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International Journal of Otolaryngology and Head & Neck Surgery 2013年第5期2卷 207-210页

作者： Cory A. Vaughn kaitlin R. Jaqua ryan k. meacham Fransisco Vieira Department of Otolaryngology Head & Neck Surgery University of Tennessee Memphis USA MD Candidate University of Tennessee Health Science Center Memphis USA

Prostate cancer is the most common noncutaneous malignancy of American males and typically presents with genitourinary symptoms, however, head and neck extension is a rare finding. We present a case of a 53-year-old male initially presenting with a large supraclavicular mass as the only complaint. After an initial non-diagnostic FNA biopsy, PSA levels, histology and immunohistochemical findings were consistent with metastatic prostatic adenocarcinoma. The patient was started on anti-hormonal treatment after diagnosis. Due to the increasing reports of such cases, we suggest PSA levels and appropriate immunohistochemical staining should be obtained on all unknown neck masses.

关键词： Neck Mass Prostate Adenocarcinoma Metastasis

Superconvergence and the Numerical Flux: a Study Using the Upwind-Biased Flux in Discontinuous Galerkin Methods

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Communications on Applied Mathematics and Computation 2020年第3期2卷 461-486页

作者： Daniel J.Frean Jennifer k.ryan School of Mathematics University of East AngliaNorwichUK Applied Mathematics and Statistics Colorado School of MinesGoldenCOUSA

One of the beneficial properties of the discontinuous Galerkin method is the accurate wave propagation *** is,the semi-discrete error has dissipation errors of order 2k+1(≤Ch2k+1)and order 2k+2 for dispersion(≤Ch2k+2).Previous studies have concentrated on the order of accuracy,and neglected the important role that the error constant,C,plays in these *** this article,we show the important role of the error constant in the dispersion and dissipation error for discontinuous Galerkin approximation of polynomial degree k,where k=0,1,2,*** gives insight into why one may want a more centred flux for a piecewise constant or quadratic approximation than for a piecewise linear or cubic *** provide an explicit formula for these error *** is illustrated through one particular flux,the upwind-biased flux introduced by Meng et al.,as it is a convex combination of the upwind and downwind *** studies of wave propagation are typically done through a Fourier *** higher order Fourier information can be extracted using the smoothness-increasing accuracy-conserving(SIAC)*** SIAC filter ties the higher order Fourier information to the negative-order norm in physical *** show that both the proofs of the ability of the SIAC filter to extract extra accuracy and numerical results are unaffected by the choice of flux.

关键词： Discontinuous Galerkin Smoothness-increasing accuracy-conserving(SIAC)filtering Superconvergence

Strategies in boosting photosensitization for biomedical applications

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Science China Chemistry 2022年第4期65卷 647-649页

作者： Ming Chen ryan T.k.kwok Youhong Tang Dan Ding College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical BiologyKey Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China Department of Nephrology Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second HospitalHuai’an 223002China Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong KongChina Australia-China Joint Centre for Personal Health Technologies Medical Device Research InstituteCollege of Science and EngineeringFlinders UniversitySouth Australia 5042Australia Guangdong Provincial key Laboratory of Luminescence from Molecular Aggregates South China University of TechnologyGuangzhou 510640China

Photodynamic therapy(PDT)has emerged as an effective treatment method for its few adverse effects,little invasiveness,short treatment time and low cost[1,2].The rapid development of PDT has dramatically boosted its mu... 详细信息

关键词： treatment boosting immunotherapy

Efficient HIV-1 in vitro reverse transcription: optimal capsid stability is required

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Signal Transduction and Targeted Therapy 2021年第2期6卷 195-196页

作者： ryan C.Burdick Vinay k.Pathak Viral Mutation Section HIV Dynamics and Replication ProgramCenter for Cancer ResearchNational Cancer Institute at FrederickFrederickMD 21702USA

Recently,Christensen et *** HIV-1 reverse transcription and integration in a cell-free system and found that viral double-stranded DNA that is capable of integration into a target plasmid DNA was efficiently synthesized within viral cores,indicating that the capsid protein shell plays an important role in viral genome replication.1 HIV-1 reverse transcriptase(RT)copies the viral genomic RNA into a double-stranded DNA,and HIV-1 integrase(IN)inserts the viral DNA into the host genome to form a *** RT and IN have been successfully targeted with potent antiretroviral drugs to inhibit these enzymes and treat patients infected with HIV-1,the causative agent of acquired immunodeficiency syndrome(AIDS).Despite decades of research,the molecular mechanisms of reverse transcription and integration in vivo are not fully characterized,in part because cell-free assays that efficiently and faithfully recapitulate the processes in the context of a virion have not been available。

关键词： al. drugs optimal

Prioritizing Strategies for Building the Resilience of Public Health Systems to Disasters Across Multiple Communities and Countries

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International Journal of Disaster Risk Science 2024年第1期15卷 1-17页

