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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 60-61页

作者： ruurda j.p. Gooszen H.G. Breeders I.A.M.j. 王志宇 Dept. of Surgery H.P. G04.228 University Medical Centre Utrecht P.O. Box 85500 NL-3508 GA Utrecht Netherlands Dr.

Heller myotomy for achalasia is routinely performed laparoscopically. This offers patients significant benefits compared to open surgery. Surgeons, however, are limited in their manipulation and visualization during laparoscopic interventions. Robotic telemanipulation systems were introduced with the objective of alleviating these limitations. The purpose of this study was to demonstrate the efficacy and safety of performing a Heller myotomy with the use of a robotic telemanipulation system. Fourteen patients were operated on with the da Vinci robot system. Robotic system set-up time, per-and postoperative complications, blood loss, operating time and hospital stay were recorded. Follow-up included manometry and symptom score. The robotic system set-up time was 15 min (10-15). Thirteen procedures (13/14: 93%) were completed by laparoscopic surgery. One procedure was converted because of inadequate exposure. One peroperative mucosal perforation was closed laparoscopically. The median blood loss was 10 mL (10-200). Median operating time was 90 min (75-150). Hospitalization ranged from 2 to 8 days (median 3). No complications occurred during a 30-day postoperative period. Dysphagia was relieved in 12/14 patients (86%). Heartburn was present postoperatively in 2/14 patients (14%). Manometry showed a significant decrease in median lower oesophageal sphincter (LOS) pressure from 2.9 preoperatively to 1 kpa postoperatively (p = 0.008). Robot-assisted laparoscopic Heller myotomy was demonstrated to be safe and effective in reducing basal LOS pressure and dysphagia. The results of this study clearly support the feasibility of the use of this system in performing a delicate laparoscopic surgical procedure. The use of a robotic system was experienced as being highly supportive in manipulation and visualization by the surgical team involved.

关键词：早期经验肌切开术 Heller 腔镜机器人系统贲门失弛缓症腹腔镜操作失血量开腹手术操作时间

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postoperative complications and weight loss following jejunostomy tube feeding after total gastrectomy for advanced adenocarcinomas

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Chinese journal of Cancer Research 2017年第4期29卷 333-340页

作者： hylke j.f.brenkman stéphanie v.s.roelen elles steenhagen jelle p.ruurda richard van hillegersberg cancer center department of surgeryuniversity medical center utrechtPO Box 855003508 GAUtrechtthe Netherlands internal medicine and dermatology department of dieteticsuniversity medical center utrechtPO Box 855003508 GAUtrechtthe Netherlands

Objective： patients undergoing total gastrectomy for cancer are at risk of malnourishment. The aim of this self- controlled study was to examine the effect of jejunostomy tube feeding （jTF） and other factors on postoperative weight and the incidence of jejunostomy-related complications in patients undergoing total gastrectomy for cancer. Methods： All consecutive patients who underwent total gastrectomy for gastric cancer with jejunostomy plaeement were included from a prospective single-center database （2003-2014）. jejunostomy-related complications and postoperative weight changes were evaluated up to 12 months after surgery. Multivariable linear regression analysis was performed to identify factors associated with weight loss 12 months after gastreetomy. Results： Of 113 patients operated in the study period, 65 received jTF after total gastrectomy for a median duration of 18 d [interquartile range （IQR）, 10-55 d]. jejunostomy-related complieations occurred in 11 （17%） patients, including skin leakage （n=3） and peritoneal leakage （n=2）, luxation （n=3）, occlusion （n=2）, infection （n=l） and torsion （n=l）. In 2 （3%） patients, a reoperation was needed due to jejtmostomy-related complications. The mean preoperative weight of patients was 71.8 kg （100%）, and remained stable during jTF （73.9 kg, 103%, p=0.331）. After jTF was stopped, the mean weight of patients decreased to 64.9 kg （90%） at 12 months after surgery （p〈0.001）. A high preoperative body mass index （BMI）（〉_25 kg/m2） was associated with high postoperative weight loss compared to patients with a low BMI （〈25 kg/m2）（16.3% vs. 8.6%, p=0.016）. Conclusions： jTF can prevent weight loss in the early postoperative phase. However, this is at the prize of possible complications. As weight loss in the long term is not prevented, routine jTF should be re-evaluated and balanced against the selected use in preoperatively malnourished patients. Special attention should be paid to patients with a high preoperative BMI, who ar

关键词： Gastric cancer total gastrectomy jejunostomy tube feeding weight

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科学严谨的患者信息登记是高质量胃癌外科研究的基石——荷兰上消化道癌症审计数据库11年经验分享

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中华胃肠外科杂志 2023年第2期26卷 148-153页

