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Smartphone-Based Photoelectrochemical Immunoassay with Co_(9)S_(8)@ZnIn_(2)S_(4) for Point-of-Care Diagnosis of Breast Cancer Biomarker

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Research 2023年第2期2022卷 203-211页

作者： ruijin zeng Yuxuan Li Yanli Li Qing Wan Zhisheng Huang Zhenli Qiu Dianping Tang Key Laboratory of Analytical Sciencefor Food Safety and Biology(MOE Fujian Province) State Key Laboratory of Photocatalysis on Energy and EnvironmentDepartment of ChemistryFuzhou UniversityFuzhou 350108China School of Electronics and Information Engineering Hubei University of Science and TechnologyXianning 437100China Collge of Materials and Chemical Engineering Minjiang UniversityFuzhou 350108China

Photoelectrochemical immunoassays incorporating specific antigen-antibody recognition reactions with the photon-electron conversion capabilities of photocatalysts have been developed for biomarker detection,but most i... 详细信息

关键词： Breast Cancer Immunoassay

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闽南山地桉树人工杂交子代性状测定及选择

森林与环境学报 2016年第2期36卷 160-166页

作者：曾瑞金福建省平和天马国有林场福建平和363704

为选育出一批产量高、抗性强、适合闽南山地栽植的桉树优良家系和优良单株,对闽南山地22个桉树杂种子代家系的生长性状进行分析。结果表明:不同杂种子代家系间的树高均存在显著到极显著的差异,在8.5年生和10年生时,胸径表现出显著到极... 详细信息

为选育出一批产量高、抗性强、适合闽南山地栽植的桉树优良家系和优良单株,对闽南山地22个桉树杂种子代家系的生长性状进行分析。结果表明:不同杂种子代家系间的树高均存在显著到极显著的差异,在8.5年生和10年生时,胸径表现出显著到极显著的差异,单株材积表现出极显著的差异。10年生时,各个家系树高范围为15.61-23.79 m,胸径范围为13.13-20.99 cm,单株材积范围为0.108 7-0.402 1 m3。通过试验选出21号和5号2个杂交子代家系为优良家系,优良家系入选率为9.1%。通过对6个父本类型的子代生长表现进行比较,初步判断以尾叶桉为母本与以巨桉或巨尾桉为父本进行杂交,其子代在闽南地区表现突出。同时,通过试验选出了7株优于尾巨桉无性系-DH32-29的优良单株,其中21号家系中有4株,其单株材积范围为0.476 1-1.633 3 m3,比尾巨桉无性系-DH32-29高出22.42%-319.98%,家系内平均现实增益118.95%;5号家系中有3株,单株材积范围为0.410 7-0.686 4 m3,比尾巨桉无性系-DH32-29高出5.61%-76.50%,家系内平均现实增益75.49%。

关键词：桉树人工杂种子代家系优良单株

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福建漳州巨桉优良家系选择及遗传增益研究

南昌工程学院学报 2016年第3期35卷 55-59页

作者：曾瑞金漳州天马国有林场福建漳州363704

以巨桉子代林30个种源地的150个家系为对象,在福建漳州建立树木园并对其生长性状进行调查分析,结果表明,4年生巨桉平均单株树高、胸径和单株材积分别达到13.12 m、11.2 cm和0.060 2 m3。参试的150个家系中,树高、胸径和材积生长量超过... 详细信息

以巨桉子代林30个种源地的150个家系为对象,在福建漳州建立树木园并对其生长性状进行调查分析,结果表明,4年生巨桉平均单株树高、胸径和单株材积分别达到13.12 m、11.2 cm和0.060 2 m3。参试的150个家系中,树高、胸径和材积生长量超过平均值的分别占家系总数46.7%、38.7%、39.3%,家系136、139、138、134、149、7、126、131、79、120、130、2号在树高、胸径和材积生长量上明显优于其他家系。入选的家系主要分布在新南威尔士范围,树高、胸径和材积累积遗传增益分别为2.96%、9.23%和23.60%,增产效益明显,可作为主要种源地。

关键词：优良家系遗传力巨桉

Multi-site occupancies and luminescence properties of cyan-emitting Ca_(9-x)NaGd_(2/3)(PO_(4))_(7):Eu^(2+)phosphors for white light-emitting diodes

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Journal of Rare Earths 2022年第2期40卷 243-252,I0003页