作者： Benjamin J.ryan Mayumi kako Shelby Garner Rok Fink Ismail Tayfur Jonathan Abrahams Sanjaya Bhatia Adriana Campelo Matthew Fendt Alicia Fontenot Nahuel Arenas Garcia Tim Hatch Ryoma kayano LaShonda Malrey‑Horne Makiko MacDermot Md Moshiur Rahman Chaverle Noel Shuhei Nomura Jeremy P.Novak Maria Opazo kendell Oliver Luciana Peters Sohel Rahman PerihanŞimşek Andrew Stricklin Raymond Swienton Bryan W.Brooks Frist College of Medicine Belmont UniversityNashvilleTN 37212USA Department of Environmental Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Health Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Faculty of Health Sciences University of Ljubljana1000 LjubljanaSlovenia Department of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Monash University Accident Research Center MelbourneVIC 3800Australia Global Education and Training Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for the Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering and Computer Science Baylor UniversityWacoTX 76798USA Department of Public Health Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA Alabama Department of Public Health MontgomeryAL 36092USA World Health Organization Centre for Health Development(WHO kobe Centre) Kobe 651-0073Japan Waco-McLennan County Public Health District WacoTX 76707USA Department of Health Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tokyo Foundation for Policy Research Tokyo 106-6234Japan Global Development College BrisbaneQLD 4000Australia Municipality of Pudahuel 13124 PudahuelChile City Hall of Porto Alegre Porto Alegre 90010-170Brazil Ministry of Health and Family Welfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Department of Emergency Aid and Disaster Management Trabzon University61335 TrabzonTurkey Department of Emergency Medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pandemic highlighted the urgent need to strengthen public health *** response,the United Nations Disaster Risk Reduction(UNDRR) Public Health System Resilience Scorecard(Scorecard) was applied in workshops across multiple *** aim of our research was to explore the workshop findings to develop priority strategies for strengthening public health system *** conducted a workshop from 14 to 16 March 2023,at the UNDRR Global Education and Training Institute in Incheon,Republic of korea.A sequential modified Delphi method was utilized to develop a set of prioritized resilience *** were drawn from 70 strategies identified from 13 distinct workshops in eight *** two surveys,23 strategies were *** received ratings of "High" or Very High" from89% of *** related to the inclusion of public health risks in emergency plans,integrating multidisciplinary teams into public health,enabling local transport mechanisms,and improving the ability to manage an influx of *** Scorecard provides an adaptable framework to identify and prioritize strategies for strengthening public health system *** leveraging this methodology,our study demonstrated how resilience strategies could inform disaster risk reduction funding,policies,and actions.

关键词： Health system resilience Public policy Resilience scorecard Workshops

Nexus between polymer support and metal oxide nanoparticles in hybrid nanosorbent materials （HNMs） for sorption/desorption of target ligands

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 929-938页

作者： ryan C. SMITH Jinze LI Surapol PADUNGTHON Arup k. SENGUPTA Environmental Engineering Program Department of Civil and Environmental Engineering Lehigh University Bethlehem PA 18015 USA

Metal oxide nanoparticles like hydrated ferric oxide （HFO） or hydrated zirconium oxide （HZrO） are excellent sorbents for environmentally significant ligands like phosphate, arsenic, or fluoride, present at trace concentrations. Since the sorption capacity is surface dependent for HFO and HZrO, nanoscale sizes offer significant enhancement in performance. However, due to their miniscule sizes, low attrition resistance, and poor durability they are unable to be used in typical plug-flow column setups. Meanwhile ion exchange resins, which have no specific affinity toward anionic ligands, are durable and chemically stable. By impregnating metal oxide nanoparticles inside a polymer support, with or without functional groups, a hybrid nanosorbent material （HNM） can be prepared. A HNM is durable, mechanically strong, and chemically stable. The functional groups of the polymeric support will affect the overall removal effi- ciency of the ligands exerted by the Donnan Membrane Effect. For example, the removal of arsenic by HFO or the removal of fluoride by HZrO is enhanced by using anion exchange resins. The HNM can be precisely tuned to remove one type of contaminant over another type. Also, the physical morphology of the support material, spherical bead versus ion exchange fiber, has a significant effect on kinetics of sorption and desorption. HNMs also possess dual sorption sites and are capable of removing multiple contaminants, namely, arsenate and perchlorate, concurrently.

关键词： ion exchange sorpfion arsenic perchlorat~,fluoride

Unmet supportive care needs in families of children with chronic health conditions: an Australian cross‑sectional study

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World Journal of Pediatrics 2023年第12期19卷 1181-1191页

作者： Sangeetha Thomas Linda k.Byrne Nicholas P.ryan Christel Hendrieckx Victoria White School of Psychology Faculty of HealthDeakin UniversityMelbourneVIC 3125Australia Department of Paediatrics University of MelbourneMelbourneVICAustralia Australian Centre for Behavioural Research in Diabetes MelbourneVICAustralia Institute of Health Transformation Deakin UniversityMelbourneVICAustralia Cancer Council Victoria MelbourneVICAustralia

