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Worsening of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in patients with prostate cancer after androgen deprivation therapy

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Asian Journal of Andrology 2018年第6期20卷 634-636页

作者： ryo oka Takanobu Utsumi Takumi Endo Masashi Yano Shuichi Kamijima Naoto Kamiya Hiroyoshi Suzuki Department of Urology Toho University Sakura Medical Center Sakura-shi Chiba 285-8741 Japan Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC 27599-7295 USA

Dear Editor, Prostate cancer （PCa） is the most frequently diagnosed male cancer in Western countries, and the number of PCa patients is also rapidly increasing in ]apan.1,2 Simultaneously, androgen deprivation therapy （ADT） has also been increasingly used in PCa patients in recent years2-5 However, the long-term use of ADT is associated with a variety of pivotal adverse events, including diabetes, anemia, osteoporosis, serum lipid profile changes, and cardiovascular disease （CVD）.1,2 Higher low-density lipoprotein cholesterol （LDL-C） and/or lower high-density lipoprotein cholesterol （HDL-C） are well-established risk factors for CVD, and control of their levels has been an important goal in the treatment and prevention of CVD.6,7 Recently, another alternative parameter, the LDL-C to HDL-C （L/H） ratio, has been reported to be strongly associated with CVD and is thought to be a better predictor of future CVD than LDL-C alone. Closely monitoring serum lipid profile, including the L/H ratio changes affected by ADT, is a key to preventing CVD in PCa patients. Moreover, we previously suggested that a higher L/H ratio might have an impact on the development of arterial stiffness after ADT administration,r Although some cutoff points of the L/H ratio have been reported in clinical use, it has been suggested that thrombosis can occur when the L/H ratio increases to around 2.5 or more in East Asian populations.6 The aim of the present study was to investigate the changes in serum lipid profile and to identify the clinical factors associated with an increased L/H ratio in PCa patients who received ADT.

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Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel

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World Journal of Clinical Urology 2014年第2期3卷 139-143页

作者： Takumi Endo Naoto Kamiya Hiroyoshi Suzuki ryo oka Fang-Ching Lee Takanobu Utsumi Masashi Yano Shuichi Kamijima Koji Kawamura Takashi Imamoto Tomohiko Ichikawa Department of Urology Toho University Sakura Medical CenterSakura-shiChiba 285-8741Japan Department of Urology Graduate School of MedicineChiba UniversityChiba-shiChiba 260-8670Japan

AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC) patients treated with ***: Thirty-three patients were enrolled in this study. Serum levels of carboxyterminal cross-linked telopeptide of type 1 collagen generated by metalloproteinases(1CTP) and alkaline phosphatase(ALP) were measured at the start of docetaxel chemotherapy. We examined the relationship between clinicopathological features and serum levels of 1CTP and ALP levels in CRPC patients treated with ***: For the total patient group, the mean ± standard deviation(SD) values for docetaxel chemotherapy dose, dose intensity, dosage interval, and num-ber of cycles were 59.3 ± 10.6 mg/m2, 13.9 ± 5.2 mg/m2 per week, 4.7 ± 1.2 wk, and 11.2 ± 7.4, respectively. Fourteen patients died from prostate cancer. Patients were divided into two groups according to mean + SD of serum 1CTP(8.2 ng/m L) and ALP(538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels(P < 0.05).CONCLUSION: Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel.

关键词： Prostate cancer Docetaxel chemotherapy Carboxy-terminal pyridinoline cross-linked telopeptide parts of type-1 collagen Alkaline phosphatase Prognostic factor

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Possibility of a Novel Warm-Up Strategy Using Capacitive and Resistive Electric Transfer: A Pilot Study

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Open Journal of Therapy and Rehabilitation 2022年第3期10卷 89-100页

作者： Michio Wachi Takumi Jiroumaru Ayako Satonaka Masae Ikeya ryo Fujitani oka Yasumasa Takamitsu Fujikawa Department of Physical Therapy Biwako Professional University of Rehabilitation Higashiomi City Japan Graduate School of Medicine Nagoya University Nagoya City Japan Department of Physical Therapy Bukkyo University Kyoto City Japan Department of Applied Biology Graduate School of Science and Technology Kyoto Institute of Technology Kyoto City Japan Department of Rehabilitation Kanazawa Orthopaedic & Sports Medicine Clinic Ritto City Japan

[Purpose] Capacitive and resistive electric transfer (CRET) is becoming prevalent in sports settings. CRET is effective for improving pain and healing injured tissue;however, its influence on muscle function and morphology is still unclear. This study confirmed the immediate effects of CRET on the duration of muscular stiffness and range of motion (ROM). [Method] This study describes the protocol for a single-arm trial with the non-blinding of participants and researchers. Twenty-four healthy men participated in the study. They received CRET therapy for their low back areas. The muscular stiffness of the multifidus muscle (superficial and deep) and the ROM using the active straight leg raise (ASLR) test were measured pre-intervention, post-intervention (immediately), and 15 and 30 min post-intervention. We compared these parameters using a one-way analysis of variance and Dunnett’s test (multiple comparison tests for subtests). [Results] The muscular stiffness of the superficial and deep multifidus muscles was significantly decreased, and the ASLR test showed a significant increase compared with the test performed pre-intervention. In addition, these effects persisted for 30 min. [Conclusion] Warm-up is vital for improving muscular stiffness and increasing the ROM. CRET is a useful device for achieving these aims, particularly as a passive warm-up method in sports settings.

关键词： Capacitive and Resistive Electric Transfer Muscular Stiffness Range of Motion Active Straight Leg Raise Multifidus Muscle

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740 Gbit/s (37 x 20 Gbit/s) DWDM Transmission Experiment Using Er^(3+)-Doped Tellurite Fiber Amplifiers and Distributed Raman Amplification

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光学学报 2003年第S1期23卷 569-570页

作者： Hiroyuki Toda Maoki Suzuki ryo Takami Tetsuya Miyazaki Takeshi Makino Fumito Kubota Graduate School of Engineering Osaka University 2-1 Yamada-Oka Suita Osaka 565-0871 Japan Communications Research Laboratory 4-2-1 Nukui-Kitamachi Koganei Tokyo 184-8795 Japan

We demonstrate 740 Gbit/s (37 x 20 Gbit/s) DWDM recirculating transmission experiment with 59 nm continuous bandwidth over 300 km by employing Er3+-doped tellurite fiber amplifiers. The use of Raman amplification is e... 详细信息

关键词： Raman Amplification transmission bandwidth Raman amplification fiber amplifiers

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