait Xun Gong Yuemao Shen Motoo Tori Department of Chemistry and Department of Life Science Rikkyo University Nishi-Ikebukuro Toshima-kuTokyo171-8501 Japan Kunming Institute of Botany Chinese Academy of Science Kunming 654204 China Faculty of Pharmaceutical Sciences Tokushima Bunri University Yamashiro-cho Tokushima 770-8514 Japan

Ligularia Cass., (Compositae) is a highly diversified genus, and more than 100 species of which are distributed in the eastern Qinghai-Tibet Plateau and adjacent areas. Ligularia species have been studied with respect to secondary metabolites, and many sesquiterpenes of the furanoeremophilane type have been isolated from them. In order to find correlates among these variations, and ultimately understand the diversity-generating mechanism of Ligularia species in the Hengduan Mountains, we initiated an extensive study that uses furanoeremophilanes as a chemical index and the DNA sequence as a genetic index. Furanoeremophilanes have been detected conventionally by Ehrlich' s test, which has been used in a search for novel natural products. As for the DNA sequence, we determined the nucleotide sequence of the atpB-rbcL intergenic region in the present study.

关键词：中国云南四川橐吾植物生物化学遗传多样性

Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion

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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1329-1339页

作者： ryo Yamamoto Sayuri Suzuki Koichiro Homma Shintaro Yamaguchi Tomohisa Sujino Junichi Sasaki Department of Emergency and Critical Care Medicine Keio University School of MedicineTokyo 1608582Japan Division of Endocrinology Metabolism and NephrologyDepartment of Internal MedicineKeio University School of MedicineTokyo 1608582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 1608582Japan

BACKGROUND Patients with mesenteric ischemia frequently suffer from bowel necrosis even after *** gas has showed promising effects for ischemiareperfusion injury by reducing reactive oxygen species in various animal and clinical *** examined intestinal tissue injury by ischemia and reperfusion under continuous initiation of 3%hydrogen *** To clarify the treatment effects and target cells of hydrogen gas for mesenteric *** Three rat groups underwent 60-min mesenteric artery occlusion(ischemia),60-min reperfusion following 60-min occlusion(reperfusion),or ischemiareperfusion with the same duration under continuous 3%hydrogen gas inhalation(hydrogen).The distal ileum was *** staining with caspase-3 and leucine-rich repeat-containing G-protein-coupled 5(LGR5),a specific marker of intestinal stem cell,was conducted to evaluate the injury location and cell types protected by *** expressions of LGR5,olfactomedin 4(OLFM4),hairy and enhancer of split 1,Jagged 2,and Neurogenic locus notch homolog protein 1 were measured by quantitative polymerase chain *** oxidative stress was analyzed with immunostaining for 8-hydroxy-2'-deoxyguanosine(8-OHdG).Systemic oxidative stress was evaluated by plasma *** Ischemia damaged the epithelial layer at the tip of the villi,whereas reperfusion induced extensive apoptosis of the cells at the crypt base,which were identified as intestinal stem cells with double immunofluorescence *** mitigated such apoptosis at the crypt base,and the LGR5 expression of the tissues was higher in the hydrogen group than in the reperfusion ***4 was also relatively higher in the hydrogen group,whereas other measured RNAs were comparable between the groups.8-OHdG concentration was high in the reperfusion group,which was reduced by hydrogen,particularly at the crypt *** 8-OHdG concentrations were relatively higher in both reperfusion and

关键词： Hydrogen molecule Intestinal ischemia Ischemia-reperfusion injury Tissue protection Nonoperative management Leucine-rich repeat-containing G-protein-coupled 5

ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status

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World Journal of Gastroenterology 2015年第7期21卷 2159-2168页

作者： ryo Inada Shigeki Sekine Hirokazu Taniguchi Hitoshi Tsuda Hitoshi Katai Toshiyoshi Fujiwara ryoji Kushima Pathology and Clinical Laboratory Division National Cancer Center Hospital Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Molecular Pathology Division National Cancer Center Research Institute Gastric Surgery Division National Cancer Center Hospital

AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric ***:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric *** results were further correlated with clinicopathological ***:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,P<0.001),a female sex(55.3%vs 31.3%,P=0.004),an antral location(44.7%vs 25.7%,P=0.021),and a differentiated histology(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,P<0.001).A multivariate analysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas.

