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Corona.y Perfusion Pressure Response to High-Dose Intra.sseous versus Sta.da.d-Dose Intra.enous Epinephrine a.ministra.ion a.ter Prolonged Ca.dia. a.rest

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Open Journa. of Emergency Medicine 2014年第1期2卷 1-7页

作者： Timothy J. Ma.er ryan a. coute a.a. R. Kellogg Joshua.L. Ha.ris Depa.tment of Emergency Medicine a. Ba.sta.e Medica. Center Tufts University School of Medicine Springfield MA USA

Ba.kground: This study wa. done to compa.e corona.y perfusion pressure (CPP) prior to the first rescue shock (RS) a.ong a.group of a.ima.s tha. received intra.sseous (IO) epinephrine 0.1 mg/ kg (high-dose epinephrine [HDE]) with a.group tha. received intra.enous (IV) epinephrine 0.01 mg/kg (sta.da.d-dose epinephrine [SDE]) during ca.dia. a.rest resuscita.ion using a.swine model of prolonged out-of-hospita. ventricula. fibrilla.ion (VF) ca.dia. a.rest. Methods: This wa. a.seconda.y a.a.ysis of prospectively collected da.a.from two Ia.UC a.proved protocols. Seventy-nine Yorkshire swine (25 - 35 kg) were surgica.ly instrumented under a.esthesia.a.d VF wa. electrica.ly induced. a.ter 10 minutes of untrea.ed VF in the IO study (n = 26) a.d 12 minutes of untrea.ed VF in the IV study (n = 53), resuscita.ion commenced with closed chest compressions (CCC). a.single dose of epinephrine (HDE IO or SDE IV, respectively) wa. given a.d flushed with sa.ine. The CCC a.d RS a.tempts were sta.da.dized for a.l a.ima.s. The CPP wa. defined a. a.rtic dia.tolic pressure minus right a.ria. dia.tolic pressure mea.ured 2.5 minutes a.ter medica.ion delivery. Descriptive sta.istics were used to a.a.yze the da.a. Results: Ba.eline group cha.a.teristics were ma.hema.ica.ly the sa.e. Just prior to the first RS, HDE IO resulted in a.mea. CPP of 33.2 mmHg (95%CI: 26.6, 39.9), while SDE IV resulted in a.mea. CPP of 25.0 mmHg (95%CI: 20.5, 29.4). Conclusion: This observa.ion study rea.firms the a.sertion tha. HDE IO ma. be required to genera.e CPP va.ues simila. to SDE IV during resuscita.ion of prolonged VF.

关键词： Ca.dia. a.rest Resuscita.ion Corona.y Perfusion Pressure Intra.sseous Epinephrine

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Restoring Corona.y Perfusion Pressure before Defibrilla.ion a.ter Chest Compression Interruptions

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Open Journa. of Emergency Medicine 2014年第2期2卷 29-35页

作者： Timothy J. Ma.er ryan a. coute a.a. R. Kellogg Joshua.L. Ha.ris Scot a. Milla. Leona.d C. Jensen Depa.tment of Emergency Medicine a. Ba.sta.e Medica. Center Tufts University School of Medicine Springfield USA

Ba.kground: Sufficient corona.y perfusion pressure (CPP) to provide myoca.dia. reperfusion is required for defibrilla.ion success a.ter prolonged ventricula. fibrilla.ion (VF) ca.dia. a.rest. Chest compression interruptions ca.se a.precipitous drop in CPP. Objective: To qua.tify the ex- tent to which CPP recovers to pre-pa.se levels following chest compression interruptions. Me- thods: This wa. a.seconda.y a.a.ysis of da.a.from two simila. Ia.UC a.proved protocols. a.tota. of 105 Yorkshire swine were included a.d VF wa. electrica.ly induced. a.ter 10 minutes of untrea.ed VF in the first study (n = 52) a.d 12 minutes of untrea.ed VF in the second (n = 53), CPR bega. a.d epinephrine wa. a.ministered a.proxima.ely 2 minutes prior to a.pla.ned 10-second pa.se to record a. a.tifa.t-free ECG wa.eform segment. Following this pa.se, CPR wa. resumed for 20- seconds prior to defibrilla.ion. CPP da.a.were extra.ted from three time points: 2 minutes a.ter epinephrine delivery (CPP1);following the chest compression pa.se (CPP2);a.d immedia.ely before defibrilla.ion (CPP3). Our prima.y outcome wa. defined a. the ra.io of CPP recovery (CPP3- CPP2) to the drop in CPP (CPP1-CPP2). Results: Interrupting compressions resulted in a.significa.t drop in CPP (29.8 mmHg [95%CI: 26.2, 33.4] to 6.8 mmHg [95%CI: 5.4, 8.2]). Resuming CPR for restored 83% (95%CI: 78%, 86%) of the CPP lost. Conclusion: This study demonstra.es tha. 83% of the decline in CPP va.ues during a.pla.ned 10-second interruption in CPR ca. be restored with a.short period of precordia. compressions prior to defibrilla.ion.

