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Chinese Chemical Letters 2024年第10期35卷 152-164页

作者： Qiyan Wu ruixin zhou Zhangyi Yao Tanyuan Wang Qing Li State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology

Water splitting with proton exchange membrane water electrolyzers(PEMWE) is regarded as a promising pathway for sustainable hydrogen conversion. Additionally, oxygen evolution reaction(OER) is considered as the dominant factor during the whole process due to the sluggish kinetics. Among the catalysts, Rubased catalysts draw special attention because of their excellent activity and relatively low price. However, the limited stability impedes their further commercialization and tremendous efforts have been devoted to overcome this challenge. This review firstly introduces the basic mechanisms of OER. Then the evaluation protocols and techniques to investigate the stability of Ru-based catalysts are summarized.A detailed elucidation of the possible degradation mechanisms is also critically analyzed. Furthermore,effective strategies to design durable Ru-based catalysts for acidic OER are discussed. Such as heteroatom doping, phase and facet engineering, heterostructure building and support optimization. Finally, promises,perspectives and challenges in developing highly durable Ru-based catalysts for acidic OER are outlined.

关键词： Acidic oxygen evolution Degradation mechanisms Optimization strategies Ru-based catalysts Stability

A chaos genetic algorithm for optimizing an artificial neural network of predicting silicon content in hot metal

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Journal of University of Science and Technology Beijing 2003年第2期10卷 68-71页

作者： Deling Zheng, ruixin Liang, Ying zhou, and Ying WangInformation Engineering School, University of Science and Technology Beijing, Beijing 100083, China Information Engineering School University of Science and Technology Beijing Beijing 100083 China

A genetic algorithm based on the nested intervals chaos search (NICGA) hasbeen given. Because the nested intervals chaos search is introduced into the NICGA to initialize thepopulation and to lead the evolution of the population, the NICGA has the advantages of decreasingthe population size, enhancing the local search ability, and improving the computational efficiencyand optimization precision. In a multi4ayer feed forward neural network model for predicting thesilicon content in hot metal, the NICGA was used to optimize the connection weights and thresholdvalues of the neural network to improve the prediction precision. The application results show thatthe precision of predicting the silicon content has been increased.

关键词： blast furnace optimization chaos genetic algorithm neural network silicon content prediction

Coupling Effect of Cryogenic Freeze-Thaw Cycles and Chloride Ion Erosion Effect in Pre-Cracked Reinforced Concrete

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Structural Durability & Health Monitoring 2024年第3期18卷 255-276页

作者： Yang Li Sibo Jiang ruixin Lan School of Civil Engineering and Architecture Hubei University of TechnologyWuhan430068China

Chloride (Cl−) ion erosion effects can seriously impact the safety and service life of marine liquefied natural gas(LNG) storage tanks and other polar offshore structures. This study investigates the impact of different low-temperaturecycles (20°C, –80°C, and −160°C) and concrete specimen crack widths (0, 0.3, and 0.6 mm) on the Cl−ion diffusion performance through rapid erosion tests conducted on pre-cracked concrete. The results show thatthe minimum temperature and crack width of freeze-thaw cycles enhance the erosive effect of chloride ions. TheCl− ion concentration and growth rate increased with the increasing crack width. Based on the experimental modeland in accordance with Fick’s second law of diffusion, the Cl− ion diffusion equation was modified by introducingcorrection factors in consideration of the freeze-thaw temperature, crack width, and their coupling *** experimental and fitting results obtained from this model can provide excellent reference for practical engineeringapplications.

关键词： Chloride ions freeze-thaw cycles cracks

An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer

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Science Bulletin 2024年第13期69卷 2122-2135页

作者： Lingping Kong Fanlu Meng Ping zhou ruixin Ge Xiaoshan Geng Zhihao Yang Guo Li Linlin Zhang Jing Wang Jinfeng Ma Cheng Dong Jun zhou Sijin Wu Diansheng Zhong Songbo Xie Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China Center for Cell Structure and Function Collaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer InstituteTianjin Medical University General HospitalTianjin 300052China Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Wisdom Lake Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215028China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Key Laboratory of Ocular TraumaTianjin Medical UniversityTianjin 300052China

