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初中生 2024年第18期 25-29页

作者： rus buyok 瀚瀚(编译) 不详

喜欢钻研文字的本想在新学校结交新朋友。辛迪把他介绍给同样喜欢文字的“活字典”戴夫。很快,本发现戴夫爱用一些难词,虽然单词的拼写正确,但他总是用得不恰当。经过了解,本发现戴夫是被自己的哥哥捉弄了。这到底是怎么一回事呢?

关键词：戴夫文字学校钻研

PLCG2 Mutation in a Patient Presenting with Type 2 Autoimmune Hepatitis

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 685-687页

作者： Antoine Gardin Léa Gaigne Aude Magérus Frédéric Rieux-Laucat Emmanuel Jacquemin Pediatric Hepatology and Liver Transplantation Unit National Reference Centre for Inflammatory Diseases of the Bile Ducts and Autoimmune HepatitisFILFOIEERN RARE LIVERBicêtre HospitalAssistance Publique–Hôpitaux de ParisUniversity Paris-SaclayLe Kremlin-BicêtreFrance INSERM UMR 1193 HepatinovParis-Saclay UniversityOrsayFrance Laboratory of Immunogenetics of Pediatric Autoimmune Diseases INSERM UMR 1163Imagine InstituteParis CitéUniversityParisFrance

The combination of defective immune tolerance and external triggers is thought to underlie the pathophysiology of autoimmune hepatitis.1,2 Some polymorphisms associated with susceptibility to autoimmune hepatitis have been reported,and some cases have been described in patients with monogenic primary immune deficiencies or systemic diseases.

关键词： autoimmune Autoimmune immune

Review of EU projects with a focus on environmental quality: Innovation, eco-innovation, and circular-economy elements

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International Journal of Innovation Studies 2024年第1期8卷 1-12页

作者： Jana Hojnik Mitja Ruzzier Maja Konecnik Ruzzier Boris Sucic Brandon Soltwisch Matej rus University of Primorska Faculty of ManagementIzolska Vrata 26000KoperSlovenia University of Ljubljana School of Economics and BusinessKardeljeva Ploscad 171000LjubljanaSlovenia Jozef Stefan Institute Energy Efficiency CentreJamova 391000LjubljanaSlovenia Tulane University Freeman School of Business6823 St Charles AveNew OrleansLA 70118USA University of Maribor Faculty of Economics and BusinessRazlagova 142000MariborSlovenia

The primary objective of this study is to delve into transnational projects conducted between 2014 and 2020,with a strong emphasis on environmental *** focus is directed toward projects that encompass either eco-innovation or feature elements intrinsic to a circular *** achieve this goal,we introduce a pioneering analytical framework tailored to dissect transnational projects,which intricately interweaves the diverse dimensions of environmental quality and innovation,facilitating a comparative assessment across various program *** approach aligns with the overarching mission of the four flagship initiatives,in which we evaluate the combined impacts on sustainability and *** evaluation considers three fundamental factors:(1)resource allocation,(2)innovation type,and(3)infusion of eco-innovation or circular economy *** methodology unfolds through a systematic,step-by-step ***,we meticulously handpick programs,specifically Interreg,Horizon,and Life projects,within the scope of TSG3(Environmental Quality).Each of these programs corresponds to one of the following four flagship initiatives:(1)overseeing and managing marine species,(2)fostering sustainable development in coastal and maritime zones,(3)safeguarding and elevating natural habitats and terrestrial ecosystems,and(4)formulating transnational contingency strategies for maritime *** an exhaustive review,we identify projects that either directly or indirectly champion eco-innovation or other facets of the circular ***,we uncover broader manifestations of innovation,eco-innovation,and circular economy *** the Oslo Manual as a guide,we methodically categorize these innovations into the product,process,organizational,and marketing *** the timeframe under scrutiny,a relatively modest subset of projects embraced eco-innovations and practices aligned with the circular *** findings culminate in

