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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu rui wang Hanyue Zhang Xiou wang Sijia Zhou Bo Ma Yan Luan Xin wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology research 2025年第1期33卷 225-234页

作者： Wei Zhang Weicheng wang rui wang Xiao Han Lijun Zhu Wenjie Guo Yanhong Gu Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China. Department of Oncology The Affiliated Taizhou People's Hospital of Nanjing Medical University Taizhou 225300 China. State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210023 China.

Background:As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC. This study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating CRC.Methods and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax's efficacy against tumors. Then we employed various techniques to evaluate different aspects of the experimental outcomes. Immunohistochemistry was used to detect cell proliferation and angiogenesis in tumor tissues. Western blot analysis was utilized to examine the occurrence of cell apoptosis, and flow cytometry to quantitate immune cells within the tumor tissues. Moreover, immunofluorescence was employed to measure cytokine levels.Results:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax, as opposed to individual drug use. Venetoclax was found to amplify the impact of fruquintinib, leading to decreased cancer cell proliferation, increased cancer cell apoptosis, lowered angiogenesis, better vascular structure normalization, and improved immune cell infiltration.Conclusion:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune microenvironment. Our study presents the justification for utilizing the fruquintinib and venetoclax combination in treating CRC. Venetoclax holds promise in being assimilated into anticancer medications for CRC.

关键词： Anti-angiogenesis B-cell lymphoma protein 2 (BCL2) Colorectal cancer (CRC) Fruquintinib Immunotherapy Vascular endothelial growth factor receptor (VEGFR) Venetoclax

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基于应急疏散的滨海地下交通枢纽空间精细化分区研究

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灾害学 2025年第1期40卷 227-234页

作者：瞿扬李彦潼张赫王睿天津大学建筑学院天津300072

暴雨和洪涝对滨海城市的地下空间构成严重威胁,应急疏散效率在受灾场景中至关重要。研究表明空间分区能有效提高疏散效率。目前传统分区方法依赖单一的最短路径方法,无法兼顾安全与高效。该文基于安全性评估提出了一种精细化分区方法。... 详细信息

暴雨和洪涝对滨海城市的地下空间构成严重威胁,应急疏散效率在受灾场景中至关重要。研究表明空间分区能有效提高疏散效率。目前传统分区方法依赖单一的最短路径方法,无法兼顾安全与高效。该文基于安全性评估提出了一种精细化分区方法。首先以应急疏散为目的,对地下空间按功能划分;其次考虑到灾害风险性、人员聚集性和设施高效性三个维度的影响因素,并构建安全性分区评价体系;最后综合上述因素,构建精细化分区划定体系。文章以深圳红树湾地铁站为案例,验证了新方法在保障疏散安全的同时,提升了疏散效率,为地下交通枢纽的防灾规划提供了理论支持。

关键词：地下交通枢纽空间应急疏散安全性分区精细化分区

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An explanation about the flat radio spectrum for Mrk 421

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Research in Astronomy and Astrophysics 2021年第4期21卷 311-318页

作者： rui Xue Ze-rui wang Department of Physics Zhejiang Normal UniversityJinhua 321004China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China

It is well known that a flat radio spectrum is a common property in the spectral energy distribution of *** one-zone leptonic models are generally successful in explaining the multi-wave band emission,they are problematic in reproducing the radio *** the study of Mrk 421,one-zone models suggest that in order to avoid overproducing the radio flux,the minimum electron Lorentz factor should be larger than a few hundred at least,even considering the synchrotron self-absorption *** result suggests that the model predicted spectral index in the radio band of Mrk 421 should be-1/*** the basis of this result,by assuming there is a neglected region that will also contribute the radio emission and its electron energy index naturally originates from the simplest first-order Fermi acceleration mechanism,we can get a superimposed flat radio *** this paper,a two-zone model is proposed to reproduce the quiescent state spectral energy distribution of Mrk *** addition to taking into account the emission from a conventional radiation zone,we further consider emission from the acceleration zone in which particles are accelerated at a shock *** the present model,our fitting result suggests that the low frequency flat radio spectrum of Mrk 421 might be explained as a superposition of the synchrotron emission from acceleration zone and radiation zone.