Background The aim of this study was to identify similarities and diferences in the unmet supportive care needs(USCN)of families of children with major chronic health conditions(CHCs)using a universal need assessment *** A cross-sectional online survey involving parents of children with congenital heart disease(CHD),type 1 diabetes mellitus(T1D),cancer,and asthma diagnosed within the last 5 years recruited via social media and support ***-four items assessing the USCN across six domains(care needs,physical and social needs,informational needs,support needs,fnancial needs,child-related emotional needs)were responded to on a 4-point Likert scale[no need(1)to high need(4)].Descriptive statistics identifed the level of need,and linear regressions identifed factors associated with higher need domain *** to small numbers,the asthma group was excluded from comparisons across *** One hundred and ninety-four parents completed the survey(CHD:n=97,T1D:n=50,cancer:n=39,and asthma:n=8).Parents of children with cancer were most likely to report at least one USCN(92%),followed by parents of children with T1D(62%).The fve most commonly reported USCN across CHCs were drawn from four domains:child-related emotional,support,care,and *** need items were included in the top fve needs for all conditions.A higher USCN was associated with a greater frequency of hospital visits and the absence of parental *** Using a universal need assessment tool,this is one of the frst studies to characterize USCN in families of children diagnosed with common *** proportions endorsing diferent needs varied across conditions,the most endorsed needs were similar across the illness *** suggests that support programs or services could be shared across diferent CHCs.

关键词： Children Chronic illness Need assessment Unmet supportive care needs

Compositionally restricted attention-based network for materials property predictions

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npj Computational Materials 2021年第1期7卷 684-693页

作者： Anthony Yu-Tung Wang Steven k.kauwe ryan J.Murdock Taylor D.Sparks Fachgebiet keramische Werkstoffe/Chair of Advanced Ceramic Materials Technische Universität BerlinBerlinGermany Department of Materials Science&Engineering University of UtahSalt Lake CityUTUSA

In this paper,we demonstrate an application of the Transformer self-attention mechanism in the context of materials *** network,the Compositionally Restricted Attention-Based network(CrabNet),explores the area of structure-agnostic materials property predictions when only a chemical formula is *** results show that CrabNet’s performance matches or exceeds current best-practice methods on nearly all of 28 total benchmark *** also demonstrate how CrabNet’s architecture lends itself towards model interpretability by showing different visualization approaches that are made possible by its *** feel confident that CrabNet and its attention-based framework will be of keen interest to future materials informatics researchers.

关键词： network property restricted

Preface to the Focused Issue in Honor of Professor Philip Roe on the Occasion of His 80th Birthday

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Communications on Applied Mathematics and Computation 2020年第3期2卷 319-320页

作者： Rémi Abgrall Jennifer k.ryan Chi-Wang Shu Institüt für Mathematik Universität ZürichWinterhurerstrasse 1908057ZurichSwitzerland Department of Applied Mathematics and Statistics Colorado School of MinesGoldenCO80401USA Division of Applied Mathematics Brown UniversityProvidenceRI02912USA

On July 3-4,2018,an international workshop was organised at the University of Cambridge,by ***,to mark the 80th anniversary of a young scientist,Philip ***'s scientific achievements are numerous,and it is quite difficult to adequately address his accomplishments in a short *** began his journey at Cambridge,first for his Bachelor's degree and then obtaining his Master's degree in *** left for the Royal Aircraft Establishment(RAE)between 1962 to 1984 to work as an *** was a period of adventure,and the design of mature CFD codes for solving the Euler equations was far from being *** the Lax-Wendroff theorem was known(published in 1960),as for many novelties,it had taken some time before it became a gold *** the RAE,Phil was assigned by his manager to work in a direction that eventually led to Roe's Riemann solver and *** method is now standard in every specialised textbook,but the jump from generalizing the Murman scheme for Euler equations to what is now commonly known as the Roe flux is far from *** Roe relates this adventure,and others,in his"scientific autobiography",one of the papers of this focused issue.

关键词： eventually accomplishment assigned

Heat stress management in underground mines

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International Journal of Mining Science and Technology 2017年第4期27卷 651-655页

作者： ryan Anderson Euler De Souza k1 Mine Maintenance Mosaic Potash Esterhazy SOA2AO Canada Department of Mining Engineering Queen's University Kingston KTL3N6 Canada

Heat management must be maintained within the mine working environment to minimize stress on equipment and personnel. The issue is a growing concern as mines continue to expand in size, depth and infrastructure. Heat management is a concern as it relates to both heat sensitive equipment and more importantly the health and safety of the workers found within the mine. Proper application of engineering protocols and work practice controls will have a direct impact on the health and safety of workers and increased productivity. Using continuous monitoring stations placed in strategic locations throughout the mine to capture the environmental conditions, various strategies can be used in the planning and prevention of potential hazard exposure. Economic analysis is used to select the most feasible strategy for heat stress control. This paper presents a step by step methodology that may be considered by ventilation specialists to effectively implement a heat management control system. A case study based on a detailed heat management assessment conducted for a potash mine in Saskatchewan, Canada is presented.

关键词： Heat Management Enthalpy Mine Environment monitoring