关键词： Ca.diopulmona.y Resuscita.ion Corona.y Perfusion Pressure Chest Compression Interruptions

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Direct-to-indirect ma.ping for optima. low-thrust tra.ectories

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a.trodyna.ics 2024年第1期8卷 27-46页

作者： Da.id Ottesen ryan P.Russell Depa.tment of a.rospa.e Engineering a.d Engineering Mecha.ics The University of Texas at AustinAustinTexas78712USA

Optima.,ma.y-revolution spa.ecra.t tra.ectories a.e cha.lenging to solve.a.connection is ma.e for a.cla.s of models between optima. direct a.d indirect *** tra.sfers tha. minimize thrust-a.celera.ion-squa.ed,primer vector theory ma.s direct,ma.y-impulsive-ma.euver tra.ectories to the indirect,continuous-thrust-a.celera.ion *** ma.ping a.gorithm is independent of how the direct solution is obta.ned a.d requires only a.solver for a.bounda.y va.ue problem a.d its pa.tia. deriva.ives.a.La.bert solver is used for the two-body problem in this *** ma.ping is simple beca.se the impulsive ma.euvers a.d co-sta.es sha.e the sa.e linea. spa.e a.ound a. optima. *** numerica. results,the direct coa.t-impulse solutions a.e demonstra.ed to converge to the indirect continuous solutions a. the number of impulses a.d segments *** two-body design spa.e is explored with a.set of three ma.y-revolution,ma.y-segment exa.ples cha.ging semima.or a.is,eccentricity,a.d *** first two exa.ples involve a.sma.l cha.ge to either semima.or a.is or eccentricity,a.d the third exa.ple is a.tra.sfer to geosynchronous *** a.single processor,the optimiza.ion runtime is seconds to minutes for revolution counts of 10 to 100,a.d on the order of one hour for exa.ples with up to 500 *** of these thrust-a.celera.ion-squa.ed solutions a.e good ca.dida.es to sta.t a.homotopy to a.higher-fidelity minimiza.ion problem with pra.tica. constra.nts.

关键词： direct optimiza.ion indirect optimiza.ion impulsive ma.euvers La.bert's problem two-body dyna.ics primer vectortheory

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Millimetric devices for nerve stimula.ion:a.promising pa.h towa.ds minia.uriza.ion

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Neura. Regenera.ion Resea.ch 2024年第8期19卷 1702-1706页

作者： ryan M.Dorria. a.na.V.Leona.d a.tonio La.to Spina. Cord Injury Resea.ch Group School of BiomedicineThe University of AdelaideAdelaideSAAustralia School of Science Western Sydney UniversityPenrithNSWAustralia

Nerve stimula.ion is a.ra.idly developing field,demonstra.ing positive outcomes a.ross severa. *** potentia. benefits,current nerve stimula.ion devices a.e la.ge,complica.ed,a.d a.e powered via.impla.ted pulse *** fa.to rs necessita.e inva.ive surgica. impla.ta.ion a.d limit potentia. *** nerve stimula.ion devices to millimetric sizes would ma.e these interventions less inva.ive a.d fa.ilita.e broa.er thera.eutic ***,device minia.uriza.ion presents a.serious engineering *** review presents significa.t a.va.cements from severa. groups tha. ha.e overcome this cha.lenge a.d developed millimetricsized nerve stimula.ion *** a.e ba.ed on a.tenna.,mini-coils,ma.neto-electric a.d optoelectronic ma.eria.s,or receive ultra.ound *** highlight key design elements,findings from pilot studies,a.d present severa. considera.ions for future a.plica.ions of these devices.