关键词： Environment Sustainability Eco-innovation Innovation EU projects Entrepreneurship

Assessment of Oral Anticoagulation with Vitamin K Antagonists in Patients Living in a Low-Income Country of West Africa

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World Journal of Cardiovascular Diseases 2024年第1期14卷 27-42页

作者： Komlavi Yayehd Tchaa Tcherou Hervé Libérus A. Edorh Agossou Defodji Mohamed Kpelafia Ekpé Togbossi Ablawa Adzodo Soulemane Pessinaba Machihude Pio Soodogoua Baragou Findibe Damorou Department of Cardiology Faculty of Health Sciences University of Lomé Lomé Togo Department of Cardiology Faculty of Health Sciences University of Kara Kara Togo

Introduction: Despite the rise of direct oral anticoagulants (DOACs), vitamin K antagonists (VKA) remain the most widely used oral anticoagulants in developing countries. The aim of this study was to estimate the prevalence of good anticoagulation in patients treated with VKA in Lomé and describe associated factors. Methods: This was a cross-sectional study conducted from November 2019 to October 2020 in the cardiology departments of two University teaching hospitals in Lomé (CHU Sylvanus Olympio and CHU Campus), involving patients on VKA for ≥3 months, with a target international normalized ratio (INR) of 2.5 and a therapeutic margin between 2 and 3. The quality of anticoagulation was assessed by the time in therapeutic range (TTR) which was assessed by the Rosendaal method. Good anticoagulation was defined by a TTR > 70%. Results: A total of 344 patients were included (mean age = 58 ± 13.8 years, women = 56.1%). Indications for VKA treatment were represented by venous thromboembolic disease (43.3%), supraventricular arrhythmia (28.2%), severe left ventricular systolic dysfunction (19.8%) and pulmonary hypertension (8.7%). The average TTR was 47.6 ± 20.8%. The rate of good anticoagulation was 17.7%. Factors associated with good anticoagulation were the use of fluindione vs acenocoumarol (OR = 11.17;95% CI: 3.2 - 39.6;p = 0.0002), concomitant low-dose aspirin (OR 4.44;95% CI: 1.4 - 13.9;p = 0.01) and INR monitoring exclusively by the patient himself (OR = 4.92;95% CI: 1.5 - 16.3;p = 0.008). The rate of thromboembolic and hemorrhagic complications was each 2.6% and was not correlated with the quality of anticoagulation. Quality of anticoagulation by VKAs was poor in our practice. Factors associated with good anticoagulation were the use of fluindione vs acenocoumarol, concomitant low-dose aspirin and monitoring of INR exclusively by the patient himself. Conclusion: The quality of oral anticoagulation by VKAs could be improved in our practice by the creation of antico

关键词： Vitamin K Antagonists Time in Therapeutic Range Lomé Togo

A qualitative correlation between friction coefficient and steel surface wear in linear dry sliding contact to polymers with SGF

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Friction 2014年第1期2卷 47-57页

作者： Dorin rus Lucian CAPITANU Liliana-Laura BADITA Mechanical Department Institute of Civil EngineeringBucharest050153Romania Tribology Department Institute of Solid Mechanics of the Romanian AcademyBucharest010141Romania National Institute of Research and Development in Mechatronics and Measurement Technique Bucharest 0211631Romania

In this paper we tried to present a qualitative correlation,based on extensive experimental determinations between the value and the evolution of the friction coefficient,wear,and contact temperature,in the case of linear dry contact,for thermoplastic material reinforced with short glass fibers(SGF)and various steel *** aim was to highlight the evolution of the wear process depending on the evolution of the friction *** a result,it was possible to graphically illustrate the evolution of the friction coefficient and the change of the wear process,emphasizing the abrasive,adhesive and corrosive *** evolution of the plastic material transfer function of the contact temperature,namely of the power lost by friction(product between the contact pressure and sliding speed,p and v)was aimed and it was *** has been demonstrated that in the case of a 30%SGF content it can reach and even exceed contact temperatures very close to the flow limit of the plastic *** tried,believing successfully,the graphic illustration of the evolution of the steel surface wear and of the contact temperature,depending on the friction *** influence of the normal load and sliding speed was evaluated in detail,but also the influence of the metallic surface roughness on the friction coefficient was discussed.

