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An overview of the geology and production of the Fuling shale gas field,Sichuan Basin,China

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Energy Geoscience 2020年第3期1卷 147-164页

作者： Haikuan Nie Donghui Li Guangxiang Liu Zhiyuan Lu Hu Wang ruyue Wang Guangrong zhang State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing100083China Sinopec Petroleum Exploration and Production Research Institute Beijing100083China Sinopec Key Laboratory of Shale Oil/Gas Exploration&Production Beijing100083China China University of Geosciences(Beijing) Beijing100083China

The Fuling shale gas field in China is the largest shale gas field as well as the largest of its type discovered in any Lower Paleozoic *** this study,the geology and production of the upper and lower gas layers in the Fuling shale gas field are evaluated in terms of structure,shale quality,fault,initial production,and estimated ultimate recovery(EUR).The shale in the lower gas layer of the Jiaoshiba anticline is a high-quality reservoir,where the space is dominated by organic pores in kerogen,and the gas content is *** shale gas wells reveal relatively high initial production and ***,the shale in the upper gas layer of the Jiaoshiba anticline has reservoir space mainly composed of clay mineral pores and organic pores within bitumen,and the gas content is *** terms of structure,primary gas migration may occur in the upper gas layer,resulting in free gas accumulation in the structural high,where the development effects are generally better than those in the structural *** lower gas layer in the Pingqiao anticline,is the main interval for shale gas accumulation and development due to the high-quality *** the influence of faults,the efficiency of exploration wells emplaced on top of the anticline is much lower a compared with those in the *** residual synclines close to the Sichuan Basin,including the Baima and Baitao anticlines,are characterized by more recent uplifts,larger area,greater distance from the deep and large faults,and early fracture ***,we recommend that the shale gas exploration and development should be carried out preferentially in areas close to the center of the residual synclines,featuring relatively high-pressure coefficient and moderate burial depth.

关键词： Geologic characteristics Production features Longmaxi formation Fuling shale gas field Sichuan basin

Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment

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Bioactive Materials 2021年第11期6卷 3962-3975页

作者： Yuxuan Yang Xiaodan Zhao Jing Yu Xingxing Chen ruyue Wang Mengyuan zhang Qiang zhang Yanfeng zhang Shuang Wang Yilong Cheng Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an710049China School of Chemistry Xi’an Jiaotong UniversityXi’an710049China

The treatment of diabetic chronic wounds remains a global challenge due to the up-regulated inflammation response,oxidant stress,and persistent infection during healing *** wound dressing materials with ideal biocompatibility,adequate mechanical strength,considerable under-water adhesion,sufficient anti-inflammation,antioxidant,and antibacterial properties is on-demand for clinical *** this study,we developed a bioactive skin-mimicking hydrogel band-aid through the combination of tannic acid(TA)and imidazolidinyl urea reinforced polyurethane(PMI)(TAP hydrogel)and explored its potentials in various medical applications,including hemostasis,normal skin incision,full-thickness skin wounds,and bacterial-infection skin incision on diabetic *** was loaded into PMI hydrogel network to enhance the mechanical properties of TAP hydrogels through multiple non-covalent interactions(break strength:0.28-0.64 MPa;elongation at break:650-930%),which could resist the local stress and maintain the structural integrity of wound dressings during ***,owing to the promising moisture-resistant adhesiveness and organ hemostasis,outstanding anti-inflammation,antibacterial,and antioxidant properties,TAP hydrogels could efficiently promote the recovery of skin incision and defects on diabetic *** further simulate the practical situation and explore the potential in clinical application,we also verified the treatment efficiency of TAP hydrogel in ***-infected skin incision model on diabetic mice.