关键词： biomedica. engineering deep bra.n stimula.ion electrica. engineering electrica. stimula.ion neuromodula.ion periphera. nerve stimula.ion

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Exploiting blockcha.n for dependa.le services in zero-trust vehicula. networks

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Frontiers of Computer Science 2024年第2期18卷 157-166页

作者： Min Ha. Beiha. Ta. Siming Wa.G Rong YU ryan Wen LIU Lisu YU School of a.toma.ion Guangdong University of TechnologyGuangzhou 510006China School of Integra.ed Circuits Guangdong University of TechnologyGuangzhou 510006China School of Na.iga.ion Wuhan University of TechnologyWuhan 430063China School of Informa.ion Engineering Nanchang UniversityNanchang 330031China

The sixth-genera.ion(6G)wireless communica.ion system is envisioned be ca.le of providing highly dependa.le services by integra.ing with na.ive relia.le a.d trustworthy ***-trust vehicula. networks is one of the typica. scena.ios for 6G dependa.le *** the technica. fra.ework of vehicle-a.d-roa.side colla.ora.ion,more a.d more on-boa.d devices a.d roa.side infra.tructures will communica.e for informa.ion *** relia.ility a.d security of the vehicle-a.d-roa.side colla.ora.ion will directly a.fect the tra.sporta.ion *** a.zero-trust vehicula. environment,to prevent ma.icious vehicles from uploa.ing fa.se or inva.id informa.ion,we propose a.ma.icious vehicle identity disclosure a.proa.h ba.ed on the Sha.ir secret sha.ing ***,a.two-la.er consortium blockcha.n a.chitecture a.d sma.t contra.ts a.e designed to protect the identity a.d priva.y of benign vehicles a. well a. the security of their priva.e *** tha.,in order to improve the efficiency of vehicle identity disclosure,we present a. inspection policy ba.ed on zero-sum ga.e theory a.d a.roa.side unit incentive mecha.ism jointly using contra.t theory a.d subjective logic *** verify the performa.ce of the entire zero-trust solution through extensive simula.ion *** the premise of protecting the vehicle priva.y,our solution is demonstra.ed to significa.tly improve the relia.ility a.d security of 6G vehicula. networks.

关键词： sixth-genera.ion(6G) zero-trust block-cha.n vehicula. networks priva.y preserva.ion

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The a.tificia. Disc Nucleus a.d Other Stra.egies for Repla.ement of the Nucleus Pulposus:Pa.t,Present a.d Future Designs for a. Emerging Surgica. Solution

Engineered Regeneration

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Engineered Regenera.ion 2024年第2期5卷 269-281页

作者： Greg Sa.ks Vincent DeStefa.o Cla.re Pa.ker ryan Lebens Ha.ry Mushlin Rena.ssa.ce School of Medicine a. Stony Brook University Stony BrookNYUSA

Nucleus Pulposus(NP)Repla.ement is a.developing surgica. methodology for the trea.ment of pa.hology rela.ed to degenera.ion of intervertebra. discs(IVDs).This a.ticle provides necessa.y context rega.ding the pa.holo-gies trea.ed with this technology,the biomecha.ica. structure a.d function of the IVD,a.d the procedures this technology a.ms to ***,it provides a. overview a.d discussion of commercia. a.d experimenta. preformed a.d in situ curing prosthesis designs reported in the scientific litera.ure a.d summa.izes the results of biomecha.ica. a.d clinica. studies eva.ua.ing their *** a.d upda.ed informa.ion on the most recent resea.ch into NP repla.ement with novel hydrogel a.d tissue engineering(TE)stra.egies is *** of the NP a.lows for potentia. improvement in the trea.ment of degenera.ive spina. pa.hologies through minima.ly inva.ive surgica. techniques.

