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OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility

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Research 2024年第1期2023卷 455-469页

作者： Yinghong Cui Wei Chen Li du Zuping He The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province The Research Center of Reproduction and Translational Medicine of Hunan ProvinceHunan Normal University School of MedicineChangsha 410013HunanChina

Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative ***,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain ***,we have demonstrated for the first time that OIP5(Opa interacting protein 5)controlled the self-renewal and apoptosis of human *** sequencing identified that NCK2 was a target for OIP5 in human SSCs,and interestingly,OIP5 could interact with NCK2 as shown by Co-IP(co-immunoprecipitation),IP-MS(mass spectrometry),and GST pulldown ***2 silencing decreased human SSC proliferation and DNA synthesis but enhanced their ***,NCK2 knockdown reversed the influence of OIP5 overexpression on human ***,OIP5 inhibition decreased the numbers of human SSCs at S and G2/M phases,while the levels of numerous cell cycle proteins,including cyclins A2,B1,D1,E1 and H,especially cyclin D1,were remarkably ***,whole-exome sequencing of 777 patients with nonobstructive azoospermia(NOA)revealed 54 singlenucleotide polymorphism mutations of the OIP5 gene(6.95%),while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile ***,these results implicate that OIP5 interacts with NCK2 to modulate human SSC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with *** such,this study offers novel insights into molecular mechanisms underlying the fate determinations of human SSCs and the pathogenesis of NOA,and it provides new targets for treating male infertility.

关键词： OIP5 Apoptosis reversed

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Nonlinear uncertainty impact of geometric variations on aerodynamic performance of low-pressure turbine blades with ultra-high loading under extreme operational conditions

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Chinese Journal of Aeronautics 2024年第5期37卷 281-300页

作者： Xiaojing WANG Zhengping ZOU Chao FU Pengcheng du School of Energy and Power Engineering Beihang UniversityBeijing 100191China National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing 100191China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China

Uncertainty impact of random geometric variations on the aerodynamic performance of low-pressure turbine blades is considerable,which is further amplified by the current ultra-high-lift design trend for weight ***,this uncertainty impact on ultra-highly loaded blades under extreme operational conditions near the margins with potential large-scale open separation is focused on in this *** is demonstrated that this impact is significant,unfavourable,and nonlinear,which is clearly severer under extreme *** addition to the overall attenuation and notable scattering of specific performance,the operational margins with open separation are also notably scattered with great risk of significant *** scattering and nonlinearity are dominated by the variations in leading-edge *** thinning of leading edge triggers local transition,enhancing downstream friction and reducing resistance to open separation,which is further exacerbated by operational ***,the opposite thickening yields less benefit,implying *** unfavourable impact highlights the need for robust aerodynamic design,where both a safer operational condition and a more robust blade are indispensable,i.e.,a compromise among performance,weight,and *** the necessary limitation of loading levels,a mid-loaded design is recommended to reduce adverse pressure gradients in both the leading edge and rear region of the suction side,which helps to decrease the susceptibility of the transition and open separation to random *** improvements can also be achieved by appropriately thickening the leading edge.

关键词： Ultra-highly loaded turbine blade Geometric variations Uncertainty analysis Operational margins Robust aerodynamic design Nonlinearity

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Distributed collaborative complete coverage path planning based on hybrid strategy

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Journal of Systems Engineering and Electronics 2024年第2期35卷 463-472页

作者： ZHANG Jia du Xin DONG Qichen XIN Bin School of Automation Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing Institute of TechnologyBeijing 100081China

Collaborative coverage path planning(CCPP) refers to obtaining the shortest paths passing over all places except obstacles in a certain area or space. A multi-unmanned aerial vehicle(UAV) collaborative CCPP algorithm is proposed for the urban rescue search or military search in outdoor *** to flexible control of small UAVs, it can be considered that all UAVs fly at the same altitude, that is, they perform search tasks on a two-dimensional plane. Based on the agents’ motion characteristics and environmental information, a mathematical model of CCPP problem is established. The minimum time for UAVs to complete the CCPP is the objective function, and complete coverage constraint, no-fly constraint, collision avoidance constraint, and communication constraint are considered. Four motion strategies and two communication strategies are designed. Then a distributed CCPP algorithm is designed based on hybrid strategies. Simulation results compared with patternbased genetic algorithm(PBGA) and random search method show that the proposed method has stronger real-time performance and better scalability and can complete the complete CCPP task more efficiently and stably.