关键词： Adenocarcinoma ARID1A Mismatch Repair Stomach Immu

In situ observation of the phase transformation kinetics of bismuth during shock release

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Chinese Physics B 2024年第4期33卷 586-592页

作者：李江涛王倩男徐亮柳雷张航 Sota Takagi Kouhei Ichiyanagi ryo Fukaya Shunsuke Nozawa 胡建波 Laboratory for Shock Wave and Detonation Physics Research Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China State Key Laboratory for Environment-Friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China Japan Society for the Promotion of Science Tokyo102-0083Japan Institute of Materials Structure Science High Energy Accelerator Research OrganizationIbaraki305-8572Japan

A time-resolved x-ray diffraction technique is employed to monitor the structural transformation of laser-shocked *** reveal a retarded transformation from the shock-induced Bi-Ⅴphase to a metastable Bi-Ⅳphase during the shock release,instead of the thermodynamically stable Bi-Ⅲ*** emergence of the metastable Bi-Ⅳphase is understood by the competitive interplay between two transformation pathways towards the Bi-Ⅳand Bi-Ⅲ,*** former is more rapid than the latter because the Bi-Ⅴto B-Ⅳtransformation is driven by interaction between the closest atoms while the Bi-Ⅴto B-Ⅲtransformation requires interaction between the second-closest *** nucleation time for the Bi-Ⅴto Bi-Ⅳtransformation is determined to be 5.1±0.9 ns according to a classical nucleation *** observation demonstrates the importance of the formation of the transient metastable phases,which can change the phase transformation pathway in a dynamic process.

关键词： phase transformation time-resolved x-ray diffraction(XRD) bismuth metastable phase nonequilibrium phase diagram

Microfluidic Device for Simple Diagnosis of Plant Growth Condition by Detecting miRNAs from Filtered Plant Extracts

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Plant Phenomics 2024年第2期6卷 364-376页

作者： Yaichi Kawakatsu ryo Okada Mitsuo Hara Hiroki Tsutsui Naoki Yanagisawa Tetsuya Higashiyama Akihide Arima Yoshinobu Baba Ken-ichi Kurotani Michitaka Notaguchi Bioscience and Biotechnology Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Graduate School of Bioagricultural Sciences Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Department of Molecular and Macromolecular Chemistry Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoyaAichi 464-8603Japan Graduate School of Science Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Institute of Transformative Bio-Molecules Nagoya UniversityNagoya 464-8601Japan Department of Biological Sciences Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Institute of Nano-Life-Systems Institutes of Innovation for Future SocietyNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Department of Biomolecular Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Institute of Quantum Life Science National Institutes for Quantum Science and Technology(QST)Anagawa 4-9-1Inage-kuChiba 263-8555Japan Department of Botany Graduate School of ScienceKyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto 606-8502Japan

Plants are exposed to a variety of environmental stress,and starvation of inorganic phosphorus can be a major constraint in crop *** plants,in response to phosphate deficiency in soil,miR399,a type of microRNA(miRNA),is *** detecting miR399,the early diagnosis of phosphorus deficiency stress in plants can be ***,general miRNA detection methods require complicated experimental ***,simple and rapid miRNA detection methods are required for early plant nutritional diagnosis.

关键词： mirnas plant device simple growth from condition detecting diagnosis extracts

Worsening of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in patients with prostate cancer after androgen deprivation therapy

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Asian Journal of Andrology 2018年第6期20卷 634-636页

作者： ryo Oka Takanobu Utsumi Takumi Endo Masashi Yano Shuichi Kamijima Naoto Kamiya Hiroyoshi Suzuki Department of Urology Toho University Sakura Medical Center Sakura-shi Chiba 285-8741 Japan Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC 27599-7295 USA