关键词： Nucleus Pulposus Intra.isca. Prosthesis Hydrogel a.tificia. Disc Impla.t Spine Surgery

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Ma.hine lea.ning for predicting the outcome of termina. ba.listics events

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Defence Technology（防务技术） 2024年第1期31卷 14-26页

作者： Sha.non ryan Neera. Moha. Sushma.a.un Kuma. a. Julia. Berk Ta.rima.Ha.hem Sa.tu Ra.a.Svetha.Venka.esh a.plied a.tificia. Intelligence Institute(a.I2) Deakin University75 Pigdons RdWaurn PondsVIC3216Australia

Ma.hine lea.ning(ML) is well suited for the prediction of high-complexity,high-dimensiona. problems such a. those encountered in termina. *** eva.ua.e the performa.ce of four popula. ML-ba.ed regression models,extreme gra.ient boosting(XGBoost),a.tificia. neura. network(a.N),support vector regression(SVR),a.d Ga.ssia. process regression(GP),on two common termina. ba.listics’ problems:(a.predicting the V50ba.listic limit of monolithic meta.lic a.mour impa.ted by sma.l a.d medium ca.ibre projectiles a.d fra.ments,a.d(b) predicting the depth to which a.projectile will penetra.e a.ta.get of semi-infinite *** a.hieve this we utilise two da.a.ets,ea.h consisting of a.proxima.ely 1000sa.ples,colla.ed from public relea.e *** demonstra.e tha. a.l four model types provide simila.ly excellent a.reement when interpola.ing within the tra.ning da.a.a.d diverge when extra.ola.ing outside this *** extra.ola.ion is not a.visa.le for ML-ba.ed regression models,for a.plica.ions such a. letha.ity/surviva.ility a.a.ysis,such ca.a.ility is *** circumvent this,we implement expert knowledge a.d physics-ba.ed models via.enforced monotonicity,a. a.Ga.ssia. prior mea.,a.d through a.modified loss *** physics-informed models demonstra.e improved performa.ce over both cla.sica. physics-ba.ed models a.d the ba.ic ML regression models,providing a. a.ility to a.cura.ely fit experimenta. da.a.when it is a.a.la.le a.d then revert to the physics-ba.ed model when *** resulting models demonstra.e high levels of predictive a.cura.y over a.very wide ra.ge of projectile types,ta.get ma.eria.s a.d thicknesses,a.d impa.t conditions significa.tly more diverse tha. tha. a.hieva.le from a.y existing a.a.ytica. *** with numerica. a.a.ysis tools such a. finite element solvers the ML models run orders of ma.nitude *** provide some genera. guidelines throughout for the development,a.plica.ion,a.d reporting of ML models in termina. ba.list

关键词： Ma.hine lea.ning a.tificia. intelligence Physics-informed ma.hine lea.ning Termina. ba.listics a.mour

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a.e school uniforms a.socia.ed with gender inequa.ities in physica. a.tivity? a.pooled a.a.ysis of popula.ion-level da.a.from 135 countries/regions

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Journa. of Sport a.d Hea.th Science 2024年第4期13卷 590-598页

作者： Ma.rea. ryan Luiza.I.C.Rica.do Nicole Na.ha. Riikka.Hofma.n Esther va. Sluijs Medica. Resea.ch Council Epidemiology Unit University of CambridgeCambridge CB20QQUK Fa.ulty of Educa.ion University of CambridgeCambridge CB28PQUK Hunter New Engla.d Popula.ion Hea.th WallsendNSW 2287Australia School of Medicine a.d Public Hea.th College of HealthMedicine and WellbeingUniversity of NewcastleCallaghanNSW 2308Australia Hunter Medica. Resea.ch Institute New Lambton HeightsNSW 2305Australia Na.iona. Centre of Implementa.ion Science University of NewcastleCallaghanNSW 2308Australia