Targeting oncogenic mutant p53 represents an attractive strategy for cancer treatment due to the high frequency of gain-of-function mutations and ectopic expression in various cancer *** extensive efforts,the absence of a druggable active site for small molecules has rendered these mutants therapeutically *** we develop a selective and effective proteolysis-targeting chimera(PROTAC)for p53-R175H,a common hotspot mutant with dominant-negative and oncogenic *** a novel iterative molecular docking-guided post-SELEX(systematic evolution of ligands by exponential enrichment)approach,we rationally engineer a high-performance DNA aptamer with improved affinity and specificity for *** this resulting aptamer as a binder for PROTACs,we successfully developed a selective p53-R175H degrader,named ***53m induces the ubiquitin–protea some-dependent degradation of p53-R175H while sparing wildtype ***,dp53m demonstrates significant antitumor efficacy in p53-R175H-driven cancer cells both in vitro and in vivo,without ***,dp53m significantly and synergistically improves the sensitivity of these cells to cisplatin,a commonly used chemotherapy *** findings provide evidence of the potential therapeutic value of dp53m in p53-R175H-driven cancers.

关键词： P53 Aptamer PROTAC Cancer Drug resistance

Neurotoxicity of tetramethylammonium ion on larval and juvenile zebrafish:Effects on neurobehaviors and multiple biomarkers

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Journal of Environmental Sciences 2024年第9期143卷 138-147页

作者： ruixin Zhang Rui Wang Jiajun Chang GDaniel Sheng Daqiang Yin Key Laboratory of Yangtze River Water Environment Ministry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Tetramethylammonium hydroxide(TMAH)is an important compound that utilized and released by the rapidly expanding semiconductor industry,which could hardly be removed by the conventional wastewater treatment *** a cholinergic agonist,the tetramethylammonium ion(TMA^(+))has been reported to induce toxicity to muscular and respiratory systems of mammals and human,however the toxicity on aquatic biota remains poorly *** investigated the neurotoxic effects of TMA^(+)exposure on zebrafish,based on neurobehavior tests and a series of *** inhibitions on the swimming distance of zebrafish larvae were observed when the exposure level exceeded 50 mg/L,and significant alterations on swimming path angles(straight and deflective movements)occurred even at 10 mg/*** tested neurobehavioral endpoints of zebrafish larvae were significantly positively correlated with reactive oxygen species(ROS)and malondialdehyde(MDA),significantly negatively related with the activities of antioxidant enzymes,but not significantly correlated with the level of acetylcholinesterase(AChE).Such relationship indicates that the observed neurotoxic effects on swimming behavior of zebrafish larvae is mainly driven by oxidative stress,rather than the alterations of *** the highest exposure concentration(200 mg/L),TMA^(+)evoked more severe toxicity on zebrafish juveniles,showing significantly stronger elevation on the MDA activity,and greater inhibitions on the activities of antioxidant enzymes and ACh E,suggesting juveniles were more susceptible to TMA^(+)exposure than larval zebrafish.

关键词： Tetramethylammonium Zebrafish Oxidative stress Acetylcholinesterase Neurobehavior

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双螺杆真空泵工作过程数值模拟

西安交通大学学报 2015年第7期49卷 67-71页

作者：卢阳郭蓓周瑞鑫西安交通大学能源与动力工程学院西安710049

对等螺距和变螺距2种螺杆真空泵分别进行了分析,通过能量守恒、质量守恒方程及泄漏模型分别计算了2种真空泵工作过程中的气体压力变化及极限真空度、功耗、抽速等性能参数,由此搭建了真空泵实验系统试验台,展开了双螺杆真空泵压力变化... 详细信息

对等螺距和变螺距2种螺杆真空泵分别进行了分析,通过能量守恒、质量守恒方程及泄漏模型分别计算了2种真空泵工作过程中的气体压力变化及极限真空度、功耗、抽速等性能参数,由此搭建了真空泵实验系统试验台,展开了双螺杆真空泵压力变化及泄漏的实验研究,分析了2种真空泵性能差别的原因及变螺距螺杆真空泵的优势,并对变螺距真空泵性能进行了实验研究。数值模拟结果表明,变螺距真空泵不论在极限真空压力,还是在指示功率大小方面,均优于等螺距真空泵。实验结果表明,所建物理模型能很好地描述真空泵的实际工作过程,对于所研究的机型,变螺距齿型相对于等螺距齿型,其极限真空压力从3.75Pa降低到2.32Pa,指示功率降低了11%。以上内容在螺杆真空泵设计和改型,以及螺杆真空泵产品开发和性能的预测方面都有指导意义。