关键词： Hydrogel Tannic acid Wound dressing Chronic diabetic wound Hydrogen bonding

A photon-controlled diode with a new signal-processing behavior

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National Science Review 2022年第8期9卷 110-117页

作者： Shun Feng ruyue Han Lili zhang Chi Liu Bo Li Honglei Zhu Qianbing Zhu Wei Chen Hui-Ming Cheng Dong-Ming Sun Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences School of Physical Science and Technology Shanghai Tech University School of Materials Science and Engineering University of Science and Technology of China Faculty of Materials Science and Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences

The photodetector is a key component in optoelectronic integrated circuits. Although there are various device structures and mechanisms, the output current changes either from rectified to fully-on or from fully-off to fully-on after illumination. A device that changes the output current from fully-off to rectified should be possible. We report the first photon-controlled diode based on a n/n-molybdenum disulfide junction. Schottky junctions formed at the cathode and anode either prevent or allow the device to be rectifying, so that the output current of the device changes from fully-off to rectified. By increasing the thickness of the photogating layer, the behavior of the device changes from a photodetector to a multifunctional photomemory with the highest non-volatile responsivity of 4.8 × 10~7A/W and the longest retention time of 6.5 × 10~6s reported so far. Furthermore, a 3 × 3 photomemory array without selectors shows no crosstalk between adjacent devices and has optical signal-processing functions including wavelength and power-density selectivity.

关键词： photon-controlled diode fully-off rectifying photomemory array

Investigation of the feasibility of NRAV as a biomarker for hepatocellular carcinoma

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Oncology Research 2024年第4期32卷 717-726页

作者： JUN LIU WENLI LI ruyue LU JIAQING XU CHUNHUI JIANG JUNLIN DUAN LINGZHI zhang GUANFU WANG JIAXI CHEN Department of Clinical Laboratory Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhaiChina Key Laboratory of System Medicine and Precision Diagnosis and Treatment of Taizhou TaizhouChina Department of Clinical Laboratory Dongguan Hospital of Traditional Chinese MedicineDongguanChina School of Basic Medical Sciences Forensic Medicine Hangzhou Medical CollegeHangzhouChina

The long non-coding RNA,Negative Regulator of Antiviral Response(NRAV)has been identified as a participant in both respiratory virus replication and immune checkpoints,however,its involvement in pan-cancer immune regulation and prognosis,particularly those of hepatocellular carcinoma(HCC),remains *** address this knowledge gap,we analyzed expression profiles obtained from The Cancer Genome Atlas(TCGA)database,comparing normal and malignant tumor *** found that NRAV expression is significantly upregulated in tumor tissues compared to adjacent nontumor ***-Meier(K-M)analysis revealed the prognostic power of NRAV,wherein overexpression was significantly linked to reduced overall survival in a diverse range of tumor ***,noteworthy associations were observed between NRAV,immune checkpoints,immune cell infiltration,genes related to autophagy,epithelial-mesenchymal transition(EMT),pyroptosis,tumor mutational burden(TMB),and microsatellite instability(MSI)across different cancer types,including ***,NRAV upregulation expression was associated with multiple pathological stages by clinical ***,our investigation revealed a substantial elevation in the expression of NRAV in both HCC tumor tissues and cells compared to normal tissues and *** inhibition of NRAV resulted in the inhibition of cell proliferation,migration,and invasion in HCC cells,while also influencing the expression of CD274(PD-L1)and CD44,along with various biomarkers associated with EMT,autophagy,and *** aforementioned results propose NRAV as a promising prognostic biomarker for HCC.

关键词： NRAV Hepatocellular carcinoma Prognosis Biomarker Pan-cancer

Wet-milling synthesis of immobilized Pt/Ir nanoclusters as promising heterogeneous catalysts

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Nano Research 2022年第4期15卷 3065-3072页

作者： Peng Du Kai Huang Xiaoyuan Fan Jingteng Ma Naveed Hussain ruyue Wang Bohan Deng Binghui Ge Haolin Tang Ru zhang Ming Lei Hui Wu State Key Laboratory of Information Photonics and Optical Communications&School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China