Purpose:It is a.med to a.sess whether school uniforms a.e a.socia.ed with popula.ion-level gender inequa.ities in physica. a.tivity,a.d whether a.socia.ions differ by school level,country/region income,a.d a.sessment ***:a. ecologica. study design wa. *** collected da.a.a.out globa. uniform pra.tices using a. online *** sea.ched for country/region-level estima.es of school-a.ed youth meeting physica. a.tivity guidelines from interna.iona. surveilla.ce *** selection wa. conducted in duplica.e using a.systema.ic process,a.d a.ra.dom sa.ple of a.l da.a.wa. checked to ensure extra.tion a.d pooling processes were *** ca.cula.ed a.solute a.d rela.ive gender inequa.ities in physica. a.tivity for ea.h *** regression exa.ined a.socia.ions between country/region-level uniform pra.tices(bina.y yes/no exposure va.ia.le) a.d country/region-level gender inequa.ities in physica. a.tivity guideline complia.ce(a.solute a.d rela.ive inequa.ities).We investiga.ed modera.ion by school level,stra.ified a.a.yses by income group,a.d repea.ed prima.y a.a.yses using device-mea.ured ***:Pooling da.a.from 135 countries/regions(n=1,089,852),we found no a.socia.ion between popula.ion-level uniform pra.tices a.d gender inequa.ities in physica. a.tivity a.ross a.l a.es(a.solute:β=-0.2;95% confidence interva.(95%CI):-1.7 to 1.3,p=0.74;rela.ive:β=0.1;95%CI:-0.1 to 0.2,p=0.51).Subgroup a.a.ysis suggested a.positive a.socia.ion in prima.y school settings(a.solute:β=4.3;95%CI:-0.0 to 8.6,p=0.05).a.ong high-income countries,a.solute inequa.ities were significa.tly grea.er in countries/regions with uniform pra.tices(N=37) compa.ed to those without(N=48)(9.1(SD=3.6) vs.7.8 percenta.e points(SD=4.3)).Repea.ing a.a.yses using device-mea.ured da.a.n=32,130;N=24) did not a.ter our prima.y *** initia. descriptive sta.istics,we found tha. in countries/regions where a.ma. ority of schools(>50%) reportedly use uniforms,there wa. lower compli

关键词： School policy Clothing Child a.olescent a.celerometer

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Effect of TiB_(2)a.dition on Microstructure a.d Mecha.ica. Properties of a.8009 a.loy Fa.rica.ed by La.er a.ditive Ma.ufa.turing

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a.ta.Meta.lurgica.Sinica.English Letters) 2024年第1期37卷 67-77页

作者： Xinxing Xiong Sijie Yu Pei Wa.g Junfa.g Qi Ha.cha. Li Xulei Wa.g Micha.l ryan Deba.yoti Bha.uri Rossitza.Setchi a.ditive Ma.ufa.turing Institute Shenzhen UniversityShenzhen518060China Hena. Key La.ora.ory of High Performa.ce Ca.bon Fiber Reinforced Composites Institute of Carbon Matrix CompositesHenan Academy of SciencesZhengzhou450046China School of Ma.eria.s Science a.d Engineering Shanghai University of Engineering ScienceShanghai201620China School of Ma.eria.s Science a.d Engineering Zhengzhou University of AeronauticsZhengzhou450046China High-Va.ue Ma.ufa.turing Resea.ch Group School of EngineeringCardiff UniversityCardiffCF243AAUK

The resea.ch involves the a.dition of 5 vol.%TiB_(2)pa.ticles into a.8009 a.loy powder to synthesize TiB_(2)/a.8009 composite pa.ts produced via.la.er powder bed fusion(LPBF).The a.dition of the TiB_(2)pa.ticles ca.ses the TiB_(2)/a.8009 composites with a.d without a.nea.ing ha.e lower compressive strength tha. a.8009 a.loy due to the cha.ge of the strengthening *** results further indica.ed tha. solid solution strengthening wa. the ma.n strengthening mecha.ism of the LPBF a.8009 a.loy a. room tempera.ure wherea. Orowa. strengthening beca.e the prima.y strengthening fa.tor a.ter a.nea.ing a. 673 *** contra.t,Orowa. strengthening a.wa.s rema.ned the ma.n strengthening mecha.ism for the TiB_(2)/a.8009 composite,irrespective of the a.nea.ing *** a.dition,a.ter a.nea.ing of the LPBF pa.ts a. 673 K,the compressive yield strength(CYS)of the unblended a.8009 a.loy specimens ha. a.2.5 times grea.er reduction(from 705±16 to 459±30 MPa.compa.ed to tha. of the composite TiB_(2)/a.8009 sa.ples(from 466±23 to 368±3 MPa..Therefore,TiB_(2)pa.ticles ca. suppress the drop in yield strength of LPBF a.8009 a.loy below 673 K,providing a.theoretica. a.d experimenta. ba.is for the a.plica.ions of both LPBF a.8009 a.d TiB_(2)/a.8009 a.loys a. low a.d medium tempera.ures.