作者：王敬普 Eline M de Groot Maurits R Visser Misha D.p Luyer jelle p ruurda Richard van Hillegersberg 荷兰乌特勒支大学医学中心外科部荷兰乌特勒支3584CX 荷兰临床审计研究所科学局荷兰莱顿2333AA 凯瑟琳那医院外科部荷兰埃因霍温5623EJ

随着过去数十年微创技术、围手术期康复干预和集中化医疗制度的逐步应用,胃癌术后30 d病死率和并发症发生率有了显著改善。然而,当前阶段的胃癌术后短期预后依然不容乐观,可能对胃癌手术治疗的疗效产生严重的负面影响,仍有很大的改善空... 详细信息

随着过去数十年微创技术、围手术期康复干预和集中化医疗制度的逐步应用,胃癌术后30 d病死率和并发症发生率有了显著改善。然而,当前阶段的胃癌术后短期预后依然不容乐观,可能对胃癌手术治疗的疗效产生严重的负面影响,仍有很大的改善空间。高质量的临床研究是分析治疗结果和评估新治疗策略的重要工具。因此,严谨的胃癌患者信息登记作为高质量外科研究的基础应受到足够重视。在过去的11年里,荷兰上消化道癌症审计(DUCA)数据库在上消化道肿瘤患者的数据登记和维护方面拥有丰富的经验,它在数据登记、数据质量控制、数据申请和使用以及数据安全等方面采取的有效措施,使得该数据库中患者数据的质量保持在较高水平。这些数据已被广泛用于医疗质量监测和科学研究,对改善上消化道癌症患者的术后短期预后产生了非常积极的影响。DUCA的工作可能对建立基于人群的临床数据库具有一定的参考价值。

关键词：胃肿瘤并发症荷兰上消化道癌症审计,数据库

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Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries:the impact of decreasing resection rates

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Cancer Communications 2022年第7期42卷 648-662页

作者： Lei Huang Lina jansen Rob H.A.Verhoeven jelle p.ruurda Liesbet Van Eycken Harlinde De Schutter jan johansson Mats Lindblad Tom B.johannesen Vesna Zadnik Tina Zagar Sjoerd M.Lagarde Cornelis j.Hvan de Velde petra Schrotz-King Hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)Heidelberg 69120Germany Medical Faculty Heidelberg of Heidelberg University Heidelberg 69120Germany German Cancer Consortium German Cancer Research CenterHeidelberg 69120Germany Department of Research&Development Netherlands Comprehensive Cancer OrganizationUtrecht 3501 DBThe Netherlands Department of Medical Oncology Amsterdam University Medical CentersAmsterdam 1105 AZThe Netherlands Department of Surgery University Medical Center UtrechtUtrecht 3508 GAThe Netherlands Belgian Cancer Registry Brussels B-1210Belgium Department of Esophageal and Gastric Surgery Lund University HospitalLund 22185Sweden Department of Clinical Science Interventionand TechnologyDivision of SurgeryKarolinska University HospitalStockholm 17176Sweden Registry Department The Cancer Registry of NorwayOslo 0379Norway Epidemiology and Cancer Registry Institute of Oncology LjubljanaLjubljana 1000Slovenia Department of Surgery Erasmus Medical Centre-University Medical Centre RotterdamRotterdam 3015 CEThe Netherlands Department of Surgical Oncology Leiden University Medical CenterLeiden 2300 RCThe Netherlands Division of preventive Oncology German Cancer Research Center and National Center for Tumor DiseasesHeidelberg 69120Germany

Background:We previously observed decreasing resection rates of nonmetastatic gastric adenocarcinoma(GaC)in the US and some European *** and to what extent these trends affect the trends in overall survival(OS)of patients with non-metastatic GaC at the population level remain *** large international population-based cohort study aimed to assess the impact of the previously observed decreasing resection rates on multivariable-adjusted trends in the long-term OS of patients with non-metastatic ***:Individual-level data of patients with non-metastatic GaC were obtained from the national cancer registries of the Netherlands,Belgium,Sweden,Norway,and Slovenia,and the US Surveillance,Epidemiology,and End Results *** analyzed data for each country *** between year of diagnosis and OS were assessed using Cox proportional hazards regression model with adjustment for multiple prognostic variables,with and without including resection and chemotherapy as potential explanatory ***:A total of 66,398 non-metastatic GaC patients diagnosed in 2003-2016 were analyzed,with an accumulated follow-up of 172,357 *** adjustment for resection,OS was improved only slightly in the US[hazard ratio(HR)_(per year)=0.99;HR_(≥vs.provement was observed in the investigated European countries,with OS even worsening in Sweden(HR_(per year)=1.03;HR_(≥vs.justing for resection,the increasing OS trend became stronger in the US(HR_(per year)=0.98;HR_(≥vs.poral trend became insignificant in *** Slovenia(HR_(per year)=0.99;HR_(≥vs.per year)=0.97;HR_(≥vs.proved OS over time emerged after resection *** OS in patients undergoing resection was observed in the US,the Netherlands,and *** for chemotherapy did not alter the observed *** analyses by tumor location showedm