关键词： friction coefficient evolution steel surface wear contact temperature plastic material transfer hardness of steel surface influence

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俄罗斯转向东方:历史意义与现实任务

俄罗斯学刊 2024年第4期14卷 70-97页

作者： [俄]基里尔·巴巴耶夫胡巍葳(编译) 俄罗斯科学院中国与现代亚洲研究所黑龙江大学俄罗斯语言文学与文化研究中心

作为自称为“国家-文明”的伟大欧亚大国,俄罗斯正在为欧亚大陆和整个世界赋予新的内涵,并迅速调集其资源以切实实施新东方战略。现代俄罗斯外交政策的这一主要趋势在短时间内不仅会令俄罗斯发生显著变化,而且会改变整个地缘政治状况,... 详细信息

作为自称为“国家-文明”的伟大欧亚大国,俄罗斯正在为欧亚大陆和整个世界赋予新的内涵,并迅速调集其资源以切实实施新东方战略。现代俄罗斯外交政策的这一主要趋势在短时间内不仅会令俄罗斯发生显著变化,而且会改变整个地缘政治状况,形成新的国际关系体系。真正的“转向东方”是在科学和技术、教育和文化上的根本转向。至于各国人民之间的互动水平、人文联系以及总体上的文化和文明互动领域的转变远未完成,其任务仍然极为紧迫。俄罗斯完成“转向东方”政策的主要任务,可以在2030年之前完全平衡俄罗斯的外交政策和对外经济活动,消除来自西方的大部分制裁带来的风险,显著提高俄罗斯在东方国家进行各类活动的效果。

关键词：俄中关系外交政策对外经济活动俄罗斯

Systematic exploration of signal-based indicators for failure diagnosis in the context of cyber-physical systems

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 152-175页

作者： Santiago RUIZ-ARENAS Zoltán rusáK Imre HORVáTH Ricardo MEJí-GUTIERREZ Faculty of Industrial Design Engineering Delft University of Technology Grupo de Investigación en Ingeniería de Diseno Universidad EAFIT

Malfunction or breakdown of certain mission critical systems(MCSs) may cause losses of life, damage the environments, and/or lead to high costs. Therefore, recognition of emerging failures and preventive maintenance are essential for reliable operation of MCSs. There is a practical approach for identifying and forecasting failures based on the indicators obtained from real life processes. We aim to develop means for performing active failure diagnosis and forecasting based on monitoring statistical changes of generic signal features in the specific operation modes of the system. In this paper, we present a new approach for identifying emerging failures based on their manifestations in system signals. Our approach benefits from the dynamic management of the system operation modes and from simultaneous processing and characterization of multiple heterogeneous signal sources. It improves the reliability of failure diagnosis and forecasting by investigating system performance in various operation modes, includes reasoning about failures and forming of failures using a failure indicator matrix which is composed of statistical deviation of signal characteristics between normal and failed operations, and implements a failure indicator concept that can be used as a plug and play failure diagnosis and failure forecasting feature of cyber-physical systems. We demonstrate that our method can automate failure diagnosis in the MCSs and lend the MCSs to the development of decision support systems for preventive maintenance.