关键词：双螺杆真空泵变螺距泄漏模型

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小河口水库工程地质问题分析及处理措施

中国水利 2010年第16期 52-54页

作者：周瑞馨山西省临汾市水利勘测设计院

小河口水库始建于1959年，大坝为水中倒土均质碾压坝，现坝高41m。经过多年运行，水库出现了渗漏、不均匀沉陷、坝体裂缝等一些工程地质问题，直接影响水库的安全运行。通过对小河口水库地质问题进行分析研究，对工程处理措施进行了阐述。

关键词：工程地质工程措施劈裂灌浆

Development and parentage analysis of SNP markers for Chestnut-vented Nuthatch(Sitta nagaensis)based on ddRAD-seq data

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Avian Research 2024年第2期15卷 271-278页

作者： Qingmiao Yuan Xi Lu ruixin Mo Xianyin Xu Xu Luo Yubao Duan Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunming 650224China Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China Ministry of EducationSouthwest Forestry UniversityKunming 650224China Key Laboratory of Forest Disaster Warning and Control of Yunnan Province Southwest Forestry UniversityKunming 650224China College of Forestry Southwest Forestry UniversityKunming 650224China Administration of Zixi Mountain Provincial Nature Reserve Chuxiong 675008China

Extra-pair paternity(EPP)is commonly found in socially monogamous birds,especially in small passerine birds,and there are interspecific and intraspecific variations in the extent of *** Chestnut-vented Nuthatch(Sitta nagaensis)is a socially monogamous passerine bird,and verifying whether this species has EPP relies on parentage *** is not known to have *** this study,we developed SNP markers of this species that are informative for parentage analysis from double digest restriction site-associated DNA sequencing(ddRAD-seq)data.A panel consisting of 50 SNP markers,with a mean heterozygosity of 0.343,was used to resolve 95% of nestlings to *** combined exclusion probabilities for the first parent and second parent were 0.991 and 0.9999,*** panel of SNP markers is a powerful tool for parentage assignments in *** addition,we found that three offspring(7.9%)from three nests(23.1%)were the result of extra-pair fertilization out of 38 offspring in 13 *** study provided information on parentage analysis that has not been reported before in *** also supplemented the understudied EPP behavior of birds in Asia,contributing to a general understanding of the EPP behaviors of birds.

关键词： Chestnut-vented Nuthatch ddRAD sequencing Extra-pair paternity Parentage analysis SNPs

Research progress on the design of electrolyte additives and their functions for zinc-ion batteries

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Materials Futures 2024年第1期3卷 31-62页

作者： Yuxin Cui ruixin Zhang Sinian Yang Lili Liu Shimou Chen 1 College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048People’s Republic of China State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology of MaterialsBeijing University of Chemical TechnologyBeijing 10029People’s Republic of China

In recent years,zinc-ion batteries(ZIBs)have been considered one of the most promising candidates for next-generation electrochemical energy storage systems due to their advantages of high safety,high specific capacity and high economic *** an indispensable component,the electrolyte has the function of connecting the cathode and the anode,and plays a key role in the performance of the *** types of electrolytes have different effects on the performance of ZIBs,and the use of additives has further developed the research on modified electrolytes,thus effectively solving many serious problems faced by ***,to further explore the improvement of ZIBs by electrolyte engineering,it is necessary to summarize the current status of the design of various electrolyte additives,as well as their functions and mechanism in *** paper analyzes the challenges faced by different electrolytes,reviews the different solutions of additives to solve battery problems in liquid electrolytes and solid electrolytes,and finally makes suggestions for the development of modified ZIB *** is hoped that the review and strategies proposed in this paper will facilitate development of new electrolyte additives for ZIBs.

关键词： zinc-ion batteries additives liquid electrolytes solid electrolytes interface

Clinical management of a rare melanoma case arising from congenital melanocytic nevus

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Genes & Diseases 2024年第3期11卷 79-82页

作者： ruixin Jiang Yan Wang Xuhui Ma Xinyang Xuanyuan Yanjie Zhang Bin Jiang Weizhen Zhang Hanlin Zeng Department of Oncology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 201900China Department of Oncology The Third People's Hospital of ZhengzhouZhengzhouHenan 450000China Department of Oral&Maxillofacial-Head and Neck Oncology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Shanghai Institute of Precision Medicine Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai200125China Department of Dermatology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China

Congenital melanocytic nevi(CMNs)are skin lesions characterized by benign melanocytic proliferations and present at birth or shortly *** and giant CMNs,with a projected adult size≥20 cm and 40 cm in diameter respectively,are more likely to develop into malignant *** most cases,melanoma arising from congenital melanocytic nevus(CMN)is particularly aggressive.

关键词： melanoma congenital melan