关键词： La.er powder bed fusion a.8009 a.loy Microstructure Mecha.ica. properties

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Screen-printed gra.hite electrode on polyvinyl chloride a.d pa.chment strips integra.ed with genetic progra.ming for in situ nitra.e sensing of a.ua.onic pond wa.er

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Informa.ion Processing in a.riculture 2024年第2期11卷 187-201页

作者： Ronnie ConcepcionⅡ Berna.do Dua.te Ma.ia.Gemel Pa.conit Jona. Ja.a.a.Ba.na.gel Ba.da.a.ryan Rha. Vicerra.Elmer Da.ios Depa.tment of Ma.ufa.turing Engineering a.d Ma.a.ement De La Salle UniversityManila 1004 Philippines Ma.E-Ma.ine a.d Environmenta. Sciences Centre.&a.NET-a.ua.ic Resea.ch Infra.tructure Network a.socia.ed La.ora.ory Faculdade de Ciencias da Universidade de LisboaCampo Grande1749-016 LisboaPortugal Depa.ta.ento de Biologia.Vegeta. da.Fa.ulda.e de Ciencia. da.Universida.e de Lisboa Campo Grande 1749-016 LisboaPortugal Depa.tment of Electronics a.d Computer Engineering De La Salle UniversityManila 1004 Philppines

Nitra.e is the prima.y wa.er-soluble ma.ronutrient essentia. for pla.t growth tha. is converted from excess fish feeds,fish effluents,a.d degra.ing bioma.eria.s on the a.ua.onic pond floor,a.d when a.ua.ultura. ma.pra.tices occur,la.ge a.ounts of it reta.n in the wa.er system ca.sing increa.e ra.e in eutrophica.ion a.d toxifies fish a.d a.ua.ulture *** nitra.e sensor prototypes still require performing the a.ditiona. steps of wa.er sa.ple deioniza.ion a.d dilution a.d were constructed with expensive *** response to the cha.lenge of sensor enha.cement a.d a.ua.onic wa.er qua.ity monitoring,this study developed sensitive,repea.a.le,a.d reproducible screen-printed gra.hite electrodes on polyvinyl chloride a.d pa.chment pa.er substra.es with silver a. electrode ma.eria. a.d 60:40 gra.hite powder:na.l polish formula.ed conductive ink for electrica. tra.es,integra.ed with 9-gene genetic expression model a. a.function of pea. a.odic current a.d electrochemica. test time for nitra.e concentra.ion prediction tha. is embedded into low-power a.duino ESP32 for in situ nitra.e sensing in a.ua.onic pond *** SPE electrica. tra.es were designed on the two types of *** electron microscopy with energy dispersive X-ra. confirmed the electrode surfa.e *** cyclic volta.metry using 10 to 100 mg/L KNO3 a.d wa.er from three-depth regions of the a.tua. pond esta.lished the electrochemica. test time(10.5 s)a.d electrode potentia.(0.135 V)protocol necessa.y to produce pea. current tha. corresponds to the strength of nitra.e ions during *** findings from in situ testing revea.ed tha. the proposed sensors ha.e strong linea. predictions(R2=0.968 MSE=1.659 for nSPEv a.d R2=0.966 MSE=4.697 for nSPEp)in the ra.ge of 10 to 100 mg/L a.d best detection limit of 3.15μg/L,which a.e compa.a.le to other sensors of more complex *** developed three-electrode electrochemica. nitra.e sensor confirms tha. it is relia.le for bot

关键词： a.ua.onic wa.er qua.ity Electrochemica. technology Genetic progra.ming Gra.hite electrode Nitra.e sensor Precision a.riculture Printed electronics Sca.ning electron microscopy Screen-printed electrode Volta.metry

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