关键词： Failure indicators Failure classification Failure detection and diagnosis Complex systems

The mRNA Binding Proteome of Proliferating and Differentiated Muscle Cells

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 384-396页

作者： Monika Hiller Miriam Geissler George Janssen Peter van Veelen Annemieke Aartsma-rus Pietro Spitali Department of Human Genetics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands Center for Proteomics and Metabolomics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands

Muscle formation is a coordinated process driven by extensive gene expression changes where single cells fuse together to form multinucleated muscle fibers. Newly synthesized m RNAs are then regulated by RNA binding proteins(RBPs), affecting post-transcriptional transcript metabolism. Here, we determined how large-scale gene expression changes affect the catalog of RBPs by studying proliferating and differentiated muscle cells in healthy and dystrophic conditions. Transcriptomic analysis showed that the expression of more than 7000 genes was affected during myogenesis. We identified 769 RBPs, of which 294 were muscle-specific and 49 were uniquely shared with cardiomyocytes. A subset of 32 RBPs(half of which were muscle-specific) was found to be preferentially associated with target mRNAs in either myoblasts(MBs) or myotubes(MTs). A large proportion of catalytic proteins were bound to mRNAs even though they lack classical RNA binding domains. Finally, we showed how the identification of cell-specific RBPs enabled the identification of biomarkers that can separate healthy individuals from dystrophic patients. Our data show how interactome data can shed light on new basic RNA biology as well as provide cell-specific data that can be used for diagnostic purposes.

关键词： RNA binding protein Interactome Duchenne muscular dystrophy Proteomics Skeletal muscle

Road Pricing Design Based on Game Theory and Multi-agent Consensus

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IEEE/CAA Journal of Automatica Sinica 2014年第1期1卷 31-39页

作者： Nan Xiao Xuehe Wang Lihua Xie Tichakorn Wongpiromsarn Emilio Frazzoli Daniela rus the Singapore-MIT Alliance for Research and Technology Centre the EXQUISITUS Centre for ECity School of Electrical and Electronic Engineering Nanyang Technological University the Ministry of Science and Technology the Massachusetts Institute of Technology

Consensus theory and noncooperative game theory respectively deal with cooperative and noncooperative interactions among multiple players/agents. They provide a natural framework for road pricing design, since each motorist may myopically optimize his or her own utility as a function of road price and collectively communicate with his or her friends and neighbors on traffic situation at the same time. This paper considers the road pricing design by using game theory and consensus theory. For the case where a system supervisor broadcasts information on the overall system to each agent, we present a variant of standard fictitious play called average strategy fictitious play(ASFP) for large-scale repeated congestion *** a weighted running average of all other players actions is assumed to be available to each player. The ASFP reduces the burden of both information gathering and information processing for each player. Compared to the joint strategy fictitious play(JSFP) studied in the literature, the updating process of utility functions for each player is avoided. We prove that there exists at least one pure strategy Nash equilibrium for the congestion game under investigation, and the players actions generated by the ASFP with inertia(players reluctance to change their previous actions) converge to a Nash equilibrium almost surely. For the case without broadcasting, a consensus protocol is introduced for individual agents to estimate the percentage of players choosing each resource, and the convergence property of players action profile is still ensured. The results are applied to road pricing design to achieve socially local optimal trip timing. Simulation results are provided based on the real traffic data for the Singapore case study.

关键词： Average strategy fictitious play(ASFP) gametheory multi-agent consensus road pricing

Computer Integration within Problem Solving Process

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Journal of Software Engineering and Applications 2022年第4期15卷 75-102页

作者： Teodor rus Department of Computer Science The University of Iowa Iowa City USA

The complexity of current software tools increases with the complexity of problem solving tasks they are designed to assist and are mainly dedicated to computer educated people. On the other hand current computer technology is deeply involved in people’s everyday life. This gap deepens and stresses software technology and computer education. The purpose of this paper is to discuss the feasibility of a new computer based problem solving methodology based on software tools that can be manipulated through the use of natural language. By computational emancipation the natural language becomes a family of non-ambiguous languages. This means that every problem solver uses a non-ambiguous natural language, termed here as Domain Algorithmic Language, DAL. Here we show how to develop software tools dedicated to the problem domain and illustrate the methodology we propose with the software tools required by teaching high school algebra.

关键词： Computer Ontology Problem-Solving Problem-Domain Software-Tool