关键词： multi-agent cooperation unmanned aerial vehicles(UAV) distributed algorithm complete coverage path planning(CCPP)

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Numerical Analysis of Heat Transfer Characteristics to Supercritical CO_(2) in a Vertical Mini-Channel:Transition and Pseudo-Boiling

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Journal of Thermal Science 2024年第1期33卷 101-113页

作者： YUAN Baoqiang WANG Wei XIN Gongming du Wenjing School of Energy and Power Engineering Shandong UniversityJi'nan 250061China

Large eddy simulations have been conducted to study upward transitional flows and heat transfer characteristics of supercritical CO_(2) in a vertical *** numerical simulation was carried out on a modified buoyantPimpleFOAM solver in OpenFOAM 7,and was verified using experiment *** results indicate that increasing the Grashof numbers can reduce the flow stability and make the flow transition *** are four stages of heat transfer in the transition process,i.e.,weakened,improved,recovered and normal heat *** heat transfer phenomena in the transition process were explained from three perspectives:thermal boundary layer theory,turbulent transport and pseudo-boiling *** transfer enhancement during transition is related to the transport of supercritical molecular clusters,and these molecular clusters are regarded as pseudo-bubbles in pseudo-boiling *** flow pattern of the pseudo-phases in the dia-Widom process contains single-phase flow,steady pseudo-film flow,unsteady pseudo-film flow,partial pseudo-bubbles flow and flocculent pseudo-film ***-bubbles have similar behaviors to subcritical bubbles,i.e.,break-up,deformation,condensation and *** researches in this work are favorable for understanding the heat transfer mechanism of supercritical fluids during flow transition.

关键词： supercritical heat transfer large eddy simulation transition pseudo-boiling

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Comparative analysis between single-train passing and double-train intersection in a tunnel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 429-442页

作者： Jianming du Qian FANG Xuan ZHANG Hualao WANG Bridge and Tunnel Research Center Research Institute of Highway Ministry of TransportBeijing 100088China Tunnel and Underground Engineering Research Center of Ministry of Education Beijing Jiaotong UniversityBeijing 00044China

Aerodynamic pressure significantly impacts the scientific evaluation of tunnel service *** aerodynamic pressure of two trains running in a double-track tunnel is considerably more complicated than that of a single *** used the numerical method to investigate the difference in aerodynamic pressure between a single train and two trains running in a double-track ***,the numerical method was verified by comparing the results of numerical simulation and on-site ***,the characteristics of aerodynamic pressure were ***,the influence of various train-tunnel factors on the characteristics of aerodynamic pressure was *** results show that the aerodynamic pressure variation can be divided into stage I:irregular pressure fluctuations before the train tail leaves the tunnel exit,and stage II:periodic pressure declines after the train tail leaves the tunnel *** addition,the aerodynamic pressure simultaneously jumps positively or drops negatively for a single train or two trains running in double-track tunnel *** pressure amplitude in the two-train case is higher than that for a single *** maximum positive peak pressure difference(P_(STP))and maximum negative peak pressure difference(P_(STN))increase as train speed rises to the power from 2.256 to 2.930 in stage *** P_(STP) and P_(STN) first increase and then decrease with the increase of tunnel length in stage *** P_(STP) and P_(STN) increase as the blockage ratio rises to the power from 2.032 to 2.798 in stages I and II.

关键词： Railway tunnel Aerodynamic effect Pressure characteristic Train speed Tunnel length Blockage ratio

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Maximizing Submodular+Supermodular Functions Subject to a Fairness Constraint

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Tsinghua Science and Technology 2024年第1期29卷 46-55页

作者： Zhenning Zhang Kaiqiao Meng Donglei du Yang Zhou Beijing Institute for Scientific and Engineering Computing Beijing University of TechnologyBeijing 100124China Faculty of Management University of New BrunswickFredericton E3B 5A3Canada School of Mathematics and Statistics Shandong Normal UniversityJinan 250014China

We investigate the problem of maximizing the sum of submodular and supermodular functions under a fairness *** sum function is non-submodular in *** an offline model,we introduce two approximation algorithms:A greedy algorithm and a threshold greedy *** a streaming model,we propose a one-pass streaming *** also analyze the approximation ratios of these algorithms,which all depend on the total curvature of the supermodular *** total curvature is computable in polynomial time and widely utilized in the literature.