关键词： galaxies:active galaxies:jets radiation mechanisms:non-thermal

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Hadronuclear interpretation of the possible neutrino emission from PKS B1424-418,GB6 J1040+0617 and PKS 1502+106

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Research in Astronomy and Astrophysics 2021年第12期21卷 375-382页

作者： Ze-rui wang rui Xue College of Physics and Electronic Engineering Qilu Normal UniversityJinhua 321004China Department of Physics Zhejiang Normal UniversityJinan 250200China

In addition to neutrino event IceCube-170922 A which is observed to be associated with aγ-ray flare from blazar TXS 0506+056,there are also several neutrino events that may be associated with *** them,PKS B1424-418,GB6 J1040+0617 and PKS 1502+106 are low synchrotron peaked sources,which are usually believed to have the broad line region in the vicinity of the central black *** are considered as counterparts of IceCube event 35,IceCube-141209 A and IceCube-190730 A,*** considering the proton-proton(pp)interactions between the dense gas clouds in the broad line region and the relativistic protons in the jet,we show that the pp model that is applied in this work can not only reproduce the multi-waveband spectral energy distribution but also suggest a considerable annual neutrino detection *** also discuss the emission from the photopion production and Bethe-Heitler pair production with a sub-Eddington jet power that is suggested in our model and find that it has little effect on the spectrum of total emission for all of three sources.

关键词： neutrinos galaxies:active galaxies:jets radiation mechanisms:non-thermal

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Origin and tectonic setting of low-Si alkaline magma

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Science China Earth Sciences 2024年第5期67卷 1417-1435页

作者： Qiushi ZHOU rui wang State Key Laboratory of Geological Processes and Mineral Resources and Institute of Earth SciencesChina University of GeosciencesBeijing 100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing 100083China

Despite of the relatively rare occurrence of alkaline igneous rocks on Earth, they are the most diverse group of igneous rocks due to variations in their mineral assemblages and geochemical compositions. Alkaline igneous rocks are generally characterized by Si undersaturation, and K-Na(and in some cases C) enrichment. Although there is no unified alkaline igneous rock classification scheme, diagrams such as total alkalis-SiO_(2) or K_(2)O-SiO_(2) can be used to classify alkaline igneous rocks. The origins of silica-saturated alkaline rocks(SiO_(2)>52 wt.%) are relatively complex because multiple episodes of magmatism are often involved, therefore most studies have focused on the origins of silica-undersaturated alkaline *** experimental petrological studies have been conducted in the past few decades. Initially, it was considered that enrichment of trace elements was only achieved by low-degree partial melting of mantle peridotite, but the experimental melts could not reproduce the geochemical composition of natural alkaline igneous rocks. Subsequent studies have focused on carbonate-bearing eclogites that represent the average component of subducted oceanic crust. Although experimental studies indicate that silica-undersaturated and alkali-oversaturated melts can be generated from eclogites, some studies have considered that natural silica-undersaturated alkaline igneous rocks are the result of multi-stage source enrichment by incompatible elements. Low-degree partial melts of the mantle can be emplaced in the lithospheric mantle, forming veins consisting of phlogopite, amphibole, and pyroxene. Melting experiments including these components show that the produced melts better reproduce the naturally occurring silica-undersaturated alkaline magmas. Silica-deficient alkaline igneous rocks occur in various tectonic settings. Those in intraplate and divergent settings(i.e., mainly continental rifts) normally involve contributions from recycled components su

关键词： Alkaline igneous rock Tectonic setting Petrogenesis Big data

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Adaptive formation control of quadrotor unmanned aerial vehicles with bounded control thrust

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Chinese Journal of Aeronautics 2017年第2期30卷 807-817页

作者： wang rui Liu Jinkun School of Automation Science and Electrical Engineering Beihang University Beijing 100083 China

In this paper,the flight formation control problem of a group of quadrotor unmanned aerial vehicles（UAVs） with parametric uncertainties and external disturbances is *** are used to represent the attitudes of the quadrotor *** the model into a translational subsystem and a rotational subsystem,an intermediary control input is introduced to track a desired velocity and extract desired *** considering the internal parametric uncertainties and external disturbances of the quadrotor UAVs,the priori-bounded intermediary adaptive control input is designed for velocity tracking and formation keeping,by which the bounded control thrust and the desired orientation can be ***,an adaptive control torque input is designed for the rotational subsystem to track the desired *** the proposed control scheme,the desired velocity is tracked and a desired formation shape is built *** stability of the closed-loop system is proven via Lyapunov-based stability *** simulation results are presented to illustrate the effectiveness of the proposed control scheme.