关键词： gastric adenocarcinoma resection rate adjusted overall survival temporal trend prognostic factors international population-based cohort study

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Worldwide practice in gastric cancer surgery

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World journal of Gastroenterology 2016年第15期22卷 4041-4048页

作者： Hylke jF Brenkman Leonie Haverkamp jelle p ruurda Richard van Hillegersberg Department of Surgery University Medical Center Utrecht

AIM: To evaluate the current status of gastric cancer surgery ***: An international cross-sectional survey on gastric cancer surgery was performed amongst international upper gastro-intestinal surgeons. All surgical members of the International Gastric Cancer Association were invited by e-mail to participate. An English web-based survey had to be filled in with regard to their surgical preferences. Questions asked included hospital volume, the use of neoadjuvant treatment, preferred surgical approach, extent of the lymphadenectomy and preferred anastomotic technique. The invitations were sent in September 2013 and the survey was closed in january ***: The corresponding specific response rate was 227/615(37%). The majority of respondents: originated from Asia( 5 4 %), performed > 2 1 gastrectomies per year(79%) and used neoadjuvant chemotherapy(73%). An open surgical procedure was performed by the majority of surgeons for distal gastrectomy for advanced cancer(91%) and total gastrectomy for both early and advanced cancer(52% and 94%). A minimally invasive procedure was preferred for distal gastrectomy for early cancer(65%). In Asia surgeons preferred a minimally invasive procedure for total gastrectomy for early cancer also(63%). A D1+ lymphadenectomy was preferred in early gastric cancer(52% for distal, 54% for total gastrectomy) and a D 2 lymphadenectomy was preferred in advanced gastric cancer(93% for distal, 92% for total gastrectomy) CONCLUSION: Surgical preferences for gastric cancer surgery vary between surgeons worldwide. Although the majority of surgeons use neoadjuvant chemotherapy, minimally invasive techniques are still not widely adapted.

关键词： Gastric cancer Gastrectomy Laparoscopy neoplasm minimally invasive surgery

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Strategies to reduce pulmonary complications after esophagectomy

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World journal of Gastroenterology 2013年第39期19卷 6509-6514页

作者： Teus j Weijs jelle p ruurda Grard Ap Nieuwenhuijzen Richard van Hillegersberg Misha Dp Luyer Department of Surgery University Medical Center Utrecht3584 CX UtrechtThe Netherlands Department of Surgery Catharina Hospital Eindhoven5623 EJ EindhovenThe Netherlands

Esophagectomy,the surgical removal of all or part of the esophagus,is a surgical procedure that is associated with high morbidity and *** complications are an especially important postoperative ***,many perioperative strategies to prevent pulmonary complications after esophagectomy have been investigated and introduced in daily clinical ***,we review these strategies,including improvement of patient performance and technical advances such as minimally invasive surgery that have been implemented in recent ***,interventions such as methylprednisolone,neutrophil elastase inhibitor and epidural analgesia,which have been shown to reduce pulmonary complications,are *** of the commonly applied routine nasogastric decompression,delay of oral intake and prophylactic mechanical ventilation are unclear,and many of these strategies are also evaluated ***,we will discuss recent insights and new developments aimed to improve pulmonary outcomes after esophagectomy.

关键词： Esophagectomy Complications pneumonia Acute lung injury Acute respiratory distress syndrome

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CT评分系统对食管切除术后吻合口瘘的诊断效能:与经验性CT评估相比较

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国际医学放射学杂志 2017年第6期 747-747页

作者： L.Goense p.M.Stassen F.j.Wessels p.S.van Rossum j.p.ruurda M.S.van Leeuwen 刘瑶 Department of Surgery University Medical Center Utrecht

摘要目的建立评估食管切除术后吻合口瘘的CT预测评分系统,并将其与经验性CT评估进行比较。方法分析2003年—2014年间食管切除颈部吻合术后,临床怀疑吻合

关键词：吻合口瘘食管切除术诊断效能经验性 CT

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供应胃管动脉的钙化:食管术后吻合口漏的一项新危险因素

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国际医学放射学杂志 2015年第2期 167-167页

作者： p.S.N.van Rossum L.Haverkamp H.M.Verkooijen M.S.van Leeuwen R.van Hillegersberg j.p.ruurda 庞国栋 Department of Surgery University Medical Centre UtrechtHeidelberglaan 1003584CX Utrecht the Netherlands

摘要目的本研究旨在应用血管钙化评分系统并根据食管癌病人食管切除与胃管重建术后的吻合口漏的发生来评估胃管的供血动脉钙化的数量和位置的关系。材料与方法

关键词：吻合口漏动脉钙化病人胃管动脉

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