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Measurement of in-bore side loads and comparison to first maximum yaw

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Defence Technology（防务技术） 2016年第2期12卷 106-112页

作者： Donald E.CARLUCCI ryan decker Julio VEGA Douglas RAY U.S.Army ARDEC RDAR-DSM Building 942nd FloorPicatinnyNJ 07806-5000USA U.S.Army ARDEC RDAR-EIQ-SB Building 62PicatinnyNJ 07806-5000USA

In-bore yaw of a projectile in a gun tube has been shown to result in range loss if the yaw is significant. An attempt was made to determine if relationships between in-bore yaw and projectile First Maximum Yaw(FMY) were observable. Experiments were conducted in which pressure transducers were mounted near the muzzle of a 155 mm cannon in three sets of four. Each set formed a cruciform pattern to obtain a differential pressure across the projectile. These data were then integrated to form a picture of what the overall pressure distribution was along the side of the projectile. The pressure distribution was used to determine a magnitude and direction of the overturning moment acting on the projectile. This moment and its resulting angular acceleration were then compared to the actual first maximum yaw observed in the test. The degree of correlation was examined using various statistical techniques. Overall uncertainty in the projectile dynamics was between 20% and 40% of the mean values of FMY.

关键词：偏航负载测量压力分布压力传感器发射动力学倾覆力矩角加速度统计技术

Mass asymmetry and tricyclic wobble motion assessment using automated launch video analysis

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Defence Technology（防务技术） 2016年第2期12卷 113-116页

作者： ryan decker Joseph DONINI William GARDNER Jobin JOHN Walter KOENIG Armaments Research Design and Engineering CenterPicatinny Arsenal

This paper describes an approach to identify epicyclic and tricyclic motion during projectile flight caused by mass asymmetries in spinstabilized projectiles. Flight video was captured following projectile launch of several M110A2E1 155 mm artillery projectiles. These videos were then analyzed using the automated flight video analysis method to attain their initial position and orientation *** of the pitch and yaw histories clearly indicates that in addition to epicyclic motion's nutation and precession oscillations, an even faster wobble amplitude is present during each spin revolution, even though some of the amplitudes of the oscillation are smaller than 0.02 *** results are compared to a sequence of shots where little appreciable mass asymmetries were present, and only nutation and precession frequencies are predominantly apparent in the motion history results. Magnitudes of the wobble motion are estimated and compared to product of inertia measurements of the asymmetric projectiles.

关键词：弹丸质量视频分析摆动运动不对称性自动启动三环评估行星运动

Experimental assessment of a 3-D plenoptic endoscopic imaging system

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Chinese Optics Letters 2017年第5期15卷 68-72页

作者： Hanh N. D. Le ryan decker Axel Krieger Jin U. Kang Electrical and Computer Engineering Department Johns Hopkins University Baltimore MD 21218 USA Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Health System Washington DC 20010 USA

All endoscopic imaging system using a plenoptic technique to reconstruct 3-D information is demonstrated and analyzed in this Letter. The proposed setup integrates a clinical surgical endoscope with a plenoptic camera to achieve a depth accuracy error of about 1 mm and a precision error of about 2 mm, within a 25 mm×25 mm field of view, operating at 11 frames per second.

关键词： Experimental assessment of a 3-D plenoptic endoscopic imaging system FOV MLA

Detection of Estrogen Responsive Breast Cancer Circulating Tumor Cells: Assay Development for Anti-Hormone Therapy Resistance

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Journal of Cancer Therapy 2015年第9期6卷 773-782页

作者： Sally A. Litherland Louis Barr Robert Reynolds Elizabeth Griffith ryan Sause Tiffany Encarnacion Alvin J. O. Almodovar Xiang Zhu Stephanie Dickstein Yai-Ping Shao Na’im Fanaian David A. decker Translational Research Florida Hospital Cancer Institute Orlando FL USA Breast Cancer Oncology Florida Hospital Cancer Institute Orlando FL USA Diagnostic Pathology Florida Hospital Cancer Institute Orlando FL USA

Recent clinical trials with histone deacetylase inhibitors (HDACi) have shown increased progression free survival by re-sensitizing resistant estrogen receptor positive (ER+) breast cancer cells to hormone suppressive therapies (HT). However, these trials lacked a sensitive, specific assay to identify and monitor HDACi/HT sensitive or resistant tumors. We tested detection of ER expression and histone acetylation of chromatin at the growth regulation by estrogen in breast cancer 1 (GREB1) gene, an estrogen-responsive gene involved in ER expression, in circulating tumor cell (CTC) as potential candidate assays for HDACi/HT sensitivity. ER+ and ER- CTC were detected and isolated from breast cancer patient peripheral blood by high speed fluorescence activated cell sorting (FACS) for use in mRNA analysis and anti-acetylated histone-mediated Chromatin Immunoprecipitation (ChIP). cDNA from mRNA and DNA extracted from the ChIP isolates were quantified by real-time PCR for GREB1. CTC isolates from patients who had an ER+ breast cancer primary contained both ER+ and ER- cells. More ER+ than ER- CTC was found in HT sensitive patients compared to HT resistant patients (p = 0.0559). GREB1 was found in acetylated histone chromatin from both ER+ and ER- CTC. The number of ER+ and ER- CTC found in peripheral blood appears to parallel patient outcomes as to their sensitivity to HT. Acetylated histone analysis can detect chromatin containing GREB1 in CTC, suggesting it may be useful as a more specific measure of HDACi effects on breast tumor cells. A larger, longitudinal data set following patients through HT/HDACi trials is needed to confirm these observations and their development for clinical use.

关键词： Epigenetics Breast Cancer Estrogen Receptor Histone Acetylation Anti-Hormone Therapy