关键词： submodular function supermodular function fairness constraint greedy algorithm threshold greedy algorithm streaming algorithm

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The KAM theorem on the modulus of continuity about parameters

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Science China Mathematics 2024年第3期67卷 577-592页

作者： Zhicheng Tong Jiayin du Yong Li School of Mathematics Jilin UniversityChangchun 130012China Institute of Mathematics Jilin UniversityChangchun 130012China School of Mathematics and Statistics Center for Mathematics and Interdisciplinary SciencesNortheast Normal UniversityChangchun 130024China

In this paper,we study the Hamiltonian systems H(y,x,ξ,ε)=〈ω(ξ),y〉+εP(y,x,ξ,ε),where ω and P are continuous about ξ.We prove that persistent invariant tori possess the same frequency as the unperturbed tori,under a certain transversality condition and a weak convexity condition for the frequency mapping ω.As a direct application,we prove a Kolmogorov-Arnold-Moser(KAM) theorem when the perturbation P holds arbitrary Holder continuity with respect to the parameter ξ.The infinite-dimensional case is also *** our knowledge,this is the first approach to the systems with the only continuity in the parameter beyond H?lder's type.

关键词： Hamiltonian systems invariant tori frequency-preserving weak regularity

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Selective synthesis and physical properties of a bismacrocycle:Cycloparaphenylene-pillar[5]arene

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Chinese Chemical Letters 2024年第3期35卷 273-276页

作者： Yu Zhou Guilin Zhuang Pingwu du Key Laboratory of Precision and Intelligent Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleCAS Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310032China

Macrocyclic materials have attracted much attention due to their particular chemical and physical *** we report the precise synthesis and characterization of a new bismacrocycle structure base on cycloparaphenylene(CPP)and pillar[5]arene,named cycloparaphenylene-pillar[5]arenes(CPPn[5]).The bismacrocycle was fully characterized by NMR and *** photophysical properties of CPPn[5]were investigated by UV–vis,and the maximum absorption peak was located at 331 nm,which was consistent with density functional theory(DFT)*** fluorescence spectrum was further studied and the emission peak was maximized at 458 *** computational results indicate the strain energy of CPPn[5]is 27.80 kcal/mol and the HOMO-LUMO gap is 3.39 eV Notably,CPPn[5]showed interesting supramolecular properties.

关键词： Pillararene Cycloparaphenylene Bismacrocycles Supramolecular chemistry

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Asymmetric Hydrogenation of Phenanthridines with Chiral Boranes

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Chinese Journal of Chemistry 2024年第6期42卷 631-635页

作者： Guangyu Cui Xiangqing Feng Haifeng du Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190 China University of Chinese Academy of Sciences Beijing100049 China

The asymmetric hydrogenation of N-heteroarenes provides an efficient method for the synthesis of optically active cyclic secondary *** this paper,we described an asymmetric hydrogenation of phenanthridines using a chiral mono-alkene-derived borane.A variety of dihydrophenanthridines were furnished in high yields with up to 93%*** current catalytic system was very sensitive for the steric hindrance of *** substituents at one phenyl group of phenanthridines were required to obtain the high *** large substituents on the carbon of the C=N bonds would diminish the reactivity sharply.

关键词： Asymmetric catalysis Hydrogenation Nitrogen heterocycles Phenanthridines Frustrated Lewis pairs Chiral boranes

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Asymmetric Partial Hydrosilylation of 2,2-Difluoro-1,3-diketones with Chiral Frustrated Lewis Pairs

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Chinese Journal of Chemistry 2024年第8期42卷 853-857页

作者： Ting Liu Xiangqing Feng Haifeng du Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190 China University of Chinese Academy of Sciences Beijing100049 China

Comprehensive Summary,The asymmetric partial reduction of 1,3-diketones stands as a straightforward pathway to access optically active β-hydroxyketones. In this paper, an asymmetric Piers-type hydrosilylation of 2,2-difluoro-1,3-diketones was successfully realized by using a frustrated Lewis pair of chiral borane and tricyclohexylphosphine as a catalyst, delivering a variety of α,α-difluoro-β-hydroxyketones in high yields with up to 99% ee. Significantly, no over-reduced diol products were observed even with an excess amount of silanes. The product can be conveniently converted to α,α-difluoro-β-hydroxyester or 1,3-anti-diol via an oxidation with m-CPBA or a reduction with DIBAL-H without obvious loss of ee.

关键词： Asymmetric catalysis Hydrosilylation Ketones Frustrated Lewis pairs Chiral boranes

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