关键词： Adaptive control Bounded input Formation control Parametric uncertainties Quadrotor UAV Unit-quaternions

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Research on metadata in manufacturing-oriented EAI

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Journal of Systems Engineering and Electronics 2007年第2期18卷 418-426页

作者： wang rui Li Congxin National Die & Mould CAD Engineering Research Center Shanghai Jiaotong Univ. Shanghai 200030 P. R. China

Enterprise application integration （EAI） focuses on the collaboration and interconnection of various information systems, so the basic problem to be solved is how EAI guarantees that the applications will produce consistent presentation of data, message and transaction. The metadata methodology may give us certain good ideas. First, the metadata description method of manufacturing information resource, transaction process and message delivery is put forward on the basis of operation analysis of manufacturing-oriented EAI, and then the tree-structured XML schema of corresponding object is built and a framework of metadata application in the discrete Manufacturing-Oriented EAI is established. Finally, a practical enterprise information integration system in Shanghai Tobacco Machine Co., Ltd. is presented as an example to show how it functions.

关键词： Discrete manufacturing Enterprise application integration Metadata XML schema.

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Seasonal freeze-thaw processes impact microbial communities of soil aggregates associated with soil pores on the Qinghai–Tibet Plateau

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Ecological Processes 2024年第2期13卷 279-292页

作者： rui-Zhe wang Xia Hu State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical Science Beijing Normal University School of Natural Resources Faculty of Geographical Science Beijing Normal University

Background Seasonal freeze-thaw(FT) processes alter soil formation and cause changes in soil microbial communi-ties, which regulate the decomposition of organic matter in alpine ecosystems. Soil aggregates are basic structural units and play a critical role in microbial habitation. However, the impact of seasonal FT processes on the distribution of microbial communities associated with soil pores in different aggregate fractions under climate change has been overlooked. In this study, we sampled soil aggregates from two typical alpine ecosystems(alpine meadow and alpine shrubland) during the seasonal FT processes(UFP: unstable freezing period, SFP: stable frozen period, UTP: unstable thawing period and STP: stable thawed period). The phospholipid fatty acid(PLFA) method was used to determine the biomass of living microbes in different aggregate *** The microbial biomass of 0.25–2 mm and 0.053–0.25 mm aggregates did not change significantly dur-ing the seasonal FT process while the microbial biomass of > 2 mm aggregates presented a significant difference between the STP and UTP. Bacterial communities dominated the microbes in aggregates, accounting for over 80% of the total PLFAs. The microbial communities of soil aggregates in the surface layer were more sensitive to the sea-sonal FT process than those in other soil layers. In the thawing period, Gram positive bacteria(GP) was more dominant. In the freezing period, the ratio of Gram-positive to Gram-negative bacterial PLFAs(GP/GN) was low because the enrichment of plant litter facilitated the formation of organic matter. In the freezing process, pores of 30–80 μm(mesopores) favored the habitation of fungal and actinobacterial communities while total PLFAs and bacterial PLFAs were negatively correlated with mesopores in the thawing *** The freezing process caused a greater variability in microbial biomass of different aggregate fractions. The thawing process increased the differences in

关键词： Phospholipid fatty acid Seasonal freeze-thaw process Soil aggregate Soil microbial biomass Soil pore

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A Remark on Extension of Into Isometries

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Acta Mathematica Sinica,English Series 2010年第1期26卷 203-208页

作者： rui Dong wang School of Mathematics Nankai University Tianjin 300071 P. R. China Department of Mathematics Tianjin University of Technology Tianjin 300191 P. R. China

In this paper, we prove that an into isometry form S（l（n）^∞） to S（E）, which under some conditions, can be extended to be a linear isometry defined on the whole space. Therefore we improve the results of [Ding, G. G.： The isometric extension of an into mapping from the unit sphere S（l（2）^∞） to S（Lμ^1）. Acta Mathematica Sinica, English Series, 22（6）, 1721-1724 （2006）].

关键词： isometric extension Tingley's problem l(n)^∞-space

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