Being a typical state of the art heterogeneous catalyst,supported noble metal catalyst often demonstrates enhanced catalytic ***,a facile synthetic method for realizing large-scale and low-cost supported noble metal catalyst is strictly *** this end,by making use of the strong metal-support interaction(SMSI)and mechanochemical reaction,we introduce an efficient synthetic route to obtain ultrafine Pt and Ir nanoclusters immobilized on diverse substrates by wet chemical *** further demonstrate the scaling-up effect of our approach by large-scale ball-milling production of Pt nanoclusters immobilized on TiO_(2)*** synthesized Pt/Ir@Co_(3)O_(4)catalysts exhibit superior oxygen evolution reaction(OER)performance with only 230 and 290 mV overpotential to achieve current density of 10 and 100 mA·cm^(-2),beating the catalytic performance of Co_(3)O_(4)supported Pt or Ir clusters and commercial Ir/*** is envisioned that the present work strategically directs facile ways for fabricating supported noble metal heterogeneous catalysts.

关键词： heterogeneous catalysts metal clusters wet milling large-scale production strong metal–support interaction

高效液相色谱-串联质谱法测定药食同源中药材中29种农药残留

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化学分析计量 2023年第11期32卷 47-52页

作者：平文卉史玉坤杨清华杨娟施逸岚叶清华张茹玥程晓宏南通市疾病预防控制中心江苏南通226000

建立了固相萃取-高效液相色谱-串联质谱法测定药食同源中药材中29种农药的分析方法。样品用乙腈提取,固相萃取柱净化,经Agilent poroshell 120 EC-C_(18)色谱柱(100 mm×3.0 mm,2.7μm)分离,质谱采用电喷雾电离源,多反应监测模式检测,... 详细信息

建立了固相萃取-高效液相色谱-串联质谱法测定药食同源中药材中29种农药的分析方法。样品用乙腈提取,固相萃取柱净化,经Agilent poroshell 120 EC-C_(18)色谱柱(100 mm×3.0 mm,2.7μm)分离,质谱采用电喷雾电离源,多反应监测模式检测,以色谱峰面积外标法定量。29种农药质量浓度与色谱峰面积线性相关,相关系数为0.995~0.999 4,检出限为0.002~0.05 mg/kg,高、中、低3个不同浓度加标回收率为79.5%~108.7%,相对标准偏差为3.05%~6.71%(n=6)。该方法降低了药食同源样品中基质干扰,方法准确、快速,可用于大批量样品中农药残留的检测分析。

关键词：药食同源中药材农药残留高效液相色谱-串联质谱法

The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation

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Food Science and Human Wellness 2023年第6期12卷 2344-2354页

作者： Jingjing Xu ruyue Wang Weibao Liu Zhongwei Yin Jianrong Wu Xun Yu Wen Wang Hongtao zhang Zhitao Li Minjie Gao Li Zhu Xiaobei Zhan Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Wuxi Second People's Hospital Wuxi 214125China L&F Biotech.Ltd.7144 Collister Dr.Burnaby BC V5A3P6 Canada

Butyrate and butyrate-producing bacteria are important indicators of gut microbial metabolism in human *** non-digestible carbohydrates(NDCs),including inulin,fructooligosaccharide(FOS),oatsβ-glucans(OGS),oatsβ-glucan oligosaccharides(OGOS),Astragalus polysaccharides(APS),Astragalus oligosaccharides(AOS),xanthan gum oligosaccharides(XGOS),gellan gum oligosaccharides(GGOS),curdlan oligosaccharides(COS),and pullulan oligosaccharides(POS)were used to investigate NDC specifi city in modulating butyrate-producing bacteria and butyrate production in 48 h in vitro fermentation studies in combination with fecal inocula from 7 healthy donors and 11 patients with type 2 diabetes(T2D).We observed that the amount of these ten NDCs utilized depended on NDC structure and inter-individual gut microbial *** and GGOS fermentations signifi cantly increased butyrate-producing bacteria(especially f_Lachnospiraceae)and butyric acid ***,XGOS and GGOS fermentations showed a better ability to consistently modulate gut microbiota composition and metabolic properties between individuals of healthy donors or T2D patients when compared to inulin,FOS,APS,AOS,OGS,OGOS,COS and POS *** research indicated that xanthan gum and gellan gum oligosaccharides have strong specifi city to enhance butyrate-producing bacteria and butyrate production.