作者： Shihua Liu Bin Deng Junhui Yang Jinhua Liu Jun Chen Fanhua zeng Huanyou Wang ruijin Yu Gongguo Zhang College of Chemistry&Pharmacy Northwest A&F UniversityYangiing 712100China College of Chemistry&Biology and Environmental Engineering Xiangnan UniversityChenzhou 423043China Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds Research and Application Chenzhou 423043China Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials College of Materials and Chemical EngineeringChina Three Gorges UniversityYichang 443002China Department of Chemistry and Chemical Engineering Jining UniversityQufir 273155China

Cyan-emitting Ca_(9)NaGd_(2/3)(PO_(4))_(7):Eu^(2+)phosphors were synthesized via high temperature solid-state route.X-ray powder diffraction(XRD)and scanning electron microscopy(SEM)were used to verify the phase and morphology of the Ca_(9)NaGd_(2/3)(PO_(4))_(7):Eu^(2+)(CNGP:Eu^(2+))*** as-obtained phosphor exhibits a broad excitation band of 250-420 nm,which is near the ultraviolet *** intense asymmetric cyan emission at 496 nm corresponds to the 5 d-4 f transition of Eu^(2+).The multiplesite luminescent properties of Eu^(2+)ions in CNGP benefit from versatile structure ofβ-Ca3(PO4)2 *** effective energy transfer distance is 5.46 nm(through the spectral overlap calculation),validating that the resonant energy migration type is via dipole-dipole interaction *** to the initial one at room temperature,the luminescent intensity of CNGP:Eu^(2+)phosphor can maintain 77%as it is heated up to 420 K.A white light-emitting diode(WLED)with excellent luminesce nt properties was successfully ***,the CIE chromaticity coordinates of fabricated WLED driven by changing current just change slightly.

关键词： Phosphate Luminescence Eu^(2+)ion Ca_(9-x)NaGd_(2/3)(PO_(4))_(7) Rare earths

TEA domain transcription factor 1(TEAD1)induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1209-1220页

作者： Shuai Song Xiaokai Zhang Zihang Huang Yongchao Zhao Shuyang Lu Linqi zeng Fengze Cai Tongyao Wang Zhiqiang Pei Xinyu Weng Wei Luo Hao Lu Zilun Wei Jian Wu Peng Yu Li Shen Xiaochun Zhang Aijun Sun Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghaiChina State Key Laboratory of Cardiology Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Viral Heart Diseases National Health CommissionShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghaiChina National Clinical Research Center for Interventional Medicine ShanghaiChina Department of cardiac surgery Zhongshan HospitalFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Shanghai Institute of Hypertension Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Cardiac fibroblasts(CFs)are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure(HF).TEAD1 has been shown to be essential for heart development and ***,fibroblast endogenous TEAD1 in cardiac remodeling remains incompletely *** analyses revealed consistently upregulated cardiac TEAD1 expression in mice 4 weeks after transverse aortic constriction(TAC)and Ang-l *** investigation revealed that CFs were the primary cell type expressing elevated TEAD1 levels in response to pressure *** TEAD1 knockout was achieved by crossing TEAD1-floxed mice with CFs-and myofibroblasts-specific Cre *** and histological analyses demonstrated that CFs-and myofibroblasts-specific TEAD1 deficiency and treatment with TEAD1 inhibitor,VT103,ameliorated TAC-induced cardiac ***,RNA-seq and ChiP-seq analysis identified Wnt4 as a novel TEAD1 ***1 has been shown to promote the fibroblast-to-myofibroblast transition through the Wnt signalling pathway,and genetic Wnt4 knockdown inhibited the pro-transformation phenotype in CFs with TEAD1 ***,coimmunoprecipitation combined with mass spectrometry,chromatin immunoprecipitation,and luciferase assays demonstrated interaction between TEAD1 and BET protein BRD4,leading to the binding and activation of the Wnt4 *** conclusion,TEAD1 is an essential regulator of the pro-fibrotic CFs phenotype associated with pathological cardiac remodeling via the BRD4/Wnt4 signallingpathway.