Dear Editor, Prostate cancer （PCa） is the most frequently diagnosed male cancer in Western countries, and the number of PCa patients is also rapidly increasing in ]apan.1,2 Simultaneously, androgen deprivation therapy （ADT） has also been increasingly used in PCa patients in recent years2-5 However, the long-term use of ADT is associated with a variety of pivotal adverse events, including diabetes, anemia, osteoporosis, serum lipid profile changes, and cardiovascular disease （CVD）.1,2 Higher low-density lipoprotein cholesterol （LDL-C） and/or lower high-density lipoprotein cholesterol （HDL-C） are well-established risk factors for CVD, and control of their levels has been an important goal in the treatment and prevention of CVD.6,7 Recently, another alternative parameter, the LDL-C to HDL-C （L/H） ratio, has been reported to be strongly associated with CVD and is thought to be a better predictor of future CVD than LDL-C alone. Closely monitoring serum lipid profile, including the L/H ratio changes affected by ADT, is a key to preventing CVD in PCa patients. Moreover, we previously suggested that a higher L/H ratio might have an impact on the development of arterial stiffness after ADT administration,r Although some cutoff points of the L/H ratio have been reported in clinical use, it has been suggested that thrombosis can occur when the L/H ratio increases to around 2.5 or more in East Asian populations.6 The aim of the present study was to investigate the changes in serum lipid profile and to identify the clinical factors associated with an increased L/H ratio in PCa patients who received ADT.

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Paleoclimatic Change Inferred from Carbon Isotope Composition of Organic Matter in Sediments of Dabusu Lake, Jilin Province, China

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Chinese Journal of Oceanology and Limnology 2004年第2期22卷 124-129页

作者：沈吉张恩楼羊向东 ryo Matsumoto Nanjing Institute of Geography & Limnology Chinese Academy of Sciences Nanjing 210008 China Geological Institute University of Tokyo Tokyo 113 Japan

Study on the organic compounds and stable isotope composition of a sediment section in Dabusu Lake revealed that the organic materials in the sediments came mainly from terrestrial plants brought into the lake by runoff. The δ 13 C of the organic materials had high values during warm-dry climatic stages and decreased in cold-wet stages. Analysis of data on carbonate content and 14 C age showed that the lake basin had experienced several wet-cold and warm-dry climatic cycles since 15000 a BP. Since 6700 a BP, the climate reached a relatively stable warm-dry stage, so that the lake water was gradually condensed and finally a saline lake was formed.

关键词： organic carbon isotope paleoclimate Dabusu Lake

Intussusception due to rectal adenocarcinoma in a young adult:A case report

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World Journal of Gastroenterology 2014年第35期20卷 12678-12681页

作者： ryo Inada Takeshi Nagasaka Toshiaki Toshima Yoshiko Mori Yoshitaka Kondo Hiroyuki Kishimoto Toshiyoshi Fujiwara Department of Gastroenterological Surgery Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences

An intussusception due to colonic adenocarcinoma has sometimes been reported. However, to the best of our knowledge, reports of intussusception due to rectal adenocarcinoma are extremely rare. In this report, the case of a young man with rectal adenocarcinoma causing intussusception is described. A 24-year-old man visited a hospital complaining of abdominal pain, and an upper rectal cancer was diagnosed by colonoscopy. Computed tomography showed intussusception caused by a large tumor in the pelvis and absence of distant metastases. Locally advanced rectal cancer causing intussusception was diagnosed, and a low anterior resection was performed. Intraoperatively, repair of the invagination could not be accomplished easily; therefore, the repair was abandoned. Instead, the tumor was removed en bloc to avoid dissemination of the cancer. Histopathologically, the tumor was diagnosed as a poorly differentiated adenocarcinoma, pStage IIA. The patient has no evidence of recurrence at 10 mo after the operation.

关键词： Adult intussusception En bloc resection Low anterior resection Rectal adenocarcinoma Young cancer

Crowned dens syndrome developed after an endoscopic retrograde cholangiopancreatography procedure

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World Journal of Gastroenterology 2016年第39期22卷 8849-8852页

作者： Hiroyasu Nakano Kazunari Nakahara Yosuke Michikawa Keigo Suetani ryo Morita Nobuyuki Matsumoto Fumio Itoh Division of Gastroenterology and Hepatology Department of Internal Medicine St. Marianna University School of Medicine

We present a unique case of crowned dens syndrome(CDS) that developed after endoscopic retrograde cholangiopancreatography(ERCP) in a patient who presented with fever and neck pain. Administration of non-steroidal anti-inflammatory drugs was extremely effective for relieving fever and neck pain, and in the improvement of inflammatory markers. To the best of our knowledge, this is the first case report of CDS caused by an ERCP procedure. In a patient with fever and neck pain after an ERCP procedure, CDS should be considered in the differential diagnosis.

关键词： Acute cholangitis Pseudogout Endoscopic retrograde cholangiopancreatograhy Crowned dens syndrome