关键词： Non-digestible carbohydrates Gut microbiota Butyric acid Butyrate-producing bacteria

Effects of Combined Stress from Salt and Herbicide on Microbial Remediation of Soil Contaminated by n-Hexadecane and Phenanthrene

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China Petroleum Processing & Petrochemical Technology 2022年第2期24卷 126-137页

作者： Liu Bingkun Zuo Shuai Wang Ruirui Dong Kangning zhang Xiuxia Li ruyue Hao Boyu Li Jing Yin Linghao Bai Yuhao Song Jiayu Gu Yingying Sun Juan State Key Laboratory of Petroleum Pollution Control Beijing 102206 Department of Environment and Safety Engineering China University of PetroleumQingdao 266580 Department of Computer Science and Technology China University of PetroleumQingdao 266580

In this study,physicochemical,cluster,and high-throughput sequencing analyses were used to investigate the joint effects of salt and herbicide(glyphosate)stress factors on the microbial remediation of soil contaminated by n-hexadecane and *** on the soil’s physical and chemical properties,differences in microbial quantity and enzyme activities were analyzed among the samples,and how that influenced distribution of soil community structure was focused *** 120 days of indoor simulated remediation,the cumulative degradation rate of n-hexadecane decreased by 94.92%(blank control),96.96%(low concentration salt and glyphosate stress group),65.07%(high concentration salt and glyphosate stress group),while that of phenanthrene decreased by 87.33%(blank control),86.25%(low concentration salt and glyphosate stress group),58.45%(high concentration salt and glyphosate stress group).The combined stress of salt and herbicides was capable of lowering the reduction efficiency of organic matter,total nitrogen,and total phosphorus,and also restricting the growth of microorganisms and enzyme *** analysis results indicated that the non-stress group was similar to the low-concentration compound stress group during different remedial period,whereas both of those differed starkly from the high-concentration compound stress ***-throughput sequencing revealed that the dominant soil bacteria phyla shifted from Firmicutes to Actinobacteria within 120 days of remediation.

关键词： oil-contaminated soil cluster analysis common quantity sequencing microorganisms salt stress glyphosate stress

Cutting-Edge FAK-targeting PROTACs:design,synthesis,and biological evaluation

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Journal of Chinese Pharmaceutical Sciences 2024年第9期33卷 767-782页

作者： Ruifeng Wang Xin Zhao Hongbao Hou Ke Chen Shuihua Liu ruyue Ren Yunfeng Liu Yi zhang Medicinal Basic Research Innovation Center of Chronic Kidney Disease Ministry of EducationShanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Pharmacology Shanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Endocrinology First Hospital of Shanxi Medical UniversityShanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Pharmacy Shanxi Medical UniversityTaiyuan 030001ShanxiChina

Focal adhesion kinase(FAK)is an intracellular tyrosine kinase that plays a critical role in the occurrence,development,and metastasis of cancer through both its kinase-dependent catalytic functions and kinase-independent scaffolding *** kinase inhibitors target only its catalytic activity,leaving the scaffolding functions ***,proteolysis targeting chimeras(PROTACs)offers a promising approach by degrading the entire FAK protein,thereby inhibiting both functions *** this study,we designed and synthesized novel PROTAC degraders,utilizing a defactinib derivative(compound 12)as the FAK ligand and a lenalidomide analog as the E3 ligase *** structures of these compounds were confirmed through^(1)H NMR,^(13)C NMR,and high-resolution mass spectrometry(HRMS).Among the synthesized compounds,the optimized compound 16b exhibited potent degradation activity against FAK protein in A549 cells,with a DC_(50)of 6.16±1.13 n M,significantly inhibiting the proliferation and colony formation of these *** to defactinib,16b showed enhanced inhibition of A549 cell migration and ***,our research demonstrated that the rapid and effective FAK degradation induced by 16b was mediated by a CRBN-dependent proteasome mechanism.

关键词： FAK PROTAC Migration Invasion