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Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei xia Yue ma Mingtong Gao Shuai Hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

40～55岁社区妇女围绝经期症状和焦虑、抑郁症状评分及相关因素分析

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复旦学报（医学版） 2017年第1期44卷 27-33页

作者：李瑞霞马敏肖喜荣徐嬿顾超何平李斌复旦大学附属妇产科医院妇科上海200011 上海交通大学医学院附属新华医院儿科医学研究所上海200092

目的了解40~55岁社区妇女围绝经期症状和焦虑、抑郁症状评分及其相关因素,为开展社区妇女干预提供依据。方法采用简单抽样方法,从北京市东城区和上海市杨浦区抽取1 312名40~55岁社区妇女为调查对象,应用Kupperman、SAS、SDS量表和自编... 详细信息

目的了解40~55岁社区妇女围绝经期症状和焦虑、抑郁症状评分及其相关因素,为开展社区妇女干预提供依据。方法采用简单抽样方法,从北京市东城区和上海市杨浦区抽取1 312名40~55岁社区妇女为调查对象,应用Kupperman、SAS、SDS量表和自编问卷进行调查。最优尺度回归和Logistic多元回归分析围绝经期症状、焦虑和抑郁症状的相关因素。结果 40~55岁社区妇女围绝经期症状的检出率为50.8%,焦虑症表现的检出率为9.5%,抑郁症表现的检出率为25.9%。最优尺度和Logistic多元回归分析的回归模型显示:家庭月收入、有无慢性病和性生活与Kupperman、SAS、SDS评分显著相关;文化程度与SDS评分显著相关。围绝经期症状是焦虑和抑郁的相关危险因素,围绝经期症状的严重程度则是焦虑的相关危险因素。结论围绝经期症状及相关的焦虑、抑郁症状影响围绝经期妇女的身心健康,性生活、家庭月收入、慢性病等与此显著相关。

关键词：社区妇女围绝经期症状 Kupperman评分 SDS评分 SAS评分相关因素

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang ma xiaoping Gu Tianjiao xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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内蒙古对外贸易可持续发展路径分析

内蒙古财经大学学报 2017年第1期15卷 60-63页

作者：杨瑞霞麻海山内蒙古师范大学马克思主义学院内蒙古呼和浩特010022

随着我国经济发展进入新常态,对各领域发展都提出了可持续发展的新要求。十八届五中全会明确提出新常态下要坚持创新、协调、绿色、开放、共享五大发展理念。内蒙古作为我国北疆沿边地区,虽然资源丰富,但是对外贸易发展却相对缓慢且存... 详细信息

随着我国经济发展进入新常态,对各领域发展都提出了可持续发展的新要求。十八届五中全会明确提出新常态下要坚持创新、协调、绿色、开放、共享五大发展理念。内蒙古作为我国北疆沿边地区,虽然资源丰富,但是对外贸易发展却相对缓慢且存在诸多问题。在新的发展理念指导下,内蒙古必须依托资源、区位等传统优势,充分利用"一带一路"倡议构想等良好的政策环境,创新发展路径,构建动态化优势,实现对外贸易可持续发展。

关键词：内蒙古对外贸易可持续发展路径

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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基于重采样改进的多图谱分割算法

计算机工程与设计 2018年第8期39卷 2587-2592,2659页

作者：夏瑞马瑜王文娜罗宇卓尚梦玉宁夏大学物理与电子电气工程学院宁夏银川750021

为在保证多图谱分割精确度的基础上,提高算法的时间效率,提出基于重采样改进的多图谱分割算法。利用重采样代替粗配准环节,在配准分割过程中,通过两次提取分割组织为中心的感兴趣区域,有效降低数据规模。在标签融合阶段利用K近邻搜素算... 详细信息

为在保证多图谱分割精确度的基础上,提高算法的时间效率,提出基于重采样改进的多图谱分割算法。利用重采样代替粗配准环节,在配准分割过程中,通过两次提取分割组织为中心的感兴趣区域,有效降低数据规模。在标签融合阶段利用K近邻搜素算法改进基于图像块的标签融合方法。实验结果表明,该算法实现了在较高的配准精度下,高效率得到分割结果。

关键词：多图谱配准重采样感兴趣区域微分同胚图像块 K近邻搜素

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

皮下埋植避孕剂缓解子宫内膜异位症患者疼痛的临床评价

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中国初级卫生保健 2017年第10期31卷 35-36页

作者：史瑞霞董瑞马瑞兰张文辉陶明瑛甘肃省计划生育科学技术研究所兰州730000

目的研究皮下埋植避孕剂缓解子宫内膜异位症患者疼痛的临床效果。方法选择90例疑似为子宫内膜异位症的患者为研究对象,将拒绝手术治疗的60例分为皮下埋植避孕剂组(A组)和达那唑组(B组),将同意手术的30例纳入腹腔镜保守手术+Gn RH-a组(C... 详细信息

目的研究皮下埋植避孕剂缓解子宫内膜异位症患者疼痛的临床效果。方法选择90例疑似为子宫内膜异位症的患者为研究对象,将拒绝手术治疗的60例分为皮下埋植避孕剂组(A组)和达那唑组(B组),将同意手术的30例纳入腹腔镜保守手术+Gn RH-a组(C组)。A组放置Ⅱ型皮下埋植避孕剂。B组口服达那唑胶囊,2次/日,连用6个月。C组行腹腔镜保守手术治疗后,在患者月经来潮5日内肌注达菲林3.75 mg,每隔4周一次,共6次。结果治疗前和治疗6个月后采用视觉评分法(VAS)痛经、盆腔痛、性交痛评分及月经失血图评分法(PBAC)经量评分三组内比较差异均有统计学意义(P0.05)。结论皮下埋植避孕剂能有效缓解子宫内膜异位症患者的痛经、性交痛和盆腔痛,减少月经量,为不愿长期服药和拒绝手术治疗,尤其是没有生育要求的患者提供了新的选择和方法。

关键词：皮下埋植避孕剂子宫内膜异位症临床评价

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying ma Jia Liu xiang xia Ning Xu Wen Sun Jianjun Du Jiangli Fan xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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