关键词： TEAD1 expression Wnt4

两种灌草管理方式对桉树人工林土壤呼吸的影响

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南昌工程学院学报 2015年第4期34卷 20-25页

作者：蔡乾坤吴建平刘文飞段洪浪袁颖红汤建福曾瑞金樊后保南昌工程学院生态与环境科学研究所江西南昌330099 漳州天马国有林场福建漳州363704

以福建省漳州尾巨桉(Eucalyptus urophylla×***)人工林为研究对象,研究物理去除灌草和施用除草剂2种灌草管理方式对尾巨桉人工林土壤CO2排放和凋落物分解的影响。实验时间为2012年12月至2014年11月,采用LI-COR 8100系统测定土壤呼吸,... 详细信息

以福建省漳州尾巨桉(Eucalyptus urophylla×***)人工林为研究对象,研究物理去除灌草和施用除草剂2种灌草管理方式对尾巨桉人工林土壤CO2排放和凋落物分解的影响。实验时间为2012年12月至2014年11月,采用LI-COR 8100系统测定土壤呼吸,用分解袋法开展分解实验。结果表明,物理去除灌草方式下土壤温度显著升高,但土壤CO2排放降低;施用除草剂对土壤温度和土壤CO2排放无明显影响。土壤呼吸有明显的季节变化,在雨季较高,在旱季则明显降低。土壤呼吸的温度敏感系数Q10表现为去除灌草(2.49)>对照(2.38)>施用除草剂(2.15)。研究表明不同的灌草管理方式对人工林土壤碳循环影响有差异,物理去除对土壤碳排放和物质循环的效应大于施用除草剂。

关键词：土壤呼吸灌草去除除草剂凋落物桉树

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全局3-彩虹控制数等于顶点数的图的刻画

应用数学学报 2024年第3期47卷 417-428页

作者：郝国亮曾淑婷菏泽学院数学与统计学院菏泽274015 东华理工大学理学院南昌330013 瑞金第一中学赣州342506

图G的3-彩虹控制函数是指从G的顶点集V到集合{1,2,3}的幂集的映射f,使得任意满足f(v)=■的顶点v均有∪u∈N(ν)={1,2,3}成立,其中N(v)是顶点v的邻域.图G的3-彩虹控制函数f的权为∑ν∈V|f(ν)|.如果f既是图G又是其补图的3-彩虹控制函数... 详细信息

图G的3-彩虹控制函数是指从G的顶点集V到集合{1,2,3}的幂集的映射f,使得任意满足f(v)=■的顶点v均有∪u∈N(ν)={1,2,3}成立,其中N(v)是顶点v的邻域.图G的3-彩虹控制函数f的权为∑ν∈V|f(ν)|.如果f既是图G又是其补图的3-彩虹控制函数,则称f为图G的全局3-彩虹控制函数.图G的全局3-彩虹控制数是指G的全局3-彩虹控制函数的最小权.通过对图的结构分析,利用分类讨论法完全刻画了全局3-彩虹控制数等于顶点数的所有图.

关键词：全局3-彩虹控制函数全局3-彩虹控制数补图

Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng LIU Tian-shu ZHU Chun-chao GUO Wei-jian DING Hong-hua GUO Yuan-biao LIU Li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei zeng Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(P<0.001).Conclusions In real-world practice for AGC in China,therapy choices consisted with ***-drug regimen was the main first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

上皮下结缔组织瓣移植术对牙周炎附着龈过窄患者附着龈宽度及牙周指标的影响

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中国医学创新 2024年第12期21卷 52-55页

作者：曾四利瑞金市人民医院口腔科江西瑞金342500

目的:探究上皮下结缔组织瓣移植术对牙周炎附着龈过窄患者附着龈宽度及牙周指标的影响。方法:选取瑞金市人民医院口腔科在2021年6月—2023年2月收治的101例牙周炎附着龈过窄患者作为研究对象,按随机数字表法分为观察组(51例)和对照组(50... 详细信息

目的:探究上皮下结缔组织瓣移植术对牙周炎附着龈过窄患者附着龈宽度及牙周指标的影响。方法:选取瑞金市人民医院口腔科在2021年6月—2023年2月收治的101例牙周炎附着龈过窄患者作为研究对象,按随机数字表法分为观察组(51例)和对照组(50例)。对照组行根向复位瓣术,观察组行上皮下结缔组织瓣移植术。观察两组疗效、附着龈宽度、牙周指标及并发症情况。结果:观察组总有效率(96.08%)高于对照组(82.00%),差异有统计学意义(P0.05)。结论:上皮下结缔组织瓣移植术对牙周炎附着龈过窄患者有良好的疗效,可有效增加附着龈宽度,改善牙周指标。

关键词：上皮下结缔组织瓣移植术牙周炎附着龈宽度牙周指标