检索结果-南通市图书馆

Synthesis of 2-Heterocyclomethyl-5-diphenylmethylene-cyclopentanone Hydrochlorides and their Inhibitory Effect on Tumor Cell Growth

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第9期17卷 1181-1184页

作者： Yun Hai ZHANG Lin Xiang ZHAO Zhen Jun BIAN rui WANG fu yuan SUN School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016

Sixteen new 2-heterocyclomethyl-5-diphenylmethylenecyclopentanone hydrochlorides were designed and synthesized. The growth inhibitory effect of these compounds in vitro was conducted using a MTF assay in human breast ... 详细信息

关键词： Cyclopentanone synthesis growth inhibition.

基于时间节律讨论针灸应用十二经纳地支歌治疗疾病的科学内涵

在线全文

学校读者我要写书评

暂无评论

按摩与康复医学 2022年第17期13卷 1-5,9页

作者：傅睿媛朱俊成都中医药大学针灸推拿学院/第三附属医院四川成都610075

十二经纳地支歌以“时机”为核心,阐述了人体经脉气血流注与昼夜的十二时辰转换的联系,知其生理,以推其病理,以常衡变,有助于临床根据症状出现的时间,预判即将出现的症状、诊断中病脏腑、制定治疗方案、判断预后。十二经纳地支歌对于针... 详细信息

十二经纳地支歌以“时机”为核心,阐述了人体经脉气血流注与昼夜的十二时辰转换的联系,知其生理,以推其病理,以常衡变,有助于临床根据症状出现的时间,预判即将出现的症状、诊断中病脏腑、制定治疗方案、判断预后。十二经纳地支歌对于针灸治疗脏腑病、精神类疾病、时辰病的早期发现与治疗具有重要指导意义,与现代的针灸时间医学有部分共同之处。基于时间医学理论讨论针灸应用十二经纳地支歌治疗疾病的科学内涵,旨在为临床针灸使用者提供一种新的诊治思路。

关键词：十二经纳地支歌时间医学时机针刺选穴

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang yuan-Ming Pan Wei Li rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-Wei fu Yue-Jing Li Ran Yu rui-Qing Guo Li-Xia Gao Sheng-Xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect

Preparation of Polylactide/Poly(ether)urethane Blends with Excellent Electro-actuated Shape Memory via Incorporating Carbon Black and Carbon Nanotubes Hybrids Fillers

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2018年第10期36卷 1175-1186页

作者： yuan Wei rui Huang Peng Dong Xiao-Dong Qi Qiang fu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University

In this work, hybrid conductive fillers of carbon black （CB） and carbon nanotubes （CNTs） were introduced into polylactide （PLA）/thermoplastic poly（ether）urethane （TPU） blend （70/30 by weight） to tune the phase morphology and realize rapid electrically actuated shape memory effect （SME）. Particularly, the dispersion of conductive fillers, the phase morphology, the electrical conductivities and the shape memory properties of the composites containing CB or CB/CNTs were comparatively investigated. The results suggested that both CB and CNTs were selectively localized in TPU phase, and induced the morphological change from the sea-island structure to the co-continuous structure. The presence of CNTs resulted in a denser CB/CNTs network, which enhanced the continuity of TPU phase. Because the formed continuous TPU phase provided stronger recovery driving force, the PLA/TPU/CB/CNTs composites showed better shape recovery properties compared with the PLA/TPU/CB composites at the same CB content. Moreover, the CB and CNTs exerted a synergistic effect on enhancing the electrical conduetivities of the composites. As a result, the prepared composites exhibited excellent electrically actuated SME and the shape recovery speed was also greatly enhanced. This work demonstrated a promising strategy to achieve rapid electrically actuated SME via the addition of hybrid nanoparticles with self-networking ability in binary PLA/TPU blends over a much larger composition range.

关键词： Polymer composites Shape memory polymer Co-continuous structure Self-networking behavior Hybrid filler

《有机化学实验》中合成与制备实验教学方法的探讨

在线全文

学校读者我要写书评

暂无评论

铁道师院学报 2000年第4期17卷 45-49页

作者：宋瑞峰袁福根龚青苏州铁道师范学院化学系苏州215009

提出了改进有机化学实验中合成与制备实验教学的思路和方法。明确了在教学过程中建立有机合成反应研究基本思路的必要性。尝试“讨论释疑、技能训练、自我小结”的课堂教学法 ,重视思维训练。

关键词：有机化学实验教学法合成实验制备实验学生

Multiple different remote epidural hematomas after craniotomy:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第6期10卷 1863-1868页

作者： Qiang He Chuan-yuan Tao rui-Hong fu Chao You Department of Neurosurgery West China HospitalChengdu 610041Sichuan ProvinceChina Department of Neurology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Epidural hematoma is one of the common postoperative complications after ***,multiple remote epidural hematomas in different sites,including supratentorial and infratentorial regions,are exceedingly *** SUMMARY We present a rare case in which three remote epidural hematomas occurred after craniotomy.A 21-year-old woman was admitted with a headache for 1 mo,vomiting,and rapid vision loss for 1 *** magnetic resonance imaging indicated a right thalamic *** intraoperative diagnosis was a cystic tumor,posterior cerebral artery aneurysm,and vascular *** operation was ***,the patient developed three extradural hematomas within 48 *** members consented to the first two hematoma evacuations but refused the *** More attention should be paid to this kind of rare *** preoperative evaluation is important,especially for acute *** neural function and early computed tomography scanning of the brain after surgery should be highlighted.

关键词： Postoperative complication Multiple epidural hematomas Supratentorial and infratentorial regions Remote epidural hematoma Case report

The Influence of Co Addition on Phase Transformation Behavior and Mechanical Properties of TiNi Alloys

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2007年第2期20卷 153-156页

作者： JING rui-rui LIU fu-shun School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100083 China

The influences of Co-addition on phase transformation behavior and mechanical properties of TiN/alloys were investigated. Resuits indicate that, as a substitute for Ni, Co added to TiNi alloys can dramatically decrease the martensite transformation temperature, and R phase transformation and martensite transformation are accordingly separated. When Co-content reach 10 at.%, the martensite transformation temperature is lower than that of liquid nitrogen. During deformation at room temperature, Ti50Ni48Co2 alloy exhibits good ductility with a lower stress plateau caused by stress-induced martensite and martensite reorientation.

关键词： TiNiCo shape memory alloy martensite transformation mechanical property

Recent advances in theoretical models of respiratory mechanics

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2012年第1期28卷 1-7页

作者： Bo Huo rui-Rong fu Key Laboratory of Microgravity&Center for Biomechanicsand Bioengineering Institute of Mechanics Chinese Academy of Sciences100190 BeijingChina

As an important branch of biomedical engineering, respiratory mechanics helps to understand the physiology of the respiratory system and provides fundamental data for developing such clinical technologies as ventilators. To solve different clinical problems, researchers have developed numerous models at various scales that describe biological and mechanical properties of the respiratory system. During the past decade, benefiting from the continuous accumulation of clinical data and the dramatic progress of biomedical technologies （e.g. biomedical imaging）, the theoretical modeling of respiratory mechanics has made remarkable progress regarding the macroscopic properties of the respiratory process, complexities of the respiratory system, gas exchange within the lungs, and the coupling interaction between lung and heart. The present paper reviews the advances in the above fields and proposes potential future projects.

关键词： Respiratory mechanics Biomechanics Gas exchange